Sh3bp5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sh3bp5
Entrez Gene ID	24056
Full Name	SH3-domain binding protein 5 (BTK-associated)
Synonyms	AI606498,SH3BP-5,Sab
General protein information	Preferred Names SH3-domain binding protein 5 (BTK-associated) Names SH3 domain-binding protein 5 SH3 domain-binding protein that preferentially associates with BTK
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 B

mRNA and Protein(s)

mRNA	Protein	Name
XM_030247814.1	XP_030103674.1	SH3 domain-binding protein 5 isoform X1
XM_030247815.1	XP_030103675.1	SH3 domain-binding protein 5 isoform X1
NM_001347585.1	NP_001334514.1	SH3 domain-binding protein 5 isoform 2
XM_006519015.2	XP_006519078.1	SH3 domain-binding protein 5 isoform X1
NM_011894.3	NP_036024.2	SH3 domain-binding protein 5 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SH3BP5	NP_004835.2
Pan troglodytes (chimpanzee)	SH3BP5	XP_526142.3
Canis lupus familiaris (dog)	SH3BP5	XP_005634458.1
Mus musculus (house mouse)	Sh3bp5	NP_036024.2
Bos taurus (cattle)	SH3BP5	NP_001193217.1
Rattus norvegicus (Norway rat)	Sh3bp5	NP_446463.2
Danio rerio (zebrafish)	sh3bp5b	NP_998623.1
Gallus gallus (chicken)	SH3BP5	NP_001026160.1
Xenopus tropicalis (tropical clawed frog)	sh3bp5	NP_989213.2

Gene Ontology
Bibliography

Related articles in PubMed

The role of MAP2 kinases and p38 kinase in acute murine liver injury models.
Zhang J, Min RWM, Le K, Zhou S, Aghajan M, Than TA, Win S, Kaplowitz N
Cell death & disease8(6)e2903(2017 Jun)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.
Win S, Than TA, Min RW, Aghajan M, Kaplowitz N
Hepatology (Baltimore, Md.)63(6)1987-2003(2016 06)

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.
Win S, Than TA, Le BH, Garc?a-Ruiz C, Fernandez-Checa JC, Kaplowitz N
Journal of hepatology62(6)1367-74(2015 Jun)

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death.
Win S, Than TA, Fernandez-Checa JC, Kaplowitz N
Cell death & disease5e989(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The binding to and phosphorylation of Sab by p-JNK on the outer mitochondrial membrane leads to SHP1-dependent and DOK4-dependent inactivation of p-Src on the inner membrane; inactivation of mitochondrial Src inhibits electron transport and increases reactive oxygen species release, which sustains JNK activation and promotes cell death and organ injury.
Title: c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.

The interplay of p-JNK with mitochondrial Sab leads to impaired respiration, ROS production, sustained JNK activation, and apoptosis.
Title: Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.

ER stress triggers an interaction of JNK with mitochondrial Sab, which leads to impaired respiration and increased mitochondrial reactive oxygen species.
Title: JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death.

SH3BP5 binds to JNK and directly inhibits JNK through its two putative mitogen-activated protein kinase interaction motifs (KIMs).
Title: SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase.

JNK-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice
Title: c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice.

