Hspb7 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hspb7
Entrez Gene ID	29818
Full Name	heat shock protein family, member 7 (cardiovascular)
Synonyms	27kDa,Hsp25-2,cvHsp
General protein information	Preferred Names heat shock protein family, member 7 (cardiovascular) Names heat shock protein beta-7 cardiovascular heat shock protein heat shock 27kDa protein family, member 7 (cardiovascular) heat shock protein 25 kDa 2 (cardiovascular) protein p19/6.8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 D3

mRNA and Protein(s)

mRNA	Protein	Name
NM_013868.4	NP_038896.2	heat shock protein beta-7

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HSPB7	XP_865029.1
Bos taurus (cattle)	HSPB7	XP_003585853.1
Gallus gallus (chicken)	HSPB7	XP_427836.2
Danio rerio (zebrafish)	hspb7	NP_001006040.1
Pan troglodytes (chimpanzee)	HSPB7	XP_001152022.2
Rattus norvegicus (Norway rat)	Hspb7	NP_113795.1
Homo sapiens (human)	HSPB7	NP_055239.1
Mus musculus (house mouse)	Hspb7	NP_038896.2

Gene Ontology
Bibliography

Related articles in PubMed

HSPB7 is indispensable for heart development by modulating actin filament assembly.
Wu T, Mu Y, Bogomolovas J, Fang X, Veevers J, Nowak RB, Pappas CT, Gregorio CC, Evans SM, Fowler VM, Chen J
Proceedings of the National Academy of Sciences of the United States of America114(45)11956-11961(2017 Nov)

HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity.
Liao WC, Juo LY, Shih YL, Chen YH, Yan YT
PLoS genetics13(8)e1006984(2017 Aug)

Regulation of Hspb7 by MEF2 and AP-1: implications for Hspb7 in muscle atrophy.
Tobin SW, Yang D, Girgis J, Farahzad A, Blais A, McDermott JC
Journal of cell science129(21)4076-4090(2016 11)

HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles.
Juo LY, Liao WC, Shih YL, Yang BY, Liu AB, Yan YT
Journal of cell science129(8)1661-70(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our findings characterize HSPB7 as an intercalated disc protein and suggest it has an essential role in maintaining intercalated disc integrity and conduction function in the adult heart.
Title: HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity.

these data indicate that MEF2 and AP-1 confer antagonistic regulation of Hspb7 gene expression in skeletal muscle, with implications for autophagy and muscle atrophy.
Title: Regulation of Hspb7 by MEF2 and AP-1: implications for Hspb7 in muscle atrophy.

this paper shows that skeletal-muscle-specific ablation of the HspB7 causes postnatal death owing to a respiration defect, with progressive myopathy phenotypes in the diaphragm
Title: HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles.

HSPB7 is a potential early biomarker after MI and serves as an independent risk factor of ACS in patients with acute chest pain.
Title: Association of plasma concentration of small heat shock protein B7 with acute coronary syndrome.

These results imply that HspB2 and HspB7 might be up-regulated by ethanol during the short-term differentiation of neural stem cells.
Title: Ethanol-induced small heat shock protein genes in the differentiation of mouse embryonic neural stem cells.

The following Hspb7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hspb7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10087	NM_013868.4 Latest version!	Mus musculus heat shock protein family, member 7 (cardiovascular) (Hspb7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hspb7 ( NM_013868.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038896.2 Mus musculus heat shock protein family, member 7 (cardiovascular) (Hspb7), mRNA.

