Plod2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Plod2
Entrez Gene ID	26432
Full Name	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms	D530025C14Rik,LH2,Plod-2
General protein information	Preferred Names procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 Names procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 lysyl hydroxylase 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9 E3.3\|9 48.4 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011961.3	NP_036091.2	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 2 precursor
XM_030244393.1	XP_030100253.1	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1
NM_001142916.1	NP_001136388.1	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 1 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PLOD2	XP_542822.4
Bos taurus (cattle)	PLOD2	NP_001094619.1
Danio rerio (zebrafish)	plod2	NP_001082933.1
Homo sapiens (human)	PLOD2	NP_891988.1
	LOC715820	XP_002808385.1
Mus musculus (house mouse)	Plod2	NP_001136388.1
Rattus norvegicus (Norway rat)	Plod2	NP_787065.2
Xenopus tropicalis (tropical clawed frog)	plod2	XP_004914412.1
Pan troglodytes (chimpanzee)	PLOD2	XP_516801.3
Gallus gallus (chicken)	PLOD2	XP_004943367.1

Gene Ontology
Bibliography

Related articles in PubMed

FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch.
Chen Y, Terajima M, Banerjee P, Guo H, Liu X, Yu J, Yamauchi M, Kurie JM
Scientific reports746021(2017 Apr)

A UBE2O-AMPK?2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.
Vila IK, Yao Y, Kim G, Xia W, Kim H, Kim SJ, Park MK, Hwang JP, Gonz?lez-Billalabeitia E, Hung MC, Song SJ, Song MS
Cancer cell31(2)208-224(2017 Feb)

Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space.
Chen Y, Guo H, Terajima M, Banerjee P, Liu X, Yu J, Momin AA, Katayama H, Hanash SM, Burns AR, Fields GB, Yamauchi M, Kurie JM
The Journal of biological chemistry291(50)25799-25808(2016 Dec)

Endothelial cells regulate neural crest and second heart field morphogenesis.
Milgrom-Hoffman M, Michailovici I, Ferrara N, Zelzer E, Tzahor E
Biology open3(8)679-88(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The finding that LH2 modifies collagen in the extracellular space challenges the current view that LH2 functions solely on the endoplasmic reticulum and could also have important implications for cancer biology.
Title: Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space.

Authors propose that lysyl hydroxylase 2, and the subsequent increase in pyridinoline cross-links, is responsible for the persistent fibrosis in experimental osteoarthritis.
Title: Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression.

TIA1 and TIAL1 regulate the alternate splicing of lysyl hydroxylase 2
Title: TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2.

analysis of the specific regulation for the expression of LH isoforms as well as for alternative splicing of LH2 during embryogenesis and in different tissues
Title: The lysyl hydroxylase isoforms are widely expressed during mouse embryogenesis, but obtain tissue- and cell-specific patterns in the adult.

LH2b catalyzes post-translational modification of collagen in collagen matrix formation and mineralization in bone.
Title: Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization.

The following Plod2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plod2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu90188	XM_030244393.1 Latest version!	Mus musculus procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 (Plod2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu06622	NM_001142916.1 Latest version!	Mus musculus procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 (Plod2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$447.30 $639.00
OMu15290	NM_011961.3 Latest version!	Mus musculus procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 (Plod2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$433.30 $619.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Plod2 ( XM_030244393.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030100253.1 Mus musculus procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 (Plod2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu90188
Clone ID Related Accession (Same CDS sequence)	XM_030244393.1
Accession Version	XM_030244393.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCATGG ATTTCTGCCG TCAGGATGAA AAGTGTGATT ACTACTTTAG TGTGGATGCA 
GATGTTGTTT TGACAAACCC AAGAACTTTA AAATTTTTGA TTGAACAAAA CAGGAAAATC 
ATTGCTCCTC TTGTGACACG TCATGGAAAG TTGTGGTCCA ACTTTTGGGG AGCACTGAGT 
CCTGATGGGT ACTATGCTCG CTCTGAAGAT TACGTGGATA TTGTTCAGGG GAACAGAGTA 
GGAATCTGGA ATGTCCCATA TATGGCTAAT GTGTACTTAA TTCAAGGAAA GACACTCCGA 
TCTGAGATGA ATGAAAGGAA CTATTTTGTC CGTGATAAGT TGGATCCCGA TATGGCTCTT 
TGCCGCAATG CTAGAGATAT GACCTTACAA AGGGAAAAAG ACTCCCCTAC TCCGGAAACA 
TTCCAAATGC TCAGCCCCCC AAAGGGTGTG TTTATGTACA TTTCTAACAG ACATGAATTT 
GGACGGCTGA TATCAACTGC TAATTACAAC ACTTCCCATC TTAACAATGA CTTCTGGCAG 
ATTTTTGAAA ATCCCGTGGA TTGGAAGGAA AAATATATAA ATCGTGATTA TTCAAAGATT 
TTCACTGAAA ATATAGTCGA GCAGCCTTGT CCAGATGTCT TCTGGTTTCC CATATTTTCT 
GAACGAGCCT GTGATGAGTT GGTAGAAGAA ATGGAGCATT ATGGCAAGTG GTCCGGCGGA 
AAGCATCACG ATAGCCGCAT ATCGGGTGGT TATGAAAATG TCCCGACTGA CGATATTCAT 
ATGAAGCAGA TCGGGCTGGA GAATGTTTGG CTTCATTTCA TCCGAGAGTT CATTGCTCCA 
GTCACACTGA AGGTCTTCGC AGGCTATTAT ACAAAGGGAT TTGCACTGCT GAATTTTGTA 
GTAAAGTACT CACCTGAAAG ACAGCGCTCG CTCCGTCCCC ACCACGATGC CTCAACCTTT 
ACCATCAACA TTGCTCTGAA TAATGTAGGA GAGGATTTTC AGGGAGGTGG ATGCAAATTT 
CTGAGGTATA ATTGCTCCAT TGAGTCCCCA CGAAAAGGCT GGAGCTTCAT GCATCCTGGG 
AGGCTCACAC ATTTGCACGA AGGACTTCCT GTTAAAAATG GAACACGATA CATTGCAGTG 
TCATTTATAG ATCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030100253.1
CDS	4354..5511
Translation	MGMDFCRQDEKCDYYFSVDADVVLTNPRTLKFLIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGIWNVPYMANVYLIQGKTLRSEMNERNYFVRDKLDPDMALCRNARDMTLQREKDSPTPETFQMLSPPKGVFMYISNRHEFGRLISTANYNTSHLNNDFWQIFENPVDWKEKYINRDYSKIFTENIVEQPCPDVFWFPIFSERACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQIGLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP

Target ORF information:

RefSeq Version	XM_030244393.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 (Plod2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030244393.1

ORF Insert Sequence:

ATGGGCATGG ATTTCTGCCG TCAGGATGAA AAGTGTGATT ACTACTTTAG TGTGGATGCA 
GATGTTGTTT TGACAAACCC AAGAACTTTA AAATTTTTGA TTGAACAAAA CAGGAAAATC 
ATTGCTCCTC TTGTGACACG TCATGGAAAG TTGTGGTCCA ACTTTTGGGG AGCACTGAGT 
CCTGATGGGT ACTATGCTCG CTCTGAAGAT TACGTGGATA TTGTTCAGGG GAACAGAGTA 
GGAATCTGGA ATGTCCCATA TATGGCTAAT GTGTACTTAA TTCAAGGAAA GACACTCCGA 
TCTGAGATGA ATGAAAGGAA CTATTTTGTC CGTGATAAGT TGGATCCCGA TATGGCTCTT 
TGCCGCAATG CTAGAGATAT GACCTTACAA AGGGAAAAAG ACTCCCCTAC TCCGGAAACA 
TTCCAAATGC TCAGCCCCCC AAAGGGTGTG TTTATGTACA TTTCTAACAG ACATGAATTT 
GGACGGCTGA TATCAACTGC TAATTACAAC ACTTCCCATC TTAACAATGA CTTCTGGCAG 
ATTTTTGAAA ATCCCGTGGA TTGGAAGGAA AAATATATAA ATCGTGATTA TTCAAAGATT 
TTCACTGAAA ATATAGTCGA GCAGCCTTGT CCAGATGTCT TCTGGTTTCC CATATTTTCT 
GAACGAGCCT GTGATGAGTT GGTAGAAGAA ATGGAGCATT ATGGCAAGTG GTCCGGCGGA 
AAGCATCACG ATAGCCGCAT ATCGGGTGGT TATGAAAATG TCCCGACTGA CGATATTCAT 
ATGAAGCAGA TCGGGCTGGA GAATGTTTGG CTTCATTTCA TCCGAGAGTT CATTGCTCCA 
GTCACACTGA AGGTCTTCGC AGGCTATTAT ACAAAGGGAT TTGCACTGCT GAATTTTGTA 
GTAAAGTACT CACCTGAAAG ACAGCGCTCG CTCCGTCCCC ACCACGATGC CTCAACCTTT 
ACCATCAACA TTGCTCTGAA TAATGTAGGA GAGGATTTTC AGGGAGGTGG ATGCAAATTT 
CTGAGGTATA ATTGCTCCAT TGAGTCCCCA CGAAAAGGCT GGAGCTTCAT GCATCCTGGG 
AGGCTCACAC ATTTGCACGA AGGACTTCCT GTTAAAAATG GAACACGATA CATTGCAGTG 
TCATTTATAG ATCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Plod2 ( NM_001142916.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001136388.1 Mus musculus procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 (Plod2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu06622
Clone ID Related Accession (Same CDS sequence)	NM_001142916.1
Accession Version	NM_001142916.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2277bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Mus musculus(house mouse)
Product	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB644981.1, AK033363.1, AC165156.3, AF080572.1, CF615856.1 and AV488215.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as LH2b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK157207.1, AK033363.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGACC GCGGAGCGAG GCCGGGGCGG CTGATGCCCA TGCTCGCCCT GCTCTCCTGG 
GCGGCCGGCC TGGGCGTGGC GGAGGAGACG CCCGGGCGCA TCCCTGCAGA TAAATTATTA 
GTCATAACTG TCGCAACAAA AGAAAATGAT GGATTCCACA GATTTATGAA TTCAGCCAAG 
TATTTCAATT ACACTGTGAA GGTTCTTGGT CAAGGTCAGG AGTGGAGAGG CGGTGATGGA 
ATGAACAGTA TCGGAGGGGG CCAGAAGGTG AGATTACTGA AAGAAGCTAT GGAGCACTAC 
GCCAGTCAGG AAGATCTGGT CATCTTGTTT ACCGAGTGTT TTGATGTTGT ATTTGCTGGT 
GGGCCTGAAG AAGTTCTTAA AAAGTTCCAA AAGACAAATC ATAAAATCGT CTTTGCAGCG 
GACGGGCTGC TGTGGCCAGA TAAGCGGCTG GCAGACAAGT ACCCTGTTGT GCACATTGGG 
AAACGCTACC TGAATTCTGG AGGCTTTATT GGCTATGCCC CGTACATCAG CCGTCTGGTC 
CAGCAGTGGA ATCTGCAGGA TAATGATGAT GATCAGCTCT TTTACACGAA AGTTTACATC 
