Mks1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mks1
Entrez Gene ID	380718
Full Name	Meckel syndrome, type 1
Synonyms	AK190930,B8d3,avc6
General protein information	Preferred Names Meckel syndrome, type 1 Names Meckel syndrome type 1 protein homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 C

mRNA and Protein(s)

mRNA	Protein	Name
XM_006533645.3	XP_006533708.1	Meckel syndrome type 1 protein homolog isoform X1
XM_017314631.2	XP_017170120.1	Meckel syndrome type 1 protein homolog isoform X1
NM_001039684.3	NP_001034773.2	Meckel syndrome type 1 protein homolog
NM_001039684.2	NP_001034773.2	Meckel syndrome type 1 protein homolog
XM_017314631.1	XP_017170120.1	Meckel syndrome type 1 protein homolog isoform X2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC101905689	XP_005220007.1
Rattus norvegicus (Norway rat)	Mks1	NP_001030089.2
Pan troglodytes (chimpanzee)	MKS1	XP_001172592.1
Mus musculus (house mouse)	Mks1	NP_001034773.2
Gallus gallus (chicken)	MKS1	XP_415705.3
Danio rerio (zebrafish)	mks1	NP_001070841.2
Xenopus tropicalis (tropical clawed frog)	mks1	NP_001039150.1
Canis lupus familiaris (dog)	MKS1	XP_003639341.1
Homo sapiens (human)	MKS1	NP_060247.2

Gene Ontology
Bibliography

Related articles in PubMed

A staging system for correct phenotype interpretation of mouse embryos harvested on embryonic day 14 (E14.5).
Geyer SH, Reissig L, Rose J, Wilson R, Prin F, Szumska D, Ramirez-Solis R, Tudor C, White J, Mohun TJ, Weninger WJ
Journal of anatomy230(5)710-719(2017 May)

The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.
Goetz SC, Bangs F, Barrington CL, Katsanis N, Anderson KV
PloS one12(3)e0173399(2017)

Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.
Burnicka-Turek O, Steimle JD, Huang W, Felker L, Kamp A, Kweon J, Peterson M, Reeves RH, Maslen CL, Gruber PJ, Yang XH, Shendure J, Moskowitz IP
Human molecular genetics25(14)3011-3028(2016 07)

Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.
Cui C, Chatterjee B, Lozito TP, Zhang Z, Francis RJ, Yagi H, Swanhart LM, Sanker S, Francis D, Yu Q, San Agustin JT, Puligilla C, Chatterjee T, Tansey T, Liu X, Kelley MW, Spiliotis ET, Kwiatkowski AV, Tuan R, Pazour GJ, Hukriede NA, Lo CW
PLoS biology11(11)e1001720(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

demonstrated that the MKS transition zone complex cooperates with the BBSome to mediate trafficking of specific trans-membrane receptors to the cilium
Title: The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.

Dnah11(avc)(4) did not disrupt SHF Hh signaling and caused Atrioventricular septal defects (AVSDs) only concurrently with heterotaxy, a left/right axis abnormality. In contrast, Mks1(avc)(6) disrupted SHF Hh signaling and caused AVSDs without heterotaxy.We speculate that cilia gene mutations contribute to both syndromic and non-syndromic AVSDs in humans
Title: Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.

Centriole localization of Mks1 is required for ciliogenesis of motile and non-motile cilia, but not for centriole assembly.
Title: Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome.

Mks1 is required for ciliogenesis and shh signaling in mouse model of human meckel syndrome.
Title: A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling.

Mks1 expression in mouse embryos, as determined by in situ hybridization, agrees well with the tissue phenotype of MKS.
Title: MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndrome.

The following Mks1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mks1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu20047	NM_001039684.3 Latest version!	Mus musculus Meckel syndrome, type 1 (Mks1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$328.30 $469.00
OMu46543	XM_006533645.3 Latest version!	Mus musculus Meckel syndrome, type 1 (Mks1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu77960	XM_017314631.2 Latest version!	Mus musculus Meckel syndrome, type 1 (Mks1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu20047	NM_001039684.2	Mus musculus Meckel syndrome, type 1 (Mks1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$328.30 $469.00
OMu77960	XM_017314631.1	Mus musculus Meckel syndrome, type 1 (Mks1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mks1 ( NM_001039684.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001034773.2 Mus musculus Meckel syndrome, type 1 (Mks1), mRNA.