The following Sh3bp5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sh3bp5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu09108	NM_011894.3 Latest version!	Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$272.30 $389.00
OMu49989	NM_001347585.1 Latest version!	Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu49991	XM_006519015.2 Latest version!	Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu49991	XM_030247815.1 Latest version!	Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu49991	XM_030247814.1 Latest version!	Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sh3bp5 ( NM_011894.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036024.2 Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu09108
Clone ID Related Accession (Same CDS sequence)	NM_011894.3
Accession Version	NM_011894.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	SH3 domain-binding protein 5 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY252555.1, AK165033.1, BM947586.1, AC108416.5, BU609611.1 and BQ173956.1. On Dec 1, 2016 this sequence version replaced NM_011894.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK165033.1, SRR1660815.19195.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACACGG CGCTGAAACG GAGCCGCTCT GACGAGCCGG CGGAGCTCCC GCCGCCTGCC 
CGGGAGGTGG AGGAGAAAGA GGAGGAGGAA GAGAGGATGG AACAGGGCCT GGAGGAGGAG 
GAGGAAGAGG TGGACCCCCG GATCCAGGGA GAACTGGAGA AGTTAAATCA ATCCACGGAT 
GATATCAACC GACGGGAGAC TGAGCTTGAG GATGCACGCC AGAAGTTCCG ATCTGTCCTG 
GTCGAGGCAA CGGTGAAACT AGACGAACTG GCAAAGAAAA TCGGCAAAGC CGTGGAGGAC 
TCGAAGCCCT ACTGGGAGGC CCGGAGGGTG GCAAGGCAGG CTCAGCTGGA GGCGCAGAAG 
GCCACACAGG ACTTCCAGAG GGCCACCGAG GTACTCCGTG CAGCCAAGGA AACAATCTCT 
CTGGCTGAGC AGCGGCTGTT GGAGGATGAC AAGCGGCAGT TTGACTCTGC TTGGCAGGAA 
ATGCTGAACC ATGCTACTCA GAGGGTCATG GAGGCCGAGC AGACCAAGAC AAGGAGTGAG 
CTAGTACACA AGGAGACGGC AGCCAGGTAC AACGCTGCCA TGGGTCGCAT GCGCCAGCTG 
GAGAAGAAAC TCAAGCGAGC CATCAACAAG TCCAAGCCTT ATTTTGAGCT AAAGGCAAAG 
TACTACGTGC AGCTTGAGCA ACTGAAGAAG ACGGTGGATG ACCTTCAGGC CAAGCTGGCC 
CTGGCAAAGG GCGAGTACAA GGCAGCCCTG AAGAGCCTGG AGAGGATCTC AGATGAGATA 
CACGAGCGGC GGCGTTCCAA TGCCATGGGG CCCCGGGGCT GTGGCGTGGG GGCAGAGGGC 
AGCATCGCCT CAGTGGAGAA CCTGCCTGTA AGCAAACCTG AGCCTGACGC CATTTCTGTG 
GCATCAGAAG CCTTTGAAGA TGACAACTGC AGCAACTTGG TGTCTGAAGA TGACTCGGAA 
ACCCAGTCTG TGTCCAGCTT TAGTTCGGGA CCGACGAGTC CGTCTGAAAT GCCTGATCAG 
TTCCCTGCAG TGGCAAGGCC TGGCAGTCTG GATCTGCCTA GCCCTGTGTC CCTGTCAGAA 
TTTGGGATGA TGTTCCCAAT ACTGGGTCCT CGAAGTGAAT GCAGTGGGGC CTCCTCCCCT 
GAATGTGAGG TTGAACGAGG AGACAGAGCA GAAGGGGCCG AGAATAAAAT GAGTGACAAA 
GCCAACAACA ACCGTGTTCT CGGCAGCACC AACGGTGGCA GTGGCAGGAG CAGGAGCCAA 
AGCAGCACGT CCCTTGAGAG CCAGGCCTTG GAAACCCGGA TGAAGCAGCT CTCCCTACAG 
TGCTCAAAAG GAAGAGATGG AATTATTGCT GACATAAAAA TGGTGCAGAT TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036024.2
CDS	144..1520
Translation	MDTALKRSRSDEPAELPPPAREVEEKEEEEERMEQGLEEEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELAKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLALAKGEYKAALKSLERISDEIHERRRSNAMGPRGCGVGAEGSIASVENLPVSKPEPDAISVASEAFEDDNCSNLVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVARPGSLDLPSPVSLSEFGMMFPILGPRSECSGASSPECEVERGDRAEGAENKMSDKANNNRVLGSTNGGSGRSRSQSSTSLESQALETRMKQLSLQCSKGRDGIIADIKMVQIG

Target ORF information:

RefSeq Version	NM_011894.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011894.3

ORF Insert Sequence:

ATGGACACGG CGCTGAAACG GAGCCGCTCT GACGAGCCGG CGGAGCTCCC GCCGCCTGCC 
CGGGAGGTGG AGGAGAAAGA GGAGGAGGAA GAGAGGATGG AACAGGGCCT GGAGGAGGAG 
GAGGAAGAGG TGGACCCCCG GATCCAGGGA GAACTGGAGA AGTTAAATCA ATCCACGGAT 
GATATCAACC GACGGGAGAC TGAGCTTGAG GATGCACGCC AGAAGTTCCG ATCTGTCCTG 
GTCGAGGCAA CGGTGAAACT AGACGAACTG GCAAAGAAAA TCGGCAAAGC CGTGGAGGAC 
TCGAAGCCCT ACTGGGAGGC CCGGAGGGTG GCAAGGCAGG CTCAGCTGGA GGCGCAGAAG 
GCCACACAGG ACTTCCAGAG GGCCACCGAG GTACTCCGTG CAGCCAAGGA AACAATCTCT 
CTGGCTGAGC AGCGGCTGTT GGAGGATGAC AAGCGGCAGT TTGACTCTGC TTGGCAGGAA 
ATGCTGAACC ATGCTACTCA GAGGGTCATG GAGGCCGAGC AGACCAAGAC AAGGAGTGAG 
CTAGTACACA AGGAGACGGC AGCCAGGTAC AACGCTGCCA TGGGTCGCAT GCGCCAGCTG 
GAGAAGAAAC TCAAGCGAGC CATCAACAAG TCCAAGCCTT ATTTTGAGCT AAAGGCAAAG 
TACTACGTGC AGCTTGAGCA ACTGAAGAAG ACGGTGGATG ACCTTCAGGC CAAGCTGGCC 
CTGGCAAAGG GCGAGTACAA GGCAGCCCTG AAGAGCCTGG AGAGGATCTC AGATGAGATA 
CACGAGCGGC GGCGTTCCAA TGCCATGGGG CCCCGGGGCT GTGGCGTGGG GGCAGAGGGC 
AGCATCGCCT CAGTGGAGAA CCTGCCTGTA AGCAAACCTG AGCCTGACGC CATTTCTGTG 
GCATCAGAAG CCTTTGAAGA TGACAACTGC AGCAACTTGG TGTCTGAAGA TGACTCGGAA 
ACCCAGTCTG TGTCCAGCTT TAGTTCGGGA CCGACGAGTC CGTCTGAAAT GCCTGATCAG 
TTCCCTGCAG TGGCAAGGCC TGGCAGTCTG GATCTGCCTA GCCCTGTGTC CCTGTCAGAA 
TTTGGGATGA TGTTCCCAAT ACTGGGTCCT CGAAGTGAAT GCAGTGGGGC CTCCTCCCCT 
GAATGTGAGG TTGAACGAGG AGACAGAGCA GAAGGGGCCG AGAATAAAAT GAGTGACAAA 
GCCAACAACA ACCGTGTTCT CGGCAGCACC AACGGTGGCA GTGGCAGGAG CAGGAGCCAA 
AGCAGCACGT CCCTTGAGAG CCAGGCCTTG GAAACCCGGA TGAAGCAGCT CTCCCTACAG 
TGCTCAAAAG GAAGAGATGG AATTATTGCT GACATAAAAA TGGTGCAGAT TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sh3bp5 ( NM_001347585.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001334514.1 Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu49989
Clone ID Related Accession (Same CDS sequence)	NM_001347585.1
Accession Version	NM_001347585.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1371bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	SH3 domain-binding protein 5 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK161427.1, AK165033.1, AC108416.5, BU609611.1 and BQ173956.1. On Dec 1, 2016 this sequence version replaced XM_006519013.3. Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK161427.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTGGG CCAGAACTGT TATGGCCTCT ACAGGGCTGG CCCCAGCTTC TGCTGCTCCT 