GACCCACTGA AGAGGGAAGC TTTTAACATC ACACTGGATC ACAAATGCAA AATTTTCCAG 
GCCTTGAATG GAGCTACAGA TGAAGTTGTT TTAAAGTTTG AAAATGGTAA AAGCAGAGTG 
AAGAATACAT TTTATGAAAC ACTGCCAGTG GCAATTAATG GAAATGGGCC CACCAAGATT 
CTCCTGAATT ACTTTGGAAA CTATGTTCCA AACTCATGGA CACAGGAAAA TGGCTGTGCG 
CTTTGTGATG TTGACACAAT TGACTTGTCT ACAGTAGATG TCCCTCCCAA GGTTACACTG 
GGTGTTTTTA TTGAACAACC AACCCCCTTT CTACCTCGAT TCCTGAACTT ACTGTTAACA 
CTGGATTATC CCAAAGAAGC CCTTCAACTC TTTATTCATA ATAAAGAAGT TTATCATGAA 
AAGGACATCA AAGTGTTTGT TGATAAAGCT AAGCATGACA TCAGCTCTAT AAAAATAGTA 
GGACCAGAGG AGAACCTAAG TCAAGCAGAA GCCAGGAACA TGGGCATGGA TTTCTGCCGT 
CAGGATGAAA AGTGTGATTA CTACTTTAGT GTGGATGCAG ATGTTGTTTT GACAAACCCA 
AGAACTTTAA AATTTTTGAT TGAACAAAAC AGGAAAATCA TTGCTCCTCT TGTGACACGT 
CATGGAAAGT TGTGGTCCAA CTTTTGGGGA GCACTGAGTC CTGATGGGTA CTATGCTCGC 
TCTGAAGATT ACGTGGATAT TGTTCAGGGG AACAGAGTAG GAATCTGGAA TGTCCCATAT 
ATGGCTAATG TGTACTTAAT TCAAGGAAAG ACACTCCGAT CTGAGATGAA TGAAAGGAAC 
TATTTTGTCC GTGATAAGTT GGATCCCGAT ATGGCTCTTT GCCGCAATGC TAGAGATATG 
ACCTTACAAA GGGAAAAAGA CTCCCCTACT CCGGAAACAT TCCAAATGCT CAGCCCCCCA 
AAGGGTGTGT TTATGTACAT TTCTAACAGA CATGAATTTG GACGGCTGAT ATCAACTGCT 
AATTACAACA CTTCCCATCT TAACAATGAC TTCTGGCAGA TTTTTGAAAA TCCCGTGGAT 
TGGAAGGAAA AATATATAAA TCGTGATTAT TCAAAGATTT TCACTGAAAA TATAGTCGAG 
CAGCCTTGTC CAGATGTCTT CTGGTTTCCC ATATTTTCTG AACGAGCCTG TGATGAGTTG 
GTAGAAGAAA TGGAGCATTA TGGCAAGTGG TCCGGCGGAA AGCATCACGA TAGCCGCATA 
TCGGGTGGTT ATGAAAATGT CCCGACTGAC GATATTCATA TGAAGCAGAT CGGGCTGGAG 
AATGTTTGGC TTCATTTCAT CCGAGAGTTC ATTGCTCCAG TCACACTGAA GGTCTTCGCA 
GGCTATTATA CAAAGGGATT TGCACTGCTG AATTTTGTAG TAAAGTACTC ACCTGAAAGA 
CAGCGCTCGC TCCGTCCCCA CCACGATGCC TCAACCTTTA CCATCAACAT TGCTCTGAAT 
AATGTAGGAG AGGATTTTCA GGGAGGTGGA TGCAAATTTC TGAGGTATAA TTGCTCCATT 
GAGTCCCCAC GAAAAGGCTG GAGCTTCATG CATCCTGGGA GGCTCACACA TTTGCACGAA 
GGACTTCCTG TTAAAAATGG AACACGATAC ATTGCAGTGT CATTTATAGA TCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001136388.1
CDS	238..2514
Translation	MGDRGARPGRLMPMLALLSWAAGLGVAEETPGRIPADKLLVITVATKENDGFHRFMNSAKYFNYTVKVLGQGQEWRGGDGMNSIGGGQKVRLLKEAMEHYASQEDLVILFTECFDVVFAGGPEEVLKKFQKTNHKIVFAADGLLWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYISRLVQQWNLQDNDDDQLFYTKVYIDPLKREAFNITLDHKCKIFQALNGATDEVVLKFENGKSRVKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQENGCALCDVDTIDLSTVDVPPKVTLGVFIEQPTPFLPRFLNLLLTLDYPKEALQLFIHNKEVYHEKDIKVFVDKAKHDISSIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKFLIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGIWNVPYMANVYLIQGKTLRSEMNERNYFVRDKLDPDMALCRNARDMTLQREKDSPTPETFQMLSPPKGVFMYISNRHEFGRLISTANYNTSHLNNDFWQIFENPVDWKEKYINRDYSKIFTENIVEQPCPDVFWFPIFSERACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQIGLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP

Target ORF information:

RefSeq Version	NM_001142916.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 (Plod2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142916.1

ORF Insert Sequence:

ATGGGGGACC GCGGAGCGAG GCCGGGGCGG CTGATGCCCA TGCTCGCCCT GCTCTCCTGG 
GCGGCCGGCC TGGGCGTGGC GGAGGAGACG CCCGGGCGCA TCCCTGCAGA TAAATTATTA 
GTCATAACTG TCGCAACAAA AGAAAATGAT GGATTCCACA GATTTATGAA TTCAGCCAAG 
TATTTCAATT ACACTGTGAA GGTTCTTGGT CAAGGTCAGG AGTGGAGAGG CGGTGATGGA 
ATGAACAGTA TCGGAGGGGG CCAGAAGGTG AGATTACTGA AAGAAGCTAT GGAGCACTAC 
GCCAGTCAGG AAGATCTGGT CATCTTGTTT ACCGAGTGTT TTGATGTTGT ATTTGCTGGT 
GGGCCTGAAG AAGTTCTTAA AAAGTTCCAA AAGACAAATC ATAAAATCGT CTTTGCAGCG 
GACGGGCTGC TGTGGCCAGA TAAGCGGCTG GCAGACAAGT ACCCTGTTGT GCACATTGGG 
AAACGCTACC TGAATTCTGG AGGCTTTATT GGCTATGCCC CGTACATCAG CCGTCTGGTC 
CAGCAGTGGA ATCTGCAGGA TAATGATGAT GATCAGCTCT TTTACACGAA AGTTTACATC 
GACCCACTGA AGAGGGAAGC TTTTAACATC ACACTGGATC ACAAATGCAA AATTTTCCAG 
GCCTTGAATG GAGCTACAGA TGAAGTTGTT TTAAAGTTTG AAAATGGTAA AAGCAGAGTG 
AAGAATACAT TTTATGAAAC ACTGCCAGTG GCAATTAATG GAAATGGGCC CACCAAGATT 
CTCCTGAATT ACTTTGGAAA CTATGTTCCA AACTCATGGA CACAGGAAAA TGGCTGTGCG 
CTTTGTGATG TTGACACAAT TGACTTGTCT ACAGTAGATG TCCCTCCCAA GGTTACACTG 
GGTGTTTTTA TTGAACAACC AACCCCCTTT CTACCTCGAT TCCTGAACTT ACTGTTAACA 
CTGGATTATC CCAAAGAAGC CCTTCAACTC TTTATTCATA ATAAAGAAGT TTATCATGAA 
AAGGACATCA AAGTGTTTGT TGATAAAGCT AAGCATGACA TCAGCTCTAT AAAAATAGTA 
GGACCAGAGG AGAACCTAAG TCAAGCAGAA GCCAGGAACA TGGGCATGGA TTTCTGCCGT 
CAGGATGAAA AGTGTGATTA CTACTTTAGT GTGGATGCAG ATGTTGTTTT GACAAACCCA 
AGAACTTTAA AATTTTTGAT TGAACAAAAC AGGAAAATCA TTGCTCCTCT TGTGACACGT 
CATGGAAAGT TGTGGTCCAA CTTTTGGGGA GCACTGAGTC CTGATGGGTA CTATGCTCGC 
TCTGAAGATT ACGTGGATAT TGTTCAGGGG AACAGAGTAG GAATCTGGAA TGTCCCATAT 
ATGGCTAATG TGTACTTAAT TCAAGGAAAG ACACTCCGAT CTGAGATGAA TGAAAGGAAC 
TATTTTGTCC GTGATAAGTT GGATCCCGAT ATGGCTCTTT GCCGCAATGC TAGAGATATG 
ACCTTACAAA GGGAAAAAGA CTCCCCTACT CCGGAAACAT TCCAAATGCT CAGCCCCCCA 
AAGGGTGTGT TTATGTACAT TTCTAACAGA CATGAATTTG GACGGCTGAT ATCAACTGCT 
AATTACAACA CTTCCCATCT TAACAATGAC TTCTGGCAGA TTTTTGAAAA TCCCGTGGAT 
TGGAAGGAAA AATATATAAA TCGTGATTAT TCAAAGATTT TCACTGAAAA TATAGTCGAG 
CAGCCTTGTC CAGATGTCTT CTGGTTTCCC ATATTTTCTG AACGAGCCTG TGATGAGTTG 
GTAGAAGAAA TGGAGCATTA TGGCAAGTGG TCCGGCGGAA AGCATCACGA TAGCCGCATA 
TCGGGTGGTT ATGAAAATGT CCCGACTGAC GATATTCATA TGAAGCAGAT CGGGCTGGAG 