Price & Availability↑

CloneID	OMu20047
Clone ID Related Accession (Same CDS sequence)	NM_001039684.3 , NM_001039684.2
Accession Version	NM_001039684.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1686bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Mus musculus(house mouse)
Product	Meckel syndrome type 1 protein homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK044912.1, DQ177342.1 and AA290154.1. On Jul 6, 2018 this sequence version replaced NM_001039684.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.175829.1, AK030982.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAAG CGGTCTGGAG CACTGACACC GGCGAGGCCG TGTATCGCTC CCGGGACCCC 
GTGCGCAACC TGCGCCTCCG AGTTCATCTG CAAAGAATCA CATCAAGCAA CTTCCTTCAT 
TACCAGCCTG CTGCCCAGAT GGGGAAGGAC CTCATAGACT TGGCCACTTT TAGGCCTCCG 
CAAGCTGCTA GTGGACACCG CCCTGACGAA GAAGAGGAGG AAGAGGTTGT AATTGGATGG 
CAGGAAAAGC TCTTTAGCCA GTTTGAAGTC GACCTGTACC AAAATGAATC CGCGTGCCAG 
AGCCCACTGG ATCATCAGTA CCGCCAAGAG ATCTTGAAAC TGGAGAATTC TGGCGGCAGG 
AAAAACCGGC GAATCTTCAC TTACACTGAC TCGGATAGAT ACACCGACTT GGAAGAGTAC 
TGTCAGAAAA TAACCACTTC AGCCAGCGAG GTGCCATCGT TTCTGGCTGA GCGGATGGCG 
AACGTCAGGC GGCGGCGGCA GGACAGGCGA GGGGTGGAGG GCAGCAAACT CAAGTCTCGG 
ATCGTCACGT GGGAACCCTC GGAAGACTTC ATCAAGAACA ACCACGCTAT TAACACTCCT 
CTTCAGACAA TGTACATCAT GGCGGACCTG GGACCCTATG GAAAGCTTGG CTATAAGGTA 
CATGAGCACG TGCTCTGCAT CCTGAAGGTG GACAGCAATG GCGTGATCAC AGTGAAGCCT 
GACTTCACCG GCATCAAAGG ACCCTACAGA ATCGAAACTG AGGGAGAGAA GCAGGAACAC 
ACTTCTGCTT GGAAATACAC AATTGACAAC GTGTCCTCCC TCGCACAGCC AGAGGAGGAA 
GAGCGGGAGC AGCGAGTGTT CAAGGACCTT TACGGCCGGC ACAAGGAGTA CCTCAGCAGC 
CTCGTGGGCA CAGACTTTGA GATGATTGCC CCAGGTGCCC TCCGGCTCTT TGTGAACGGA 
GAGGTGGTTT CAGCCCAAGG CTATGAGTAT GACAACCTCT ACGTCCACTT CTTTGTGGAG 
CTGCCAGCTG CTAACTGGTC CAGCCCGCCA TTCCAGCAGC TCTCGGGAGT AACCCAGGCC 
TGTGCCACCA AATCCCTGGG AATGGACAAG GTGGCCTATT TCTCCTTTCC GTTCACATTC 
GAAGCCTTCT TTCTGCATGA GGACGAATCG GCTGAGTCCC TCCCGGAGTG GCCTGTGCTC 
TACTGTAAGG TCCTCTCACT GGACTTCTGG CAGAGGTATC GTGTGGAAGG CTACGGGGCT 
GTGGTGCTGC CTGCCACTCC AGGATCCCAC ACCCTGACTG TCTCCACATG GAGGCCCATG 
GAGCTGGGTC TCGTGGCAGA GCTAAGGAGG TTCTTCATTG GCGGCTCTCT GGAGCTGGAG 
GACCCATCCT ATGTGAGGAT ACCAGGAACC TTCAAGGGGG AGCGCCTGAG CCGCTTTGGA 
TTCCGCACTG AGACAACGGG TACTGTCACC TTCCGATTGC ACTGCCTGCA GCAGTCCCGG 
GCTTTCATGG AATCGAACTC CCTCCAGAAA CAGATGCGGA GTGTGTTGGA CCGTCTGGAA 
GGGTTCAGCC AGCAGAGTTC CACGCACAAC GTGCTAGAAG CATTCCGTCG AGCCCGGCGT 
CGGATGCAGG AGGCCCGAGA GAGCCTCCCC CAGGACCTTG TGAGCCCCAC GGGAACGTTG 
ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034773.2
CDS	36..1721
Translation	MAEAVWSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAQMGKDLIDLATFRPPQAASGHRPDEEEEEEVVIGWQEKLFSQFEVDLYQNESACQSPLDHQYRQEILKLENSGGRKNRRIFTYTDSDRYTDLEEYCQKITTSASEVPSFLAERMANVRRRRQDRRGVEGSKLKSRIVTWEPSEDFIKNNHAINTPLQTMYIMADLGPYGKLGYKVHEHVLCILKVDSNGVITVKPDFTGIKGPYRIETEGEKQEHTSAWKYTIDNVSSLAQPEEEEREQRVFKDLYGRHKEYLSSLVGTDFEMIAPGALRLFVNGEVVSAQGYEYDNLYVHFFVELPAANWSSPPFQQLSGVTQACATKSLGMDKVAYFSFPFTFEAFFLHEDESAESLPEWPVLYCKVLSLDFWQRYRVEGYGAVVLPATPGSHTLTVSTWRPMELGLVAELRRFFIGGSLELEDPSYVRIPGTFKGERLSRFGFRTETTGTVTFRLHCLQQSRAFMESNSLQKQMRSVLDRLEGFSQQSSTHNVLEAFRRARRRMQEARESLPQDLVSPTGTLT

Target ORF information:

RefSeq Version	NM_001039684.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus Meckel syndrome, type 1 (Mks1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039684.3

ORF Insert Sequence:

