Leprot cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Leprot
Entrez Gene ID	230514
Full Name	leptin receptor overlapping transcript
Synonyms	LEPR,OB-RGRP,Obrgrp,VPS55
General protein information	Preferred Names leptin receptor overlapping transcript Names leptin receptor gene-related protein OB-R gene-related protein endospanin-1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 C6

mRNA and Protein(s)

mRNA	Protein	Name
XM_030253422.1	XP_030109282.1	leptin receptor gene-related protein isoform X1
NM_175036.4	NP_778201.1	leptin receptor gene-related protein

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	leprot	NP_001017787.1
Xenopus tropicalis (tropical clawed frog)	leprot	NP_001017102.1
Bos taurus (cattle)	LEPROT	NP_001029913.1
Mus musculus (house mouse)	Leprot	NP_778201.1
Homo sapiens (human)	LEPROT	NP_059996.1
Gallus gallus (chicken)	LEPROT	NP_001007959.1
Canis lupus familiaris (dog)	LOC609115	XP_852098.1
Rattus norvegicus (Norway rat)	Leprot	NP_064484.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression.
Wu S, Grunwald T, Kharitonenkov A, Dam J, Jockers R, De Luca F
The Journal of biological chemistry288(38)27375-83(2013 Sep)

LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.
Touvier T, Conte-Auriol F, Briand O, Cudejko C, Paumelle R, Caron S, Baug? E, Rouill? Y, Salles JP, Staels B, Bailleul B
The Journal of clinical investigation119(12)3830-8(2009 Dec)

Isolation of a novel leptin receptor gene promoter preferentially functioning in neuronal cells.
Satoh T, Yoshino S, Katano A, Ishizuka T, Tomaru T, Shibusawa N, Hashimoto K, Yamada M, Mori M
Biochemical and biophysical research communications389(4)673-7(2009 Nov)

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity.
Couturier C, Sarkis C, S?ron K, Belouzard S, Chen P, Lenain A, Corset L, Dam J, Vauthier V, Dubart A, Mallet J, Froguel P, Rouill? Y, Jockers R
Proceedings of the National Academy of Sciences of the United States of America104(49)19476-81(2007 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the increased expression of FGF21 during chronic undernutrition inhibits GH action on chondrocytes by activating LEPROT and LEPROTL1.
Title: Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression.

both LEPROT and LEPROTL1 expression were regulated in liver by physiologic and pathologic changes in glucose homeostasis
Title: LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.

The following Leprot gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Leprot cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04817	NM_175036.4 Latest version!	Mus musculus leptin receptor overlapping transcript (Leprot), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu88493	XM_030253422.1 Latest version!	Mus musculus leptin receptor overlapping transcript (Leprot), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Leprot ( NM_175036.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_778201.1 Mus musculus leptin receptor overlapping transcript (Leprot), mRNA.

Price & Availability↑

CloneID	OMu04817
Clone ID Related Accession (Same CDS sequence)	NM_175036.4
Accession Version	NM_175036.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	leptin receptor gene-related protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX323551.8 and AL929373.15. On May 2, 2007 this sequence version replaced NM_175036.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK009569.1, AK168597.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGGCG TTAAAGCTCT CGTGGCGCTC TCCTTCAGTG GGGCAATTGG GCTGACTTTT 
CTTATGCTGG GATGTGCGTT GGAGGACTAT GGCGTTTACT GGCCCCTGTT CGTCTTGATT 
TTCTACGTCA TCTCCCCCAT CCCCTACTTC ATTGCCAAAA GGGTCACATA TGACTCCGAC 
GCGACCAGCA GTGCCTGTCG GGAACTGGCG TATTTCTTCA CCACTGGGAT TGTTGTTTCT 
GCCTTTGGAC TTCCTGTTGT TCTTGCTCGT GTGGATGTGA TCAAGTGGGG AGCCTGTGGT 
CTTGTGCTGG CCGGCAACGC TGTCATTTTC CTCACAATTC AAGGCTTCTT CCTCGTCTTT 
GGAAGAGGAG ATGATTTCAG TTGGGAACAG TGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_778201.1
CDS	28..423
Translation	MAGVKALVALSFSGAIGLTFLMLGCALEDYGVYWPLFVLIFYVISPIPYFIAKRVTYDSDATSSACRELAYFFTTGIVVSAFGLPVVLARVDVIKWGACGLVLAGNAVIFLTIQGFFLVFGRGDDFSWEQW

