Dok3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dok3
Entrez Gene ID	27261
Full Name	docking protein 3
Synonyms	AI450713,Dokl
General protein information	Preferred Names docking protein 3 Names docking protein 3 DOK-L Dok-like protein downstream of tyrosine kinase 3 p62(dok)-like protein p62Dok-like protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_013739.2	NP_038767.1	docking protein 3
XM_017315524.1	XP_017171013.1	docking protein 3 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	DOK3	XP_005619500.1
Mus musculus (house mouse)	Dok3	NP_038767.1
Bos taurus (cattle)	DOK3	NP_001192253.1
Rattus norvegicus (Norway rat)	Dok3	NP_001100806.1
Homo sapiens (human)	DOK3	NP_079148.2
Gallus gallus (chicken)	DOK3	NP_001076832.1

Gene Ontology
Bibliography

Related articles in PubMed

DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis.
Cai X, Xing J, Long CL, Peng Q, Humphrey MB
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research32(11)2207-2218(2017 Nov)

A functional genomics predictive network model identifies regulators of inflammatory bowel disease.
Peters LA, Perrigoue J, Mortha A, Iuga A, Song WM, Neiman EM, Llewellyn SR, Di Narzo A, Kidd BA, Telesco SE, Zhao Y, Stojmirovic A, Sendecki J, Shameer K, Miotto R, Losic B, Shah H, Lee E, Wang M, Faith JJ, Kasarskis A, Brodmerkel C, Curran M, Das A, Friedman JR, Fukui Y, Humphrey MB, Iritani BM, Sibinga N, Tarrant TK, Argmann C, Hao K, Roussos P, Zhu J, Zhang B, Dobrin R, Mayer LF, Schadt EE
Nature genetics49(10)1437-1449(2017 Oct)

DOK3 Degradation is Required for the Development of LPS-induced ARDS in Mice.
Liu N, Liu X, Li X, Duan K, Deng Y, Yu X, Peng Q
Current gene therapy16(4)256-262(2016)

TRAF6-mediated degradation of DOK3 is required for production of IL-6 and TNF? in TLR9 signaling.
Liu N, Tang B, Wei P, Sun W, Wang S, Peng Q
Molecular immunology68(2 Pt C)699-705(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DOK3 lung expression negatively regulates the development of lipopolysaccharide-induced acute respiratory distress syndrome in mice.
Title: DOK3 Degradation is Required for the Development of LPS-induced ARDS in Mice.

we demonstrate that CpG treatment leads to ubiquitin-mediated degradation of DOK3 via interaction with an E3 ligase TNFR-associated factor 6 (TRAF6).
Title: TRAF6-mediated degradation of DOK3 is required for production of IL-6 and TNF? in TLR9 signaling.

This study reveals DOK3 as a nonredundant regulator of plasma cell differentiation by up-regulating PD-1 ligand expression through the attenuation of calcium signaling.
Title: Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands.

Data show that docking protein 3 (DOK3) plays a role in TLR3 signaling by enabling TNFR-associated factor (TRAF) 3/TANK-binding kinase (TBK) 1 binding and facilitating TBK1 and IFN regulatory factor 3 activation and the induction of IFN-beta production.
Title: DOK3 is required for IFN-? production by enabling TRAF3/TBK1 complex formation and IRF3 activation.

DOK3 physically associated with the ITAM of DAP12 through its phosphotyrosine-binding domain. In response to LPS, DOK3 was phosphorylated in a DAP12- and Src-dependent manner, which led to translocation of phosphorylated DOK3 to the plasma membrane.
Title: A physical interaction between the adaptor proteins DOK3 and DAP12 is required to inhibit lipopolysaccharide signaling in macrophages.

The following Dok3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dok3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15979	NM_013739.2 Latest version!	Mus musculus docking protein 3 (Dok3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu15979	XM_017315524.1 Latest version!	Mus musculus docking protein 3 (Dok3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dok3 ( NM_013739.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038767.1 Mus musculus docking protein 3 (Dok3), mRNA.

