Hsd17b13 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hsd17b13
Entrez Gene ID	243168
Full Name	hydroxysteroid (17-beta) dehydrogenase 13
Synonyms	AI047820,PAN1B-like,Pan1b
General protein information	Preferred Names hydroxysteroid (17-beta) dehydrogenase 13 Names 17-beta-hydroxysteroid dehydrogenase 13 17-beta-HSD 13 short-chain dehydrogenase/reductase 9
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 E5

mRNA and Protein(s)

mRNA	Protein	Name
NM_198030.2	NP_932147.2	17-beta-hydroxysteroid dehydrogenase 13 isoform 2 precursor
NM_001163486.1	NP_001156958.1	17-beta-hydroxysteroid dehydrogenase 13 isoform 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HSD17B13	XP_526627.1
Xenopus tropicalis (tropical clawed frog)	hsd17b13	NP_001011240.1
Bos taurus (cattle)	HSD17B13	NP_001040081.1
Canis lupus familiaris (dog)	HSD17B13	XP_850000.1
Mus musculus (house mouse)	Hsd17b13	NP_001156958.1
Homo sapiens (human)	HSD17B13	NP_835236.2
	LOC701104	XP_001096677.2
Rattus norvegicus (Norway rat)	Hsd17b13	NP_001009684.1

Gene Ontology
Bibliography

Related articles in PubMed

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.
Planas-Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, Xie Y, Roma G, Donovan A, Marti P, Beckmann N, Dill MT, Carbone W, Bergling S, Isken A, Mueller M, Kinzel B, Yang Y, Mao X, Nicholson TB, Zamponi R, Capodieci P, Valdez R, Rivera D, Loew A, Ukomadu C, Terracciano LM, Bouwmeester T, Cong F, Heim MH, Forbes SJ, Ruffner H, Tchorz JS
Nature cell biology18(5)467-79(2016 05)

The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation.
Rocha AS, Vidal V, Mertz M, Kendall TJ, Charlet A, Okamoto H, Schedl A
Cell reports13(9)1757-64(2015 Dec)

Comparative proteomic study reveals 17?-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease.
Su W, Wang Y, Jia X, Wu W, Li L, Tian X, Li S, Wang C, Xu H, Cao J, Han Q, Xu S, Chen Y, Zhong Y, Zhang X, Liu P, Gustafsson J?, Guan Y
Proceedings of the National Academy of Sciences of the United States of America111(31)11437-42(2014 Aug)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

17beta-HSD13 as a pathogenic protein in the development of nonalcoholic fatty liver disease.
Title: Comparative proteomic study reveals 17?-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease.

17betaHSD type 13 may have a distinct physiological role as a lipid droplet-associated protein in the liver.
Title: 17beta-Hydroxysteroid dehydrogenase type 13 is a liver-specific lipid droplet-associated protein.

The following Hsd17b13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hsd17b13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09094	NM_001163486.1 Latest version!	Mus musculus hydroxysteroid (17-beta) dehydrogenase 13 (Hsd17b13), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu08833	NM_198030.2 Latest version!	Mus musculus hydroxysteroid (17-beta) dehydrogenase 13 (Hsd17b13), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hsd17b13 ( NM_001163486.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001156958.1 Mus musculus hydroxysteroid (17-beta) dehydrogenase 13 (Hsd17b13), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu09094
Clone ID Related Accession (Same CDS sequence)	NM_001163486.1
Accession Version	NM_001163486.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 903bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	17-beta-hydroxysteroid dehydrogenase 13 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI573700.1, AI048624.1 and DV660487.1. Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (2). ##Evidence-Data-START## Transcript exon combination :: AY101768.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849386 [ECO:0000348] ##Evidence-Data-END##