CACACCGGCT CCCGTGCCCA GCCCTGCCTC TTTTTGGCTC CTGTGCCCCC ACACTTTGCT 
TGGTTTATCT TCCTGGACCC TGCTCTACCC TGCTCTACTC TGGCACAGTC GGTCAGCTTC 
AAACCCTGCT GTGGGGTCGT AAAGGATGCA CGCCAGAAGT TCCGATCTGT CCTGGTCGAG 
GCAACGGTGA AACTAGACGA ACTGGCAAAG AAAATCGGCA AAGCCGTGGA GGACTCGAAG 
CCCTACTGGG AGGCCCGGAG GGTGGCAAGG CAGGCTCAGC TGGAGGCGCA GAAGGCCACA 
CAGGACTTCC AGAGGGCCAC CGAGGTACTC CGTGCAGCCA AGGAAACAAT CTCTCTGGCT 
GAGCAGCGGC TGTTGGAGGA TGACAAGCGG CAGTTTGACT CTGCTTGGCA GGAAATGCTG 
AACCATGCTA CTCAGAGGGT CATGGAGGCC GAGCAGACCA AGACAAGGAG TGAGCTAGTA 
CACAAGGAGA CGGCAGCCAG GTACAACGCT GCCATGGGTC GCATGCGCCA GCTGGAGAAG 
AAACTCAAGC GAGCCATCAA CAAGTCCAAG CCTTATTTTG AGCTAAAGGC AAAGTACTAC 
GTGCAGCTTG AGCAACTGAA GAAGACGGTG GATGACCTTC AGGCCAAGCT GGCCCTGGCA 
AAGGGCGAGT ACAAGGCAGC CCTGAAGAGC CTGGAGAGGA TCTCAGATGA GATACACGAG 
CGGCGGCGTT CCAATGCCAT GGGGCCCCGG GGCTGTGGCG TGGGGGCAGA GGGCAGCATC 
GCCTCAGTGG AGAACCTGCC TGTAAGCAAA CCTGAGCCTG ACGCCATTTC TGTGGCATCA 
GAAGCCTTTG AAGATGACAA CTGCAGCAAC TTGGTGTCTG AAGATGACTC GGAAACCCAG 
TCTGTGTCCA GCTTTAGTTC GGGACCGACG AGTCCGTCTG AAATGCCTGA TCAGTTCCCT 
GCAGTGGCAA GGCCTGGCAG TCTGGATCTG CCTAGCCCTG TGTCCCTGTC AGAATTTGGG 
ATGATGTTCC CAATACTGGG TCCTCGAAGT GAATGCAGTG GGGCCTCCTC CCCTGAATGT 
GAGGTTGAAC GAGGAGACAG AGCAGAAGGG GCCGAGAATA AAATGAGTGA CAAAGCCAAC 
AACAACCGTG TTCTCGGCAG CACCAACGGT GGCAGTGGCA GGAGCAGGAG CCAAAGCAGC 
ACGTCCCTTG AGAGCCAGGC CTTGGAAACC CGGATGAAGC AGCTCTCCCT ACAGTGCTCA 
AAAGGAAGAG ATGGAATTAT TGCTGACATA AAAATGGTGC AGATTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334514.1
CDS	64..1434
Translation	MDWARTVMASTGLAPASAAPHTGSRAQPCLFLAPVPPHFAWFIFLDPALPCSTLAQSVSFKPCCGVVKDARQKFRSVLVEATVKLDELAKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLALAKGEYKAALKSLERISDEIHERRRSNAMGPRGCGVGAEGSIASVENLPVSKPEPDAISVASEAFEDDNCSNLVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVARPGSLDLPSPVSLSEFGMMFPILGPRSECSGASSPECEVERGDRAEGAENKMSDKANNNRVLGSTNGGSGRSRSQSSTSLESQALETRMKQLSLQCSKGRDGIIADIKMVQIG