AATGTTTGGC TTCATTTCAT CCGAGAGTTC ATTGCTCCAG TCACACTGAA GGTCTTCGCA 
GGCTATTATA CAAAGGGATT TGCACTGCTG AATTTTGTAG TAAAGTACTC ACCTGAAAGA 
CAGCGCTCGC TCCGTCCCCA CCACGATGCC TCAACCTTTA CCATCAACAT TGCTCTGAAT 
AATGTAGGAG AGGATTTTCA GGGAGGTGGA TGCAAATTTC TGAGGTATAA TTGCTCCATT 
GAGTCCCCAC GAAAAGGCTG GAGCTTCATG CATCCTGGGA GGCTCACACA TTTGCACGAA 
GGACTTCCTG TTAAAAATGG AACACGATAC ATTGCAGTGT CATTTATAGA TCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Plod2 ( NM_011961.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036091.2 Mus musculus procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 (Plod2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu15290
Clone ID Related Accession (Same CDS sequence)	NM_011961.3
Accession Version	NM_011961.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2214bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Mus musculus(house mouse)
Product	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB644981.1, AF080572.1, AC165156.3, CF615856.1 and AV488215.1. On Dec 30, 2008 this sequence version replaced NM_011961.2. Transcript Variant: This variant (2) lacks an internal in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (2, also known as LH2a) missing a 21 aa protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF080572.1, AK046364.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGACC GCGGAGCGAG GCCGGGGCGG CTGATGCCCA TGCTCGCCCT GCTCTCCTGG 
GCGGCCGGCC TGGGCGTGGC GGAGGAGACG CCCGGGCGCA TCCCTGCAGA TAAATTATTA 
GTCATAACTG TCGCAACAAA AGAAAATGAT GGATTCCACA GATTTATGAA TTCAGCCAAG 
TATTTCAATT ACACTGTGAA GGTTCTTGGT CAAGGTCAGG AGTGGAGAGG CGGTGATGGA 
ATGAACAGTA TCGGAGGGGG CCAGAAGGTG AGATTACTGA AAGAAGCTAT GGAGCACTAC 
GCCAGTCAGG AAGATCTGGT CATCTTGTTT ACCGAGTGTT TTGATGTTGT ATTTGCTGGT 
GGGCCTGAAG AAGTTCTTAA AAAGTTCCAA AAGACAAATC ATAAAATCGT CTTTGCAGCG 
GACGGGCTGC TGTGGCCAGA TAAGCGGCTG GCAGACAAGT ACCCTGTTGT GCACATTGGG 
AAACGCTACC TGAATTCTGG AGGCTTTATT GGCTATGCCC CGTACATCAG CCGTCTGGTC 
CAGCAGTGGA ATCTGCAGGA TAATGATGAT GATCAGCTCT TTTACACGAA AGTTTACATC 
GACCCACTGA AGAGGGAAGC TTTTAACATC ACACTGGATC ACAAATGCAA AATTTTCCAG 
GCCTTGAATG GAGCTACAGA TGAAGTTGTT TTAAAGTTTG AAAATGGTAA AAGCAGAGTG 
AAGAATACAT TTTATGAAAC ACTGCCAGTG GCAATTAATG GAAATGGGCC CACCAAGATT 
CTCCTGAATT ACTTTGGAAA CTATGTTCCA AACTCATGGA CACAGGAAAA TGGCTGTGCG 
CTTTGTGATG TTGACACAAT TGACTTGTCT ACAGTAGATG TCCCTCCCAA GGTTACACTG 
