Ifnl3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ifnl3
Entrez Gene ID	338374
Full Name	interferon lambda 3
Synonyms	IFL-1,IL-28B,INF-alpha,INF-lambda,Il28,Il28b
General protein information	Preferred Names interferon lambda 3 Names interferon lambda-3 IFN-lambda-3 interferon alpha interleukin 28 interleukin-28B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 B1

mRNA and Protein(s)

mRNA	Protein	Name
XM_006540130.1	XP_006540193.1	interferon lambda-3 isoform X1
NM_177396.1	NP_796370.1	interferon lambda-3 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IFNL3	NP_742151.2
Mus musculus (house mouse)	Ifnl3	NP_796370.1
Rattus norvegicus (Norway rat)	Ifnl3	XP_006228700.1
Rattus norvegicus (Norway rat)	LOC100911249	XP_003748856.1
Canis lupus familiaris (dog)	LOC612543	XP_855366.2
Gallus gallus (chicken)	IL28B	NP_001121968.1
Pan troglodytes (chimpanzee)	IL28B	XP_001135462.1
Bos taurus (cattle)	LOC100298542	XP_002695096.2
Gallus gallus (chicken)	LOC101751261	XP_004950144.1
Mus musculus (house mouse)	Ifnl2	NP_001019844.2

Gene Ontology
Bibliography

Related articles in PubMed

Involvement of NK Cells in IL-28B-Mediated Immunity against Influenza Virus Infection.
Wang Y, Li T, Chen Y, Wei H, Sun R, Tian Z
Journal of immunology (Baltimore, Md. : 1950)199(3)1012-1020(2017 Aug)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

IL-28B down-regulates regulatory T cells but does not improve the protective immunity following tuberculosis subunit vaccine immunization.
Luo Y, Ma X, Liu X, Lu X, Niu H, Yu H, Bai C, Peng J, Xian Q, Wang Y, Zhu B
International immunology28(2)77-85(2016 Feb)

Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma.
Lasfar A, Lewis-Antes A, Smirnov SV, Anantha S, Abushahba W, Tian B, Reuhl K, Dickensheets H, Sheikh F, Donnelly RP, Raveche E, Kotenko SV
Cancer research66(8)4468-77(2006 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that IL-28B induces more mature NK cells to defend against viruses, in addition to its direct antiviral activity
Title: Involvement of NK Cells in IL-28B-Mediated Immunity against Influenza Virus Infection.

IL-28B down-regulates Tregs following subunit vaccine ESAT6-Ag85B-Mpt64(190-198)-Mtb8.4-HspX vaccination but does not improve the protective immune responses.
Title: IL-28B down-regulates regulatory T cells but does not improve the protective immunity following tuberculosis subunit vaccine immunization.

Data indicate that rotavirus infection induces production of interferon-lambda (IFN-lambda) and interleukin 22 (IL-22) by intestinal epithelial cells.
Title: Interferon-? and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.

the role of IFN-lambda in IDO regulation was investigated after influenza infection of respiratory epithelial cells.
Title: Interferon Lambda Upregulates IDO1 Expression in Respiratory Epithelial Cells After Influenza Virus Infection.

IFN-lambda is involved in development and maintenance of oral tolerance in the intestines of mice.
Title: Interferon-? mediates oral tolerance and inhibits antigen-specific, T-helper 2 cell-mediated inflammation in mouse intestine.