Price & Availability↑

CloneID	OMu15979
Clone ID Related Accession (Same CDS sequence)	NM_013739.2 , XM_017315524.1
Accession Version	NM_013739.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1335bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	docking protein 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CT009762.8. On Nov 17, 2006 this sequence version replaced NM_013739.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF179242.1, AF237580.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGGAGTCTG TGGAGCCCCC GGTCAAAGAC GGCATCCTCT ACCAGCAGCA CGTAAAGTTT 
GGCAAGAAAT GCTGGCGCAA AGTGTGGGCT CTGCTGTATG CGGGAGGCCC ATCAGGGGTA 
GCTCGGCTAG AAAGCTGGGA CGTGCGTGAT GGTGGCCTGG GACCAGCAGG CGACAGGTCC 
ACAGGGCCCA GCCGTCGAGG GGAACGCCGG GTCATACGCT TGGCTGACTG TGTATCTGTC 
CTGCCTGCGG ATGGCGAGAG CTGTCCCAGG GACACTGGTG CCTTCCTGAT TACCACCACT 
GAGCGAAGCC ACCTGTTGGC TGCACAGCAC CGCCAGTCCT GGGTGGACCC CATCTGTCAG 
CTGGCCTTCC CGGGTACCGG AGAATGTTCG TCAGGATCAG GACAGGCTGA GAGTCCAAAA 
AGGGGCTTTG TTCCCATGGA GGAAAACTCT ATCTACTCCT CCTGGCAGGA AGTGACCGAG 
TTTCCGGTGA TCGTGCAGAG GACAGAGGCC ACCTCCCGCT GCCAGCTGAA AGGACCCTAC 
CTCCTGGTGC TGGGCCAAGA TGACATCCAA CTGAGGGAGA CATCCAAGCC CCAGGCCTGT 
TTTAGCTGGC CCTACCGTTT CCTGCGCAAG TACGGCTCTG ACAAGGGTGT GTTCTCGTTT 
GAGGCTGGCC GCCGCTGTGA CTCAGGTGAG GGCCTTTTTG CCTTCAGTAG CCCGCGTGCC 
CCAGACATAT GTGGGGTTGT GGCTGCCGCC ATTGCCCGCC AGCGGGAGCG TCTTCCAGAG 
CTGGCCATGT CCCCACCCTG CCCCCTGCCT CGGGCCCTCT CCCTGCCCTC CCTAGAGCCC 
CCTGGAGAGC TTCGGGAGGT GGCCCCAGGA TTTGAGCTGC CCACTCCCAG AAAGCTGCCT 
CTAACTGATC CCGGGCCTCA AAGCCTACCA CTGCTGCTCA GCCCCACACA AGAAGGACCG 
GCATCCGGTC TCTATGCGTC CGTGTGCAAG CAGACCAGCA AGCACACAGG CACGGCGGAG 
CATCTCTATG AGAACGTGTG CATGCTGGAG GCCAGCCCTG GGCTGACCAA TGGGGGTCCT 
GAAGCCCAAG AGGGCCCCCC TGGTGGCCGC AGCCCCCTGG GCAGCCCTAT CTACCATAAC 
ACTGAGGATC TGAGTTGGCC GGGCTCGGCC CAGGACAGCA ATCTGGAAGC CCAGTACCGG 
AGGCTGCTGG AACTGGAGCT GGATGAGGCC GGAAGCGCCG GCCGCTCTGG AGCGCAGGCA 
GGCATCAAGG CCAAGCTGGT GACCCTGCTG ACCCGTGAAC GGAAGAAGGG CCCCGCCCCC 
TGTGACCGGC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038767.1
CDS	25..1359
Translation	MESVEPPVKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWDVRDGGLGPAGDRSTGPSRRGERRVIRLADCVSVLPADGESCPRDTGAFLITTTERSHLLAAQHRQSWVDPICQLAFPGTGECSSGSGQAESPKRGFVPMEENSIYSSWQEVTEFPVIVQRTEATSRCQLKGPYLLVLGQDDIQLRETSKPQACFSWPYRFLRKYGSDKGVFSFEAGRRCDSGEGLFAFSSPRAPDICGVVAAAIARQRERLPELAMSPPCPLPRALSLPSLEPPGELREVAPGFELPTPRKLPLTDPGPQSLPLLLSPTQEGPASGLYASVCKQTSKHTGTAEHLYENVCMLEASPGLTNGGPEAQEGPPGGRSPLGSPIYHNTEDLSWPGSAQDSNLEAQYRRLLELELDEAGSAGRSGAQAGIKAKLVTLLTRERKKGPAPCDRP