GGTGTTTTTA TTGAACAACC AACCCCCTTT CTACCTCGAT TCCTGAACTT ACTGTTAACA 
CTGGATTATC CCAAAGAAGC CCTTCAACTC TTTATTCATA ATAAAGAAGT TTATCATGAA 
AAGGACATCA AAGTGTTTGT TGATAAAGCT AAGCATGACA TCAGCTCTAT AAAAATAGTA 
GGACCAGAGG AGAACCTAAG TCAAGCAGAA GCCAGGAACA TGGGCATGGA TTTCTGCCGT 
CAGGATGAAA AGTGTGATTA CTACTTTAGT GTGGATGCAG ATGTTGTTTT GACAAACCCA 
AGAACTTTAA AATTTTTGAT TGAACAAAAC AGGAAAATCA TTGCTCCTCT TGTGACACGT 
CATGGAAAGT TGTGGTCCAA CTTTTGGGGA GCACTGAGTC CTGATGGGTA CTATGCTCGC 
TCTGAAGATT ACGTGGATAT TGTTCAGGGG AACAGAGTAG GAATCTGGAA TGTCCCATAT 
ATGGCTAATG TGTACTTAAT TCAAGGAAAG ACACTCCGAT CTGAGATGAA TGAAAGGAAC 
TATTTTGTCC GTGATAAGTT GGATCCCGAT ATGGCTCTTT GCCGCAATGC TAGAGATATG 
GGTGTGTTTA TGTACATTTC TAACAGACAT GAATTTGGAC GGCTGATATC AACTGCTAAT 
TACAACACTT CCCATCTTAA CAATGACTTC TGGCAGATTT TTGAAAATCC CGTGGATTGG 
AAGGAAAAAT ATATAAATCG TGATTATTCA AAGATTTTCA CTGAAAATAT AGTCGAGCAG 
CCTTGTCCAG ATGTCTTCTG GTTTCCCATA TTTTCTGAAC GAGCCTGTGA TGAGTTGGTA 
GAAGAAATGG AGCATTATGG CAAGTGGTCC GGCGGAAAGC ATCACGATAG CCGCATATCG 
GGTGGTTATG AAAATGTCCC GACTGACGAT ATTCATATGA AGCAGATCGG GCTGGAGAAT 
GTTTGGCTTC ATTTCATCCG AGAGTTCATT GCTCCAGTCA CACTGAAGGT CTTCGCAGGC 
TATTATACAA AGGGATTTGC ACTGCTGAAT TTTGTAGTAA AGTACTCACC TGAAAGACAG 
CGCTCGCTCC GTCCCCACCA CGATGCCTCA ACCTTTACCA TCAACATTGC TCTGAATAAT 
GTAGGAGAGG ATTTTCAGGG AGGTGGATGC AAATTTCTGA GGTATAATTG CTCCATTGAG 
TCCCCACGAA AAGGCTGGAG CTTCATGCAT CCTGGGAGGC TCACACATTT GCACGAAGGA 
CTTCCTGTTA AAAATGGAAC ACGATACATT GCAGTGTCAT TTATAGATCC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036091.2
CDS	238..2451
Translation	MGDRGARPGRLMPMLALLSWAAGLGVAEETPGRIPADKLLVITVATKENDGFHRFMNSAKYFNYTVKVLGQGQEWRGGDGMNSIGGGQKVRLLKEAMEHYASQEDLVILFTECFDVVFAGGPEEVLKKFQKTNHKIVFAADGLLWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYISRLVQQWNLQDNDDDQLFYTKVYIDPLKREAFNITLDHKCKIFQALNGATDEVVLKFENGKSRVKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQENGCALCDVDTIDLSTVDVPPKVTLGVFIEQPTPFLPRFLNLLLTLDYPKEALQLFIHNKEVYHEKDIKVFVDKAKHDISSIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKFLIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGIWNVPYMANVYLIQGKTLRSEMNERNYFVRDKLDPDMALCRNARDMGVFMYISNRHEFGRLISTANYNTSHLNNDFWQIFENPVDWKEKYINRDYSKIFTENIVEQPCPDVFWFPIFSERACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQIGLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP

Target ORF information:

RefSeq Version	NM_011961.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 (Plod2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011961.3

ORF Insert Sequence:

ATGGGGGACC GCGGAGCGAG GCCGGGGCGG CTGATGCCCA TGCTCGCCCT GCTCTCCTGG 
GCGGCCGGCC TGGGCGTGGC GGAGGAGACG CCCGGGCGCA TCCCTGCAGA TAAATTATTA 
GTCATAACTG TCGCAACAAA AGAAAATGAT GGATTCCACA GATTTATGAA TTCAGCCAAG 
TATTTCAATT ACACTGTGAA GGTTCTTGGT CAAGGTCAGG AGTGGAGAGG CGGTGATGGA 
ATGAACAGTA TCGGAGGGGG CCAGAAGGTG AGATTACTGA AAGAAGCTAT GGAGCACTAC 
GCCAGTCAGG AAGATCTGGT CATCTTGTTT ACCGAGTGTT TTGATGTTGT ATTTGCTGGT 
GGGCCTGAAG AAGTTCTTAA AAAGTTCCAA AAGACAAATC ATAAAATCGT CTTTGCAGCG 
GACGGGCTGC TGTGGCCAGA TAAGCGGCTG GCAGACAAGT ACCCTGTTGT GCACATTGGG 
AAACGCTACC TGAATTCTGG AGGCTTTATT GGCTATGCCC CGTACATCAG CCGTCTGGTC 
CAGCAGTGGA ATCTGCAGGA TAATGATGAT GATCAGCTCT TTTACACGAA AGTTTACATC 
GACCCACTGA AGAGGGAAGC TTTTAACATC ACACTGGATC ACAAATGCAA AATTTTCCAG 
GCCTTGAATG GAGCTACAGA TGAAGTTGTT TTAAAGTTTG AAAATGGTAA AAGCAGAGTG 
AAGAATACAT TTTATGAAAC ACTGCCAGTG GCAATTAATG GAAATGGGCC CACCAAGATT 
CTCCTGAATT ACTTTGGAAA CTATGTTCCA AACTCATGGA CACAGGAAAA TGGCTGTGCG 
CTTTGTGATG TTGACACAAT TGACTTGTCT ACAGTAGATG TCCCTCCCAA GGTTACACTG 
GGTGTTTTTA TTGAACAACC AACCCCCTTT CTACCTCGAT TCCTGAACTT ACTGTTAACA 
CTGGATTATC CCAAAGAAGC CCTTCAACTC TTTATTCATA ATAAAGAAGT TTATCATGAA 
AAGGACATCA AAGTGTTTGT TGATAAAGCT AAGCATGACA TCAGCTCTAT AAAAATAGTA 
GGACCAGAGG AGAACCTAAG TCAAGCAGAA GCCAGGAACA TGGGCATGGA TTTCTGCCGT 
CAGGATGAAA AGTGTGATTA CTACTTTAGT GTGGATGCAG ATGTTGTTTT GACAAACCCA 
AGAACTTTAA AATTTTTGAT TGAACAAAAC AGGAAAATCA TTGCTCCTCT TGTGACACGT 
CATGGAAAGT TGTGGTCCAA CTTTTGGGGA GCACTGAGTC CTGATGGGTA CTATGCTCGC 
TCTGAAGATT ACGTGGATAT TGTTCAGGGG AACAGAGTAG GAATCTGGAA TGTCCCATAT 
ATGGCTAATG TGTACTTAAT TCAAGGAAAG ACACTCCGAT CTGAGATGAA TGAAAGGAAC 
TATTTTGTCC GTGATAAGTT GGATCCCGAT ATGGCTCTTT GCCGCAATGC TAGAGATATG 
GGTGTGTTTA TGTACATTTC TAACAGACAT GAATTTGGAC GGCTGATATC AACTGCTAAT 
TACAACACTT CCCATCTTAA CAATGACTTC TGGCAGATTT TTGAAAATCC CGTGGATTGG 
AAGGAAAAAT ATATAAATCG TGATTATTCA AAGATTTTCA CTGAAAATAT AGTCGAGCAG 
CCTTGTCCAG ATGTCTTCTG GTTTCCCATA TTTTCTGAAC GAGCCTGTGA TGAGTTGGTA 
GAAGAAATGG AGCATTATGG CAAGTGGTCC GGCGGAAAGC ATCACGATAG CCGCATATCG 
GGTGGTTATG AAAATGTCCC GACTGACGAT ATTCATATGA AGCAGATCGG GCTGGAGAAT 
GTTTGGCTTC ATTTCATCCG AGAGTTCATT GCTCCAGTCA CACTGAAGGT CTTCGCAGGC 
TATTATACAA AGGGATTTGC ACTGCTGAAT TTTGTAGTAA AGTACTCACC TGAAAGACAG 
CGCTCGCTCC GTCCCCACCA CGATGCCTCA ACCTTTACCA TCAACATTGC TCTGAATAAT 
GTAGGAGAGG ATTTTCAGGG AGGTGGATGC AAATTTCTGA GGTATAATTG CTCCATTGAG 
TCCCCACGAA AAGGCTGGAG CTTCATGCAT CCTGGGAGGC TCACACATTT GCACGAAGGA 
CTTCCTGTTA AAAATGGAAC ACGATACATT GCAGTGTCAT TTATAGATCC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch.
Scientific reports746021(2017 Apr)
Chen Y,Terajima M,Banerjee P,Guo H,Liu X,Yu J,Yamauchi M,Kurie JM

A UBE2O-AMPK?2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.
Cancer cell31(2)208-224(2017 Feb)
Vila IK,Yao Y,Kim G,Xia W,Kim H,Kim SJ,Park MK,Hwang JP,Gonz?lez-Billalabeitia E,Hung MC,Song SJ,Song MS

Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space.
The Journal of biological chemistry291(50)25799-25808(2016 Dec)
Chen Y,Guo H,Terajima M,Banerjee P,Liu X,Yu J,Momin AA,Katayama H,Hanash SM,Burns AR,Fields GB,Yamauchi M,Kurie JM

Endothelial cells regulate neural crest and second heart field morphogenesis.
Biology open3(8)679-88(2014 Jul)
Milgrom-Hoffman M,Michailovici I,Ferrara N,Zelzer E,Tzahor E

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Plod2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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