Selenov cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Selenov
Entrez Gene ID	280621
Full Name	selenoprotein V
Synonyms	Selv
General protein information	Preferred Names selenoprotein V Names selenoprotein V
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 A3
Summary	This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. [provided by RefSeq, Apr 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_175033.4	NP_778198.2	selenoprotein V

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC102151122	XP_005616643.1
Mus musculus (house mouse)	BC089491	NP_778198.2
Homo sapiens (human)	SELV	NP_874363.1
Pan troglodytes (chimpanzee)	SELV	NP_001140181.1
Rattus norvegicus (Norway rat)	Selv	NP_001159868.1
	SELV	XP_002801522.1

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice.
Miyata H, Castaneda JM, Fujihara Y, Yu Z, Archambeault DR, Isotani A, Kiyozumi D, Kriseman ML, Mashiko D, Matsumura T, Matzuk RM, Mori M, Noda T, Oji A, Okabe M, Prunskaite-Hyyrylainen R, Ramirez-Solis R, Satouh Y, Zhang Q, Ikawa M, Matzuk MM
Proceedings of the National Academy of Sciences of the United States of America113(28)7704-10(2016 07)

[cDNA cloning, expression and determination of substrate specificity of mice selenocysteine-containing protein SelV (Selenoprotein V)].
Varlamova EG, Novoselov SV, Novoselov VI
Molekuliarnaia biologiia49(5)785-9(2015 Sep-Oct)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

Characterization of mammalian selenoproteomes.
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guig? R, Gladyshev VN
Science (New York, N.Y.)300(5624)1439-43(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SelV posseses glutathione peroxidase and thioredoxin reductase activities.
Title: [cDNA cloning, expression and determination of substrate specificity of mice selenocysteine-containing protein SelV (Selenoprotein V)].

The following Selenov gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Selenov cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04806	NM_175033.4 Latest version!	Mus musculus selenoprotein V (Selenov), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Selenov ( NM_175033.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_778198.2 Mus musculus selenoprotein V (Selenov), mRNA.

Price & Availability↑

CloneID	OMu04806
Clone ID Related Accession (Same CDS sequence)	NM_175033.4
Accession Version	NM_175033.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-09
Organism	Mus musculus(house mouse)
Product	selenoprotein V
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK077113.2 and BC089491.1. On Apr 24, 2017 this sequence version replaced NM_175033.3. ##Evidence-Data-START## Transcript exon combination :: BC089491.1, AK077113.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred from conservation protein contains selenocysteine :: PMID: 12775843 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAATAACA AGGCGCGGGT CCCCGCTCCC TCCTCAGTCC GGGCAAACAC CCCGGCCCGG 
ACACCCGCTC CCATCCGAAC CGCGACCCCA GTCAGGGCCC CGAACCCAGC GCACAACTCG 
ACTCCAGTCC GAACTTCCAT CCGGGTCCGG GCTCCTGCCC AAGTCCCTAA CCCTGTTCCA 
ATCCGGTTCC CAACTCCAGC CCCAGTCCCT GCCCCAACCC TAACCCCAGC CCCAACTCCA 
GCTCCAGTCC GGCATGCAGC ACCGGTGCGG ACTCCAGCAC CAGTCCGGGC CCCGAATCTA 
GGTCGGGTCT TTCCTAAGAT CTCTCCAGGC AGGTTCTTCC CGAGCTTGGC CTCGCCCACG 
GCACAGCCCC TTTCTTCCAG GGCTGCTAGC GCTCTCTTGA AGGATCCCAC ACTCGCTCAA 
AATCAGAAAC CCTCGATCCA CAGCCTAGCG GAGGCCATCC AGGGGCCCCT TCCAGTGCTC 
ACTCCCTCGT CCTCCAAGAC ACAAGGCTCC ATACCGGACA CCGCCTCTCC CATAGACTCC 
TTGGCTTCTA CTGCCATGGC CTCCAGTACA TTGGGCCCCA TTCCGGGCCC CAACCCTACA 
CTAGAGTTCT TGGCCTCCCC GCTGAAGGAA ACCCCTGGTC TGGGTAAGCT CTCCACGATT 
TCCCCAGCAC CCAGCTTCGG TTCCACTAAG GAGATCCCAT CCACCAGCGA GGACGTCCCA 
ACGCCCAACA GAATCTTGAT CCGTGTGATG TACTGTGGCC TCTGAAGCTA TGGCCTTCGG 
TACATTATAC TGAAAAGGAC CCTGGAGCAT CAATTCCCAA ACCTTCTGGA GTTTGAGGAG 
GAAAGAGCTA CCCAGGTTAC AGGGGAGTTT GAAGTGTTTG TGGATGGGAA GCTGATCCAT 
TCCAAGAAGA AAGGTGATGG CTTTGTGGAT GAGTCCGGTC TGAAGAAACT TGTGGGTGCT 
ATTGACGAAG AGATCAAGAA GAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_778198.2
CDS	110..1096
Translation	MNNKARVPAPSSVRANTPARTPAPIRTATPVRAPNPAHNSTPVRTSIRVRAPAQVPNPVPIRFPTPAPVPAPTLTPAPTPAPVRHAAPVRTPAPVRAPNLGRVFPKISPGRFFPSLASPTAQPLSSRAASALLKDPTLAQNQKPSIHSLAEAIQGPLPVLTPSSSKTQGSIPDTASPIDSLASTAMASSTLGPIPGPNPTLEFLASPLKETPGLGKLSTISPAPSFGSTKEIPSTSEDVPTPNRILIRVMYCGL*SYGLRYIILKRTLEHQFPNLLEFEEERATQVTGEFEVFVDGKLIHSKKKGDGFVDESGLKKLVGAIDEEIKKR

Target ORF information:

RefSeq Version	NM_175033.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus selenoprotein V (Selenov), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175033.4

ORF Insert Sequence:

ATGAATAACA AGGCGCGGGT CCCCGCTCCC TCCTCAGTCC GGGCAAACAC CCCGGCCCGG 
ACACCCGCTC CCATCCGAAC CGCGACCCCA GTCAGGGCCC CGAACCCAGC GCACAACTCG 
ACTCCAGTCC GAACTTCCAT CCGGGTCCGG GCTCCTGCCC AAGTCCCTAA CCCTGTTCCA 
ATCCGGTTCC CAACTCCAGC CCCAGTCCCT GCCCCAACCC TAACCCCAGC CCCAACTCCA 
GCTCCAGTCC GGCATGCAGC ACCGGTGCGG ACTCCAGCAC CAGTCCGGGC CCCGAATCTA 
GGTCGGGTCT TTCCTAAGAT CTCTCCAGGC AGGTTCTTCC CGAGCTTGGC CTCGCCCACG 
GCACAGCCCC TTTCTTCCAG GGCTGCTAGC GCTCTCTTGA AGGATCCCAC ACTCGCTCAA 
AATCAGAAAC CCTCGATCCA CAGCCTAGCG GAGGCCATCC AGGGGCCCCT TCCAGTGCTC 
ACTCCCTCGT CCTCCAAGAC ACAAGGCTCC ATACCGGACA CCGCCTCTCC CATAGACTCC 
TTGGCTTCTA CTGCCATGGC CTCCAGTACA TTGGGCCCCA TTCCGGGCCC CAACCCTACA 
CTAGAGTTCT TGGCCTCCCC GCTGAAGGAA ACCCCTGGTC TGGGTAAGCT CTCCACGATT 
TCCCCAGCAC CCAGCTTCGG TTCCACTAAG GAGATCCCAT CCACCAGCGA GGACGTCCCA 
ACGCCCAACA GAATCTTGAT CCGTGTGATG TACTGTGGCC TCTGAAGCTA TGGCCTTCGG 
TACATTATAC TGAAAAGGAC CCTGGAGCAT CAATTCCCAA ACCTTCTGGA GTTTGAGGAG 
GAAAGAGCTA CCCAGGTTAC AGGGGAGTTT GAAGTGTTTG TGGATGGGAA GCTGATCCAT 
TCCAAGAAGA AAGGTGATGG CTTTGTGGAT GAGTCCGGTC TGAAGAAACT TGTGGGTGCT 
ATTGACGAAG AGATCAAGAA GAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice.
Proceedings of the National Academy of Sciences of the United States of America113(28)7704-10(2016 07)
Miyata H,Castaneda JM,Fujihara Y,Yu Z,Archambeault DR,Isotani A,Kiyozumi D,Kriseman ML,Mashiko D,Matsumura T,Matzuk RM,Mori M,Noda T,Oji A,Okabe M,Prunskaite-Hyyrylainen R,Ramirez-Solis R,Satouh Y,Zhang Q,Ikawa M,Matzuk MM

[cDNA cloning, expression and determination of substrate specificity of mice selenocysteine-containing protein SelV (Selenoprotein V)].
Molekuliarnaia biologiia49(5)785-9(2015 Sep-Oct)
Varlamova EG,Novoselov SV,Novoselov VI

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

Characterization of mammalian selenoproteomes.
Science (New York, N.Y.)300(5624)1439-43(2003 May)
Kryukov GV,Castellano S,Novoselov SV,Lobanov AV,Zehtab O,Guig? R,Gladyshev VN

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Selenov cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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