Price & Availability↑

CloneID	OMu10087
Clone ID Related Accession (Same CDS sequence)	NM_013868.4
Accession Version	NM_013868.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 510bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-02
Organism	Mus musculus(house mouse)
Product	heat shock protein beta-7
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL670285.10. On May 1, 2007 this sequence version replaced NM_013868.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK030025.1, BC089584.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCATC GGACCTCCTC CGCCTTCAGA GCGGAGAGAA GCTTCCGTTC CTCTTCCTCC 
TCCTCCTCCT CCTCTTCTTC TTCGGCCTCC CGTGCCCTTC CAGCCCAGGA CCCACCCATG 
GAGAAGGCTT TGAGCATGTT TTCAGACGAC TTTGGCAGTT TTATGCTGCC CCACTCGGAG 
CCCCTGGCCT TCCCAGCCCG TCCCGGGGGC CAAGGAAACA TCAAGACCCT CGGGGATGCC 
TACGAGTTTA CAGTGGACAT GAGAGACTTC TCCCCTGAAG ACATCATTGT CACCACCTTC 
AACAACCACA TCGAGGTGCG GGCTGAGAAG CTGGCAGCTG ATGGCACAGT CATGAACACC 
TTTGCTCACA AGTGCCAACT ACCAGAGGAT GTGGACCCAA CATCGGTGAC CTCGGCCCTT 
CGAGAGGATG GTAGCCTCAC CATCCGGGCG CGGCGCCACC CCCACACAGA ACATGTCCAG 
CAGACCTTCC GGACTGAGAT AAAAATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038896.2
CDS	1007..1516
Translation	MSHRTSSAFRAERSFRSSSSSSSSSSSSASRALPAQDPPMEKALSMFSDDFGSFMLPHSEPLAFPARPGGQGNIKTLGDAYEFTVDMRDFSPEDIIVTTFNNHIEVRAEKLAADGTVMNTFAHKCQLPEDVDPTSVTSALREDGSLTIRARRHPHTEHVQQTFRTEIKI

Target ORF information:

RefSeq Version	NM_013868.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus heat shock protein family, member 7 (cardiovascular) (Hspb7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013868.4

ORF Insert Sequence:

ATGAGCCATC GGACCTCCTC CGCCTTCAGA GCGGAGAGAA GCTTCCGTTC CTCTTCCTCC 
TCCTCCTCCT CCTCTTCTTC TTCGGCCTCC CGTGCCCTTC CAGCCCAGGA CCCACCCATG 
GAGAAGGCTT TGAGCATGTT TTCAGACGAC TTTGGCAGTT TTATGCTGCC CCACTCGGAG 
CCCCTGGCCT TCCCAGCCCG TCCCGGGGGC CAAGGAAACA TCAAGACCCT CGGGGATGCC 
TACGAGTTTA CAGTGGACAT GAGAGACTTC TCCCCTGAAG ACATCATTGT CACCACCTTC 
AACAACCACA TCGAGGTGCG GGCTGAGAAG CTGGCAGCTG ATGGCACAGT CATGAACACC 
TTTGCTCACA AGTGCCAACT ACCAGAGGAT GTGGACCCAA CATCGGTGAC CTCGGCCCTT 
CGAGAGGATG GTAGCCTCAC CATCCGGGCG CGGCGCCACC CCCACACAGA ACATGTCCAG 
CAGACCTTCC GGACTGAGAT AAAAATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HSPB7 is indispensable for heart development by modulating actin filament assembly.
Proceedings of the National Academy of Sciences of the United States of America114(45)11956-11961(2017 Nov)
Wu T,Mu Y,Bogomolovas J,Fang X,Veevers J,Nowak RB,Pappas CT,Gregorio CC,Evans SM,Fowler VM,Chen J

HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity.
PLoS genetics13(8)e1006984(2017 Aug)
Liao WC,Juo LY,Shih YL,Chen YH,Yan YT

Regulation of Hspb7 by MEF2 and AP-1: implications for Hspb7 in muscle atrophy.
Journal of cell science129(21)4076-4090(2016 11)
Tobin SW,Yang D,Girgis J,Farahzad A,Blais A,McDermott JC

HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles.
Journal of cell science129(8)1661-70(2016 Apr)
Juo LY,Liao WC,Shih YL,Yang BY,Liu AB,Yan YT