Prnd cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prnd
Entrez Gene ID	26434
Full Name	prion like protein doppel
Synonyms	AI450264,Dpl,PrPLP,doppel
General protein information	Preferred Names prion like protein doppel Names prion-like protein doppel doppelganger prion protein dublet prion protein-like protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 F2\|2 64.07 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001278257.1	NP_001265186.1	prion-like protein doppel precursor
NM_001126338.2	NP_001119810.1	prion-like protein doppel precursor
NM_023043.3	NP_075530.1	prion-like protein doppel precursor
NM_001278520.1	NP_001265449.1	prion-like protein doppel precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PRND	XP_525256.1
Canis lupus familiaris (dog)	PRND	XP_005634877.1
Bos taurus (cattle)	PRND	NP_776583.1
Rattus norvegicus (Norway rat)	Prnd	NP_001095901.1
Homo sapiens (human)	PRND	NP_036541.2
	PRND	XP_001115569.1
Mus musculus (house mouse)	Prn	NP_001265187.1
Mus musculus (house mouse)	Prnd	NP_001119810.1

Gene Ontology
Bibliography

Related articles in PubMed

Endoproteolytic processing of the mammalian prion glycoprotein family.
Mays CE, Coomaraswamy J, Watts JC, Yang J, Ko KW, Strome B, Mercer RC, Wohlgemuth SL, Schmitt-Ulms G, Westaway D
The FEBS journal281(3)862-76(2014 Feb)

The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.
Mercer RC, Ma L, Watts JC, Strome R, Wohlgemuth S, Yang J, Cashman NR, Coulthart MB, Schmitt-Ulms G, Jhamandas JH, Westaway D
The Journal of biological chemistry288(52)37241-55(2013 Dec)

Prion versus doppel protein misfolding: new insights from replica-exchange molecular dynamics simulations.
Baillod P, Garrec J, Tavernelli I, Rothlisberger U
Biochemistry52(47)8518-26(2013 Nov)

Ataxia with cerebellar lesions in mice expressing chimeric PrP-Dpl protein.
Lemaire-Vieille C, Bailly Y, Erlich P, Loeuillet C, Brocard J, Haeberl? AM, Bombarde G, Rak C, Demais V, Dumestre-P?rard C, Gagnon J, Cesbron JY
The Journal of neuroscience : the official journal of the Society for Neuroscience33(4)1391-9(2013 Jan)

Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity.
Qin K, Ding T, Xiao Y, Ma W, Wang Z, Gao J, Zhao L
PloS one8(12)e82130(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that glycosylation status of the prion protein and yet-to-be-identified proteases modulate internal C1 and C2 endoproteolysis of Doppel (doppelganger prion) and Shadoo (shadow of prion protein) in mouse neurons.
Title: Endoproteolytic processing of the mammalian prion glycoprotein family.

Data on residue secondary structure propensities suggest that novel beta-sheets of doppel protein (Prnd) and prion protein (Prnp) are formed by amino acids belonging to helices that are the least stable in the respective native structures.
Title: Prion versus doppel protein misfolding: new insights from replica-exchange molecular dynamics simulations.

This finding identifies a protein domain that plays a role in mediating Dpl-related toxicity.
Title: Ataxia with cerebellar lesions in mice expressing chimeric PrP-Dpl protein.

in GC-1 spg cells, phosphorylation of p21 and N-terminal truncated PrP may play roles in the control of Dpl-induced apoptosis, which may benefit the physiological function of Dpl in the male reproduction system.
Title: Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity.

Findings raise the possibility that Bax and caspase-3 feature in Dpl-mediated apoptosis.
Title: The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells.