ATGGCGGAAG CGGTCTGGAG CACTGACACC GGCGAGGCCG TGTATCGCTC CCGGGACCCC 
GTGCGCAACC TGCGCCTCCG AGTTCATCTG CAAAGAATCA CATCAAGCAA CTTCCTTCAT 
TACCAGCCTG CTGCCCAGAT GGGGAAGGAC CTCATAGACT TGGCCACTTT TAGGCCTCCG 
CAAGCTGCTA GTGGACACCG CCCTGACGAA GAAGAGGAGG AAGAGGTTGT AATTGGATGG 
CAGGAAAAGC TCTTTAGCCA GTTTGAAGTC GACCTGTACC AAAATGAATC CGCGTGCCAG 
AGCCCACTGG ATCATCAGTA CCGCCAAGAG ATCTTGAAAC TGGAGAATTC TGGCGGCAGG 
AAAAACCGGC GAATCTTCAC TTACACTGAC TCGGATAGAT ACACCGACTT GGAAGAGTAC 
TGTCAGAAAA TAACCACTTC AGCCAGCGAG GTGCCATCGT TTCTGGCTGA GCGGATGGCG 
AACGTCAGGC GGCGGCGGCA GGACAGGCGA GGGGTGGAGG GCAGCAAACT CAAGTCTCGG 
ATCGTCACGT GGGAACCCTC GGAAGACTTC ATCAAGAACA ACCACGCTAT TAACACTCCT 
CTTCAGACAA TGTACATCAT GGCGGACCTG GGACCCTATG GAAAGCTTGG CTATAAGGTA 
CATGAGCACG TGCTCTGCAT CCTGAAGGTG GACAGCAATG GCGTGATCAC AGTGAAGCCT 
GACTTCACCG GCATCAAAGG ACCCTACAGA ATCGAAACTG AGGGAGAGAA GCAGGAACAC 
ACTTCTGCTT GGAAATACAC AATTGACAAC GTGTCCTCCC TCGCACAGCC AGAGGAGGAA 
GAGCGGGAGC AGCGAGTGTT CAAGGACCTT TACGGCCGGC ACAAGGAGTA CCTCAGCAGC 
CTCGTGGGCA CAGACTTTGA GATGATTGCC CCAGGTGCCC TCCGGCTCTT TGTGAACGGA 
GAGGTGGTTT CAGCCCAAGG CTATGAGTAT GACAACCTCT ACGTCCACTT CTTTGTGGAG 
CTGCCAGCTG CTAACTGGTC CAGCCCGCCA TTCCAGCAGC TCTCGGGAGT AACCCAGGCC 
TGTGCCACCA AATCCCTGGG AATGGACAAG GTGGCCTATT TCTCCTTTCC GTTCACATTC 
GAAGCCTTCT TTCTGCATGA GGACGAATCG GCTGAGTCCC TCCCGGAGTG GCCTGTGCTC 
TACTGTAAGG TCCTCTCACT GGACTTCTGG CAGAGGTATC GTGTGGAAGG CTACGGGGCT 
GTGGTGCTGC CTGCCACTCC AGGATCCCAC ACCCTGACTG TCTCCACATG GAGGCCCATG 
GAGCTGGGTC TCGTGGCAGA GCTAAGGAGG TTCTTCATTG GCGGCTCTCT GGAGCTGGAG 
GACCCATCCT ATGTGAGGAT ACCAGGAACC TTCAAGGGGG AGCGCCTGAG CCGCTTTGGA 
TTCCGCACTG AGACAACGGG TACTGTCACC TTCCGATTGC ACTGCCTGCA GCAGTCCCGG 
GCTTTCATGG AATCGAACTC CCTCCAGAAA CAGATGCGGA GTGTGTTGGA CCGTCTGGAA 
GGGTTCAGCC AGCAGAGTTC CACGCACAAC GTGCTAGAAG CATTCCGTCG AGCCCGGCGT 
CGGATGCAGG AGGCCCGAGA GAGCCTCCCC CAGGACCTTG TGAGCCCCAC GGGAACGTTG 
ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mks1 ( NM_001039684.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001034773.2 Mus musculus Meckel syndrome, type 1 (Mks1), mRNA.

