Ik cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ik
Entrez Gene ID	24010
Full Name	IK cytokine
Synonyms	MuRED
General protein information	Preferred Names IK cytokine Names protein Red IK factor arginine/glutamic acid/aspartic acid repeat containing protein cytokine IK
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 B2

mRNA and Protein(s)

mRNA	Protein	Name
NM_011879.2	NP_036009.1	protein Red

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ik	NP_001005537.1
Bos taurus (cattle)	IK	NP_001096819.1
Pan troglodytes (chimpanzee)	IK	XP_003310921.2
Canis lupus familiaris (dog)	IK	XP_848793.1
Gallus gallus (chicken)	IK	NP_001006145.1
Danio rerio (zebrafish)	ik	NP_955883.1
Drosophila melanogaster (fruit fly)	beag	NP_649865.1
	IK	XP_002804586.1
Homo sapiens (human)	IK	NP_006074.2
Mus musculus (house mouse)	Ik	NP_036009.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004738	XP_318083.4

Gene Ontology
Bibliography

Related articles in PubMed

IK acts as an immunoregulator of inflammatory arthritis by suppressing T
Park HL, Lee SM, Min JK, Moon SJ, Kim I, Kang KW, Park S, Choi S, Jung HN, Lee DH, Nam JH
Scientific reports740280(2017 Jan)

Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases.
Lee S, Han S, Jeong AL, Park JS, Yang Y
FEBS letters588(17)2844-50(2014 Aug)

IK induced by coxsackievirus B3 infection transiently downregulates expression of MHC class II through increasing cAMP.
Park HL, Kim YJ, Na HN, Park MY, Kim JY, Yun CW, Nam JH
Viral immunology26(1)13-24(2013 Feb)

The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.
Youngren KK, Coveney D, Peng X, Bhattacharya C, Schmidt LS, Nickerson ML, Lamb BT, Deng JM, Behringer RR, Capel B, Rubin EM, Nadeau JH, Matin A
Nature435(7040)360-4(2005 May)

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Piao Y, Ko NT, Lim MK, Ko MS
Genome research11(9)1553-8(2001 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IK is an essential protein for achieving correct mitotic progress through the regulation of mitotic kinases and phosphatases
Title: Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases.

Taken together, these results imply that IK plays a role in downregulating MHC class II expression on B cells during coxsackievirus B3 infection through the induction of cAMP.
Title: IK induced by coxsackievirus B3 infection transiently downregulates expression of MHC class II through increasing cAMP.

The following Ik gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ik cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15009	NM_011879.2 Latest version!	Mus musculus IK cytokine (Ik), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$328.30 $469.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ik ( NM_011879.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036009.1 Mus musculus IK cytokine (Ik), mRNA.