ATGAACCTCA TCCTGGAATT TCTCCTTCTG GTGGGCGTCA TCATCTACTC CTACCTGGAG 
TCACTGGTAA AGTTCTTCAT TCCCCGGAGA AGGAAATCTG TGACCGGGCA GACCGTTCTC 
ATCACGGGGG CCGGACACGG AATAGGCAGG CTGACTGCAT ATGAATTTGC AAAGCAGAAA 
AGCAGACTGG TTCTATGGGA TATCAATAAG CGTGGTGTTG AGGAAACCGC GGACAAATGC 
AGGAAACTGG GGGCCGTCGT GCACGTGTTT GTGGTGGACT GCAGCAACCG GGCCGAGATT 
TACAACTCTG TGGATCAGGT AAAGAGAGAA GTAGGTGATG TCGAGATCGT GGTAAACAAC 
GCCGGGGCGA TATATCCAGC AGACCTTCTT AGTGCCAAGG ACGAGGAGAT CACCAAGACC 
TTTGAGGTCA ATATCCTCGG ACATTTTTGG ATCATAAAAG CACTCCTTCC ATCGATGCTG 
AGAAGAAACT CTGGCCACAT TGTCACAGTG GCTTCGGTGT GCGGCCATGG AGTGATTCCT 
TATCTCATCC CTTATTGCTC CAGCAAGTTT GCTGCTGTGG GCTTCCACCG AGCACTGACC 
GCAGAACTGG ACACCTTGGG GAAAACCGGT ATCCAAACCT CGTGTCTCTG CCCTGTGTTC 
GTGAATACTG GCTTCACCAA AAACCCGAGT ACAAGGTTAT GGCCTGTATT AGAGCCGGAA 
GAAGTTGCAA GGAGTCTGAT CAATGGAATA CTTACCAACA AGAAAATGAT CTTCGTTCCA 
TCCTATATCA ATATTTCTCT GATCCTGGAA AAGTTTCTTC CTGAGCGTGC CTTAAAAGCG 
ATCAGTCGTA TACAGAACAT TCAATTTGAA GCAATTGTGG GCCACAAAAC CAAGATGAAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001156958.1
CDS	74..976
Translation	MNLILEFLLLVGVIIYSYLESLVKFFIPRRRKSVTGQTVLITGAGHGIGRLTAYEFAKQKSRLVLWDINKRGVEETADKCRKLGAVVHVFVVDCSNRAEIYNSVDQVKREVGDVEIVVNNAGAIYPADLLSAKDEEITKTFEVNILGHFWIIKALLPSMLRRNSGHIVTVASVCGHGVIPYLIPYCSSKFAAVGFHRALTAELDTLGKTGIQTSCLCPVFVNTGFTKNPSTRLWPVLEPEEVARSLINGILTNKKMIFVPSYINISLILEKFLPERALKAISRIQNIQFEAIVGHKTKMK

Target ORF information:

RefSeq Version	NM_001163486.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus hydroxysteroid (17-beta) dehydrogenase 13 (Hsd17b13), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001163486.1

ORF Insert Sequence:

ATGAACCTCA TCCTGGAATT TCTCCTTCTG GTGGGCGTCA TCATCTACTC CTACCTGGAG 
TCACTGGTAA AGTTCTTCAT TCCCCGGAGA AGGAAATCTG TGACCGGGCA GACCGTTCTC 
ATCACGGGGG CCGGACACGG AATAGGCAGG CTGACTGCAT ATGAATTTGC AAAGCAGAAA 
AGCAGACTGG TTCTATGGGA TATCAATAAG CGTGGTGTTG AGGAAACCGC GGACAAATGC 
AGGAAACTGG GGGCCGTCGT GCACGTGTTT GTGGTGGACT GCAGCAACCG GGCCGAGATT 
TACAACTCTG TGGATCAGGT AAAGAGAGAA GTAGGTGATG TCGAGATCGT GGTAAACAAC 
GCCGGGGCGA TATATCCAGC AGACCTTCTT AGTGCCAAGG ACGAGGAGAT CACCAAGACC 
TTTGAGGTCA ATATCCTCGG ACATTTTTGG ATCATAAAAG CACTCCTTCC ATCGATGCTG 
AGAAGAAACT CTGGCCACAT TGTCACAGTG GCTTCGGTGT GCGGCCATGG AGTGATTCCT 
TATCTCATCC CTTATTGCTC CAGCAAGTTT GCTGCTGTGG GCTTCCACCG AGCACTGACC 
GCAGAACTGG ACACCTTGGG GAAAACCGGT ATCCAAACCT CGTGTCTCTG CCCTGTGTTC 
GTGAATACTG GCTTCACCAA AAACCCGAGT ACAAGGTTAT GGCCTGTATT AGAGCCGGAA 
GAAGTTGCAA GGAGTCTGAT CAATGGAATA CTTACCAACA AGAAAATGAT CTTCGTTCCA 
TCCTATATCA ATATTTCTCT GATCCTGGAA AAGTTTCTTC CTGAGCGTGC CTTAAAAGCG 
ATCAGTCGTA TACAGAACAT TCAATTTGAA GCAATTGTGG GCCACAAAAC CAAGATGAAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hsd17b13 ( NM_198030.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_932147.2 Mus musculus hydroxysteroid (17-beta) dehydrogenase 13 (Hsd17b13), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu08833
Clone ID Related Accession (Same CDS sequence)	NM_198030.2
Accession Version	NM_198030.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	17-beta-hydroxysteroid dehydrogenase 13 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI573700.1, AI048624.1, DV660487.1 and AL714024.31. On Jul 22, 2009 this sequence version replaced NM_198030.1. Transcript Variant: This variant (2) uses an alternate exon at its 3' terminus, compared to variant 1, which results in a protein (isoform 2) with a longer and distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC019427.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END##

ATGAACCTCA TCCTGGAATT TCTCCTTCTG GTGGGCGTCA TCATCTACTC CTACCTGGAG 
TCACTGGTAA AGTTCTTCAT TCCCCGGAGA AGGAAATCTG TGACCGGGCA GACCGTTCTC 
ATCACGGGGG CCGGACACGG AATAGGCAGG CTGACTGCAT ATGAATTTGC AAAGCAGAAA 
AGCAGACTGG TTCTATGGGA TATCAATAAG CGTGGTGTTG AGGAAACCGC GGACAAATGC 
AGGAAACTGG GGGCCGTCGT GCACGTGTTT GTGGTGGACT GCAGCAACCG GGCCGAGATT 
TACAACTCTG TGGATCAGGT AAAGAGAGAA GTAGGTGATG TCGAGATCGT GGTAAACAAC 
GCCGGGGCGA TATATCCAGC AGACCTTCTT AGTGCCAAGG ACGAGGAGAT CACCAAGACC 
TTTGAGGTCA ATATCCTCGG ACATTTTTGG ATCATAAAAG CACTCCTTCC ATCGATGCTG 
AGAAGAAACT CTGGCCACAT TGTCACAGTG GCTTCGGTGT GCGGCCATGG AGTGATTCCT 
TATCTCATCC CTTATTGCTC CAGCAAGTTT GCTGCTGTGG GCTTCCACCG AGCACTGACC 
GCAGAACTGG ACACCTTGGG GAAAACCGGT ATCCAAACCT CGTGTCTCTG CCCTGTGTTC 
GTGAATACTG GCTTCACCAA AAACCCGAGT ACAAGGTTAT GGCCTGTATT AGAGCCGGAA 
GAAGTTGCAA GGAGTCTGAT CAATGGAATA CTTACCAACA AGAAAATGAT CTTCGTTCCA 
TCCTATATCA ATATTTCTCT GATCCTGGAA AAAGGACCTG GATTCAGTTC CAAGCACCCA 
CATGGTGGTT CTCAACAGCC TGTTACTCCA ATCCCAGGGG ATTTGACACC CTCTTCAGAC 
TTTCTCAAAC ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_932147.2
CDS	74..988
Translation	MNLILEFLLLVGVIIYSYLESLVKFFIPRRRKSVTGQTVLITGAGHGIGRLTAYEFAKQKSRLVLWDINKRGVEETADKCRKLGAVVHVFVVDCSNRAEIYNSVDQVKREVGDVEIVVNNAGAIYPADLLSAKDEEITKTFEVNILGHFWIIKALLPSMLRRNSGHIVTVASVCGHGVIPYLIPYCSSKFAAVGFHRALTAELDTLGKTGIQTSCLCPVFVNTGFTKNPSTRLWPVLEPEEVARSLINGILTNKKMIFVPSYINISLILEKGPGFSSKHPHGGSQQPVTPIPGDLTPSSDFLKH