Price & Availability↑

CloneID	OMu20047
Clone ID Related Accession (Same CDS sequence)	NM_001039684.3 , NM_001039684.2
Accession Version	NM_001039684.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1686bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Mus musculus(house mouse)
Product	Meckel syndrome type 1 protein homolog
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ177342.1. On Jun 10, 2007 this sequence version replaced NM_001039684.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ177342.1, SRR1660815.175829.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGAAG CGGTCTGGAG CACTGACACC GGCGAGGCCG TGTATCGCTC CCGGGACCCC 
GTGCGCAACC TGCGCCTCCG AGTTCATCTG CAAAGAATCA CATCAAGCAA CTTCCTTCAT 
TACCAGCCTG CTGCCCAGAT GGGGAAGGAC CTCATAGACT TGGCCACTTT TAGGCCTCCG 
CAAGCTGCTA GTGGACACCG CCCTGACGAA GAAGAGGAGG AAGAGGTTGT AATTGGATGG 
CAGGAAAAGC TCTTTAGCCA GTTTGAAGTC GACCTGTACC AAAATGAATC CGCGTGCCAG 
AGCCCACTGG ATCATCAGTA CCGCCAAGAG ATCTTGAAAC TGGAGAATTC TGGCGGCAGG 
AAAAACCGGC GAATCTTCAC TTACACTGAC TCGGATAGAT ACACCGACTT GGAAGAGTAC 
TGTCAGAAAA TAACCACTTC AGCCAGCGAG GTGCCATCGT TTCTGGCTGA GCGGATGGCG 
AACGTCAGGC GGCGGCGGCA GGACAGGCGA GGGGTGGAGG GCAGCAAACT CAAGTCTCGG 
ATCGTCACGT GGGAACCCTC GGAAGACTTC ATCAAGAACA ACCACGCTAT TAACACTCCT 
CTTCAGACAA TGTACATCAT GGCGGACCTG GGACCCTATG GAAAGCTTGG CTATAAGGTA 
CATGAGCACG TGCTCTGCAT CCTGAAGGTG GACAGCAATG GCGTGATCAC AGTGAAGCCT 
GACTTCACCG GCATCAAAGG ACCCTACAGA ATCGAAACTG AGGGAGAGAA GCAGGAACAC 
ACTTCTGCTT GGAAATACAC AATTGACAAC GTGTCCTCCC TCGCACAGCC AGAGGAGGAA 
GAGCGGGAGC AGCGAGTGTT CAAGGACCTT TACGGCCGGC ACAAGGAGTA CCTCAGCAGC 
CTCGTGGGCA CAGACTTTGA GATGATTGCC CCAGGTGCCC TCCGGCTCTT TGTGAACGGA 
GAGGTGGTTT CAGCCCAAGG CTATGAGTAT GACAACCTCT ACGTCCACTT CTTTGTGGAG 
CTGCCAGCTG CTAACTGGTC CAGCCCGCCA TTCCAGCAGC TCTCGGGAGT AACCCAGGCC 
TGTGCCACCA AATCCCTGGG AATGGACAAG GTGGCCTATT TCTCCTTTCC GTTCACATTC 
GAAGCCTTCT TTCTGCATGA GGACGAATCG GCTGAGTCCC TCCCGGAGTG GCCTGTGCTC 
TACTGTAAGG TCCTCTCACT GGACTTCTGG CAGAGGTATC GTGTGGAAGG CTACGGGGCT 
GTGGTGCTGC CTGCCACTCC AGGATCCCAC ACCCTGACTG TCTCCACATG GAGGCCCATG 
GAGCTGGGTC TCGTGGCAGA GCTAAGGAGG TTCTTCATTG GCGGCTCTCT GGAGCTGGAG 
GACCCATCCT ATGTGAGGAT ACCAGGAACC TTCAAGGGGG AGCGCCTGAG CCGCTTTGGA 
TTCCGCACTG AGACAACGGG TACTGTCACC TTCCGATTGC ACTGCCTGCA GCAGTCCCGG 
GCTTTCATGG AATCGAACTC CCTCCAGAAA CAGATGCGGA GTGTGTTGGA CCGTCTGGAA 
GGGTTCAGCC AGCAGAGTTC CACGCACAAC GTGCTAGAAG CATTCCGTCG AGCCCGGCGT 
CGGATGCAGG AGGCCCGAGA GAGCCTCCCC CAGGACCTTG TGAGCCCCAC GGGAACGTTG 
ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034773.2
CDS	26..1711
Translation	MAEAVWSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAQMGKDLIDLATFRPPQAASGHRPDEEEEEEVVIGWQEKLFSQFEVDLYQNESACQSPLDHQYRQEILKLENSGGRKNRRIFTYTDSDRYTDLEEYCQKITTSASEVPSFLAERMANVRRRRQDRRGVEGSKLKSRIVTWEPSEDFIKNNHAINTPLQTMYIMADLGPYGKLGYKVHEHVLCILKVDSNGVITVKPDFTGIKGPYRIETEGEKQEHTSAWKYTIDNVSSLAQPEEEEREQRVFKDLYGRHKEYLSSLVGTDFEMIAPGALRLFVNGEVVSAQGYEYDNLYVHFFVELPAANWSSPPFQQLSGVTQACATKSLGMDKVAYFSFPFTFEAFFLHEDESAESLPEWPVLYCKVLSLDFWQRYRVEGYGAVVLPATPGSHTLTVSTWRPMELGLVAELRRFFIGGSLELEDPSYVRIPGTFKGERLSRFGFRTETTGTVTFRLHCLQQSRAFMESNSLQKQMRSVLDRLEGFSQQSSTHNVLEAFRRARRRMQEARESLPQDLVSPTGTLT

Target ORF information:

RefSeq Version	NM_001039684.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Meckel syndrome, type 1 (Mks1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039684.2

ORF Insert Sequence:

ATGGCGGAAG CGGTCTGGAG CACTGACACC GGCGAGGCCG TGTATCGCTC CCGGGACCCC 
GTGCGCAACC TGCGCCTCCG AGTTCATCTG CAAAGAATCA CATCAAGCAA CTTCCTTCAT 
TACCAGCCTG CTGCCCAGAT GGGGAAGGAC CTCATAGACT TGGCCACTTT TAGGCCTCCG 
CAAGCTGCTA GTGGACACCG CCCTGACGAA GAAGAGGAGG AAGAGGTTGT AATTGGATGG 
CAGGAAAAGC TCTTTAGCCA GTTTGAAGTC GACCTGTACC AAAATGAATC CGCGTGCCAG 
AGCCCACTGG ATCATCAGTA CCGCCAAGAG ATCTTGAAAC TGGAGAATTC TGGCGGCAGG 
AAAAACCGGC GAATCTTCAC TTACACTGAC TCGGATAGAT ACACCGACTT GGAAGAGTAC 
TGTCAGAAAA TAACCACTTC AGCCAGCGAG GTGCCATCGT TTCTGGCTGA GCGGATGGCG 
AACGTCAGGC GGCGGCGGCA GGACAGGCGA GGGGTGGAGG GCAGCAAACT CAAGTCTCGG 
ATCGTCACGT GGGAACCCTC GGAAGACTTC ATCAAGAACA ACCACGCTAT TAACACTCCT 
CTTCAGACAA TGTACATCAT GGCGGACCTG GGACCCTATG GAAAGCTTGG CTATAAGGTA 
CATGAGCACG TGCTCTGCAT CCTGAAGGTG GACAGCAATG GCGTGATCAC AGTGAAGCCT 
GACTTCACCG GCATCAAAGG ACCCTACAGA ATCGAAACTG AGGGAGAGAA GCAGGAACAC 
ACTTCTGCTT GGAAATACAC AATTGACAAC GTGTCCTCCC TCGCACAGCC AGAGGAGGAA 
GAGCGGGAGC AGCGAGTGTT CAAGGACCTT TACGGCCGGC ACAAGGAGTA CCTCAGCAGC 
CTCGTGGGCA CAGACTTTGA GATGATTGCC CCAGGTGCCC TCCGGCTCTT TGTGAACGGA 
GAGGTGGTTT CAGCCCAAGG CTATGAGTAT GACAACCTCT ACGTCCACTT CTTTGTGGAG 
CTGCCAGCTG CTAACTGGTC CAGCCCGCCA TTCCAGCAGC TCTCGGGAGT AACCCAGGCC 
TGTGCCACCA AATCCCTGGG AATGGACAAG GTGGCCTATT TCTCCTTTCC GTTCACATTC 
GAAGCCTTCT TTCTGCATGA GGACGAATCG GCTGAGTCCC TCCCGGAGTG GCCTGTGCTC 
TACTGTAAGG TCCTCTCACT GGACTTCTGG CAGAGGTATC GTGTGGAAGG CTACGGGGCT 
GTGGTGCTGC CTGCCACTCC AGGATCCCAC ACCCTGACTG TCTCCACATG GAGGCCCATG 
GAGCTGGGTC TCGTGGCAGA GCTAAGGAGG TTCTTCATTG GCGGCTCTCT GGAGCTGGAG 
GACCCATCCT ATGTGAGGAT ACCAGGAACC TTCAAGGGGG AGCGCCTGAG CCGCTTTGGA 
TTCCGCACTG AGACAACGGG TACTGTCACC TTCCGATTGC ACTGCCTGCA GCAGTCCCGG 
GCTTTCATGG AATCGAACTC CCTCCAGAAA CAGATGCGGA GTGTGTTGGA CCGTCTGGAA 
GGGTTCAGCC AGCAGAGTTC CACGCACAAC GTGCTAGAAG CATTCCGTCG AGCCCGGCGT 
CGGATGCAGG AGGCCCGAGA GAGCCTCCCC CAGGACCTTG TGAGCCCCAC GGGAACGTTG 
ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mks1 ( XM_006533645.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006533708.1 Mus musculus Meckel syndrome, type 1 (Mks1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu46543
Clone ID Related Accession (Same CDS sequence)	XM_006533645.3
Accession Version	XM_006533645.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	Meckel syndrome type 1 protein homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006533645.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGAAG CGGTCTGGAG CACTGACACC GGCGAGGCCG TGTATCGCTC CCGGGACCCC 
GTGCGCAACC TGCGCCTCCG AGTTCATCTG CAAAGAATCA CATCAAGCAA CTTCCTTCAT 
TACCAGCCTG CTGCCCAGAT GGGGAAGGAC CTCATAGACT TGGCCACTTT TAGGCCTCCG 
CAAGCTGCTA GTGGACACCG CCCTGACGAA GAAGAGGAGG AAGAGGTTGT AATTGGATGG 
CAGGAAAAGC TCTTTAGCCA GTTTGAAGTC GACCTGTACC AAAATGAATC CGCGTGCCAG 
AGCCCACTGG ATCATCAGTA CCGCCAAGAG ATCTTGAAAC TGGAGAATTC TGGCGGCAGG 
AAAAACCGGC GAATCTTCAC TTACACTGAC TCGGATAGAT ACACCGACTT GGAAGAGTAC 
TGTCAGAAAA TAACCACTTC AGCCAGCGAG GTGCCATCGT TTCTGGCTGA GCGGATGGCG 
AACGTCAGGC GGCGGCGGCA GGACAGGCGA GGGGTGGAGG GCAGCAAACT CAAGTCTCGG 
ATCGTCACGT GGGAACCCTC GGAAGACTTC ATCAAGAACA ACCACGCTAT TAACACTCCT 
CTTCAGACAA TGTACATCAT GGCGGACCTG GGACCCTATG GAAAGCTTGG CTATAAGGTA 
CATGAGCACG TGCTCTGCAT CCTGAAGGTG GACAGCAATG GCGTGATCAC AGTGAAGCCT 
GACTTCACCG GCATCAAAGG ACCCTACAGA ATCGAAACTG AGGGAGAGAA GCAGGAACAC 
ACTTCTGCTT GGAAATACAC AATTGACAAC GTGTCCTCCC TCGCACAGCC AGAGGAGGAA 
GAGCGGGAGC AGCGAGTGTT CAAGGACCTT TACGGCCGGC ACAAGGAGTA CCTCAGCAGC 
CTCGTGGGCA CAGACTTTGA GATGATTGCC CCAGGTGCCC TCCGGCTCTT TGTGAACGGA 
GAGTTTCAGC CCAAGGCTAT GAGTATGACA ACCTCTACGT CCACTTCTTT GTGGAGCTGC 
CAGCTGCTAA CTGGTCCAGC CCGCCATTCC AGCAGCTCTC GGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006533708.1
CDS	322..1389
Translation	MAEAVWSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAQMGKDLIDLATFRPPQAASGHRPDEEEEEEVVIGWQEKLFSQFEVDLYQNESACQSPLDHQYRQEILKLENSGGRKNRRIFTYTDSDRYTDLEEYCQKITTSASEVPSFLAERMANVRRRRQDRRGVEGSKLKSRIVTWEPSEDFIKNNHAINTPLQTMYIMADLGPYGKLGYKVHEHVLCILKVDSNGVITVKPDFTGIKGPYRIETEGEKQEHTSAWKYTIDNVSSLAQPEEEEREQRVFKDLYGRHKEYLSSLVGTDFEMIAPGALRLFVNGEFQPKAMSMTTSTSTSLWSCQLLTGPARHSSSSRE