The following Ifnl3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ifnl3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu38353	XM_006540130.1 Latest version!	Mus musculus interferon lambda 3 (Ifnl3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu06390	NM_177396.1 Latest version!	Mus musculus interferon lambda 3 (Ifnl3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ifnl3 ( XM_006540130.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006540193.1 Mus musculus interferon lambda 3 (Ifnl3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu38353
Clone ID Related Accession (Same CDS sequence)	XM_006540130.1
Accession Version	XM_006540130.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	interferon lambda-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCTCC TGCTGTTGCC TCTGCTGCTG GCCGCAGTGC TGACAAGAAC CCAAGCTGAC 
CCTGTCCCCA GGGCCACCAG GCTCCCAGTG GAAGCAAAGG ATTGCCACAT TGCTCAGTTC 
AAGTCTCTGT CCCCAAAAGA GCTGCAGGCC TTCAAAAAGG CCAAGGGTGC CATCGAGAAG 
AGGCTGCTTG AGAAGGACAT GAGGTGCAGT TCCCACCTCA TCTCCAGGGC CTGGGACCTG 
AAGCAGCTGC AGGTCCAAGA GCGCCCCAAG GCCTTGCAGG CTGAGGTGGC CCTGACCCTG 
AAGGTCTGGG AGAACATAAA TGACTCAGCC CTGACCACCA TCCTGGGCCA GCCTCTTCAT 
ACACTGAGCC ACATTCACTC CCAGCTGCAG ACCTGTGTGA GTCCTGGGTC CCTGGCTCCT 
CCTCAGTGTT CTCCAGCCAC TTGGGCTTCT CCTGTGTCCC AGCAGCAGCC TCACAGTCCC 
CATCCTCTAT CCACAGACAC AGCTTCAGGC CACAGCAGAG CCCAAGCCCC CGAGTCGCCG 
CCTCTCCCGC TGGCTGCACA GGCTCCAGGA GGCCCAGAGC AAGGAGACTC CTGGCTGCCT 
GGAGGACTCT GTCACCTCCA ACCTGTTTCA ACTGCTCCTC CGGGACCTCA AGTGTGTGGC 
CAGTGGAGAC CAGTGTGTCT GACCTGGAAC CCTCCTGCCA GCTTCAGGAA TTCTTCACTG 
TGTGGATGCA CCAAGACCAC ACCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006540193.1
CDS	4..750
Translation	MLLLLLPLLLAAVLTRTQADPVPRATRLPVEAKDCHIAQFKSLSPKELQAFKKAKGAIEKRLLEKDMRCSSHLISRAWDLKQLQVQERPKALQAEVALTLKVWENINDSALTTILGQPLHTLSHIHSQLQTCVSPGSLAPPQCSPATWASPVSQQQPHSPHPLSTDTASGHSRAQAPESPPLPLAAQAPGGPEQGDSWLPGGLCHLQPVSTAPPGPQVCGQWRPVCLTWNPPASFRNSSLCGCTKTTP

Target ORF information:

RefSeq Version	XM_006540130.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus interferon lambda 3 (Ifnl3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006540130.1

ORF Insert Sequence:

ATGCTCCTCC TGCTGTTGCC TCTGCTGCTG GCCGCAGTGC TGACAAGAAC CCAAGCTGAC 
CCTGTCCCCA GGGCCACCAG GCTCCCAGTG GAAGCAAAGG ATTGCCACAT TGCTCAGTTC 
AAGTCTCTGT CCCCAAAAGA GCTGCAGGCC TTCAAAAAGG CCAAGGGTGC CATCGAGAAG 
AGGCTGCTTG AGAAGGACAT GAGGTGCAGT TCCCACCTCA TCTCCAGGGC CTGGGACCTG 
AAGCAGCTGC AGGTCCAAGA GCGCCCCAAG GCCTTGCAGG CTGAGGTGGC CCTGACCCTG 
AAGGTCTGGG AGAACATAAA TGACTCAGCC CTGACCACCA TCCTGGGCCA GCCTCTTCAT 
ACACTGAGCC ACATTCACTC CCAGCTGCAG ACCTGTGTGA GTCCTGGGTC CCTGGCTCCT 
CCTCAGTGTT CTCCAGCCAC TTGGGCTTCT CCTGTGTCCC AGCAGCAGCC TCACAGTCCC 
CATCCTCTAT CCACAGACAC AGCTTCAGGC CACAGCAGAG CCCAAGCCCC CGAGTCGCCG 
CCTCTCCCGC TGGCTGCACA GGCTCCAGGA GGCCCAGAGC AAGGAGACTC CTGGCTGCCT 
GGAGGACTCT GTCACCTCCA ACCTGTTTCA ACTGCTCCTC CGGGACCTCA AGTGTGTGGC 
CAGTGGAGAC CAGTGTGTCT GACCTGGAAC CCTCCTGCCA GCTTCAGGAA TTCTTCACTG 
TGTGGATGCA CCAAGACCAC ACCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ifnl3 ( NM_177396.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_796370.1 Mus musculus interferon lambda 3 (Ifnl3), mRNA.