Price & Availability↑

CloneID	OMu15009
Clone ID Related Accession (Same CDS sequence)	NM_011879.2
Accession Version	NM_011879.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1674bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Mus musculus(house mouse)
Product	protein Red
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG084120.2, BC029694.1 and BM211698.2. On Nov 20, 2007 this sequence version replaced NM_011879.1. ##Evidence-Data-START## Transcript exon combination :: AK087976.1, BC029671.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCAGAAC GAGATAGTGA GCCCTTCTCT AACCCTTTGG CTCCAGATGG CCACGATGTG 
GATGATCCTC ATTCCTTCCA CCAATCAAAA CTTACCAATG AAGACTTCAG GAAACTTCTT 
ATGACCCCAA GAGCTGCACC TACTTCTGCG CCACCTTCTA AGTCACGTCA CCATGAGATG 
CCAAGGGAGT ACAATGAGGA TGAAGACCCA GCTGCACGAA GGAGGAAAAA GAAAAGTTAT 
TATGCCAAGC TTCGCCAGCA AGAAATTGAG AGAGAGAGAG AACTCGCAGA GAAATACCGG 
GACCGTGCCA AGGAACGGAG AGATGGTGTG AACAAAGACT ATGAGGAAAC TGAGCTGATA 
AGTACCACAG CCAACTACAG GGCTGTGGGC CCCACTGCTG AGGCGGACAA ATCAGCAGCA 
GAGAAGAGAA GACAGTTGAT TCAGGAGTCC AAATTCTTGG GTGGTGATAT GGAACACACC 
CATTTGGTGA AAGGTTTGGA TTTTGCGTTG CTTCAAAAGG TGCGCGCTGA GATTGCCAGC 
AAAGAGAAGG AGGAAGAGGA ACTCATGGAA AAGCCCCAAA AGGAAACCAA GAAAGATGAG 
GATCCTGAGA ACAAAATTGA ATTTAAAACA CGCCTTGGCC GGAATGTGTA TCGGATGCTT 
TTCAAGAGTA AATCATATGA GCGAAATGAG CTGTTCTTAC CAGGACGTAT GGCCTATGTA 
GTAGACCTGG ATGATGAGTA CGCAGACACA GATATCCCCA CCACTCTCAT ACGCAGCAAA 
GCTGATTGCC CCACTATGGA GGCCCAGACT ACACTGACTA CAAATGACAT TGTTATTAGC 
AAGCTCACCC AGATTTTGTC ATACCTGAGG CAGGGGACCC GAAACAAGAA GCTCAAGAAG 
AAGGATAAAG GAAAACTGGA AGAGAAGAAA CCTCCTGAGG CTGACATGAA CATTTTTGAA 
GACATTGGGG ATTACGTTCC TTCTACAACC AAGACACCTC GGGACAAGGA ACGTGAGAGA 
TACCGGGAAC GTGAACGTGA TCGGGAACGG GACAGAGACA GGGAGCGAGA CAGGGAGCGA 
GACCGTGAGA GGGAGAGAGA GCGAGACCGG GAACGGGAAC GAGAGGAGGA AAAGAAAAGG 
CACAGCTACT TTGAGAAGCC AAAAGTGGAT GATGAGCCCA TGGATGTTGA CAAAGGACCT 
GGATCTGCAA AAGAGTTGAT CAAGTCCATC AATGAAAAAT TCGCTGGGTC TGCTGGCTGG 
GAAGGCACTG AATCGTTGAA GAAGCCAGAA GATAAGAAGC AGCTGGGCGA TTTCTTTGGC 
ATGTCCAACA GTTACGCAGA ATGCTATCCA GCCACGATGG ATGACATGGC TGTAGATAGT 
GATGAAGAGG TAGATTATAG CAAAATGGAC CAGGGTAACA AGAAGGGTCC CTTAGGCCGC 
TGGGACTTCG ATACTCAGGA GGAATACAGC GAGTACATGA ACAACAAGGA GGCTCTGCCC 
AAGGCTGCAT TCCAGTATGG CATCAAGATG TCTGAAGGAC GGAAAACCAG ACGATTCAAA 
GAAACCAATG ATAAGGCAGA GCTTGATCGA CAGTGGAAGA AAATAAGTGC AATCATTGAG 
AAGAGGAAGA GGATGGAAGC AGATGGGGTC GAAGTGAAAA GACCAAAGTA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036009.1
CDS	118..1791
Translation	MPERDSEPFSNPLAPDGHDVDDPHSFHQSKLTNEDFRKLLMTPRAAPTSAPPSKSRHHEMPREYNEDEDPAARRRKKKSYYAKLRQQEIERERELAEKYRDRAKERRDGVNKDYEETELISTTANYRAVGPTAEADKSAAEKRRQLIQESKFLGGDMEHTHLVKGLDFALLQKVRAEIASKEKEEEELMEKPQKETKKDEDPENKIEFKTRLGRNVYRMLFKSKSYERNELFLPGRMAYVVDLDDEYADTDIPTTLIRSKADCPTMEAQTTLTTNDIVISKLTQILSYLRQGTRNKKLKKKDKGKLEEKKPPEADMNIFEDIGDYVPSTTKTPRDKERERYRERERDRERDRDRERDRERDRERERERDREREREEEKKRHSYFEKPKVDDEPMDVDKGPGSAKELIKSINEKFAGSAGWEGTESLKKPEDKKQLGDFFGMSNSYAECYPATMDDMAVDSDEEVDYSKMDQGNKKGPLGRWDFDTQEEYSEYMNNKEALPKAAFQYGIKMSEGRKTRRFKETNDKAELDRQWKKISAIIEKRKRMEADGVEVKRPKY

Target ORF information:

RefSeq Version	NM_011879.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus IK cytokine (Ik), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011879.2

ORF Insert Sequence:

ATGCCAGAAC GAGATAGTGA GCCCTTCTCT AACCCTTTGG CTCCAGATGG CCACGATGTG 
GATGATCCTC ATTCCTTCCA CCAATCAAAA CTTACCAATG AAGACTTCAG GAAACTTCTT 
ATGACCCCAA GAGCTGCACC TACTTCTGCG CCACCTTCTA AGTCACGTCA CCATGAGATG 
CCAAGGGAGT ACAATGAGGA TGAAGACCCA GCTGCACGAA GGAGGAAAAA GAAAAGTTAT 
TATGCCAAGC TTCGCCAGCA AGAAATTGAG AGAGAGAGAG AACTCGCAGA GAAATACCGG 
GACCGTGCCA AGGAACGGAG AGATGGTGTG AACAAAGACT ATGAGGAAAC TGAGCTGATA 
AGTACCACAG CCAACTACAG GGCTGTGGGC CCCACTGCTG AGGCGGACAA ATCAGCAGCA 
GAGAAGAGAA GACAGTTGAT TCAGGAGTCC AAATTCTTGG GTGGTGATAT GGAACACACC 
CATTTGGTGA AAGGTTTGGA TTTTGCGTTG CTTCAAAAGG TGCGCGCTGA GATTGCCAGC 
AAAGAGAAGG AGGAAGAGGA ACTCATGGAA AAGCCCCAAA AGGAAACCAA GAAAGATGAG 
GATCCTGAGA ACAAAATTGA ATTTAAAACA CGCCTTGGCC GGAATGTGTA TCGGATGCTT 
TTCAAGAGTA AATCATATGA GCGAAATGAG CTGTTCTTAC CAGGACGTAT GGCCTATGTA 
GTAGACCTGG ATGATGAGTA CGCAGACACA GATATCCCCA CCACTCTCAT ACGCAGCAAA 
GCTGATTGCC CCACTATGGA GGCCCAGACT ACACTGACTA CAAATGACAT TGTTATTAGC 
AAGCTCACCC AGATTTTGTC ATACCTGAGG CAGGGGACCC GAAACAAGAA GCTCAAGAAG 
AAGGATAAAG GAAAACTGGA AGAGAAGAAA CCTCCTGAGG CTGACATGAA CATTTTTGAA 
GACATTGGGG ATTACGTTCC TTCTACAACC AAGACACCTC GGGACAAGGA ACGTGAGAGA 
TACCGGGAAC GTGAACGTGA TCGGGAACGG GACAGAGACA GGGAGCGAGA CAGGGAGCGA 
GACCGTGAGA GGGAGAGAGA GCGAGACCGG GAACGGGAAC GAGAGGAGGA AAAGAAAAGG 
CACAGCTACT TTGAGAAGCC AAAAGTGGAT GATGAGCCCA TGGATGTTGA CAAAGGACCT 
GGATCTGCAA AAGAGTTGAT CAAGTCCATC AATGAAAAAT TCGCTGGGTC TGCTGGCTGG 
GAAGGCACTG AATCGTTGAA GAAGCCAGAA GATAAGAAGC AGCTGGGCGA TTTCTTTGGC 
ATGTCCAACA GTTACGCAGA ATGCTATCCA GCCACGATGG ATGACATGGC TGTAGATAGT 
GATGAAGAGG TAGATTATAG CAAAATGGAC CAGGGTAACA AGAAGGGTCC CTTAGGCCGC 
TGGGACTTCG ATACTCAGGA GGAATACAGC GAGTACATGA ACAACAAGGA GGCTCTGCCC 
AAGGCTGCAT TCCAGTATGG CATCAAGATG TCTGAAGGAC GGAAAACCAG ACGATTCAAA 
GAAACCAATG ATAAGGCAGA GCTTGATCGA CAGTGGAAGA AAATAAGTGC AATCATTGAG 
AAGAGGAAGA GGATGGAAGC AGATGGGGTC GAAGTGAAAA GACCAAAGTA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IK acts as an immunoregulator of inflammatory arthritis by suppressing T
Scientific reports740280(2017 Jan)
Park HL,Lee SM,Min JK,Moon SJ,Kim I,Kang KW,Park S,Choi S,Jung HN,Lee DH,Nam JH

Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases.
FEBS letters588(17)2844-50(2014 Aug)
Lee S,Han S,Jeong AL,Park JS,Yang Y

IK induced by coxsackievirus B3 infection transiently downregulates expression of MHC class II through increasing cAMP.
Viral immunology26(1)13-24(2013 Feb)
Park HL,Kim YJ,Na HN,Park MY,Kim JY,Yun CW,Nam JH

The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.
Nature435(7040)360-4(2005 May)
Youngren KK,Coveney D,Peng X,Bhattacharya C,Schmidt LS,Nickerson ML,Lamb BT,Deng JM,Behringer RR,Capel B,Rubin EM,Nadeau JH,Matin A

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Genome research11(9)1553-8(2001 Sep)
Piao Y,Ko NT,Lim MK,Ko MS