Psmc4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Psmc4
Entrez Gene ID	23996
Full Name	proteasome (prosome, macropain) 26S subunit, ATPase, 4
Synonyms	CIP21,MIP224
General protein information	Preferred Names proteasome (prosome, macropain) 26S subunit, ATPase, 4 Names 26S proteasome regulatory subunit 6B 26S protease regulatory subunit 6B 26S proteasome AAA-ATPase subunit RPT3 CAR interacing protein 21 CAR interacting protein 21 MB67-interacting protein TAT-binding protein 7 TBP-7 proteasome 26S ATPase subunit 4 proteasome 26S subunit ATPase 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 A3\|7 16.11 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011874.2	NP_036004.2	26S proteasome regulatory subunit 6B

Pathways from BioSystems

Homologies

	PSMC4	XP_001090787.1
Saccharomyces cerevisiae (baker's yeast)	RPT3	NP_010682.3
Kluyveromyces lactis	KLLA0C06534g	XP_452488.1
Neurospora crassa	NCU02260	XP_959904.1
Homo sapiens (human)	PSMC4	NP_006494.1
Arabidopsis thaliana (thale cress)	RPT3	NP_200637.1
Bos taurus (cattle)	PSMC4	NP_001030255.1
Mus musculus (house mouse)	Psmc4	NP_036004.2
Caenorhabditis elegans (roundworm)	rpt-3	NP_498429.1
Schizosaccharomyces pombe (fission yeast)	rpt3	NP_588437.1
Xenopus tropicalis (tropical clawed frog)	psmc4	NP_001008010.1
Pan troglodytes (chimpanzee)	PSMC4	XP_001141307.1
Canis lupus familiaris (dog)	PSMC4	XP_005616634.1
Danio rerio (zebrafish)	psmc4	NP_956044.2
Eremothecium gossypii	AGOS_AFR394W	NP_985941.2
Magnaporthe oryzae (rice blast fungus)	MGG_00908	XP_003718052.1
Rattus norvegicus (Norway rat)	Psmc4	NP_476463.1
Drosophila melanogaster (fruit fly)	Rpt3	NP_572686.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003008	XP_003436353.1
Oryza sativa (rice)	Os02g0325100	NP_001046700.1

Gene Ontology
Bibliography

Related articles in PubMed

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H, Stuart JM, Gu W
BMC immunology17(1)25(2016 08)

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
Hjerpe R, Bett JS, Keuss MJ, Solovyova A, McWilliams TG, Johnson C, Sahu I, Varghese J, Wood N, Wightman M, Osborne G, Bates GP, Glickman MH, Trost M, Knebel A, Marchesi F, Kurz T
Cell166(4)935-949(2016 Aug)

Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.
Guo X, Wang X, Wang Z, Banerjee S, Yang J, Huang L, Dixon JE
Nature cell biology18(2)202-12(2016 Feb)

Proteasome dysfunction induces muscle growth defects and protein aggregation.
Kitajima Y, Tashiro Y, Suzuki N, Warita H, Kato M, Tateyama M, Ando R, Izumi R, Yamazaki M, Abe M, Sakimura K, Ito H, Urushitani M, Nagatomi R, Takahashi R, Aoki M
Journal of cell science127(Pt 24)5204-17(2014 Dec)

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis.
Tashiro Y, Urushitani M, Inoue H, Koike M, Uchiyama Y, Komatsu M, Tanaka K, Yamazaki M, Abe M, Misawa H, Sakimura K, Ito H, Takahashi R
The Journal of biological chemistry287(51)42984-94(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Psmc4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psmc4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09054	NM_011874.2 Latest version!	Mus musculus proteasome (prosome, macropain) 26S subunit, ATPase, 4 (Psmc4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Psmc4 ( NM_011874.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036004.2 Mus musculus proteasome (prosome, macropain) 26S subunit, ATPase, 4 (Psmc4), mRNA.

Price & Availability↑

CloneID	OMu09054
Clone ID Related Accession (Same CDS sequence)	NM_011874.2
Accession Version	NM_011874.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	26S proteasome regulatory subunit 6B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV646128.1, AK077507.1 and BY385516.1. On Jan 27, 2007 this sequence version replaced NM_011874.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK153991.1, AK050677.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGAGA TAGGCATTTT GGTGGAAAAG ATTCAGGATG AGATTCCAGC ACTGTCCGTG 
TCTCGGCCGC AGACCGGCCT GTCCTTTCTG GGACCCGAAC CTGAAGACCT GGAGGACCTG 
TACAGCCGCT ACAAGAAGCT GCAGCAGGAG CTGGAGTTCC TGGAAGTGCA GGAGGAGTAT 
ATCAAGGACG AGCAGAAGAA CCTGAAGAAG GAATTCCTCC ACGCCCAGGA GGAGGTGAAG 
CGGATCCAGA GCATCCCCTT GGTCATCGGT CAGTTCTTGG AAGCTGTGGA TCAGAACACA 
GCCATCGTGG GCTCCACCAC AGGCTCTAAC TATTATGTGC GCATCCTGAG TACCATCGAC 
CGGGAGCTGC TCAAGCCCAA CGCCTCGGTG GCCCTGCACA AGCACAGCAA TGCCCTGGTG 
GACGTGCTGC CTCCCGAGGC CGACAGCAGC ATCATGATGC TCACCTCAGA CCAGAAGCCA 
GATGTGATGT ATGCCGATAT CGGAGGCATG GACATCCAGA AGCAGGAGGT GAGGGAGGCT 
GTGGAACTCC CGCTTACACA CTTCGAGCTG TACAAGCAGA TTGGCATCGA TCCTCCCCGA 
GGTGTCCTCA TGTATGGCCC TCCTGGCTGT GGAAAGACAA TGTTAGCAAA GGCTGTGGCA 
CATCACACGA CAGCTGCATT TATCCGTGTG GTGGGCTCGG AGTTTGTTCA GAAGTACCTG 
GGTGAGGGCC CCCGGATGGT CCGGGATGTG TTCCGCCTAG CTAAGGAGAA TGCACCTGCC 
ATCATCTTCA TAGATGAAAT TGATGCCATT GCCACCAAGA GATTCGATGC CCAGACAGGA 
GCTGACAGGG AGGTTCAGAG GATCCTGCTG GAACTACTGA ATCAAATGGA TGGATTTGAC 
CAGAACGTCA ATGTGAAGGT AATCATGGCC ACAAACAGAG CAGACACCTT GGATCCAGCT 
CTACTGCGGC CAGGACGCCT GGACCGAAAA ATTGAATTCC CACTCCCTGA CCGTCGCCAG 
AAGAGGTTGA TTTTCTCCAC CATCACCAGC AAAATGAACC TCTCTGAGGA GGTCGACCTG 
GAAGACTATG TGGCCCGTCC AGATAAGATT TCAGGAGCCG ATATCAACTC CATCTGTCAG 
GAGAGTGGAA TGTTGGCTGT CCGTGAGAAC CGCTACATTG TCCTGGCCAA GGACTTCGAG 
AAAGCATACA AGACCGTGAT CAAGAAAGAT GAACAGGAAC ATGAATTTTA CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036004.2
CDS	75..1331
Translation	MEEIGILVEKIQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK

Target ORF information:

RefSeq Version	NM_011874.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus proteasome (prosome, macropain) 26S subunit, ATPase, 4 (Psmc4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011874.2

ORF Insert Sequence:

ATGGAGGAGA TAGGCATTTT GGTGGAAAAG ATTCAGGATG AGATTCCAGC ACTGTCCGTG 
TCTCGGCCGC AGACCGGCCT GTCCTTTCTG GGACCCGAAC CTGAAGACCT GGAGGACCTG 
TACAGCCGCT ACAAGAAGCT GCAGCAGGAG CTGGAGTTCC TGGAAGTGCA GGAGGAGTAT 
ATCAAGGACG AGCAGAAGAA CCTGAAGAAG GAATTCCTCC ACGCCCAGGA GGAGGTGAAG 
CGGATCCAGA GCATCCCCTT GGTCATCGGT CAGTTCTTGG AAGCTGTGGA TCAGAACACA 
GCCATCGTGG GCTCCACCAC AGGCTCTAAC TATTATGTGC GCATCCTGAG TACCATCGAC 
CGGGAGCTGC TCAAGCCCAA CGCCTCGGTG GCCCTGCACA AGCACAGCAA TGCCCTGGTG 
GACGTGCTGC CTCCCGAGGC CGACAGCAGC ATCATGATGC TCACCTCAGA CCAGAAGCCA 
GATGTGATGT ATGCCGATAT CGGAGGCATG GACATCCAGA AGCAGGAGGT GAGGGAGGCT 
GTGGAACTCC CGCTTACACA CTTCGAGCTG TACAAGCAGA TTGGCATCGA TCCTCCCCGA 
GGTGTCCTCA TGTATGGCCC TCCTGGCTGT GGAAAGACAA TGTTAGCAAA GGCTGTGGCA 
CATCACACGA CAGCTGCATT TATCCGTGTG GTGGGCTCGG AGTTTGTTCA GAAGTACCTG 
GGTGAGGGCC CCCGGATGGT CCGGGATGTG TTCCGCCTAG CTAAGGAGAA TGCACCTGCC 
ATCATCTTCA TAGATGAAAT TGATGCCATT GCCACCAAGA GATTCGATGC CCAGACAGGA 
GCTGACAGGG AGGTTCAGAG GATCCTGCTG GAACTACTGA ATCAAATGGA TGGATTTGAC 
CAGAACGTCA ATGTGAAGGT AATCATGGCC ACAAACAGAG CAGACACCTT GGATCCAGCT 
CTACTGCGGC CAGGACGCCT GGACCGAAAA ATTGAATTCC CACTCCCTGA CCGTCGCCAG 
AAGAGGTTGA TTTTCTCCAC CATCACCAGC AAAATGAACC TCTCTGAGGA GGTCGACCTG 
GAAGACTATG TGGCCCGTCC AGATAAGATT TCAGGAGCCG ATATCAACTC CATCTGTCAG 
GAGAGTGGAA TGTTGGCTGT CCGTGAGAAC CGCTACATTG TCCTGGCCAA GGACTTCGAG 
AAAGCATACA AGACCGTGAT CAAGAAAGAT GAACAGGAAC ATGAATTTTA CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
BMC immunology17(1)25(2016 08)
Liu X,Jiao Y,Cao Y,Deng N,Ma Y,Hasty KA,Kang A,Chen H,Stuart JM,Gu W

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
Cell166(4)935-949(2016 Aug)
Hjerpe R,Bett JS,Keuss MJ,Solovyova A,McWilliams TG,Johnson C,Sahu I,Varghese J,Wood N,Wightman M,Osborne G,Bates GP,Glickman MH,Trost M,Knebel A,Marchesi F,Kurz T

Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.
Nature cell biology18(2)202-12(2016 Feb)
Guo X,Wang X,Wang Z,Banerjee S,Yang J,Huang L,Dixon JE

Proteasome dysfunction induces muscle growth defects and protein aggregation.
Journal of cell science127(Pt 24)5204-17(2014 Dec)
Kitajima Y,Tashiro Y,Suzuki N,Warita H,Kato M,Tateyama M,Ando R,Izumi R,Yamazaki M,Abe M,Sakimura K,Ito H,Urushitani M,Nagatomi R,Takahashi R,Aoki M

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis.
The Journal of biological chemistry287(51)42984-94(2012 Dec)
Tashiro Y,Urushitani M,Inoue H,Koike M,Uchiyama Y,Komatsu M,Tanaka K,Yamazaki M,Abe M,Misawa H,Sakimura K,Ito H,Takahashi R

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Psmc4 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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