Target ORF information:

RefSeq Version	NM_001347585.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347585.1

ORF Insert Sequence:

ATGGACTGGG CCAGAACTGT TATGGCCTCT ACAGGGCTGG CCCCAGCTTC TGCTGCTCCT 
CACACCGGCT CCCGTGCCCA GCCCTGCCTC TTTTTGGCTC CTGTGCCCCC ACACTTTGCT 
TGGTTTATCT TCCTGGACCC TGCTCTACCC TGCTCTACTC TGGCACAGTC GGTCAGCTTC 
AAACCCTGCT GTGGGGTCGT AAAGGATGCA CGCCAGAAGT TCCGATCTGT CCTGGTCGAG 
GCAACGGTGA AACTAGACGA ACTGGCAAAG AAAATCGGCA AAGCCGTGGA GGACTCGAAG 
CCCTACTGGG AGGCCCGGAG GGTGGCAAGG CAGGCTCAGC TGGAGGCGCA GAAGGCCACA 
CAGGACTTCC AGAGGGCCAC CGAGGTACTC CGTGCAGCCA AGGAAACAAT CTCTCTGGCT 
GAGCAGCGGC TGTTGGAGGA TGACAAGCGG CAGTTTGACT CTGCTTGGCA GGAAATGCTG 
AACCATGCTA CTCAGAGGGT CATGGAGGCC GAGCAGACCA AGACAAGGAG TGAGCTAGTA 
CACAAGGAGA CGGCAGCCAG GTACAACGCT GCCATGGGTC GCATGCGCCA GCTGGAGAAG 
AAACTCAAGC GAGCCATCAA CAAGTCCAAG CCTTATTTTG AGCTAAAGGC AAAGTACTAC 
GTGCAGCTTG AGCAACTGAA GAAGACGGTG GATGACCTTC AGGCCAAGCT GGCCCTGGCA 
AAGGGCGAGT ACAAGGCAGC CCTGAAGAGC CTGGAGAGGA TCTCAGATGA GATACACGAG 
CGGCGGCGTT CCAATGCCAT GGGGCCCCGG GGCTGTGGCG TGGGGGCAGA GGGCAGCATC 
GCCTCAGTGG AGAACCTGCC TGTAAGCAAA CCTGAGCCTG ACGCCATTTC TGTGGCATCA 
GAAGCCTTTG AAGATGACAA CTGCAGCAAC TTGGTGTCTG AAGATGACTC GGAAACCCAG 
TCTGTGTCCA GCTTTAGTTC GGGACCGACG AGTCCGTCTG AAATGCCTGA TCAGTTCCCT 
GCAGTGGCAA GGCCTGGCAG TCTGGATCTG CCTAGCCCTG TGTCCCTGTC AGAATTTGGG 
ATGATGTTCC CAATACTGGG TCCTCGAAGT GAATGCAGTG GGGCCTCCTC CCCTGAATGT 
GAGGTTGAAC GAGGAGACAG AGCAGAAGGG GCCGAGAATA AAATGAGTGA CAAAGCCAAC 
AACAACCGTG TTCTCGGCAG CACCAACGGT GGCAGTGGCA GGAGCAGGAG CCAAAGCAGC 
ACGTCCCTTG AGAGCCAGGC CTTGGAAACC CGGATGAAGC AGCTCTCCCT ACAGTGCTCA 
AAAGGAAGAG ATGGAATTAT TGCTGACATA AAAATGGTGC AGATTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sh3bp5 ( XM_006519015.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006519078.1 Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OMu49991
Clone ID Related Accession (Same CDS sequence)	XM_030247814.1 , XM_030247815.1 , XM_006519015.2
Accession Version	XM_006519015.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	SH3 domain-binding protein 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006519015.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGAACC ATGCTACTCA GAGGGTCATG GAGGCCGAGC AGACCAAGAC AAGGAGTGAG 
CTAGTACACA AGGAGACGGC AGCCAGGTAC AACGCTGCCA TGGGTCGCAT GCGCCAGCTG 
GAGAAGAAAC TCAAGCGAGC CATCAACAAG TCCAAGCCTT ATTTTGAGCT AAAGGCAAAG 
TACTACGTGC AGCTTGAGCA ACTGAAGAAG ACGGTGGATG ACCTTCAGGC CAAGCTGGCC 
CTGGCAAAGG GCGAGTACAA GGCAGCCCTG AAGAGCCTGG AGAGGATCTC AGATGAGATA 
CACGAGCGGC GGCGTTCCAA TGCCATGGGG CCCCGGGGCT GTGGCGTGGG GGCAGAGGGC 
AGCATCGCCT CAGTGGAGAA CCTGCCTGTA AGCAAACCTG AGCCTGACGC CATTTCTGTG 
GCATCAGAAG CCTTTGAAGA TGACAACTGC AGCAACTTGG TGTCTGAAGA TGACTCGGAA 
ACCCAGTCTG TGTCCAGCTT TAGTTCGGGA CCGACGAGTC CGTCTGAAAT GCCTGATCAG 
TTCCCTGCAG TGGCAAGGCC TGGCAGTCTG GATCTGCCTA GCCCTGTGTC CCTGTCAGAA 
TTTGGGATGA TGTTCCCAAT ACTGGGTCCT CGAAGTGAAT GCAGTGGGGC CTCCTCCCCT 
GAATGTGAGG TTGAACGAGG AGACAGAGCA GAAGGGGCCG AGAATAAAAT GAGTGACAAA 
GCCAACAACA ACCGTGTTCT CGGCAGCACC AACGGTGGCA GTGGCAGGAG CAGGAGCCAA 
AGCAGCACGT CCCTTGAGAG CCAGGCCTTG GAAACCCGGA TGAAGCAGCT CTCCCTACAG 
TGCTCAAAAG GAAGAGATGG AATTATTGCT GACATAAAAA TGGTGCAGAT TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006519078.1
CDS	166..1062
Translation	MLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLALAKGEYKAALKSLERISDEIHERRRSNAMGPRGCGVGAEGSIASVENLPVSKPEPDAISVASEAFEDDNCSNLVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVARPGSLDLPSPVSLSEFGMMFPILGPRSECSGASSPECEVERGDRAEGAENKMSDKANNNRVLGSTNGGSGRSRSQSSTSLESQALETRMKQLSLQCSKGRDGIIADIKMVQIG

Target ORF information:

RefSeq Version	XM_006519015.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006519015.2

ORF Insert Sequence:

ATGCTGAACC ATGCTACTCA GAGGGTCATG GAGGCCGAGC AGACCAAGAC AAGGAGTGAG 
CTAGTACACA AGGAGACGGC AGCCAGGTAC AACGCTGCCA TGGGTCGCAT GCGCCAGCTG 
GAGAAGAAAC TCAAGCGAGC CATCAACAAG TCCAAGCCTT ATTTTGAGCT AAAGGCAAAG 
TACTACGTGC AGCTTGAGCA ACTGAAGAAG ACGGTGGATG ACCTTCAGGC CAAGCTGGCC 
CTGGCAAAGG GCGAGTACAA GGCAGCCCTG AAGAGCCTGG AGAGGATCTC AGATGAGATA 
CACGAGCGGC GGCGTTCCAA TGCCATGGGG CCCCGGGGCT GTGGCGTGGG GGCAGAGGGC 
AGCATCGCCT CAGTGGAGAA CCTGCCTGTA AGCAAACCTG AGCCTGACGC CATTTCTGTG 
GCATCAGAAG CCTTTGAAGA TGACAACTGC AGCAACTTGG TGTCTGAAGA TGACTCGGAA 
ACCCAGTCTG TGTCCAGCTT TAGTTCGGGA CCGACGAGTC CGTCTGAAAT GCCTGATCAG 
TTCCCTGCAG TGGCAAGGCC TGGCAGTCTG GATCTGCCTA GCCCTGTGTC CCTGTCAGAA 
TTTGGGATGA TGTTCCCAAT ACTGGGTCCT CGAAGTGAAT GCAGTGGGGC CTCCTCCCCT 
GAATGTGAGG TTGAACGAGG AGACAGAGCA GAAGGGGCCG AGAATAAAAT GAGTGACAAA 
GCCAACAACA ACCGTGTTCT CGGCAGCACC AACGGTGGCA GTGGCAGGAG CAGGAGCCAA 
AGCAGCACGT CCCTTGAGAG CCAGGCCTTG GAAACCCGGA TGAAGCAGCT CTCCCTACAG 
TGCTCAAAAG GAAGAGATGG AATTATTGCT GACATAAAAA TGGTGCAGAT TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sh3bp5 ( XM_030247814.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030103674.1 Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu49991
Clone ID Related Accession (Same CDS sequence)	XM_030247814.1 , XM_030247815.1 , XM_006519015.2
Accession Version	XM_030247814.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	SH3 domain-binding protein 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGAACC ATGCTACTCA GAGGGTCATG GAGGCCGAGC AGACCAAGAC AAGGAGTGAG 
CTAGTACACA AGGAGACGGC AGCCAGGTAC AACGCTGCCA TGGGTCGCAT GCGCCAGCTG 
GAGAAGAAAC TCAAGCGAGC CATCAACAAG TCCAAGCCTT ATTTTGAGCT AAAGGCAAAG 
TACTACGTGC AGCTTGAGCA ACTGAAGAAG ACGGTGGATG ACCTTCAGGC CAAGCTGGCC 
CTGGCAAAGG GCGAGTACAA GGCAGCCCTG AAGAGCCTGG AGAGGATCTC AGATGAGATA 
CACGAGCGGC GGCGTTCCAA TGCCATGGGG CCCCGGGGCT GTGGCGTGGG GGCAGAGGGC 
AGCATCGCCT CAGTGGAGAA CCTGCCTGTA AGCAAACCTG AGCCTGACGC CATTTCTGTG 
GCATCAGAAG CCTTTGAAGA TGACAACTGC AGCAACTTGG TGTCTGAAGA TGACTCGGAA 
ACCCAGTCTG TGTCCAGCTT TAGTTCGGGA CCGACGAGTC CGTCTGAAAT GCCTGATCAG 
TTCCCTGCAG TGGCAAGGCC TGGCAGTCTG GATCTGCCTA GCCCTGTGTC CCTGTCAGAA 
TTTGGGATGA TGTTCCCAAT ACTGGGTCCT CGAAGTGAAT GCAGTGGGGC CTCCTCCCCT 
GAATGTGAGG TTGAACGAGG AGACAGAGCA GAAGGGGCCG AGAATAAAAT GAGTGACAAA 
GCCAACAACA ACCGTGTTCT CGGCAGCACC AACGGTGGCA GTGGCAGGAG CAGGAGCCAA 
AGCAGCACGT CCCTTGAGAG CCAGGCCTTG GAAACCCGGA TGAAGCAGCT CTCCCTACAG 
TGCTCAAAAG GAAGAGATGG AATTATTGCT GACATAAAAA TGGTGCAGAT TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030103674.1
CDS	954..1850
Translation	MLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLALAKGEYKAALKSLERISDEIHERRRSNAMGPRGCGVGAEGSIASVENLPVSKPEPDAISVASEAFEDDNCSNLVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVARPGSLDLPSPVSLSEFGMMFPILGPRSECSGASSPECEVERGDRAEGAENKMSDKANNNRVLGSTNGGSGRSRSQSSTSLESQALETRMKQLSLQCSKGRDGIIADIKMVQIG