Target ORF information:

RefSeq Version	NM_013739.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus docking protein 3 (Dok3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013739.2

ORF Insert Sequence:

ATGGAGTCTG TGGAGCCCCC GGTCAAAGAC GGCATCCTCT ACCAGCAGCA CGTAAAGTTT 
GGCAAGAAAT GCTGGCGCAA AGTGTGGGCT CTGCTGTATG CGGGAGGCCC ATCAGGGGTA 
GCTCGGCTAG AAAGCTGGGA CGTGCGTGAT GGTGGCCTGG GACCAGCAGG CGACAGGTCC 
ACAGGGCCCA GCCGTCGAGG GGAACGCCGG GTCATACGCT TGGCTGACTG TGTATCTGTC 
CTGCCTGCGG ATGGCGAGAG CTGTCCCAGG GACACTGGTG CCTTCCTGAT TACCACCACT 
GAGCGAAGCC ACCTGTTGGC TGCACAGCAC CGCCAGTCCT GGGTGGACCC CATCTGTCAG 
CTGGCCTTCC CGGGTACCGG AGAATGTTCG TCAGGATCAG GACAGGCTGA GAGTCCAAAA 
AGGGGCTTTG TTCCCATGGA GGAAAACTCT ATCTACTCCT CCTGGCAGGA AGTGACCGAG 
TTTCCGGTGA TCGTGCAGAG GACAGAGGCC ACCTCCCGCT GCCAGCTGAA AGGACCCTAC 
CTCCTGGTGC TGGGCCAAGA TGACATCCAA CTGAGGGAGA CATCCAAGCC CCAGGCCTGT 
TTTAGCTGGC CCTACCGTTT CCTGCGCAAG TACGGCTCTG ACAAGGGTGT GTTCTCGTTT 
GAGGCTGGCC GCCGCTGTGA CTCAGGTGAG GGCCTTTTTG CCTTCAGTAG CCCGCGTGCC 
CCAGACATAT GTGGGGTTGT GGCTGCCGCC ATTGCCCGCC AGCGGGAGCG TCTTCCAGAG 
CTGGCCATGT CCCCACCCTG CCCCCTGCCT CGGGCCCTCT CCCTGCCCTC CCTAGAGCCC 
CCTGGAGAGC TTCGGGAGGT GGCCCCAGGA TTTGAGCTGC CCACTCCCAG AAAGCTGCCT 
CTAACTGATC CCGGGCCTCA AAGCCTACCA CTGCTGCTCA GCCCCACACA AGAAGGACCG 
GCATCCGGTC TCTATGCGTC CGTGTGCAAG CAGACCAGCA AGCACACAGG CACGGCGGAG 
CATCTCTATG AGAACGTGTG CATGCTGGAG GCCAGCCCTG GGCTGACCAA TGGGGGTCCT 
GAAGCCCAAG AGGGCCCCCC TGGTGGCCGC AGCCCCCTGG GCAGCCCTAT CTACCATAAC 
ACTGAGGATC TGAGTTGGCC GGGCTCGGCC CAGGACAGCA ATCTGGAAGC CCAGTACCGG 
AGGCTGCTGG AACTGGAGCT GGATGAGGCC GGAAGCGCCG GCCGCTCTGG AGCGCAGGCA 
GGCATCAAGG CCAAGCTGGT GACCCTGCTG ACCCGTGAAC GGAAGAAGGG CCCCGCCCCC 
TGTGACCGGC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dok3 ( XM_017315524.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017171013.1 Mus musculus docking protein 3 (Dok3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu15979
Clone ID Related Accession (Same CDS sequence)	NM_013739.2 , XM_017315524.1