Target ORF information:

RefSeq Version	NM_198030.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus hydroxysteroid (17-beta) dehydrogenase 13 (Hsd17b13), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198030.2

ORF Insert Sequence:

ATGAACCTCA TCCTGGAATT TCTCCTTCTG GTGGGCGTCA TCATCTACTC CTACCTGGAG 
TCACTGGTAA AGTTCTTCAT TCCCCGGAGA AGGAAATCTG TGACCGGGCA GACCGTTCTC 
ATCACGGGGG CCGGACACGG AATAGGCAGG CTGACTGCAT ATGAATTTGC AAAGCAGAAA 
AGCAGACTGG TTCTATGGGA TATCAATAAG CGTGGTGTTG AGGAAACCGC GGACAAATGC 
AGGAAACTGG GGGCCGTCGT GCACGTGTTT GTGGTGGACT GCAGCAACCG GGCCGAGATT 
TACAACTCTG TGGATCAGGT AAAGAGAGAA GTAGGTGATG TCGAGATCGT GGTAAACAAC 
GCCGGGGCGA TATATCCAGC AGACCTTCTT AGTGCCAAGG ACGAGGAGAT CACCAAGACC 
TTTGAGGTCA ATATCCTCGG ACATTTTTGG ATCATAAAAG CACTCCTTCC ATCGATGCTG 
AGAAGAAACT CTGGCCACAT TGTCACAGTG GCTTCGGTGT GCGGCCATGG AGTGATTCCT 
TATCTCATCC CTTATTGCTC CAGCAAGTTT GCTGCTGTGG GCTTCCACCG AGCACTGACC 
GCAGAACTGG ACACCTTGGG GAAAACCGGT ATCCAAACCT CGTGTCTCTG CCCTGTGTTC 
GTGAATACTG GCTTCACCAA AAACCCGAGT ACAAGGTTAT GGCCTGTATT AGAGCCGGAA 
GAAGTTGCAA GGAGTCTGAT CAATGGAATA CTTACCAACA AGAAAATGAT CTTCGTTCCA 
TCCTATATCA ATATTTCTCT GATCCTGGAA AAAGGACCTG GATTCAGTTC CAAGCACCCA 
CATGGTGGTT CTCAACAGCC TGTTACTCCA ATCCCAGGGG ATTTGACACC CTCTTCAGAC 
TTTCTCAAAC ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.
Nature cell biology18(5)467-79(2016 05)
Planas-Paz L,Orsini V,Boulter L,Calabrese D,Pikiolek M,Nigsch F,Xie Y,Roma G,Donovan A,Marti P,Beckmann N,Dill MT,Carbone W,Bergling S,Isken A,Mueller M,Kinzel B,Yang Y,Mao X,Nicholson TB,Zamponi R,Capodieci P,Valdez R,Rivera D,Loew A,Ukomadu C,Terracciano LM,Bouwmeester T,Cong F,Heim MH,Forbes SJ,Ruffner H,Tchorz JS

The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation.
Cell reports13(9)1757-64(2015 Dec)
Rocha AS,Vidal V,Mertz M,Kendall TJ,Charlet A,Okamoto H,Schedl A

Comparative proteomic study reveals 17?-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease.
Proceedings of the National Academy of Sciences of the United States of America111(31)11437-42(2014 Aug)
Su W,Wang Y,Jia X,Wu W,Li L,Tian X,Li S,Wang C,Xu H,Cao J,Han Q,Xu S,Chen Y,Zhong Y,Zhang X,Liu P,Gustafsson J?,Guan Y

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

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Hsd17b13 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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