Target ORF information:

RefSeq Version	XM_006533645.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus Meckel syndrome, type 1 (Mks1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006533645.3

ORF Insert Sequence:

ATGGCGGAAG CGGTCTGGAG CACTGACACC GGCGAGGCCG TGTATCGCTC CCGGGACCCC 
GTGCGCAACC TGCGCCTCCG AGTTCATCTG CAAAGAATCA CATCAAGCAA CTTCCTTCAT 
TACCAGCCTG CTGCCCAGAT GGGGAAGGAC CTCATAGACT TGGCCACTTT TAGGCCTCCG 
CAAGCTGCTA GTGGACACCG CCCTGACGAA GAAGAGGAGG AAGAGGTTGT AATTGGATGG 
CAGGAAAAGC TCTTTAGCCA GTTTGAAGTC GACCTGTACC AAAATGAATC CGCGTGCCAG 
AGCCCACTGG ATCATCAGTA CCGCCAAGAG ATCTTGAAAC TGGAGAATTC TGGCGGCAGG 
AAAAACCGGC GAATCTTCAC TTACACTGAC TCGGATAGAT ACACCGACTT GGAAGAGTAC 
TGTCAGAAAA TAACCACTTC AGCCAGCGAG GTGCCATCGT TTCTGGCTGA GCGGATGGCG 
AACGTCAGGC GGCGGCGGCA GGACAGGCGA GGGGTGGAGG GCAGCAAACT CAAGTCTCGG 
ATCGTCACGT GGGAACCCTC GGAAGACTTC ATCAAGAACA ACCACGCTAT TAACACTCCT 
CTTCAGACAA TGTACATCAT GGCGGACCTG GGACCCTATG GAAAGCTTGG CTATAAGGTA 
CATGAGCACG TGCTCTGCAT CCTGAAGGTG GACAGCAATG GCGTGATCAC AGTGAAGCCT 
GACTTCACCG GCATCAAAGG ACCCTACAGA ATCGAAACTG AGGGAGAGAA GCAGGAACAC 
ACTTCTGCTT GGAAATACAC AATTGACAAC GTGTCCTCCC TCGCACAGCC AGAGGAGGAA 
GAGCGGGAGC AGCGAGTGTT CAAGGACCTT TACGGCCGGC ACAAGGAGTA CCTCAGCAGC 
CTCGTGGGCA CAGACTTTGA GATGATTGCC CCAGGTGCCC TCCGGCTCTT TGTGAACGGA 
GAGTTTCAGC CCAAGGCTAT GAGTATGACA ACCTCTACGT CCACTTCTTT GTGGAGCTGC 
CAGCTGCTAA CTGGTCCAGC CCGCCATTCC AGCAGCTCTC GGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mks1 ( XM_017314631.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017170120.1 Mus musculus Meckel syndrome, type 1 (Mks1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu77960
Clone ID Related Accession (Same CDS sequence)	XM_017314631.2 , XM_017314631.1
Accession Version	XM_017314631.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	Meckel syndrome type 1 protein homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017314631.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGAAG CGGTCTGGAG CACTGACACC GGCGAGGCCG TGTATCGCTC CCGGGACCCC 
GTGCGCAACC TGCGCCTCCG AGTTCATCTG CAAAGAATCA CATCAAGCAA CTTCCTTCAT 
TACCAGCCTG CTGCCCAGAT GGGGAAGGAC CTCATAGACT TGGCCACTTT TAGGCCTCCG 
CAAGCTGCTA GTGGACACCG CCCTGACGAA GAAGAGGAGG AAGAGGTTGT AATTGGATGG 
CAGGAAAAGC TCTTTAGCCA GTTTGAAGTC GACCTGTACC AAAATGAATC CGCGTGCCAG 
AGCCCACTGG ATCATCAGTA CCGCCAAGAG ATCTTGAAAC TGGAGAATTC TGGCGGCAGG 
AAAAACCGGC GAATCTTCAC TTACACTGAC TCGGATAGAT ACACCGACTT GGAAGAGTAC 
TGTCAGAAAA TAACCACTTC AGCCAGCGAG GTGCCATCGT TTCTGGCTGA GCGGATGGCG 
AACGTCAGGC GGCGGCGGCA GGACAGGCGA GGGGTGGAGG GCAGCAAACT CAAGTCTCGG 
ATCGTCACGT GGGAACCCTC GGAAGACTTC ATCAAGAACA ACCACGCTAT TAACACTCCT 
CTTCAGACAA TGTACATCAT GGCGGACCTG GGACCCTATG GAAAGCTTGG CTATAAGGTA 
CATGAGCACG TGCTCTGCAT CCTGAAGGTG GACAGCAATG GCGTGATCAC AGTGAAGCCT 
GACTTCACCG GCATCAAAGG ACCCTACAGA ATCGAAACTG AGGGAGAGAA GCAGGAACAC 
ACTTCTGCTT GGAAATACAC AATTGACAAC GTGTCCTCCC TCGCACAGCC AGAGGAGGAA 
GAGCGGGAGC AGCGAGTGTT CAAGGACCTT TACGGCCGGC ACAAGGAGTA CCTCAGCAGC 
CTCGTGGGCA CAGACTTTGA GATGGGATTC AATTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017170120.1
CDS	69..1007
Translation	MAEAVWSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAQMGKDLIDLATFRPPQAASGHRPDEEEEEEVVIGWQEKLFSQFEVDLYQNESACQSPLDHQYRQEILKLENSGGRKNRRIFTYTDSDRYTDLEEYCQKITTSASEVPSFLAERMANVRRRRQDRRGVEGSKLKSRIVTWEPSEDFIKNNHAINTPLQTMYIMADLGPYGKLGYKVHEHVLCILKVDSNGVITVKPDFTGIKGPYRIETEGEKQEHTSAWKYTIDNVSSLAQPEEEEREQRVFKDLYGRHKEYLSSLVGTDFEMGFNF