Accession Version	XM_017315524.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1335bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	docking protein 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTCTG TGGAGCCCCC GGTCAAAGAC GGCATCCTCT ACCAGCAGCA CGTAAAGTTT 
GGCAAGAAAT GCTGGCGCAA AGTGTGGGCT CTGCTGTATG CGGGAGGCCC ATCAGGGGTA 
GCTCGGCTAG AAAGCTGGGA CGTGCGTGAT GGTGGCCTGG GACCAGCAGG CGACAGGTCC 
ACAGGGCCCA GCCGTCGAGG GGAACGCCGG GTCATACGCT TGGCTGACTG TGTATCTGTC 
CTGCCTGCGG ATGGCGAGAG CTGTCCCAGG GACACTGGTG CCTTCCTGAT TACCACCACT 
GAGCGAAGCC ACCTGTTGGC TGCACAGCAC CGCCAGTCCT GGGTGGACCC CATCTGTCAG 
CTGGCCTTCC CGGGTACCGG AGAATGTTCG TCAGGATCAG GACAGGCTGA GAGTCCAAAA 
AGGGGCTTTG TTCCCATGGA GGAAAACTCT ATCTACTCCT CCTGGCAGGA AGTGACCGAG 
TTTCCGGTGA TCGTGCAGAG GACAGAGGCC ACCTCCCGCT GCCAGCTGAA AGGACCCTAC 
CTCCTGGTGC TGGGCCAAGA TGACATCCAA CTGAGGGAGA CATCCAAGCC CCAGGCCTGT 
TTTAGCTGGC CCTACCGTTT CCTGCGCAAG TACGGCTCTG ACAAGGGTGT GTTCTCGTTT 
GAGGCTGGCC GCCGCTGTGA CTCAGGTGAG GGCCTTTTTG CCTTCAGTAG CCCGCGTGCC 
CCAGACATAT GTGGGGTTGT GGCTGCCGCC ATTGCCCGCC AGCGGGAGCG TCTTCCAGAG 
CTGGCCATGT CCCCACCCTG CCCCCTGCCT CGGGCCCTCT CCCTGCCCTC CCTAGAGCCC 
CCTGGAGAGC TTCGGGAGGT GGCCCCAGGA TTTGAGCTGC CCACTCCCAG AAAGCTGCCT 
CTAACTGATC CCGGGCCTCA AAGCCTACCA CTGCTGCTCA GCCCCACACA AGAAGGACCG 
GCATCCGGTC TCTATGCGTC CGTGTGCAAG CAGACCAGCA AGCACACAGG CACGGCGGAG 
CATCTCTATG AGAACGTGTG CATGCTGGAG GCCAGCCCTG GGCTGACCAA TGGGGGTCCT 
GAAGCCCAAG AGGGCCCCCC TGGTGGCCGC AGCCCCCTGG GCAGCCCTAT CTACCATAAC 
ACTGAGGATC TGAGTTGGCC GGGCTCGGCC CAGGACAGCA ATCTGGAAGC CCAGTACCGG 
AGGCTGCTGG AACTGGAGCT GGATGAGGCC GGAAGCGCCG GCCGCTCTGG AGCGCAGGCA 
GGCATCAAGG CCAAGCTGGT GACCCTGCTG ACCCGTGAAC GGAAGAAGGG CCCCGCCCCC 
TGTGACCGGC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017171013.1
CDS	1668..3002
Translation	MESVEPPVKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWDVRDGGLGPAGDRSTGPSRRGERRVIRLADCVSVLPADGESCPRDTGAFLITTTERSHLLAAQHRQSWVDPICQLAFPGTGECSSGSGQAESPKRGFVPMEENSIYSSWQEVTEFPVIVQRTEATSRCQLKGPYLLVLGQDDIQLRETSKPQACFSWPYRFLRKYGSDKGVFSFEAGRRCDSGEGLFAFSSPRAPDICGVVAAAIARQRERLPELAMSPPCPLPRALSLPSLEPPGELREVAPGFELPTPRKLPLTDPGPQSLPLLLSPTQEGPASGLYASVCKQTSKHTGTAEHLYENVCMLEASPGLTNGGPEAQEGPPGGRSPLGSPIYHNTEDLSWPGSAQDSNLEAQYRRLLELELDEAGSAGRSGAQAGIKAKLVTLLTRERKKGPAPCDRP