The following Prnd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prnd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu20183	NM_001278520.1 Latest version!	Mus musculus prion like protein doppel (Prnd), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu20183	NM_001126338.2 Latest version!	Mus musculus prion like protein doppel (Prnd), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu20183	NM_023043.3 Latest version!	Mus musculus prion like protein doppel (Prnd), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu20183	NM_001278257.1 Latest version!	Mus musculus prion like protein doppel (Prnd), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prnd ( NM_001278257.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001265186.1 Mus musculus prion like protein doppel (Prnd), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu20183
Clone ID Related Accession (Same CDS sequence)	NM_001278257.1 , NM_001126338.2 , NM_023043.3 , NM_001278520.1
Accession Version	NM_001278257.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	prion-like protein doppel precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK043023.1 and BY450477.1. Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK043023.1, CF723706.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAACC GGCTGGGTAC ATGGTGGGTG GCCATCCTCT GCATGCTGCT TGCCAGCCAC 
CTCTCCACGG TCAAGGCAAG GGGCATAAAG CACAGGTTCA AGTGGAACCG GAAGGTCCTG 
CCCAGCAGCG GCGGCCAGAT CACCGAAGCT CGGGTAGCTG AGAACCGCCC AGGAGCCTTC 
ATCAAGCAAG GCCGGAAGCT GGACATCGAC TTTGGAGCAG AGGGCAACAG GTACTACGCG 
GCTAACTATT GGCAGTTCCC TGATGGGATC TACTACGAAG GCTGCTCTGA AGCCAACGTG 
ACCAAGGAGA TGCTGGTGAC CAGCTGCGTC AACGCCACCC AGGCGGCCAA CCAGGCTGAG 
TTCTCCCGGG AGAAGCAGGA TAGCAAGCTC CACCAGCGAG TCCTGTGGCG GCTGATCAAA 
GAGATCTGCT CCGCCAAGCA CTGCGATTTC TGGCTGGAAA GGGGAGCTGC GCTTCGGGTC 
GCCGTGGACC AACCGGCGAT GGTCTGCCTG CTGGGTTTCG TTTGGTTCAT TGTGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265186.1
CDS	63..602
Translation	MKNRLGTWWVAILCMLLASHLSTVKARGIKHRFKWNRKVLPSSGGQITEARVAENRPGAFIKQGRKLDIDFGAEGNRYYAANYWQFPDGIYYEGCSEANVTKEMLVTSCVNATQAANQAEFSREKQDSKLHQRVLWRLIKEICSAKHCDFWLERGAALRVAVDQPAMVCLLGFVWFIVK

Target ORF information:

RefSeq Version	NM_001278257.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus prion like protein doppel (Prnd), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278257.1

ORF Insert Sequence:

ATGAAGAACC GGCTGGGTAC ATGGTGGGTG GCCATCCTCT GCATGCTGCT TGCCAGCCAC 
CTCTCCACGG TCAAGGCAAG GGGCATAAAG CACAGGTTCA AGTGGAACCG GAAGGTCCTG 
CCCAGCAGCG GCGGCCAGAT CACCGAAGCT CGGGTAGCTG AGAACCGCCC AGGAGCCTTC 
ATCAAGCAAG GCCGGAAGCT GGACATCGAC TTTGGAGCAG AGGGCAACAG GTACTACGCG 
GCTAACTATT GGCAGTTCCC TGATGGGATC TACTACGAAG GCTGCTCTGA AGCCAACGTG 
ACCAAGGAGA TGCTGGTGAC CAGCTGCGTC AACGCCACCC AGGCGGCCAA CCAGGCTGAG 
TTCTCCCGGG AGAAGCAGGA TAGCAAGCTC CACCAGCGAG TCCTGTGGCG GCTGATCAAA 
GAGATCTGCT CCGCCAAGCA CTGCGATTTC TGGCTGGAAA GGGGAGCTGC GCTTCGGGTC 
GCCGTGGACC AACCGGCGAT GGTCTGCCTG CTGGGTTTCG TTTGGTTCAT TGTGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Prnd ( NM_001126338.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001119810.1 Mus musculus prion like protein doppel (Prnd), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu20183
Clone ID Related Accession (Same CDS sequence)	NM_001278257.1 , NM_001126338.2 , NM_023043.3 , NM_001278520.1
Accession Version	NM_001126338.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	prion-like protein doppel precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK043023.1 and BY450477.1. On May 21, 2013 this sequence version replaced NM_001126338.1. Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ832281.1, AF192385.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAACC GGCTGGGTAC ATGGTGGGTG GCCATCCTCT GCATGCTGCT TGCCAGCCAC 
CTCTCCACGG TCAAGGCAAG GGGCATAAAG CACAGGTTCA AGTGGAACCG GAAGGTCCTG 
CCCAGCAGCG GCGGCCAGAT CACCGAAGCT CGGGTAGCTG AGAACCGCCC AGGAGCCTTC 
ATCAAGCAAG GCCGGAAGCT GGACATCGAC TTTGGAGCAG AGGGCAACAG GTACTACGCG 
GCTAACTATT GGCAGTTCCC TGATGGGATC TACTACGAAG GCTGCTCTGA AGCCAACGTG 
ACCAAGGAGA TGCTGGTGAC CAGCTGCGTC AACGCCACCC AGGCGGCCAA CCAGGCTGAG 
TTCTCCCGGG AGAAGCAGGA TAGCAAGCTC CACCAGCGAG TCCTGTGGCG GCTGATCAAA 
GAGATCTGCT CCGCCAAGCA CTGCGATTTC TGGCTGGAAA GGGGAGCTGC GCTTCGGGTC 
GCCGTGGACC AACCGGCGAT GGTCTGCCTG CTGGGTTTCG TTTGGTTCAT TGTGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001119810.1
CDS	63..602
Translation	MKNRLGTWWVAILCMLLASHLSTVKARGIKHRFKWNRKVLPSSGGQITEARVAENRPGAFIKQGRKLDIDFGAEGNRYYAANYWQFPDGIYYEGCSEANVTKEMLVTSCVNATQAANQAEFSREKQDSKLHQRVLWRLIKEICSAKHCDFWLERGAALRVAVDQPAMVCLLGFVWFIVK

Target ORF information:

RefSeq Version	NM_001126338.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus prion like protein doppel (Prnd), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001126338.2

ORF Insert Sequence:

ATGAAGAACC GGCTGGGTAC ATGGTGGGTG GCCATCCTCT GCATGCTGCT TGCCAGCCAC 
CTCTCCACGG TCAAGGCAAG GGGCATAAAG CACAGGTTCA AGTGGAACCG GAAGGTCCTG 
CCCAGCAGCG GCGGCCAGAT CACCGAAGCT CGGGTAGCTG AGAACCGCCC AGGAGCCTTC 
ATCAAGCAAG GCCGGAAGCT GGACATCGAC TTTGGAGCAG AGGGCAACAG GTACTACGCG 
GCTAACTATT GGCAGTTCCC TGATGGGATC TACTACGAAG GCTGCTCTGA AGCCAACGTG 
ACCAAGGAGA TGCTGGTGAC CAGCTGCGTC AACGCCACCC AGGCGGCCAA CCAGGCTGAG 
TTCTCCCGGG AGAAGCAGGA TAGCAAGCTC CACCAGCGAG TCCTGTGGCG GCTGATCAAA 
GAGATCTGCT CCGCCAAGCA CTGCGATTTC TGGCTGGAAA GGGGAGCTGC GCTTCGGGTC 
GCCGTGGACC AACCGGCGAT GGTCTGCCTG CTGGGTTTCG TTTGGTTCAT TGTGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Prnd ( NM_023043.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075530.1 Mus musculus prion like protein doppel (Prnd), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu20183
Clone ID Related Accession (Same CDS sequence)	NM_001278257.1 , NM_001126338.2 , NM_023043.3 , NM_001278520.1
Accession Version	NM_023043.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	prion-like protein doppel precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK161043.1, AF192384.1, AK043023.1 and BY450477.1. On May 21, 2013 this sequence version replaced NM_023043.2. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF192384.1, AK161043.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAACC GGCTGGGTAC ATGGTGGGTG GCCATCCTCT GCATGCTGCT TGCCAGCCAC 
CTCTCCACGG TCAAGGCAAG GGGCATAAAG CACAGGTTCA AGTGGAACCG GAAGGTCCTG 
CCCAGCAGCG GCGGCCAGAT CACCGAAGCT CGGGTAGCTG AGAACCGCCC AGGAGCCTTC 
ATCAAGCAAG GCCGGAAGCT GGACATCGAC TTTGGAGCAG AGGGCAACAG GTACTACGCG 
GCTAACTATT GGCAGTTCCC TGATGGGATC TACTACGAAG GCTGCTCTGA AGCCAACGTG 
ACCAAGGAGA TGCTGGTGAC CAGCTGCGTC AACGCCACCC AGGCGGCCAA CCAGGCTGAG 
TTCTCCCGGG AGAAGCAGGA TAGCAAGCTC CACCAGCGAG TCCTGTGGCG GCTGATCAAA 
GAGATCTGCT CCGCCAAGCA CTGCGATTTC TGGCTGGAAA GGGGAGCTGC GCTTCGGGTC 
GCCGTGGACC AACCGGCGAT GGTCTGCCTG CTGGGTTTCG TTTGGTTCAT TGTGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075530.1
CDS	63..602
Translation	MKNRLGTWWVAILCMLLASHLSTVKARGIKHRFKWNRKVLPSSGGQITEARVAENRPGAFIKQGRKLDIDFGAEGNRYYAANYWQFPDGIYYEGCSEANVTKEMLVTSCVNATQAANQAEFSREKQDSKLHQRVLWRLIKEICSAKHCDFWLERGAALRVAVDQPAMVCLLGFVWFIVK