Target ORF information:

RefSeq Version	XM_030247814.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030247814.1

ORF Insert Sequence:

ATGCTGAACC ATGCTACTCA GAGGGTCATG GAGGCCGAGC AGACCAAGAC AAGGAGTGAG 
CTAGTACACA AGGAGACGGC AGCCAGGTAC AACGCTGCCA TGGGTCGCAT GCGCCAGCTG 
GAGAAGAAAC TCAAGCGAGC CATCAACAAG TCCAAGCCTT ATTTTGAGCT AAAGGCAAAG 
TACTACGTGC AGCTTGAGCA ACTGAAGAAG ACGGTGGATG ACCTTCAGGC CAAGCTGGCC 
CTGGCAAAGG GCGAGTACAA GGCAGCCCTG AAGAGCCTGG AGAGGATCTC AGATGAGATA 
CACGAGCGGC GGCGTTCCAA TGCCATGGGG CCCCGGGGCT GTGGCGTGGG GGCAGAGGGC 
AGCATCGCCT CAGTGGAGAA CCTGCCTGTA AGCAAACCTG AGCCTGACGC CATTTCTGTG 
GCATCAGAAG CCTTTGAAGA TGACAACTGC AGCAACTTGG TGTCTGAAGA TGACTCGGAA 
ACCCAGTCTG TGTCCAGCTT TAGTTCGGGA CCGACGAGTC CGTCTGAAAT GCCTGATCAG 
TTCCCTGCAG TGGCAAGGCC TGGCAGTCTG GATCTGCCTA GCCCTGTGTC CCTGTCAGAA 
TTTGGGATGA TGTTCCCAAT ACTGGGTCCT CGAAGTGAAT GCAGTGGGGC CTCCTCCCCT 
GAATGTGAGG TTGAACGAGG AGACAGAGCA GAAGGGGCCG AGAATAAAAT GAGTGACAAA 
GCCAACAACA ACCGTGTTCT CGGCAGCACC AACGGTGGCA GTGGCAGGAG CAGGAGCCAA 
AGCAGCACGT CCCTTGAGAG CCAGGCCTTG GAAACCCGGA TGAAGCAGCT CTCCCTACAG 
TGCTCAAAAG GAAGAGATGG AATTATTGCT GACATAAAAA TGGTGCAGAT TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sh3bp5 ( XM_030247815.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030103675.1 Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu49991
Clone ID Related Accession (Same CDS sequence)	XM_030247814.1 , XM_030247815.1 , XM_006519015.2
Accession Version	XM_030247815.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	SH3 domain-binding protein 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGAACC ATGCTACTCA GAGGGTCATG GAGGCCGAGC AGACCAAGAC AAGGAGTGAG 
CTAGTACACA AGGAGACGGC AGCCAGGTAC AACGCTGCCA TGGGTCGCAT GCGCCAGCTG 
GAGAAGAAAC TCAAGCGAGC CATCAACAAG TCCAAGCCTT ATTTTGAGCT AAAGGCAAAG 
TACTACGTGC AGCTTGAGCA ACTGAAGAAG ACGGTGGATG ACCTTCAGGC CAAGCTGGCC 
CTGGCAAAGG GCGAGTACAA GGCAGCCCTG AAGAGCCTGG AGAGGATCTC AGATGAGATA 
CACGAGCGGC GGCGTTCCAA TGCCATGGGG CCCCGGGGCT GTGGCGTGGG GGCAGAGGGC 
AGCATCGCCT CAGTGGAGAA CCTGCCTGTA AGCAAACCTG AGCCTGACGC CATTTCTGTG 
GCATCAGAAG CCTTTGAAGA TGACAACTGC AGCAACTTGG TGTCTGAAGA TGACTCGGAA 
ACCCAGTCTG TGTCCAGCTT TAGTTCGGGA CCGACGAGTC CGTCTGAAAT GCCTGATCAG 
TTCCCTGCAG TGGCAAGGCC TGGCAGTCTG GATCTGCCTA GCCCTGTGTC CCTGTCAGAA 
TTTGGGATGA TGTTCCCAAT ACTGGGTCCT CGAAGTGAAT GCAGTGGGGC CTCCTCCCCT 
GAATGTGAGG TTGAACGAGG AGACAGAGCA GAAGGGGCCG AGAATAAAAT GAGTGACAAA 
GCCAACAACA ACCGTGTTCT CGGCAGCACC AACGGTGGCA GTGGCAGGAG CAGGAGCCAA 
AGCAGCACGT CCCTTGAGAG CCAGGCCTTG GAAACCCGGA TGAAGCAGCT CTCCCTACAG 
TGCTCAAAAG GAAGAGATGG AATTATTGCT GACATAAAAA TGGTGCAGAT TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030103675.1
CDS	3134..4030
Translation	MLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLALAKGEYKAALKSLERISDEIHERRRSNAMGPRGCGVGAEGSIASVENLPVSKPEPDAISVASEAFEDDNCSNLVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVARPGSLDLPSPVSLSEFGMMFPILGPRSECSGASSPECEVERGDRAEGAENKMSDKANNNRVLGSTNGGSGRSRSQSSTSLESQALETRMKQLSLQCSKGRDGIIADIKMVQIG