Price & Availability↑

CloneID	OMu06390
Clone ID Related Accession (Same CDS sequence)	NM_177396.1
Accession Version	NM_177396.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	interferon lambda-3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY184375.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY184375.1, AY869696.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

ATGCTCCTCC TGCTGTTGCC TCTGCTGCTG GCCGCAGTGC TGACAAGAAC CCAAGCTGAC 
CCTGTCCCCA GGGCCACCAG GCTCCCAGTG GAAGCAAAGG ATTGCCACAT TGCTCAGTTC 
AAGTCTCTGT CCCCAAAAGA GCTGCAGGCC TTCAAAAAGG CCAAGGGTGC CATCGAGAAG 
AGGCTGCTTG AGAAGGACAT GAGGTGCAGT TCCCACCTCA TCTCCAGGGC CTGGGACCTG 
AAGCAGCTGC AGGTCCAAGA GCGCCCCAAG GCCTTGCAGG CTGAGGTGGC CCTGACCCTG 
AAGGTCTGGG AGAACATAAA TGACTCAGCC CTGACCACCA TCCTGGGCCA GCCTCTTCAT 
ACACTGAGCC ACATTCACTC CCAGCTGCAG ACCTGTACAC AGCTTCAGGC CACAGCAGAG 
CCCAAGCCCC CGAGTCGCCG CCTCTCCCGC TGGCTGCACA GGCTCCAGGA GGCCCAGAGC 
AAGGAGACTC CTGGCTGCCT GGAGGACTCT GTCACCTCCA ACCTGTTTCA ACTGCTCCTC 
CGGGACCTCA AGTGTGTGGC CAGTGGAGAC CAGTGTGTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_796370.1
CDS	1..582
Translation	MLLLLLPLLLAAVLTRTQADPVPRATRLPVEAKDCHIAQFKSLSPKELQAFKKAKGAIEKRLLEKDMRCSSHLISRAWDLKQLQVQERPKALQAEVALTLKVWENINDSALTTILGQPLHTLSHIHSQLQTCTQLQATAEPKPPSRRLSRWLHRLQEAQSKETPGCLEDSVTSNLFQLLLRDLKCVASGDQCV

Target ORF information:

RefSeq Version	NM_177396.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus interferon lambda 3 (Ifnl3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177396.1

ORF Insert Sequence:

ATGCTCCTCC TGCTGTTGCC TCTGCTGCTG GCCGCAGTGC TGACAAGAAC CCAAGCTGAC 
CCTGTCCCCA GGGCCACCAG GCTCCCAGTG GAAGCAAAGG ATTGCCACAT TGCTCAGTTC 
AAGTCTCTGT CCCCAAAAGA GCTGCAGGCC TTCAAAAAGG CCAAGGGTGC CATCGAGAAG 
AGGCTGCTTG AGAAGGACAT GAGGTGCAGT TCCCACCTCA TCTCCAGGGC CTGGGACCTG 
AAGCAGCTGC AGGTCCAAGA GCGCCCCAAG GCCTTGCAGG CTGAGGTGGC CCTGACCCTG 
AAGGTCTGGG AGAACATAAA TGACTCAGCC CTGACCACCA TCCTGGGCCA GCCTCTTCAT 
ACACTGAGCC ACATTCACTC CCAGCTGCAG ACCTGTACAC AGCTTCAGGC CACAGCAGAG 
CCCAAGCCCC CGAGTCGCCG CCTCTCCCGC TGGCTGCACA GGCTCCAGGA GGCCCAGAGC 
AAGGAGACTC CTGGCTGCCT GGAGGACTCT GTCACCTCCA ACCTGTTTCA ACTGCTCCTC 
CGGGACCTCA AGTGTGTGGC CAGTGGAGAC CAGTGTGTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Involvement of NK Cells in IL-28B-Mediated Immunity against Influenza Virus Infection.
Journal of immunology (Baltimore, Md. : 1950)199(3)1012-1020(2017 Aug)
Wang Y,Li T,Chen Y,Wei H,Sun R,Tian Z

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

IL-28B down-regulates regulatory T cells but does not improve the protective immunity following tuberculosis subunit vaccine immunization.
International immunology28(2)77-85(2016 Feb)
Luo Y,Ma X,Liu X,Lu X,Niu H,Yu H,Bai C,Peng J,Xian Q,Wang Y,Zhu B

Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma.
Cancer research66(8)4468-77(2006 Apr)
Lasfar A,Lewis-Antes A,Smirnov SV,Anantha S,Abushahba W,Tian B,Reuhl K,Dickensheets H,Sheikh F,Donnelly RP,Raveche E,Kotenko SV

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Ifnl3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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