Rxfp3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rxfp3
Entrez Gene ID	239336
Full Name	relaxin family peptide receptor 3
Synonyms	BC053073,GPCR135,Rln3r1,Salpr
General protein information	Preferred Names relaxin family peptide receptor 3 Names relaxin-3 receptor 1 G-protein coupled receptor SALPR RLN3 receptor 1 g protein-coupled receptor SALPR homolog relaxin-3/INSL7 receptor 1 somatostatin and angiotensin-like peptide receptor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 A1

mRNA and Protein(s)

mRNA	Protein	Name
NM_178717.3	NP_848832.1	relaxin-3 receptor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	RXFP3	NP_057652.1
Danio rerio (zebrafish)	rxfp3	NP_001122260.1
Mus musculus (house mouse)	Rxfp3	NP_848832.1
Gallus gallus (chicken)	RXFP3	XP_004937231.1
Pan troglodytes (chimpanzee)	RXFP3	XP_526961.2
Xenopus tropicalis (tropical clawed frog)	rxfp3	XP_002941625.1
	RXFP3	XP_001087833.1
Canis lupus familiaris (dog)	RXFP3	XP_005619474.1
Bos taurus (cattle)	RXFP3	XP_005221682.1
Rattus norvegicus (Norway rat)	Rxfp3	NP_001008311.1

Gene Ontology
Bibliography

Related articles in PubMed

Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in "floxed-RXFP3" mice impairs spatial memory.
Haidar M, Gu?vremont G, Zhang C, Bathgate RAD, Timofeeva E, Smith CM, Gundlach AL
Hippocampus27(5)529-546(2017 05)

Relaxin-3 receptor (Rxfp3) gene deletion reduces operant sucrose- but not alcohol-responding in mice.
Walker AW, Smith CM, Gundlach AL, Lawrence AJ
Genes, brain, and behavior14(8)625-34(2015 Nov)

Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: implications for role of relaxin-3/RXFP3 signalling in sustained arousal.
Hosken IT, Sutton SW, Smith CM, Gundlach AL
Behavioural brain research278167-75(2015 Feb)

Relaxin-3 receptor (RXFP3) signalling mediates stress-related alcohol preference in mice.
Walker AW, Smith CM, Chua BE, Krstew EV, Zhang C, Gundlach AL, Lawrence AJ
PloS one10(4)e0122504(2015)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate endogenous RLN3/RXFP3 signaling can modulate hippocampal-dependent spatial reference and working memory via effects on somatostatin interneurons, and further our knowledge of hippocampal cognitive processing
Title: Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in "floxed-RXFP3" mice impairs spatial memory.

we investigated the effect of Rxfp3 gene deletion in C57BL/6J mice on sucrose and alcohol self-administration and cue-induced reinstatement (RNST) of sucrose- and alcohol-seeking.
Title: Relaxin-3 receptor (Rxfp3) gene deletion reduces operant sucrose- but not alcohol-responding in mice.

This study demonstrated that Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: implications for role of relaxin-3/RXFP3 signalling in sustained arousal.
Title: Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: implications for role of relaxin-3/RXFP3 signalling in sustained arousal.

Rxfp3 KO mice displayed a stress-induced reduction in alcohol preference that was not observed in WT littermates.
Title: Relaxin-3 receptor (RXFP3) signalling mediates stress-related alcohol preference in mice.

Central injection of the RXFP3 agonists R3/I5 or H3 relaxin (0.5 nmol, icv) did not alter chow consumption in satiated mice relative to vehicle controls, during the 60 min after treatment.
Title: Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice.

The following Rxfp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rxfp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19532	NM_178717.3 Latest version!	Mus musculus relaxin family peptide receptor 3 (Rxfp3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rxfp3 ( NM_178717.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_848832.1 Mus musculus relaxin family peptide receptor 3 (Rxfp3), mRNA.

Price & Availability↑

CloneID	OMu19532
Clone ID Related Accession (Same CDS sequence)	NM_178717.3
Accession Version	NM_178717.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1419bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Mus musculus(house mouse)
Product	relaxin-3 receptor 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK084001.1. On Apr 6, 2007 this sequence version replaced NM_178717.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK084001.1 [ECO:0000345] ##Evidence-Data-END##

ATGCAGGTGG CTTCTGCAAC CCCCGCGGCC ACCGTGAGGA AAGCAGCTGC GGGTGATGAG 
CTCTCAGAAT TCTTCGCTCT GACCCCAGAC TTGCTGGAAG TGGCCAACGC CAGCGGCAAT 
GCGTCGCTGC AGCTTCAGGA TCTGTGGTGG GAGCTGGGGC TAGAGTTGCC AGACGGTGCG 
GCGCCTGGGC ATCCTCCGGG TGGCGGCGGG GCAGAGAGCA CAGACACTGA GGCCAGGGTA 
CGGATCCTCA TCAGCGCGGT TTACTGGGTG GTTTGTGCCC TGGGACTGGC CGGCAACCTG 
CTGGTTCTCT ACCTGATGAA GAGCAAGCAA GGCTGGCGCA AATCCTCCAT CAACCTCTTT 
GTCACTAACC TGGCACTGAC TGACTTTCAG TTCGTGCTCA CTCTGCCCTT TTGGGCTGTG 
GAGAACGCAC TAGACTTCAA GTGGCCCTTC GGCAAGGCCA TGTGTAAGAT CGTGTCCATG 
GTGACATCCA TGAACATGTA CGCCAGCGTC TTCTTCCTCA CTGCTATGAG CGTGGCGCGC 
TACCACTCGG TGGCCTCGGC TCTCAAGAGC CATCGGACCC GAGGGCGTGG CCGTGGCGAC 
TGCTGCGGCC AGAGCTTGAG GGAGAGCTGC TGTTTTTCAG CCAAGGTGCT GTGTGGGTTG 
ATCTGGGCTT CGGCTGCGCT GGCCTCGCTG CCCAATGCCA TTTTTTCCAC CACCATCAGG 
GTGTTGGGTG AGGAGCTCTG CCTCATGCAC TTTCCAGACA AGCTACTGGG CTGGGACAGG 
CAGTTCTGGC TGGGTTTGTA CCACCTGCAG AAGGTGCTGC TGGGCTTCCT GCTGCCGCTG 
AGCATCATCA GTCTGTGTTA CCTGTTGCTT GTGCGCTTCA TCTCCGACCG TCGCGTAGTT 
GGGACAACAG ATGCAGTAGG AGCAGCAGCA GCGCCTGGGG GAGGCCTGAG TACAGCCAGC 
GCTAGGAGAC GCTCCAAGGT CACCAAGTCG GTGACCATCG TCGTCCTCTC CTTCTTCCTG 
TGTTGGCTGC CCAACCAGGC GCTTACCACC TGGAGCATCC TCATCAAGTT CAACGCCGTG 
CCCTTCAGCC AGGAGTACTT TCAGTGCCAA GTGTACGCGT TCCCAGTCAG CGTGTGCCTG 
GCGCACTCCA ACAGCTGCCT CAACCCGATC CTCTACTGCT TAGTGCGCCG CGAGTTCCGC 
AAGGCGCTCA AGAACCTGCT GTGGCGGATA GCCTCGCCTT CGCTCACCAA CATGCGCCCT 
TTCACCGCCA CCACCAAGCC AGAACCTGAA GATCACGGGC TGCAGGCCCT GGCGCCGCTT 
AATGCTGCTG CCGAACCTGA CCTGATCTAC TATCCACCCG GTGTGGTGGT CTACAGCGGG 
GGTCGCTACG ACCTGCTCCC TAGTAGCTCT GCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848832.1
CDS	685..2103
Translation	MQVASATPAATVRKAAAGDELSEFFALTPDLLEVANASGNASLQLQDLWWELGLELPDGAAPGHPPGGGGAESTDTEARVRILISAVYWVVCALGLAGNLLVLYLMKSKQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVARYHSVASALKSHRTRGRGRGDCCGQSLRESCCFSAKVLCGLIWASAALASLPNAIFSTTIRVLGEELCLMHFPDKLLGWDRQFWLGLYHLQKVLLGFLLPLSIISLCYLLLVRFISDRRVVGTTDAVGAAAAPGGGLSTASARRRSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFQCQVYAFPVSVCLAHSNSCLNPILYCLVRREFRKALKNLLWRIASPSLTNMRPFTATTKPEPEDHGLQALAPLNAAAEPDLIYYPPGVVVYSGGRYDLLPSSSAY

Target ORF information:

RefSeq Version	NM_178717.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus relaxin family peptide receptor 3 (Rxfp3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178717.3

ORF Insert Sequence:

ATGCAGGTGG CTTCTGCAAC CCCCGCGGCC ACCGTGAGGA AAGCAGCTGC GGGTGATGAG 
CTCTCAGAAT TCTTCGCTCT GACCCCAGAC TTGCTGGAAG TGGCCAACGC CAGCGGCAAT 
GCGTCGCTGC AGCTTCAGGA TCTGTGGTGG GAGCTGGGGC TAGAGTTGCC AGACGGTGCG 
GCGCCTGGGC ATCCTCCGGG TGGCGGCGGG GCAGAGAGCA CAGACACTGA GGCCAGGGTA 
CGGATCCTCA TCAGCGCGGT TTACTGGGTG GTTTGTGCCC TGGGACTGGC CGGCAACCTG 
CTGGTTCTCT ACCTGATGAA GAGCAAGCAA GGCTGGCGCA AATCCTCCAT CAACCTCTTT 
GTCACTAACC TGGCACTGAC TGACTTTCAG TTCGTGCTCA CTCTGCCCTT TTGGGCTGTG 
GAGAACGCAC TAGACTTCAA GTGGCCCTTC GGCAAGGCCA TGTGTAAGAT CGTGTCCATG 
GTGACATCCA TGAACATGTA CGCCAGCGTC TTCTTCCTCA CTGCTATGAG CGTGGCGCGC 
TACCACTCGG TGGCCTCGGC TCTCAAGAGC CATCGGACCC GAGGGCGTGG CCGTGGCGAC 
TGCTGCGGCC AGAGCTTGAG GGAGAGCTGC TGTTTTTCAG CCAAGGTGCT GTGTGGGTTG 
ATCTGGGCTT CGGCTGCGCT GGCCTCGCTG CCCAATGCCA TTTTTTCCAC CACCATCAGG 
GTGTTGGGTG AGGAGCTCTG CCTCATGCAC TTTCCAGACA AGCTACTGGG CTGGGACAGG 
CAGTTCTGGC TGGGTTTGTA CCACCTGCAG AAGGTGCTGC TGGGCTTCCT GCTGCCGCTG 
AGCATCATCA GTCTGTGTTA CCTGTTGCTT GTGCGCTTCA TCTCCGACCG TCGCGTAGTT 
GGGACAACAG ATGCAGTAGG AGCAGCAGCA GCGCCTGGGG GAGGCCTGAG TACAGCCAGC 
GCTAGGAGAC GCTCCAAGGT CACCAAGTCG GTGACCATCG TCGTCCTCTC CTTCTTCCTG 
TGTTGGCTGC CCAACCAGGC GCTTACCACC TGGAGCATCC TCATCAAGTT CAACGCCGTG 
CCCTTCAGCC AGGAGTACTT TCAGTGCCAA GTGTACGCGT TCCCAGTCAG CGTGTGCCTG 
GCGCACTCCA ACAGCTGCCT CAACCCGATC CTCTACTGCT TAGTGCGCCG CGAGTTCCGC 
AAGGCGCTCA AGAACCTGCT GTGGCGGATA GCCTCGCCTT CGCTCACCAA CATGCGCCCT 
TTCACCGCCA CCACCAAGCC AGAACCTGAA GATCACGGGC TGCAGGCCCT GGCGCCGCTT 
AATGCTGCTG CCGAACCTGA CCTGATCTAC TATCCACCCG GTGTGGTGGT CTACAGCGGG 
GGTCGCTACG ACCTGCTCCC TAGTAGCTCT GCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in "floxed-RXFP3" mice impairs spatial memory.
Hippocampus27(5)529-546(2017 05)
Haidar M,Gu?vremont G,Zhang C,Bathgate RAD,Timofeeva E,Smith CM,Gundlach AL

Relaxin-3 receptor (Rxfp3) gene deletion reduces operant sucrose- but not alcohol-responding in mice.
Genes, brain, and behavior14(8)625-34(2015 Nov)
Walker AW,Smith CM,Gundlach AL,Lawrence AJ

Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: implications for role of relaxin-3/RXFP3 signalling in sustained arousal.
Behavioural brain research278167-75(2015 Feb)
Hosken IT,Sutton SW,Smith CM,Gundlach AL

Relaxin-3 receptor (RXFP3) signalling mediates stress-related alcohol preference in mice.
PloS one10(4)e0122504(2015)
Walker AW,Smith CM,Chua BE,Krstew EV,Zhang C,Gundlach AL,Lawrence AJ

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Rxfp3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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