Target ORF information:

RefSeq Version	XM_030247815.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030247815.1

ORF Insert Sequence:

ATGCTGAACC ATGCTACTCA GAGGGTCATG GAGGCCGAGC AGACCAAGAC AAGGAGTGAG 
CTAGTACACA AGGAGACGGC AGCCAGGTAC AACGCTGCCA TGGGTCGCAT GCGCCAGCTG 
GAGAAGAAAC TCAAGCGAGC CATCAACAAG TCCAAGCCTT ATTTTGAGCT AAAGGCAAAG 
TACTACGTGC AGCTTGAGCA ACTGAAGAAG ACGGTGGATG ACCTTCAGGC CAAGCTGGCC 
CTGGCAAAGG GCGAGTACAA GGCAGCCCTG AAGAGCCTGG AGAGGATCTC AGATGAGATA 
CACGAGCGGC GGCGTTCCAA TGCCATGGGG CCCCGGGGCT GTGGCGTGGG GGCAGAGGGC 
AGCATCGCCT CAGTGGAGAA CCTGCCTGTA AGCAAACCTG AGCCTGACGC CATTTCTGTG 
GCATCAGAAG CCTTTGAAGA TGACAACTGC AGCAACTTGG TGTCTGAAGA TGACTCGGAA 
ACCCAGTCTG TGTCCAGCTT TAGTTCGGGA CCGACGAGTC CGTCTGAAAT GCCTGATCAG 
TTCCCTGCAG TGGCAAGGCC TGGCAGTCTG GATCTGCCTA GCCCTGTGTC CCTGTCAGAA 
TTTGGGATGA TGTTCCCAAT ACTGGGTCCT CGAAGTGAAT GCAGTGGGGC CTCCTCCCCT 
GAATGTGAGG TTGAACGAGG AGACAGAGCA GAAGGGGCCG AGAATAAAAT GAGTGACAAA 
GCCAACAACA ACCGTGTTCT CGGCAGCACC AACGGTGGCA GTGGCAGGAG CAGGAGCCAA 
AGCAGCACGT CCCTTGAGAG CCAGGCCTTG GAAACCCGGA TGAAGCAGCT CTCCCTACAG 
TGCTCAAAAG GAAGAGATGG AATTATTGCT GACATAAAAA TGGTGCAGAT TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of MAP2 kinases and p38 kinase in acute murine liver injury models.
Cell death & disease8(6)e2903(2017 Jun)
Zhang J,Min RWM,Le K,Zhou S,Aghajan M,Than TA,Win S,Kaplowitz N

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.
Hepatology (Baltimore, Md.)63(6)1987-2003(2016 06)
Win S,Than TA,Min RW,Aghajan M,Kaplowitz N

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.
Journal of hepatology62(6)1367-74(2015 Jun)
Win S,Than TA,Le BH,Garc?a-Ruiz C,Fernandez-Checa JC,Kaplowitz N

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death.
Cell death & disease5e989(2014 Jan)
Win S,Than TA,Fernandez-Checa JC,Kaplowitz N

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Sh3bp5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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