Target ORF information:

RefSeq Version	XM_017314631.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Meckel syndrome, type 1 (Mks1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017314631.2

ORF Insert Sequence:

ATGGCGGAAG CGGTCTGGAG CACTGACACC GGCGAGGCCG TGTATCGCTC CCGGGACCCC 
GTGCGCAACC TGCGCCTCCG AGTTCATCTG CAAAGAATCA CATCAAGCAA CTTCCTTCAT 
TACCAGCCTG CTGCCCAGAT GGGGAAGGAC CTCATAGACT TGGCCACTTT TAGGCCTCCG 
CAAGCTGCTA GTGGACACCG CCCTGACGAA GAAGAGGAGG AAGAGGTTGT AATTGGATGG 
CAGGAAAAGC TCTTTAGCCA GTTTGAAGTC GACCTGTACC AAAATGAATC CGCGTGCCAG 
AGCCCACTGG ATCATCAGTA CCGCCAAGAG ATCTTGAAAC TGGAGAATTC TGGCGGCAGG 
AAAAACCGGC GAATCTTCAC TTACACTGAC TCGGATAGAT ACACCGACTT GGAAGAGTAC 
TGTCAGAAAA TAACCACTTC AGCCAGCGAG GTGCCATCGT TTCTGGCTGA GCGGATGGCG 
AACGTCAGGC GGCGGCGGCA GGACAGGCGA GGGGTGGAGG GCAGCAAACT CAAGTCTCGG 
ATCGTCACGT GGGAACCCTC GGAAGACTTC ATCAAGAACA ACCACGCTAT TAACACTCCT 
CTTCAGACAA TGTACATCAT GGCGGACCTG GGACCCTATG GAAAGCTTGG CTATAAGGTA 
CATGAGCACG TGCTCTGCAT CCTGAAGGTG GACAGCAATG GCGTGATCAC AGTGAAGCCT 
GACTTCACCG GCATCAAAGG ACCCTACAGA ATCGAAACTG AGGGAGAGAA GCAGGAACAC 
ACTTCTGCTT GGAAATACAC AATTGACAAC GTGTCCTCCC TCGCACAGCC AGAGGAGGAA 
GAGCGGGAGC AGCGAGTGTT CAAGGACCTT TACGGCCGGC ACAAGGAGTA CCTCAGCAGC 
CTCGTGGGCA CAGACTTTGA GATGGGATTC AATTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mks1 ( XM_017314631.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017170120.1 Mus musculus Meckel syndrome, type 1 (Mks1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu77960
Clone ID Related Accession (Same CDS sequence)	XM_017314631.2 , XM_017314631.1
Accession Version	XM_017314631.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	Meckel syndrome type 1 protein homolog isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGAAG CGGTCTGGAG CACTGACACC GGCGAGGCCG TGTATCGCTC CCGGGACCCC 
GTGCGCAACC TGCGCCTCCG AGTTCATCTG CAAAGAATCA CATCAAGCAA CTTCCTTCAT 
TACCAGCCTG CTGCCCAGAT GGGGAAGGAC CTCATAGACT TGGCCACTTT TAGGCCTCCG 
CAAGCTGCTA GTGGACACCG CCCTGACGAA GAAGAGGAGG AAGAGGTTGT AATTGGATGG 
CAGGAAAAGC TCTTTAGCCA GTTTGAAGTC GACCTGTACC AAAATGAATC CGCGTGCCAG 
AGCCCACTGG ATCATCAGTA CCGCCAAGAG ATCTTGAAAC TGGAGAATTC TGGCGGCAGG 
AAAAACCGGC GAATCTTCAC TTACACTGAC TCGGATAGAT ACACCGACTT GGAAGAGTAC 
TGTCAGAAAA TAACCACTTC AGCCAGCGAG GTGCCATCGT TTCTGGCTGA GCGGATGGCG 
AACGTCAGGC GGCGGCGGCA GGACAGGCGA GGGGTGGAGG GCAGCAAACT CAAGTCTCGG 
ATCGTCACGT GGGAACCCTC GGAAGACTTC ATCAAGAACA ACCACGCTAT TAACACTCCT 
CTTCAGACAA TGTACATCAT GGCGGACCTG GGACCCTATG GAAAGCTTGG CTATAAGGTA 
CATGAGCACG TGCTCTGCAT CCTGAAGGTG GACAGCAATG GCGTGATCAC AGTGAAGCCT 
GACTTCACCG GCATCAAAGG ACCCTACAGA ATCGAAACTG AGGGAGAGAA GCAGGAACAC 
ACTTCTGCTT GGAAATACAC AATTGACAAC GTGTCCTCCC TCGCACAGCC AGAGGAGGAA 
GAGCGGGAGC AGCGAGTGTT CAAGGACCTT TACGGCCGGC ACAAGGAGTA CCTCAGCAGC 
CTCGTGGGCA CAGACTTTGA GATGGGATTC AATTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017170120.1
CDS	321..1259
Translation	MAEAVWSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAQMGKDLIDLATFRPPQAASGHRPDEEEEEEVVIGWQEKLFSQFEVDLYQNESACQSPLDHQYRQEILKLENSGGRKNRRIFTYTDSDRYTDLEEYCQKITTSASEVPSFLAERMANVRRRRQDRRGVEGSKLKSRIVTWEPSEDFIKNNHAINTPLQTMYIMADLGPYGKLGYKVHEHVLCILKVDSNGVITVKPDFTGIKGPYRIETEGEKQEHTSAWKYTIDNVSSLAQPEEEEREQRVFKDLYGRHKEYLSSLVGTDFEMGFNF

