Tlx3 cDNA ORF clone, Mus musculus(house mouse)

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)

Repression by PRDM13 is critical for generating precision in neuronal identity.
Mona B, Uruena A, Kollipara RK, Ma Z, Borromeo MD, Chang JC, Johnson JE
eLife6(2017 Aug)

Genetic identification of a hindbrain nucleus essential for innate vocalization.
Hernandez-Miranda LR, Ruffault PL, Bouvier JC, Murray AJ, Morin-Surun MP, Zampieri N, Cholewa-Waclaw JB, Ey E, Brunet JF, Champagnat J, Fortin G, Birchmeier C
Proceedings of the National Academy of Sciences of the United States of America114(30)8095-8100(2017 Jul)

Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation.
Ravindran E, Hu H, Yuzwa SA, Hernandez-Miranda LR, Kraemer N, Ninnemann O, Musante L, Boltshauser E, Schindler D, H?bner A, Reinecker HC, Ropers HH, Birchmeier C, Miller FD, Wienker TF, H?bner C, Kaindl AM
PLoS genetics13(4)e1006746(2017 Apr)

Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP.
Title: Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP.

Tlx3 uses distinct mechanisms to tightly modulate Prrxl1 activity, either by controlling its transcriptional levels or by increasing Prrxl1 phosphorylation state.
Title: Dual role of Tlx3 as modulator of Prrxl1 transcription and phosphorylation.

The tlx2 knockout mice failed to exhibit escape response evoked by dynamic mechanical stimuli but retained the ability to sense innocuous cooling and/or warm and development of a subset of excitatory neurons located in laminae I and II was impaired.
Title: Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities.

Tlx3 is required for the acquisition of cholinergic phenotype at the late embryonic stage as well as the expression and maintenance of cholinergic peptides
Title: Tlx3 controls cholinergic transmitter and Peptide phenotypes in a subset of prenatal sympathetic neurons.

This study demonistrated that Tlx3 and Runx1 act in combination to coordinate the development of nociceptors, thermoceptors, and pruriceptors.
Title: Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors.