Impdh2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Impdh2
Entrez Gene ID	23918
Full Name	inosine monophosphate dehydrogenase 2
Synonyms	IMPD
General protein information	Preferred Names inosine monophosphate dehydrogenase 2 Names inosine-5'-monophosphate dehydrogenase 2 IMP dehydrogenase 2 IMP dehydrogenase type II IMPD 2 IMPDH 2 IMPDH-II inosine 5'-phosphate dehydrogenase 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 F2

mRNA and Protein(s)

mRNA	Protein	Name
NM_011830.3	NP_035960.2	inosine-5'-monophosphate dehydrogenase 2
XM_006511730.2	XP_006511793.1	inosine-5'-monophosphate dehydrogenase 2 isoform X1
NM_011830.4	NP_035960.2	inosine-5'-monophosphate dehydrogenase 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	impdh2	NP_958872.1
Xenopus tropicalis (tropical clawed frog)	impdh2	NP_001008066.1
Homo sapiens (human)	IMPDH2	NP_000875.2
Pan troglodytes (chimpanzee)	IMPDH2	XP_516452.3
	IMPDH2	XP_001110652.2
Canis lupus familiaris (dog)	IMPDH2	XP_005632626.1
Bos taurus (cattle)	IMPDH2	NP_001029588.1
Mus musculus (house mouse)	Impdh2	NP_035960.2
Rattus norvegicus (Norway rat)	Impdh2	NP_954530.1
Gallus gallus (chicken)	IMPDH2	NP_001025772.1
Mus musculus (house mouse)	Gm15210	XP_001478203.3

Gene Ontology
Bibliography

Related articles in PubMed

Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton.
Lake JI, Avetisyan M, Zimmermann AG, Heuckeroth RO
Developmental biology409(1)152-65(2016 Jan)

Cell cycle arrest triggered by conjugated eicosapentaenoic acid occurs through several mechanisms including G1 checkpoint activation by induced RPA and ATR expression.
Kumamoto-Yonezawa Y, Sasaki R, Ota Y, Suzuki Y, Fukushima S, Hada T, Uryu K, Sugimura K, Yoshida H, Mizushina Y
Biochimica et biophysica acta1790(5)339-46(2009 May)

Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase.
Mizushina Y, Dairaku I, Yanaka N, Takeuchi T, Ishimaru C, Sugawara F, Yoshida H, Kato N
Biochimie89(5)581-90(2007 May)

Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice.
Gu JJ, Tolin AK, Jain J, Huang H, Santiago L, Mitchell BS
Molecular and cellular biology23(18)6702-12(2003 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IMPDH2 mediated guanine nucleotide synthesis is essential for normal development of the enteric nervous system and other neural crest derivatives.
Title: Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton.

various carbon atom lengths and double bonds of fatty acids were examined for inhibitory strength; docking simulation of C20-fatty acids and mouse IMPDH type II was performed.
Title: Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase.

The following Impdh2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Impdh2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu43162	XM_006511730.2 Latest version!	Mus musculus inosine monophosphate dehydrogenase 2 (Impdh2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu08944	NM_011830.4 Latest version!	Mus musculus inosine monophosphate dehydrogenase 2 (Impdh2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
View Old Accession Versions >>
OMu08944	NM_011830.3	Mus musculus inosine monophosphate dehydrogenase 2 (Impdh2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Impdh2 ( XM_006511730.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006511793.1 Mus musculus inosine monophosphate dehydrogenase 2 (Impdh2), transcript variant X1, mRNA.

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CloneID	OMu43162
Clone ID Related Accession (Same CDS sequence)	XM_006511730.2
Accession Version	XM_006511730.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	inosine-5'-monophosphate dehydrogenase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006511730.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGACT ACCTGATTAG CGGAGGCACC TCTTACGTGC CGGACGACGG GCTCACAGCG 
CAGCAGCTCT TCAACTGCGG GGACGGCCTC ACCTACAATG ATTTTCTCAT TCTTCCTGGG 
TATATCGACT TCACTGCAGA TCAGGTGGAC TTGACGTCTG CTCTAACTAA GAAGATTACA 
CTAAAGACCC CATTGGTTTC CTCACCCATG GACACTGTCA CAGAGGCTGG AATGGCCATC 
GCGATGGCGC TTACAGGAGG TATTGGTTTC ATCCACCACA ACTGCACACC TGAATTCCAG 
GCCAATGAAG TTCGGAAAGT GAAGAAATAC GAACAGGGAT TCATCACTGA CCCCGTGGTC 
CTTAGCCCCA AGGATCGTGT ACGCGATGTT TTTGAGGCCA AAGCCAGGCA TGGCTTCTGT 
GGTATCCCCA TCACAGATAC AGGCCGGATG GGGAGTCGAT TGGTGGGCAT CATCTCCTCA 
AGGGACATTG ATTTCCTCAA GGAGGAAGAG CATGACCGGT TCTTGGAAGA GATCATGACT 
AAGAGGGAAG ATTTGGTGGT CGCCCCTGCC GGCGTCACTC TGAAAGAGGC AAATGAGATT 
CTGCAGCGAA GTAAAAAGGG AAAGTTGCCC ATTGTGAATG AAAATGATGA GCTGGTAGCC 
ATCATTGCCC GGACAGACCT AAAGAAGAAT CGTGATTACC CCCTGGCCTC CAAAGATGCC 
AAGAAGCAAC TGCTGTGTGG GGCAGCCATT GGCACTCATG AGGATGACAA GTATAGGCTG 
GACTTACTGG CCCTTGCTGG TGTGGATGTA GTGGTTTTGG ACTCTTCCCA GGGAAACTCC 
ATCTTCCAAA TCAATATGAT CAAATACATC AAGGAGAAGT ATCCCAGTCT ACAGGTCATT 
GGAGGCAATG TAGTCACTGC TGCGCAAGCC AAGAACCTCA TAGATGCAGG TGTAGATGCT 
TTGCGAGTCG GCATGGGAAG TGGTTCCATC TGCATCACCC AGGAAGCGGC TCCCAAGATC 
CCACCAGACA TAAAGTCCCA CAGCCCCAAA TGCCCTTCTA CTGTCTCGGG CTGCTATATG 
TTGGCCTGTG GGCGGCCCCA AGCCACAGCA GTGTACAAGG TCTCTGAGTA TGCCCGTCGC 
TTTGGTGTTC CTGTTATTGC TGATGGAGGA ATCCAAAATG TGGGTCATAT TGCCAAAGCT 
TTGGCTCTTG GGGCTTCCAC AGTCATGATG GGCTCCCTCC TGGCTGCCAC CACTGAGGCC 
CCTGGCGAGT ACTTCTTCTC AGATGGGATC CGGCTGAAGA AATACCGAGG TATGGGTTCT 
CTTGATGCCA TGGACAAACA TCTCAGCAGC CAGAACCGAT ACTTCAGTGA AGCTGACAAA 
ATCAAAGTGG CCCAAGGAGT TTCAGGGGCA GTGCAGGACA AGGGGTCTAT CCACAAGTTC 
GTTCCTTACC TGATTGCTGG CATCCAGCAT TCCTGTCAGG ACATTGGTGC CAAGAGTTTA 
ACCCAAGTCA GAGCCATGAT GTACTCGGGG GAGCTTAAAT TTGAGAAGAG GACATCCTCT 
GCTCAGGTGG AAGGTGGCGT CCACAGCCTC CATTCGTACG AGAAACGGCT TTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006511793.1
CDS	244..1860
Translation	MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEAAPKIPPDIKSHSPKCPSTVSGCYMLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF

Target ORF information:

RefSeq Version	XM_006511730.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus inosine monophosphate dehydrogenase 2 (Impdh2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006511730.2

ORF Insert Sequence:

ATGGCGGACT ACCTGATTAG CGGAGGCACC TCTTACGTGC CGGACGACGG GCTCACAGCG 
CAGCAGCTCT TCAACTGCGG GGACGGCCTC ACCTACAATG ATTTTCTCAT TCTTCCTGGG 
TATATCGACT TCACTGCAGA TCAGGTGGAC TTGACGTCTG CTCTAACTAA GAAGATTACA 
CTAAAGACCC CATTGGTTTC CTCACCCATG GACACTGTCA CAGAGGCTGG AATGGCCATC 
GCGATGGCGC TTACAGGAGG TATTGGTTTC ATCCACCACA ACTGCACACC TGAATTCCAG 
GCCAATGAAG TTCGGAAAGT GAAGAAATAC GAACAGGGAT TCATCACTGA CCCCGTGGTC 
CTTAGCCCCA AGGATCGTGT ACGCGATGTT TTTGAGGCCA AAGCCAGGCA TGGCTTCTGT 
GGTATCCCCA TCACAGATAC AGGCCGGATG GGGAGTCGAT TGGTGGGCAT CATCTCCTCA 
AGGGACATTG ATTTCCTCAA GGAGGAAGAG CATGACCGGT TCTTGGAAGA GATCATGACT 
AAGAGGGAAG ATTTGGTGGT CGCCCCTGCC GGCGTCACTC TGAAAGAGGC AAATGAGATT 
CTGCAGCGAA GTAAAAAGGG AAAGTTGCCC ATTGTGAATG AAAATGATGA GCTGGTAGCC 
ATCATTGCCC GGACAGACCT AAAGAAGAAT CGTGATTACC CCCTGGCCTC CAAAGATGCC 
AAGAAGCAAC TGCTGTGTGG GGCAGCCATT GGCACTCATG AGGATGACAA GTATAGGCTG 
GACTTACTGG CCCTTGCTGG TGTGGATGTA GTGGTTTTGG ACTCTTCCCA GGGAAACTCC 
ATCTTCCAAA TCAATATGAT CAAATACATC AAGGAGAAGT ATCCCAGTCT ACAGGTCATT 
GGAGGCAATG TAGTCACTGC TGCGCAAGCC AAGAACCTCA TAGATGCAGG TGTAGATGCT 
TTGCGAGTCG GCATGGGAAG TGGTTCCATC TGCATCACCC AGGAAGCGGC TCCCAAGATC 
CCACCAGACA TAAAGTCCCA CAGCCCCAAA TGCCCTTCTA CTGTCTCGGG CTGCTATATG 
TTGGCCTGTG GGCGGCCCCA AGCCACAGCA GTGTACAAGG TCTCTGAGTA TGCCCGTCGC 
TTTGGTGTTC CTGTTATTGC TGATGGAGGA ATCCAAAATG TGGGTCATAT TGCCAAAGCT 
TTGGCTCTTG GGGCTTCCAC AGTCATGATG GGCTCCCTCC TGGCTGCCAC CACTGAGGCC 
CCTGGCGAGT ACTTCTTCTC AGATGGGATC CGGCTGAAGA AATACCGAGG TATGGGTTCT 
CTTGATGCCA TGGACAAACA TCTCAGCAGC CAGAACCGAT ACTTCAGTGA AGCTGACAAA 
ATCAAAGTGG CCCAAGGAGT TTCAGGGGCA GTGCAGGACA AGGGGTCTAT CCACAAGTTC 
GTTCCTTACC TGATTGCTGG CATCCAGCAT TCCTGTCAGG ACATTGGTGC CAAGAGTTTA 
ACCCAAGTCA GAGCCATGAT GTACTCGGGG GAGCTTAAAT TTGAGAAGAG GACATCCTCT 
GCTCAGGTGG AAGGTGGCGT CCACAGCCTC CATTCGTACG AGAAACGGCT TTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Impdh2 ( NM_011830.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035960.2 Mus musculus inosine monophosphate dehydrogenase 2 (Impdh2), mRNA.

Price & Availability↑

CloneID	OMu08944
Clone ID Related Accession (Same CDS sequence)	NM_011830.3 , NM_011830.4
Accession Version	NM_011830.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1545bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Mus musculus(house mouse)
Product	inosine-5'-monophosphate dehydrogenase 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CT010508.10. On Nov 17, 2006 this sequence version replaced NM_011830.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC010314.1, BC052671.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGACT ACCTGATTAG CGGAGGCACC TCTTACGTGC CGGACGACGG GCTCACAGCG 
CAGCAGCTCT TCAACTGCGG GGACGGCCTC ACCTACAATG ATTTTCTCAT TCTTCCTGGG 
TATATCGACT TCACTGCAGA TCAGGTGGAC TTGACGTCTG CTCTAACTAA GAAGATTACA 
CTAAAGACCC CATTGGTTTC CTCACCCATG GACACTGTCA CAGAGGCTGG AATGGCCATC 
GCGATGGCGC TTACAGGAGG TATTGGTTTC ATCCACCACA ACTGCACACC TGAATTCCAG 
GCCAATGAAG TTCGGAAAGT GAAGAAATAC GAACAGGGAT TCATCACTGA CCCCGTGGTC 
CTTAGCCCCA AGGATCGTGT ACGCGATGTT TTTGAGGCCA AAGCCAGGCA TGGCTTCTGT 
GGTATCCCCA TCACAGATAC AGGCCGGATG GGGAGTCGAT TGGTGGGCAT CATCTCCTCA 
AGGGACATTG ATTTCCTCAA GGAGGAAGAG CATGACCGGT TCTTGGAAGA GATCATGACT 
AAGAGGGAAG ATTTGGTGGT CGCCCCTGCC GGCGTCACTC TGAAAGAGGC AAATGAGATT 
CTGCAGCGAA GTAAAAAGGG AAAGTTGCCC ATTGTGAATG AAAATGATGA GCTGGTAGCC 
ATCATTGCCC GGACAGACCT AAAGAAGAAT CGTGATTACC CCCTGGCCTC CAAAGATGCC 
AAGAAGCAAC TGCTGTGTGG GGCAGCCATT GGCACTCATG AGGATGACAA GTATAGGCTG 
GACTTACTGG CCCTTGCTGG TGTGGATGTA GTGGTTTTGG ACTCTTCCCA GGGAAACTCC 
ATCTTCCAAA TCAATATGAT CAAATACATC AAGGAGAAGT ATCCCAGTCT ACAGGTCATT 
GGAGGCAATG TAGTCACTGC TGCGCAAGCC AAGAACCTCA TAGATGCAGG TGTAGATGCT 
TTGCGAGTCG GCATGGGAAG TGGTTCCATC TGCATCACCC AGGAAGTGTT GGCCTGTGGG 
CGGCCCCAAG CCACAGCAGT GTACAAGGTC TCTGAGTATG CCCGTCGCTT TGGTGTTCCT 
GTTATTGCTG ATGGAGGAAT CCAAAATGTG GGTCATATTG CCAAAGCTTT GGCTCTTGGG 
GCTTCCACAG TCATGATGGG CTCCCTCCTG GCTGCCACCA CTGAGGCCCC TGGCGAGTAC 
TTCTTCTCAG ATGGGATCCG GCTGAAGAAA TACCGAGGTA TGGGTTCTCT TGATGCCATG 
GACAAACATC TCAGCAGCCA GAACCGATAC TTCAGTGAAG CTGACAAAAT CAAAGTGGCC 
CAAGGAGTTT CAGGGGCAGT GCAGGACAAG GGGTCTATCC ACAAGTTCGT TCCTTACCTG 
ATTGCTGGCA TCCAGCATTC CTGTCAGGAC ATTGGTGCCA AGAGTTTAAC CCAAGTCAGA 
GCCATGATGT ACTCGGGGGA GCTTAAATTT GAGAAGAGGA CATCCTCTGC TCAGGTGGAA 
GGTGGCGTCC ACAGCCTCCA TTCGTACGAG AAACGGCTTT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035960.2
CDS	34..1578
Translation	MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF

Target ORF information:

RefSeq Version	NM_011830.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus inosine monophosphate dehydrogenase 2 (Impdh2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011830.3

ORF Insert Sequence:

ATGGCGGACT ACCTGATTAG CGGAGGCACC TCTTACGTGC CGGACGACGG GCTCACAGCG 
CAGCAGCTCT TCAACTGCGG GGACGGCCTC ACCTACAATG ATTTTCTCAT TCTTCCTGGG 
TATATCGACT TCACTGCAGA TCAGGTGGAC TTGACGTCTG CTCTAACTAA GAAGATTACA 
CTAAAGACCC CATTGGTTTC CTCACCCATG GACACTGTCA CAGAGGCTGG AATGGCCATC 
GCGATGGCGC TTACAGGAGG TATTGGTTTC ATCCACCACA ACTGCACACC TGAATTCCAG 
GCCAATGAAG TTCGGAAAGT GAAGAAATAC GAACAGGGAT TCATCACTGA CCCCGTGGTC 
CTTAGCCCCA AGGATCGTGT ACGCGATGTT TTTGAGGCCA AAGCCAGGCA TGGCTTCTGT 
GGTATCCCCA TCACAGATAC AGGCCGGATG GGGAGTCGAT TGGTGGGCAT CATCTCCTCA 
AGGGACATTG ATTTCCTCAA GGAGGAAGAG CATGACCGGT TCTTGGAAGA GATCATGACT 
AAGAGGGAAG ATTTGGTGGT CGCCCCTGCC GGCGTCACTC TGAAAGAGGC AAATGAGATT 
CTGCAGCGAA GTAAAAAGGG AAAGTTGCCC ATTGTGAATG AAAATGATGA GCTGGTAGCC 
ATCATTGCCC GGACAGACCT AAAGAAGAAT CGTGATTACC CCCTGGCCTC CAAAGATGCC 
AAGAAGCAAC TGCTGTGTGG GGCAGCCATT GGCACTCATG AGGATGACAA GTATAGGCTG 
GACTTACTGG CCCTTGCTGG TGTGGATGTA GTGGTTTTGG ACTCTTCCCA GGGAAACTCC 
ATCTTCCAAA TCAATATGAT CAAATACATC AAGGAGAAGT ATCCCAGTCT ACAGGTCATT 
GGAGGCAATG TAGTCACTGC TGCGCAAGCC AAGAACCTCA TAGATGCAGG TGTAGATGCT 
TTGCGAGTCG GCATGGGAAG TGGTTCCATC TGCATCACCC AGGAAGTGTT GGCCTGTGGG 
CGGCCCCAAG CCACAGCAGT GTACAAGGTC TCTGAGTATG CCCGTCGCTT TGGTGTTCCT 
GTTATTGCTG ATGGAGGAAT CCAAAATGTG GGTCATATTG CCAAAGCTTT GGCTCTTGGG 
GCTTCCACAG TCATGATGGG CTCCCTCCTG GCTGCCACCA CTGAGGCCCC TGGCGAGTAC 
TTCTTCTCAG ATGGGATCCG GCTGAAGAAA TACCGAGGTA TGGGTTCTCT TGATGCCATG 
GACAAACATC TCAGCAGCCA GAACCGATAC TTCAGTGAAG CTGACAAAAT CAAAGTGGCC 
CAAGGAGTTT CAGGGGCAGT GCAGGACAAG GGGTCTATCC ACAAGTTCGT TCCTTACCTG 
ATTGCTGGCA TCCAGCATTC CTGTCAGGAC ATTGGTGCCA AGAGTTTAAC CCAAGTCAGA 
GCCATGATGT ACTCGGGGGA GCTTAAATTT GAGAAGAGGA CATCCTCTGC TCAGGTGGAA 
GGTGGCGTCC ACAGCCTCCA TTCGTACGAG AAACGGCTTT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Impdh2 ( NM_011830.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035960.2 Mus musculus inosine monophosphate dehydrogenase 2 (Impdh2), mRNA.

Price & Availability↑

CloneID	OMu08944
Clone ID Related Accession (Same CDS sequence)	NM_011830.3 , NM_011830.4
Accession Version	NM_011830.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1545bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	inosine-5'-monophosphate dehydrogenase 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CT010508.10. On Jun 19, 2018 this sequence version replaced NM_011830.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK169129.1, AK169788.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACT ACCTGATTAG CGGAGGCACC TCTTACGTGC CGGACGACGG GCTCACAGCG 
CAGCAGCTCT TCAACTGCGG GGACGGCCTC ACCTACAATG ATTTTCTCAT TCTTCCTGGG 
TATATCGACT TCACTGCAGA TCAGGTGGAC TTGACGTCTG CTCTAACTAA GAAGATTACA 
CTAAAGACCC CATTGGTTTC CTCACCCATG GACACTGTCA CAGAGGCTGG AATGGCCATC 
GCGATGGCGC TTACAGGAGG TATTGGTTTC ATCCACCACA ACTGCACACC TGAATTCCAG 
GCCAATGAAG TTCGGAAAGT GAAGAAATAC GAACAGGGAT TCATCACTGA CCCCGTGGTC 
CTTAGCCCCA AGGATCGTGT ACGCGATGTT TTTGAGGCCA AAGCCAGGCA TGGCTTCTGT 
GGTATCCCCA TCACAGATAC AGGCCGGATG GGGAGTCGAT TGGTGGGCAT CATCTCCTCA 
AGGGACATTG ATTTCCTCAA GGAGGAAGAG CATGACCGGT TCTTGGAAGA GATCATGACT 
AAGAGGGAAG ATTTGGTGGT CGCCCCTGCC GGCGTCACTC TGAAAGAGGC AAATGAGATT 
CTGCAGCGAA GTAAAAAGGG AAAGTTGCCC ATTGTGAATG AAAATGATGA GCTGGTAGCC 
ATCATTGCCC GGACAGACCT AAAGAAGAAT CGTGATTACC CCCTGGCCTC CAAAGATGCC 
AAGAAGCAAC TGCTGTGTGG GGCAGCCATT GGCACTCATG AGGATGACAA GTATAGGCTG 
GACTTACTGG CCCTTGCTGG TGTGGATGTA GTGGTTTTGG ACTCTTCCCA GGGAAACTCC 
ATCTTCCAAA TCAATATGAT CAAATACATC AAGGAGAAGT ATCCCAGTCT ACAGGTCATT 
GGAGGCAATG TAGTCACTGC TGCGCAAGCC AAGAACCTCA TAGATGCAGG TGTAGATGCT 
TTGCGAGTCG GCATGGGAAG TGGTTCCATC TGCATCACCC AGGAAGTGTT GGCCTGTGGG 
CGGCCCCAAG CCACAGCAGT GTACAAGGTC TCTGAGTATG CCCGTCGCTT TGGTGTTCCT 
GTTATTGCTG ATGGAGGAAT CCAAAATGTG GGTCATATTG CCAAAGCTTT GGCTCTTGGG 
GCTTCCACAG TCATGATGGG CTCCCTCCTG GCTGCCACCA CTGAGGCCCC TGGCGAGTAC 
TTCTTCTCAG ATGGGATCCG GCTGAAGAAA TACCGAGGTA TGGGTTCTCT TGATGCCATG 
GACAAACATC TCAGCAGCCA GAACCGATAC TTCAGTGAAG CTGACAAAAT CAAAGTGGCC 
CAAGGAGTTT CAGGGGCAGT GCAGGACAAG GGGTCTATCC ACAAGTTCGT TCCTTACCTG 
ATTGCTGGCA TCCAGCATTC CTGTCAGGAC ATTGGTGCCA AGAGTTTAAC CCAAGTCAGA 
GCCATGATGT ACTCGGGGGA GCTTAAATTT GAGAAGAGGA CATCCTCTGC TCAGGTGGAA 
GGTGGCGTCC ACAGCCTCCA TTCGTACGAG AAACGGCTTT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035960.2
CDS	99..1643
Translation	MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF

Target ORF information:

RefSeq Version	NM_011830.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus inosine monophosphate dehydrogenase 2 (Impdh2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011830.4

ORF Insert Sequence:

ATGGCGGACT ACCTGATTAG CGGAGGCACC TCTTACGTGC CGGACGACGG GCTCACAGCG 
CAGCAGCTCT TCAACTGCGG GGACGGCCTC ACCTACAATG ATTTTCTCAT TCTTCCTGGG 
TATATCGACT TCACTGCAGA TCAGGTGGAC TTGACGTCTG CTCTAACTAA GAAGATTACA 
CTAAAGACCC CATTGGTTTC CTCACCCATG GACACTGTCA CAGAGGCTGG AATGGCCATC 
GCGATGGCGC TTACAGGAGG TATTGGTTTC ATCCACCACA ACTGCACACC TGAATTCCAG 
GCCAATGAAG TTCGGAAAGT GAAGAAATAC GAACAGGGAT TCATCACTGA CCCCGTGGTC 
CTTAGCCCCA AGGATCGTGT ACGCGATGTT TTTGAGGCCA AAGCCAGGCA TGGCTTCTGT 
GGTATCCCCA TCACAGATAC AGGCCGGATG GGGAGTCGAT TGGTGGGCAT CATCTCCTCA 
AGGGACATTG ATTTCCTCAA GGAGGAAGAG CATGACCGGT TCTTGGAAGA GATCATGACT 
AAGAGGGAAG ATTTGGTGGT CGCCCCTGCC GGCGTCACTC TGAAAGAGGC AAATGAGATT 
CTGCAGCGAA GTAAAAAGGG AAAGTTGCCC ATTGTGAATG AAAATGATGA GCTGGTAGCC 
ATCATTGCCC GGACAGACCT AAAGAAGAAT CGTGATTACC CCCTGGCCTC CAAAGATGCC 
AAGAAGCAAC TGCTGTGTGG GGCAGCCATT GGCACTCATG AGGATGACAA GTATAGGCTG 
GACTTACTGG CCCTTGCTGG TGTGGATGTA GTGGTTTTGG ACTCTTCCCA GGGAAACTCC 
ATCTTCCAAA TCAATATGAT CAAATACATC AAGGAGAAGT ATCCCAGTCT ACAGGTCATT 
GGAGGCAATG TAGTCACTGC TGCGCAAGCC AAGAACCTCA TAGATGCAGG TGTAGATGCT 
TTGCGAGTCG GCATGGGAAG TGGTTCCATC TGCATCACCC AGGAAGTGTT GGCCTGTGGG 
CGGCCCCAAG CCACAGCAGT GTACAAGGTC TCTGAGTATG CCCGTCGCTT TGGTGTTCCT 
GTTATTGCTG ATGGAGGAAT CCAAAATGTG GGTCATATTG CCAAAGCTTT GGCTCTTGGG 
GCTTCCACAG TCATGATGGG CTCCCTCCTG GCTGCCACCA CTGAGGCCCC TGGCGAGTAC 
TTCTTCTCAG ATGGGATCCG GCTGAAGAAA TACCGAGGTA TGGGTTCTCT TGATGCCATG 
GACAAACATC TCAGCAGCCA GAACCGATAC TTCAGTGAAG CTGACAAAAT CAAAGTGGCC 
CAAGGAGTTT CAGGGGCAGT GCAGGACAAG GGGTCTATCC ACAAGTTCGT TCCTTACCTG 
ATTGCTGGCA TCCAGCATTC CTGTCAGGAC ATTGGTGCCA AGAGTTTAAC CCAAGTCAGA 
GCCATGATGT ACTCGGGGGA GCTTAAATTT GAGAAGAGGA CATCCTCTGC TCAGGTGGAA 
GGTGGCGTCC ACAGCCTCCA TTCGTACGAG AAACGGCTTT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton.
Developmental biology409(1)152-65(2016 Jan)
Lake JI,Avetisyan M,Zimmermann AG,Heuckeroth RO

Cell cycle arrest triggered by conjugated eicosapentaenoic acid occurs through several mechanisms including G1 checkpoint activation by induced RPA and ATR expression.
Biochimica et biophysica acta1790(5)339-46(2009 May)
Kumamoto-Yonezawa Y,Sasaki R,Ota Y,Suzuki Y,Fukushima S,Hada T,Uryu K,Sugimura K,Yoshida H,Mizushina Y

Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase.
Biochimie89(5)581-90(2007 May)
Mizushina Y,Dairaku I,Yanaka N,Takeuchi T,Ishimaru C,Sugawara F,Yoshida H,Kato N

Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice.
Molecular and cellular biology23(18)6702-12(2003 Sep)
Gu JJ,Tolin AK,Jain J,Huang H,Santiago L,Mitchell BS

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Impdh2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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