Target ORF information:

RefSeq Version	XM_017314631.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus Meckel syndrome, type 1 (Mks1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017314631.1

ORF Insert Sequence:

ATGGCGGAAG CGGTCTGGAG CACTGACACC GGCGAGGCCG TGTATCGCTC CCGGGACCCC 
GTGCGCAACC TGCGCCTCCG AGTTCATCTG CAAAGAATCA CATCAAGCAA CTTCCTTCAT 
TACCAGCCTG CTGCCCAGAT GGGGAAGGAC CTCATAGACT TGGCCACTTT TAGGCCTCCG 
CAAGCTGCTA GTGGACACCG CCCTGACGAA GAAGAGGAGG AAGAGGTTGT AATTGGATGG 
CAGGAAAAGC TCTTTAGCCA GTTTGAAGTC GACCTGTACC AAAATGAATC CGCGTGCCAG 
AGCCCACTGG ATCATCAGTA CCGCCAAGAG ATCTTGAAAC TGGAGAATTC TGGCGGCAGG 
AAAAACCGGC GAATCTTCAC TTACACTGAC TCGGATAGAT ACACCGACTT GGAAGAGTAC 
TGTCAGAAAA TAACCACTTC AGCCAGCGAG GTGCCATCGT TTCTGGCTGA GCGGATGGCG 
AACGTCAGGC GGCGGCGGCA GGACAGGCGA GGGGTGGAGG GCAGCAAACT CAAGTCTCGG 
ATCGTCACGT GGGAACCCTC GGAAGACTTC ATCAAGAACA ACCACGCTAT TAACACTCCT 
CTTCAGACAA TGTACATCAT GGCGGACCTG GGACCCTATG GAAAGCTTGG CTATAAGGTA 
CATGAGCACG TGCTCTGCAT CCTGAAGGTG GACAGCAATG GCGTGATCAC AGTGAAGCCT 
GACTTCACCG GCATCAAAGG ACCCTACAGA ATCGAAACTG AGGGAGAGAA GCAGGAACAC 
ACTTCTGCTT GGAAATACAC AATTGACAAC GTGTCCTCCC TCGCACAGCC AGAGGAGGAA 
GAGCGGGAGC AGCGAGTGTT CAAGGACCTT TACGGCCGGC ACAAGGAGTA CCTCAGCAGC 
CTCGTGGGCA CAGACTTTGA GATGGGATTC AATTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A staging system for correct phenotype interpretation of mouse embryos harvested on embryonic day 14 (E14.5).
Journal of anatomy230(5)710-719(2017 May)
Geyer SH,Reissig L,Rose J,Wilson R,Prin F,Szumska D,Ramirez-Solis R,Tudor C,White J,Mohun TJ,Weninger WJ

The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.
PloS one12(3)e0173399(2017)
Goetz SC,Bangs F,Barrington CL,Katsanis N,Anderson KV

Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.
Human molecular genetics25(14)3011-3028(2016 07)
Burnicka-Turek O,Steimle JD,Huang W,Felker L,Kamp A,Kweon J,Peterson M,Reeves RH,Maslen CL,Gruber PJ,Yang XH,Shendure J,Moskowitz IP

Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.
PLoS biology11(11)e1001720(2013 Nov)
Cui C,Chatterjee B,Lozito TP,Zhang Z,Francis RJ,Yagi H,Swanhart LM,Sanker S,Francis D,Yu Q,San Agustin JT,Puligilla C,Chatterjee T,Tansey T,Liu X,Kelley MW,Spiliotis ET,Kwiatkowski AV,Tuan R,Pazour GJ,Hukriede NA,Lo CW

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Mks1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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電話

FAX

オンラインフォーム