Target ORF information:

RefSeq Version	XM_017315524.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus docking protein 3 (Dok3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017315524.1

ORF Insert Sequence:

ATGGAGTCTG TGGAGCCCCC GGTCAAAGAC GGCATCCTCT ACCAGCAGCA CGTAAAGTTT 
GGCAAGAAAT GCTGGCGCAA AGTGTGGGCT CTGCTGTATG CGGGAGGCCC ATCAGGGGTA 
GCTCGGCTAG AAAGCTGGGA CGTGCGTGAT GGTGGCCTGG GACCAGCAGG CGACAGGTCC 
ACAGGGCCCA GCCGTCGAGG GGAACGCCGG GTCATACGCT TGGCTGACTG TGTATCTGTC 
CTGCCTGCGG ATGGCGAGAG CTGTCCCAGG GACACTGGTG CCTTCCTGAT TACCACCACT 
GAGCGAAGCC ACCTGTTGGC TGCACAGCAC CGCCAGTCCT GGGTGGACCC CATCTGTCAG 
CTGGCCTTCC CGGGTACCGG AGAATGTTCG TCAGGATCAG GACAGGCTGA GAGTCCAAAA 
AGGGGCTTTG TTCCCATGGA GGAAAACTCT ATCTACTCCT CCTGGCAGGA AGTGACCGAG 
TTTCCGGTGA TCGTGCAGAG GACAGAGGCC ACCTCCCGCT GCCAGCTGAA AGGACCCTAC 
CTCCTGGTGC TGGGCCAAGA TGACATCCAA CTGAGGGAGA CATCCAAGCC CCAGGCCTGT 
TTTAGCTGGC CCTACCGTTT CCTGCGCAAG TACGGCTCTG ACAAGGGTGT GTTCTCGTTT 
GAGGCTGGCC GCCGCTGTGA CTCAGGTGAG GGCCTTTTTG CCTTCAGTAG CCCGCGTGCC 
CCAGACATAT GTGGGGTTGT GGCTGCCGCC ATTGCCCGCC AGCGGGAGCG TCTTCCAGAG 
CTGGCCATGT CCCCACCCTG CCCCCTGCCT CGGGCCCTCT CCCTGCCCTC CCTAGAGCCC 
CCTGGAGAGC TTCGGGAGGT GGCCCCAGGA TTTGAGCTGC CCACTCCCAG AAAGCTGCCT 
CTAACTGATC CCGGGCCTCA AAGCCTACCA CTGCTGCTCA GCCCCACACA AGAAGGACCG 
GCATCCGGTC TCTATGCGTC CGTGTGCAAG CAGACCAGCA AGCACACAGG CACGGCGGAG 
CATCTCTATG AGAACGTGTG CATGCTGGAG GCCAGCCCTG GGCTGACCAA TGGGGGTCCT 
GAAGCCCAAG AGGGCCCCCC TGGTGGCCGC AGCCCCCTGG GCAGCCCTAT CTACCATAAC 
ACTGAGGATC TGAGTTGGCC GGGCTCGGCC CAGGACAGCA ATCTGGAAGC CCAGTACCGG 
AGGCTGCTGG AACTGGAGCT GGATGAGGCC GGAAGCGCCG GCCGCTCTGG AGCGCAGGCA 
GGCATCAAGG CCAAGCTGGT GACCCTGCTG ACCCGTGAAC GGAAGAAGGG CCCCGCCCCC 
TGTGACCGGC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research32(11)2207-2218(2017 Nov)
Cai X,Xing J,Long CL,Peng Q,Humphrey MB

A functional genomics predictive network model identifies regulators of inflammatory bowel disease.
Nature genetics49(10)1437-1449(2017 Oct)
Peters LA,Perrigoue J,Mortha A,Iuga A,Song WM,Neiman EM,Llewellyn SR,Di Narzo A,Kidd BA,Telesco SE,Zhao Y,Stojmirovic A,Sendecki J,Shameer K,Miotto R,Losic B,Shah H,Lee E,Wang M,Faith JJ,Kasarskis A,Brodmerkel C,Curran M,Das A,Friedman JR,Fukui Y,Humphrey MB,Iritani BM,Sibinga N,Tarrant TK,Argmann C,Hao K,Roussos P,Zhu J,Zhang B,Dobrin R,Mayer LF,Schadt EE

DOK3 Degradation is Required for the Development of LPS-induced ARDS in Mice.
Current gene therapy16(4)256-262(2016)
Liu N,Liu X,Li X,Duan K,Deng Y,Yu X,Peng Q

TRAF6-mediated degradation of DOK3 is required for production of IL-6 and TNF? in TLR9 signaling.
Molecular immunology68(2 Pt C)699-705(2015 Dec)
Liu N,Tang B,Wei P,Sun W,Wang S,Peng Q

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Dok3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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