Target ORF information:

RefSeq Version	NM_023043.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus prion like protein doppel (Prnd), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023043.3

ORF Insert Sequence:

ATGAAGAACC GGCTGGGTAC ATGGTGGGTG GCCATCCTCT GCATGCTGCT TGCCAGCCAC 
CTCTCCACGG TCAAGGCAAG GGGCATAAAG CACAGGTTCA AGTGGAACCG GAAGGTCCTG 
CCCAGCAGCG GCGGCCAGAT CACCGAAGCT CGGGTAGCTG AGAACCGCCC AGGAGCCTTC 
ATCAAGCAAG GCCGGAAGCT GGACATCGAC TTTGGAGCAG AGGGCAACAG GTACTACGCG 
GCTAACTATT GGCAGTTCCC TGATGGGATC TACTACGAAG GCTGCTCTGA AGCCAACGTG 
ACCAAGGAGA TGCTGGTGAC CAGCTGCGTC AACGCCACCC AGGCGGCCAA CCAGGCTGAG 
TTCTCCCGGG AGAAGCAGGA TAGCAAGCTC CACCAGCGAG TCCTGTGGCG GCTGATCAAA 
GAGATCTGCT CCGCCAAGCA CTGCGATTTC TGGCTGGAAA GGGGAGCTGC GCTTCGGGTC 
GCCGTGGACC AACCGGCGAT GGTCTGCCTG CTGGGTTTCG TTTGGTTCAT TGTGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Prnd ( NM_001278520.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001265449.1 Mus musculus prion like protein doppel (Prnd), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu20183
Clone ID Related Accession (Same CDS sequence)	NM_001278257.1 , NM_001126338.2 , NM_023043.3 , NM_001278520.1
Accession Version	NM_001278520.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	prion-like protein doppel precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL833794.9 and AK043023.1. Transcript Variant: This variant (4) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF165165.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAAGAACC GGCTGGGTAC ATGGTGGGTG GCCATCCTCT GCATGCTGCT TGCCAGCCAC 
CTCTCCACGG TCAAGGCAAG GGGCATAAAG CACAGGTTCA AGTGGAACCG GAAGGTCCTG 
CCCAGCAGCG GCGGCCAGAT CACCGAAGCT CGGGTAGCTG AGAACCGCCC AGGAGCCTTC 
ATCAAGCAAG GCCGGAAGCT GGACATCGAC TTTGGAGCAG AGGGCAACAG GTACTACGCG 
GCTAACTATT GGCAGTTCCC TGATGGGATC TACTACGAAG GCTGCTCTGA AGCCAACGTG 
ACCAAGGAGA TGCTGGTGAC CAGCTGCGTC AACGCCACCC AGGCGGCCAA CCAGGCTGAG 
TTCTCCCGGG AGAAGCAGGA TAGCAAGCTC CACCAGCGAG TCCTGTGGCG GCTGATCAAA 
GAGATCTGCT CCGCCAAGCA CTGCGATTTC TGGCTGGAAA GGGGAGCTGC GCTTCGGGTC 
GCCGTGGACC AACCGGCGAT GGTCTGCCTG CTGGGTTTCG TTTGGTTCAT TGTGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265449.1
CDS	42..581
Translation	MKNRLGTWWVAILCMLLASHLSTVKARGIKHRFKWNRKVLPSSGGQITEARVAENRPGAFIKQGRKLDIDFGAEGNRYYAANYWQFPDGIYYEGCSEANVTKEMLVTSCVNATQAANQAEFSREKQDSKLHQRVLWRLIKEICSAKHCDFWLERGAALRVAVDQPAMVCLLGFVWFIVK

