Ubl4a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ubl4a
Entrez Gene ID	27643
Full Name	ubiquitin-like 4A
Synonyms	DXHXS254E,DXS254E,DXS254Eh,Gdx,Ubl4
General protein information	Preferred Names ubiquitin-like 4A Names ubiquitin-like protein 4A housekeeping protein DXS254E ubiquitin-like 4 ubiquitin-like protein GDX
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X A7.3\|X 38.0 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_145405.2	NP_663380.1	ubiquitin-like protein 4A

Pathways from BioSystems

Homologies

	UBL4A	XP_001094573.1
Mus musculus (house mouse)	Slc10a3-ubl4	NP_001265200.1
Bos taurus (cattle)	UBL4A	NP_001029386.1
Mus musculus (house mouse)	Ubl4	NP_663380.1
Xenopus tropicalis (tropical clawed frog)	ubl4a	NP_001096510.1
Homo sapiens (human)	UBL4A	NP_055050.1
Danio rerio (zebrafish)	zgc:56596	NP_956594.1
Pan troglodytes (chimpanzee)	UBL4A	NP_001229350.1
Canis lupus familiaris (dog)	UBL4A	XP_855388.3
Rattus norvegicus (Norway rat)	Ubl4a	NP_001099816.1

Gene Ontology
Bibliography

Related articles in PubMed

Deficiency in ubiquitin-like protein Ubl4A impairs migration of fibroblasts and macrophages.
Zhao Y, Zhang H, Affonso C, Bonomo R, Ma?as A, Xiang J
Biochemical and biophysical research communications483(1)617-623(2017 01)

Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching.
Zhao Y, Lin Y, Zhang H, Ma?as A, Tang W, Zhang Y, Wu D, Lin A, Xiang J
Proceedings of the National Academy of Sciences of the United States of America112(31)9644-9(2015 Aug)

Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis.
Kuwabara N, Minami R, Yokota N, Matsumoto H, Senda T, Kawahara H, Kato R
The Journal of biological chemistry290(15)9387-98(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ubl4A has a role in fibroblast and macrophage migration-associated pathophysiological processes
Title: Deficiency in ubiquitin-like protein Ubl4A impairs migration of fibroblasts and macrophages.

ubiquitin-like protein 4A (Ubl4A) plays a crucial role in insulin-induced Akt plasma membrane translocation.
Title: Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching.

Data indicate that the BAGS domain of BAG6 (Bcl-2-associated athanogene 6) interacts with the C-terminal domain of Ubl4a (ubiquitin-like protein 4a).
Title: Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis.

GdX converts TC45, a nonspecific phosphatase, into a STAT3-specific phosphatase by bridging an association between TC45 and STAT3
Title: GdX/UBL4A specifically stabilizes the TC45/STAT3 association and promotes dephosphorylation of STAT3 to repress tumorigenesis.

GdX knockout male mice are functionally normal in the reproductive system where Ubl4B was specifically expressed.
Title: Generation of mice with conditional null allele for GdX/Ubl4A.

The following Ubl4a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ubl4a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19636	NM_145405.2 Latest version!	Mus musculus ubiquitin-like 4A (Ubl4a), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ubl4a ( NM_145405.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_663380.1 Mus musculus ubiquitin-like 4A (Ubl4a), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu19636
Clone ID Related Accession (Same CDS sequence)	NM_145405.2
Accession Version	NM_145405.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	ubiquitin-like protein 4A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY273712.1, BM932729.1, AK048689.1 and BM900115.1. On Jan 5, 2012 this sequence version replaced NM_145405.1. Transcript Variant: This variant (1) represents the longer, protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF160166.1, SRR1660813.27275.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCTGA CCGTGAAGGC GCTCCAGGGC CGGGAATGTA GCCTACAGGT GGCGGAGGAC 
GAGCTAGTGT CTACACTGAA GCACCTGGTC TCGGATAAGC TGAATGTCCC TGTGCGCCAG 
CAACGTCTGC TGTTCAAGGG CAAGGCCCTA GCAGATGAAA AACGACTGTC AGATTACAAC 
ATTGGGCCCA ATTCTAAGCT CAACCTAGTT GTTAAGCCTT TGGAGAAGGT GCTACTGGAA 
GAAGGGTCTG CCCACAGACT GGTCGACTCC CCAGCCACCC CCATCTGGCA GCTGATCTCC 
AAAGTCCTGG CCCGTCACTT CAGTGTAGCA GATGCCAGCA GGGTCCTGGA ACAACTACAG 
AGGGATTATG ACAGGTCCTT GAGCCGCCTA ACACTGGATG ACATCGAACG TTTGGCCAGC 
CGCTTTCTAC ACCCTGAAGT GACTGAGGCT ATGGAAAAAG GGTTCTGCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663380.1
CDS	86..559
Translation	MQLTVKALQGRECSLQVAEDELVSTLKHLVSDKLNVPVRQQRLLFKGKALADEKRLSDYNIGPNSKLNLVVKPLEKVLLEEGSAHRLVDSPATPIWQLISKVLARHFSVADASRVLEQLQRDYDRSLSRLTLDDIERLASRFLHPEVTEAMEKGFCK

Target ORF information:

RefSeq Version	NM_145405.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ubiquitin-like 4A (Ubl4a), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145405.2

ORF Insert Sequence:

ATGCAGCTGA CCGTGAAGGC GCTCCAGGGC CGGGAATGTA GCCTACAGGT GGCGGAGGAC 
GAGCTAGTGT CTACACTGAA GCACCTGGTC TCGGATAAGC TGAATGTCCC TGTGCGCCAG 
CAACGTCTGC TGTTCAAGGG CAAGGCCCTA GCAGATGAAA AACGACTGTC AGATTACAAC 
ATTGGGCCCA ATTCTAAGCT CAACCTAGTT GTTAAGCCTT TGGAGAAGGT GCTACTGGAA 
GAAGGGTCTG CCCACAGACT GGTCGACTCC CCAGCCACCC CCATCTGGCA GCTGATCTCC 
AAAGTCCTGG CCCGTCACTT CAGTGTAGCA GATGCCAGCA GGGTCCTGGA ACAACTACAG 
AGGGATTATG ACAGGTCCTT GAGCCGCCTA ACACTGGATG ACATCGAACG TTTGGCCAGC 
CGCTTTCTAC ACCCTGAAGT GACTGAGGCT ATGGAAAAAG GGTTCTGCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deficiency in ubiquitin-like protein Ubl4A impairs migration of fibroblasts and macrophages.
Biochemical and biophysical research communications483(1)617-623(2017 01)
Zhao Y,Zhang H,Affonso C,Bonomo R,Ma?as A,Xiang J

Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching.
Proceedings of the National Academy of Sciences of the United States of America112(31)9644-9(2015 Aug)
Zhao Y,Lin Y,Zhang H,Ma?as A,Tang W,Zhang Y,Wu D,Lin A,Xiang J

Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis.
The Journal of biological chemistry290(15)9387-98(2015 Apr)
Kuwabara N,Minami R,Yokota N,Matsumoto H,Senda T,Kawahara H,Kato R

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Ubl4a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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