Adamts12 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adamts12
Entrez Gene ID	239337
Full Name	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
Synonyms	ADAMTS-12,AI605170
General protein information	Preferred Names a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 Names A disintegrin and metalloproteinase with thrombospondin motifs 12 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 A1
Summary	This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Mice lacking the encoded protein exhibit increased angiogenic response and tumor invasion in different models of angiogenesis and, severe inflammation and delayed recovery when subjected to experimental conditions that induce colitis, endotoxic sepsis and pancreatitis. [provided by RefSeq, Jul 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_175501.3	NP_780710.2	A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	ADAMTS12	NP_112217.2
Mus musculus (house mouse)	Adamts12	NP_780710.2
Danio rerio (zebrafish)	LOC100003937	XP_001343371.4
	ADAMTS12	XP_001090049.1
Gallus gallus (chicken)	ADAMTS12	XP_003643023.2
Canis lupus familiaris (dog)	ADAMTS12	XP_536508.5
Rattus norvegicus (Norway rat)	Adamts12	NP_001099890.2
Pan troglodytes (chimpanzee)	ADAMTS12	XP_517836.3
Bos taurus (cattle)	ADAMTS12	NP_001179538.1
Xenopus tropicalis (tropical clawed frog)	adamts12	XP_002942490.2

Gene Ontology
Bibliography

Related articles in PubMed

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.
Dubail J, Apte SS
Matrix biology : journal of the International Society for Matrix Biology44-4624-37(2015 May-Jul)

ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
Wei J, Richbourgh B, Jia T, Liu C
Mediators of inflammation2014649718(2014)

ADAMTS-12 metalloprotease is necessary for normal inflammatory response.
Moncada-Pazos A, Obaya AJ, Llamazares M, Heljasvaara R, Su?rez MF, Colado E, No?l A, Cal S, L?pez-Ot?n C
The Journal of biological chemistry287(47)39554-63(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ADAMTS-12 is a multifaced metalloproteinase in arthritis and inflammation [review]
Title: ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.

ADAMTS-12 is implicated in the inflammatory response by modulating normal neutrophil apoptosis.
Title: ADAMTS-12 metalloprotease is necessary for normal inflammatory response.

ADAMTS-12 plays protective roles acting against the development of asthma phenotype upon experimental allergen exposure, interfering with immunological processes leading to inflammation and airway hyperresponsiveness.
Title: Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12.

Absence of Adamts-12 is associated with the increase in angiogenic response and tumor invasion into host tissue.
Title: Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis.

Results define a break point in mouse chromosome 15qA1 to a 27-kb region containing ADAMTS12, and show that the break is likely between exons 2 and 3 of ADAMTS12.
Title: The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break in the ADAMTS12 gene.

The following Adamts12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adamts12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20994	NM_175501.3 Latest version!	Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 (Adamts12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$811.30 $1159.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adamts12 ( NM_175501.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_780710.2 Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 (Adamts12), mRNA.

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CloneID	OMu20994
Clone ID Related Accession (Same CDS sequence)	NM_175501.3
Accession Version	NM_175501.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4803bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-30
Organism	Mus musculus(house mouse)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BB839765.1, AK135354.1, AJ537452.1, AK028459.1, AK028812.1, AC159963.7 and AI605170.1. On Jul 27, 2016 this sequence version replaced NM_175501.2. ##Evidence-Data-START## Transcript exon combination :: AJ537452.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCATGTG CTCGGGGGAG CTGGCTGGCC AAGCTCTCGA TCGTGGCTCA GCTTATTAAT 
TTTGGGGCTT TTTGCCACGG GAGACAAACT CAGCCCTGGC CGGTTCGCTT CCCAGACCCG 
AGGCAAGAAC ATTTTATCAA GTCCCTGCCA GAATACCACA TAGTGAGTCC AGTCCAAGTC 
GATGCTGGTG GCCATGTTCT GTCCTATGGC CTGCATCACC CTGTCACTAG CAGCAGGAAG 
AAGAGAGCTG CAGGTGGTTC TGGGGACCAG CTGTACTACA GAATTTCGCA TGAAGAAAAA 
GACCTGTTTT TCAATCTGAC GGTCAACTGG GAATTTCTTT CCAACGGCTA TGTCGTGGAG 
AAGAGATATG GGAACCTTTC CCATGTTAAG ATGGTGGCTT CCTCAGGCCA GCCCTGCCAT 
CTCAGGGGCA CAGTTCTGCA GCAGGGCACC ACAGTCGGGA TCGGGACAGC AGCTCTCAGT 
GCCTGCCAAG GACTGACTGG ATTTTTCCAT CTACCACATG GAGACTTTTT CATCGAGCCT 
GTTAAAAAGC ATCCACTGAC CGAGGAAGGG TCCTACCCTC ATGTCGTATA CAGGAGACAG 
AGCATCAGAG CTCCAGAGAC AAAGGAGCCC ATCTGTGGAT TAAAGGACAG TCTTGATAAC 
TCTGTGAAAC AAGAGCTACA GCGGGAGAAG TGGGAGAGGA AAACCTTGCG GAGCAGAAGC 
CTCTCCCGAC GTTCCATAAG CAAGGAGAGA TGGGTGGAGA CCCTCGTGGT GGCCGACACG 
AAGACGGTAG AGTACCATGG AAGCGAGAAC GTGGAGTCGT ACATCCTCAC CATCATGAAT 
ATGGTCACTG GGTTGTTTCA TAGCCCAAGC ATTGGCAATC TAGTCCACAT TGTTGTGGTT 
CGGCTCATTC TACTTGAAGA AGAGGAGCAA GGATTGAAAA TAGTTCATCA TGCAGAGAAG 
ACACTGTCCA GTTTCTGCAA GTGGCAGAAG AGCATCAATC CCAAGAGTGA CCTCAACCCT 
GTCCATCATG ATGTGGCTGT CCTTATCACC AGAAAGGACA TCTGTGCTGG TGTCAATCGC 
CCTTGTGAGA CTCTGGGGCT GTCCCAATTG TCAGGAATGT GCCAGCCTCA CAGGAGCTGT 
AACATCAATG AAGACTCTGG CCTCCCCCTG GCTTTCACCA TTGCACATGA ACTTGGTCAC 
AGCTTCGGCA TCCAGCATGA TGGAAAGGAA AATGACTGTG AGCCCGTGGG CAGGCACCCA 
TACATCATGT CCCAACAGAT TCAGTACGAC CCAACTCCAC TAACATGGTC GAAATGCAGC 
AAGGAGTACA TCACTCGCTT CTTGGACCGA GGCAGGGGGT TCTGTCTTGA TGATATCCCC 
AGCAAGAAAG GCTTGAAGTC CAACGTCATT GCTCCTGGAG TAATTTACGA TGTTCATCAC 
CAGTGCCAGC TCCAATATGG CCCAAATGCT ACATTCTGCC AGGAAGTGGA AAATGTTTGC 
CAGACACTGT GGTGCTCGGT GAAAGGCTTC TGTCGCTCTA AGCTAGATGC TGCTGCAGAC 
GGGACTCGTT GCGGTGAGAA GAAGTGGTGT ATGGCTGGAA AGTGTATCAC AGTGGGGAAG 
AAACCAGAGA GCATCCCTGG AGGCTGGGGA CGCTGGTCAC CCTGGTCACA CTGTTCTAGA 
ACATGTGGGG CAGGAGCTCA GAGCGCAGAG AGGCTCTGCA ACAACCCAGA ACCAAAATTT 
GGAGGGAAAT ACTGCACCGG AGAAAGAAAA CGCTATCGCT TATGCAATGT CCACCCCTGC 
CGCTCAGACA CTCCAACTTT CCGGCAGATG CAGTGCAGTG AATTTGACAC AGTCCCCTAC 
AAAAACCAAT TCTACCGCTG GTTCCCAGTG TTTAATGCAG CACATCCTTG TGAGCTGTAC 
TGCAGACCCA TAGATGAACA GTTTTCTGAG AGAATGCTGG AAGCTGTCAT TGATGGCACC 
CCATGCTTCG AAGGTGGCAA CAGCAGAAAT GTCTGTATTA ATGGCATATG TAAGAGGGTT 
GGCTGTGACT ATGAGATTGA TTCCAATGCT ACAGAGGATC GCTGTGGTGT GTGCCTTGGA 
GATGGCTCTG CCTGCCAGAC GGTGAAGAAG CTGTTTAGAC AGAAGGAAGG ATCTGGTTAC 
GTTGACATTG GACTTATTCC CAAAGGTGCG AGGGATATAA GGGTGATGGA AATCAAGGCA 
GCTGGCAATT TCCTGGCCAT TAGGAGTGAA GATCCGGAAA AATACTACCT CAACGGAGGG 
TTCATTATCC AGTGGAATGG AAACTATAAA CTGGCAGGGA CCGTTTTCCA GTATGACAGG 
AAAGGAGATC TGGAGAAACT TATAGCTCCA GGCCCCACCA ACGAGTCAGT GTGGCTCCAG 
CTACTTTTCC AGGTGACTAA CCCTGGTATC AAGTATGAGT ACACAGTCCG GAAAGATGGC 
CTTGACAATG ACGTGGAGAA GTTGCTGTAC TTCTGGCAAT TTGGCCGCTG GACAGAATGC 
AGTGTAACGT GTGGAACAGG TATCCGCCGG CAGGCTGCTC ATTGTGTCAA GAAGGGCCAC 
GGTATAGTGA AAACGACCTT CTGTAACCCA GAAACACAGC CCAGCGTGAG ACAGAAGAAG 
TGCCATGAAA AGGACTGTCC ACCCAGGTGG TGGGCAGGGG AGTGGGAAGC GTGTTCAACG 
ACATGTGGGC CCTACGGAGA AAAAAAGAGA ACGGTGCTGT GCATCCAGAC CATGGGCTCG 
GATGAACAGG CTCTCCCTGC TACAGACTGC CAGCACCTGC TGAAGCCCAA AGCACTGGTT 
TCCTGCAACA GAGATATTCT GTGTCCATCA GACTGGACAG TAGGCAACTG GAGTGAGTGC 
TCTGTTTCCT GTGGTGGTGG AGTGCGGATT CGCAGTGTCA CATGTGCCAA GAACCTTAAT 
GAGCCTTGTG ACAAGACCCG GAAACCCAAC AGTCGAGCTC TGTGCGGCCT CCAGCAGTGC 
CCATTTAGCC GTAGAGTTCT GAAACCCAAT AAAGATATAG CTCCCAGTGG GAAAAATCAA 
TCGACAGCAG AACATGACCC CTTCAAGCCC ATCCCAGCAC CAACATCCAG GCCCACGCCA 
CTGTCCACAC CCACAGTGCC TGAGTCTATG AGCACAAGTA CTCCCACAAT CAACAGCCTT 
GGCTCCACCA TAGCATCCCA AGAAGACGCA AATGGGATGG GATGGCAGAA TAATTCAACC 
CAAGCTGAAG AGGGCTCCCA CTTCCCTACT TCTTCTGGAA GCACTTCCCA GGTCCCCGTG 
ACTTCCTGGT CTTTGAGTAT CCAACCTGAT GATGAGAATG TTTCCAGCTC AGCTATAGGT 
CCTACTTCAG AGGGTGACTT TTGGGCAACC ACAACAAGTG ATTCTGGCTT ATCATCTAGC 
GATGCTATGA CTTGGCAGGT AACTCCATTT TATAGCACCA TGACCACAGA TCCAGAAGTG 
GAGATACATA GTGGTTCAGG GGAAGACAGT GACCAGCCTT TGAACAAGGA CAAAAGCAAC 
TCTGTGATAT GGAATAAGAT CGGGGTACCT GAACATGATG CTCCCATGGA GACGGATGCA 
GAACTACCAC TTGGACCTCC ACCAACATCT TATATGGGGG AAGAGCCCTC ATGGCCTCCC 
TTCAGTACAA AAATGGAAGG CTCATTACCT GCCTGGTCCT TCAAAAATGA GACACCCAGG 
GATGATGGGA TGATCGCTGA AAAATCAAGG AAGATTCCAC TCCCTCTTGC AGGAGACCAC 
CATCCAGCAA CCTCAGAGAA GTTAGAAAAC CATGACAAAT TGGCATTGCC AAATACTACA 
AATCCAACCC AAGGCTTTGG GCCTGTCCTG ACTGAAGAAG ATGCCTCCAA TCTGATTGCC 
GAGGGGTTTT TGCTAAATGC TTCTGATTAC AAGCATCTTA TGAAGGACCA CAGCCCTGCA 
TACTGGATTG TTGGAAACTG GAGTAAATGC TCCACTACCT GTGGGCTGGG GGCCTACTGG 
AGGAGTGTGG AGTGCAGCTC TGGGGTGGAC GCTGACTGCA CAACCATTCA GAGGCCAGAC 
CCTGCTAAGA AGTGCCACCT CCGCCCCTGT GCTGGCTGGC GAGTGGGAAA CTGGAGCAAG 
TGCTCCCGAA ATTGCAGTGG AGGCTTCAAG ATTCGTGAGG TTCAGTGCAT GGACAGCCTG 
GACCACCACC GGAGCCTGAG GCCGTTTCAC TGTCAATTCC TAGCTGGCGC TCCTCCTCCA 
CTGAGTATGA GCTGTAACCT GGAGCCTTGT GGAGAATGGC AAGTGGAGCC CTGGAGCCAG 
TGTTCTAGGT CCTGTGGAGG AGGTGTTCAG GAGAGAGGAG TGTCTTGTCC TGGAGGCCTC 
TGTGACTGGA CAAAAAGGCC TGCAACCACT GTGCCCTGCA ACAGACACCT TTGCTGTCAC 
TGGGCCACTG GGAACTGGGA GCTGTGTAAC ACTTCCTGTG GTGGTGGCTC TCAGAAAAGA 
ACCATTCATT GCATCCCCTC AGAAAACAGT ACAACTGAAG ATCAAGACCA GTGCCTCTGT 
GACCATCAAG TCAAACCCCC AGAATTCCAA ACATGCAACC AGCAAGCCTG CAGGAAGAGT 
GCTGATTTAA CTTGCTTGAA GGACAGACTT TCAATCAGCT TCTGCCAGAC ACTGAAATCC 
ATGAGGAAGT GCTCTGTGCC ATCAGTGCGA GCCCAGTGCT GTCTCTCGTG TCCACAGGCG 
CCCAGCATCC ACACCCAGAG GCAAAGAAAA CAGCAGTTGC TCCAAAATCA TGACATGCTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_780710.2
CDS	259..5061
Translation	MPCARGSWLAKLSIVAQLINFGAFCHGRQTQPWPVRFPDPRQEHFIKSLPEYHIVSPVQVDAGGHVLSYGLHHPVTSSRKKRAAGGSGDQLYYRISHEEKDLFFNLTVNWEFLSNGYVVEKRYGNLSHVKMVASSGQPCHLRGTVLQQGTTVGIGTAALSACQGLTGFFHLPHGDFFIEPVKKHPLTEEGSYPHVVYRRQSIRAPETKEPICGLKDSLDNSVKQELQREKWERKTLRSRSLSRRSISKERWVETLVVADTKTVEYHGSENVESYILTIMNMVTGLFHSPSIGNLVHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLITRKDICAGVNRPCETLGLSQLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSQQIQYDPTPLTWSKCSKEYITRFLDRGRGFCLDDIPSKKGLKSNVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKGFCRSKLDAAADGTRCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGAQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSDTPTFRQMQCSEFDTVPYKNQFYRWFPVFNAAHPCELYCRPIDEQFSERMLEAVIDGTPCFEGGNSRNVCINGICKRVGCDYEIDSNATEDRCGVCLGDGSACQTVKKLFRQKEGSGYVDIGLIPKGARDIRVMEIKAAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLIAPGPTNESVWLQLLFQVTNPGIKYEYTVRKDGLDNDVEKLLYFWQFGRWTECSVTCGTGIRRQAAHCVKKGHGIVKTTFCNPETQPSVRQKKCHEKDCPPRWWAGEWEACSTTCGPYGEKKRTVLCIQTMGSDEQALPATDCQHLLKPKALVSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNLNEPCDKTRKPNSRALCGLQQCPFSRRVLKPNKDIAPSGKNQSTAEHDPFKPIPAPTSRPTPLSTPTVPESMSTSTPTINSLGSTIASQEDANGMGWQNNSTQAEEGSHFPTSSGSTSQVPVTSWSLSIQPDDENVSSSAIGPTSEGDFWATTTSDSGLSSSDAMTWQVTPFYSTMTTDPEVEIHSGSGEDSDQPLNKDKSNSVIWNKIGVPEHDAPMETDAELPLGPPPTSYMGEEPSWPPFSTKMEGSLPAWSFKNETPRDDGMIAEKSRKIPLPLAGDHHPATSEKLENHDKLALPNTTNPTQGFGPVLTEEDASNLIAEGFLLNASDYKHLMKDHSPAYWIVGNWSKCSTTCGLGAYWRSVECSSGVDADCTTIQRPDPAKKCHLRPCAGWRVGNWSKCSRNCSGGFKIREVQCMDSLDHHRSLRPFHCQFLAGAPPPLSMSCNLEPCGEWQVEPWSQCSRSCGGGVQERGVSCPGGLCDWTKRPATTVPCNRHLCCHWATGNWELCNTSCGGGSQKRTIHCIPSENSTTEDQDQCLCDHQVKPPEFQTCNQQACRKSADLTCLKDRLSISFCQTLKSMRKCSVPSVRAQCCLSCPQAPSIHTQRQRKQQLLQNHDML

Target ORF information:

RefSeq Version	NM_175501.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 (Adamts12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175501.3

ORF Insert Sequence:

ATGCCATGTG CTCGGGGGAG CTGGCTGGCC AAGCTCTCGA TCGTGGCTCA GCTTATTAAT 
TTTGGGGCTT TTTGCCACGG GAGACAAACT CAGCCCTGGC CGGTTCGCTT CCCAGACCCG 
AGGCAAGAAC ATTTTATCAA GTCCCTGCCA GAATACCACA TAGTGAGTCC AGTCCAAGTC 
GATGCTGGTG GCCATGTTCT GTCCTATGGC CTGCATCACC CTGTCACTAG CAGCAGGAAG 
AAGAGAGCTG CAGGTGGTTC TGGGGACCAG CTGTACTACA GAATTTCGCA TGAAGAAAAA 
GACCTGTTTT TCAATCTGAC GGTCAACTGG GAATTTCTTT CCAACGGCTA TGTCGTGGAG 
AAGAGATATG GGAACCTTTC CCATGTTAAG ATGGTGGCTT CCTCAGGCCA GCCCTGCCAT 
CTCAGGGGCA CAGTTCTGCA GCAGGGCACC ACAGTCGGGA TCGGGACAGC AGCTCTCAGT 
GCCTGCCAAG GACTGACTGG ATTTTTCCAT CTACCACATG GAGACTTTTT CATCGAGCCT 
GTTAAAAAGC ATCCACTGAC CGAGGAAGGG TCCTACCCTC ATGTCGTATA CAGGAGACAG 
AGCATCAGAG CTCCAGAGAC AAAGGAGCCC ATCTGTGGAT TAAAGGACAG TCTTGATAAC 
TCTGTGAAAC AAGAGCTACA GCGGGAGAAG TGGGAGAGGA AAACCTTGCG GAGCAGAAGC 
CTCTCCCGAC GTTCCATAAG CAAGGAGAGA TGGGTGGAGA CCCTCGTGGT GGCCGACACG 
AAGACGGTAG AGTACCATGG AAGCGAGAAC GTGGAGTCGT ACATCCTCAC CATCATGAAT 
ATGGTCACTG GGTTGTTTCA TAGCCCAAGC ATTGGCAATC TAGTCCACAT TGTTGTGGTT 
CGGCTCATTC TACTTGAAGA AGAGGAGCAA GGATTGAAAA TAGTTCATCA TGCAGAGAAG 
ACACTGTCCA GTTTCTGCAA GTGGCAGAAG AGCATCAATC CCAAGAGTGA CCTCAACCCT 
GTCCATCATG ATGTGGCTGT CCTTATCACC AGAAAGGACA TCTGTGCTGG TGTCAATCGC 
CCTTGTGAGA CTCTGGGGCT GTCCCAATTG TCAGGAATGT GCCAGCCTCA CAGGAGCTGT 
AACATCAATG AAGACTCTGG CCTCCCCCTG GCTTTCACCA TTGCACATGA ACTTGGTCAC 
AGCTTCGGCA TCCAGCATGA TGGAAAGGAA AATGACTGTG AGCCCGTGGG CAGGCACCCA 
TACATCATGT CCCAACAGAT TCAGTACGAC CCAACTCCAC TAACATGGTC GAAATGCAGC 
AAGGAGTACA TCACTCGCTT CTTGGACCGA GGCAGGGGGT TCTGTCTTGA TGATATCCCC 
AGCAAGAAAG GCTTGAAGTC CAACGTCATT GCTCCTGGAG TAATTTACGA TGTTCATCAC 
CAGTGCCAGC TCCAATATGG CCCAAATGCT ACATTCTGCC AGGAAGTGGA AAATGTTTGC 
CAGACACTGT GGTGCTCGGT GAAAGGCTTC TGTCGCTCTA AGCTAGATGC TGCTGCAGAC 
GGGACTCGTT GCGGTGAGAA GAAGTGGTGT ATGGCTGGAA AGTGTATCAC AGTGGGGAAG 
AAACCAGAGA GCATCCCTGG AGGCTGGGGA CGCTGGTCAC CCTGGTCACA CTGTTCTAGA 
ACATGTGGGG CAGGAGCTCA GAGCGCAGAG AGGCTCTGCA ACAACCCAGA ACCAAAATTT 
GGAGGGAAAT ACTGCACCGG AGAAAGAAAA CGCTATCGCT TATGCAATGT CCACCCCTGC 
CGCTCAGACA CTCCAACTTT CCGGCAGATG CAGTGCAGTG AATTTGACAC AGTCCCCTAC 
AAAAACCAAT TCTACCGCTG GTTCCCAGTG TTTAATGCAG CACATCCTTG TGAGCTGTAC 
TGCAGACCCA TAGATGAACA GTTTTCTGAG AGAATGCTGG AAGCTGTCAT TGATGGCACC 
CCATGCTTCG AAGGTGGCAA CAGCAGAAAT GTCTGTATTA ATGGCATATG TAAGAGGGTT 
GGCTGTGACT ATGAGATTGA TTCCAATGCT ACAGAGGATC GCTGTGGTGT GTGCCTTGGA 
GATGGCTCTG CCTGCCAGAC GGTGAAGAAG CTGTTTAGAC AGAAGGAAGG ATCTGGTTAC 
GTTGACATTG GACTTATTCC CAAAGGTGCG AGGGATATAA GGGTGATGGA AATCAAGGCA 
GCTGGCAATT TCCTGGCCAT TAGGAGTGAA GATCCGGAAA AATACTACCT CAACGGAGGG 
TTCATTATCC AGTGGAATGG AAACTATAAA CTGGCAGGGA CCGTTTTCCA GTATGACAGG 
AAAGGAGATC TGGAGAAACT TATAGCTCCA GGCCCCACCA ACGAGTCAGT GTGGCTCCAG 
CTACTTTTCC AGGTGACTAA CCCTGGTATC AAGTATGAGT ACACAGTCCG GAAAGATGGC 
CTTGACAATG ACGTGGAGAA GTTGCTGTAC TTCTGGCAAT TTGGCCGCTG GACAGAATGC 
AGTGTAACGT GTGGAACAGG TATCCGCCGG CAGGCTGCTC ATTGTGTCAA GAAGGGCCAC 
GGTATAGTGA AAACGACCTT CTGTAACCCA GAAACACAGC CCAGCGTGAG ACAGAAGAAG 
TGCCATGAAA AGGACTGTCC ACCCAGGTGG TGGGCAGGGG AGTGGGAAGC GTGTTCAACG 
ACATGTGGGC CCTACGGAGA AAAAAAGAGA ACGGTGCTGT GCATCCAGAC CATGGGCTCG 
GATGAACAGG CTCTCCCTGC TACAGACTGC CAGCACCTGC TGAAGCCCAA AGCACTGGTT 
TCCTGCAACA GAGATATTCT GTGTCCATCA GACTGGACAG TAGGCAACTG GAGTGAGTGC 
TCTGTTTCCT GTGGTGGTGG AGTGCGGATT CGCAGTGTCA CATGTGCCAA GAACCTTAAT 
GAGCCTTGTG ACAAGACCCG GAAACCCAAC AGTCGAGCTC TGTGCGGCCT CCAGCAGTGC 
CCATTTAGCC GTAGAGTTCT GAAACCCAAT AAAGATATAG CTCCCAGTGG GAAAAATCAA 
TCGACAGCAG AACATGACCC CTTCAAGCCC ATCCCAGCAC CAACATCCAG GCCCACGCCA 
CTGTCCACAC CCACAGTGCC TGAGTCTATG AGCACAAGTA CTCCCACAAT CAACAGCCTT 
GGCTCCACCA TAGCATCCCA AGAAGACGCA AATGGGATGG GATGGCAGAA TAATTCAACC 
CAAGCTGAAG AGGGCTCCCA CTTCCCTACT TCTTCTGGAA GCACTTCCCA GGTCCCCGTG 
ACTTCCTGGT CTTTGAGTAT CCAACCTGAT GATGAGAATG TTTCCAGCTC AGCTATAGGT 
CCTACTTCAG AGGGTGACTT TTGGGCAACC ACAACAAGTG ATTCTGGCTT ATCATCTAGC 
GATGCTATGA CTTGGCAGGT AACTCCATTT TATAGCACCA TGACCACAGA TCCAGAAGTG 
GAGATACATA GTGGTTCAGG GGAAGACAGT GACCAGCCTT TGAACAAGGA CAAAAGCAAC 
TCTGTGATAT GGAATAAGAT CGGGGTACCT GAACATGATG CTCCCATGGA GACGGATGCA 
GAACTACCAC TTGGACCTCC ACCAACATCT TATATGGGGG AAGAGCCCTC ATGGCCTCCC 
TTCAGTACAA AAATGGAAGG CTCATTACCT GCCTGGTCCT TCAAAAATGA GACACCCAGG 
GATGATGGGA TGATCGCTGA AAAATCAAGG AAGATTCCAC TCCCTCTTGC AGGAGACCAC 
CATCCAGCAA CCTCAGAGAA GTTAGAAAAC CATGACAAAT TGGCATTGCC AAATACTACA 
AATCCAACCC AAGGCTTTGG GCCTGTCCTG ACTGAAGAAG ATGCCTCCAA TCTGATTGCC 
GAGGGGTTTT TGCTAAATGC TTCTGATTAC AAGCATCTTA TGAAGGACCA CAGCCCTGCA 
TACTGGATTG TTGGAAACTG GAGTAAATGC TCCACTACCT GTGGGCTGGG GGCCTACTGG 
AGGAGTGTGG AGTGCAGCTC TGGGGTGGAC GCTGACTGCA CAACCATTCA GAGGCCAGAC 
CCTGCTAAGA AGTGCCACCT CCGCCCCTGT GCTGGCTGGC GAGTGGGAAA CTGGAGCAAG 
TGCTCCCGAA ATTGCAGTGG AGGCTTCAAG ATTCGTGAGG TTCAGTGCAT GGACAGCCTG 
GACCACCACC GGAGCCTGAG GCCGTTTCAC TGTCAATTCC TAGCTGGCGC TCCTCCTCCA 
CTGAGTATGA GCTGTAACCT GGAGCCTTGT GGAGAATGGC AAGTGGAGCC CTGGAGCCAG 
TGTTCTAGGT CCTGTGGAGG AGGTGTTCAG GAGAGAGGAG TGTCTTGTCC TGGAGGCCTC 
TGTGACTGGA CAAAAAGGCC TGCAACCACT GTGCCCTGCA ACAGACACCT TTGCTGTCAC 
TGGGCCACTG GGAACTGGGA GCTGTGTAAC ACTTCCTGTG GTGGTGGCTC TCAGAAAAGA 
ACCATTCATT GCATCCCCTC AGAAAACAGT ACAACTGAAG ATCAAGACCA GTGCCTCTGT 
GACCATCAAG TCAAACCCCC AGAATTCCAA ACATGCAACC AGCAAGCCTG CAGGAAGAGT 
GCTGATTTAA CTTGCTTGAA GGACAGACTT TCAATCAGCT TCTGCCAGAC ACTGAAATCC 
ATGAGGAAGT GCTCTGTGCC ATCAGTGCGA GCCCAGTGCT GTCTCTCGTG TCCACAGGCG 
CCCAGCATCC ACACCCAGAG GCAAAGAAAA CAGCAGTTGC TCCAAAATCA TGACATGCTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.
Matrix biology : journal of the International Society for Matrix Biology44-4624-37(2015 May-Jul)
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ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
Mediators of inflammation2014649718(2014)
Wei J,Richbourgh B,Jia T,Liu C

ADAMTS-12 metalloprotease is necessary for normal inflammatory response.
The Journal of biological chemistry287(47)39554-63(2012 Nov)
Moncada-Pazos A,Obaya AJ,Llamazares M,Heljasvaara R,Su?rez MF,Colado E,No?l A,Cal S,L?pez-Ot?n C

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Adamts12 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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