Target ORF information:

RefSeq Version	NM_001278520.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus prion like protein doppel (Prnd), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278520.1

ORF Insert Sequence:

ATGAAGAACC GGCTGGGTAC ATGGTGGGTG GCCATCCTCT GCATGCTGCT TGCCAGCCAC 
CTCTCCACGG TCAAGGCAAG GGGCATAAAG CACAGGTTCA AGTGGAACCG GAAGGTCCTG 
CCCAGCAGCG GCGGCCAGAT CACCGAAGCT CGGGTAGCTG AGAACCGCCC AGGAGCCTTC 
ATCAAGCAAG GCCGGAAGCT GGACATCGAC TTTGGAGCAG AGGGCAACAG GTACTACGCG 
GCTAACTATT GGCAGTTCCC TGATGGGATC TACTACGAAG GCTGCTCTGA AGCCAACGTG 
ACCAAGGAGA TGCTGGTGAC CAGCTGCGTC AACGCCACCC AGGCGGCCAA CCAGGCTGAG 
TTCTCCCGGG AGAAGCAGGA TAGCAAGCTC CACCAGCGAG TCCTGTGGCG GCTGATCAAA 
GAGATCTGCT CCGCCAAGCA CTGCGATTTC TGGCTGGAAA GGGGAGCTGC GCTTCGGGTC 
GCCGTGGACC AACCGGCGAT GGTCTGCCTG CTGGGTTTCG TTTGGTTCAT TGTGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endoproteolytic processing of the mammalian prion glycoprotein family.
The FEBS journal281(3)862-76(2014 Feb)
Mays CE,Coomaraswamy J,Watts JC,Yang J,Ko KW,Strome B,Mercer RC,Wohlgemuth SL,Schmitt-Ulms G,Westaway D

The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.
The Journal of biological chemistry288(52)37241-55(2013 Dec)
Mercer RC,Ma L,Watts JC,Strome R,Wohlgemuth S,Yang J,Cashman NR,Coulthart MB,Schmitt-Ulms G,Jhamandas JH,Westaway D

Prion versus doppel protein misfolding: new insights from replica-exchange molecular dynamics simulations.
Biochemistry52(47)8518-26(2013 Nov)
Baillod P,Garrec J,Tavernelli I,Rothlisberger U

Ataxia with cerebellar lesions in mice expressing chimeric PrP-Dpl protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience33(4)1391-9(2013 Jan)
Lemaire-Vieille C,Bailly Y,Erlich P,Loeuillet C,Brocard J,Haeberl? AM,Bombarde G,Rak C,Demais V,Dumestre-P?rard C,Gagnon J,Cesbron JY

Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity.
PloS one8(12)e82130(2013)
Qin K,Ding T,Xiao Y,Ma W,Wang Z,Gao J,Zhao L

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Prnd cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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