Target ORF information:

RefSeq Version	NM_175036.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus leptin receptor overlapping transcript (Leprot), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175036.4

ORF Insert Sequence:

ATGGCGGGCG TTAAAGCTCT CGTGGCGCTC TCCTTCAGTG GGGCAATTGG GCTGACTTTT 
CTTATGCTGG GATGTGCGTT GGAGGACTAT GGCGTTTACT GGCCCCTGTT CGTCTTGATT 
TTCTACGTCA TCTCCCCCAT CCCCTACTTC ATTGCCAAAA GGGTCACATA TGACTCCGAC 
GCGACCAGCA GTGCCTGTCG GGAACTGGCG TATTTCTTCA CCACTGGGAT TGTTGTTTCT 
GCCTTTGGAC TTCCTGTTGT TCTTGCTCGT GTGGATGTGA TCAAGTGGGG AGCCTGTGGT 
CTTGTGCTGG CCGGCAACGC TGTCATTTTC CTCACAATTC AAGGCTTCTT CCTCGTCTTT 
GGAAGAGGAG ATGATTTCAG TTGGGAACAG TGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Leprot ( XM_030253422.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030109282.1 Mus musculus leptin receptor overlapping transcript (Leprot), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu88493
Clone ID Related Accession (Same CDS sequence)	XM_030253422.1
Accession Version	XM_030253422.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	leptin receptor gene-related protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGGGAT GTGCGTTGGA GGACTATGGC GTTTACTGGC CCCTGTTCGT CTTGATTTTC 
TACGTCATCT CCCCCATCCC CTACTTCATT GCCAAAAGGG TCACATATGA CTCCGACGCG 
ACCAGCAGTG CCTGTCGGGA ACTGGCGTAT TTCTTCACCA CTGGGATTGT TGTTTCTGCC 
TTTGGACTTC CTGTTGTTCT TGCTCGTGTG GATGTGATCA AGTGGGGAGC CTGTGGTCTT 
GTGCTGGCCG GCAACGCTGT CATTTTCCTC ACAATTCAAG GCTTCTTCCT CGTCTTTGGA 
AGAGGAGATG ATTTCAGTTG GGAACAGTGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030109282.1
CDS	169..501
Translation	MLGCALEDYGVYWPLFVLIFYVISPIPYFIAKRVTYDSDATSSACRELAYFFTTGIVVSAFGLPVVLARVDVIKWGACGLVLAGNAVIFLTIQGFFLVFGRGDDFSWEQW

Target ORF information:

RefSeq Version	XM_030253422.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus leptin receptor overlapping transcript (Leprot), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030253422.1

ORF Insert Sequence:

ATGCTGGGAT GTGCGTTGGA GGACTATGGC GTTTACTGGC CCCTGTTCGT CTTGATTTTC 
TACGTCATCT CCCCCATCCC CTACTTCATT GCCAAAAGGG TCACATATGA CTCCGACGCG 
ACCAGCAGTG CCTGTCGGGA ACTGGCGTAT TTCTTCACCA CTGGGATTGT TGTTTCTGCC 
TTTGGACTTC CTGTTGTTCT TGCTCGTGTG GATGTGATCA AGTGGGGAGC CTGTGGTCTT 
GTGCTGGCCG GCAACGCTGT CATTTTCCTC ACAATTCAAG GCTTCTTCCT CGTCTTTGGA 
AGAGGAGATG ATTTCAGTTG GGAACAGTGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression.
The Journal of biological chemistry288(38)27375-83(2013 Sep)
Wu S,Grunwald T,Kharitonenkov A,Dam J,Jockers R,De Luca F

LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.
The Journal of clinical investigation119(12)3830-8(2009 Dec)
Touvier T,Conte-Auriol F,Briand O,Cudejko C,Paumelle R,Caron S,Baug? E,Rouill? Y,Salles JP,Staels B,Bailleul B

Isolation of a novel leptin receptor gene promoter preferentially functioning in neuronal cells.
Biochemical and biophysical research communications389(4)673-7(2009 Nov)
Satoh T,Yoshino S,Katano A,Ishizuka T,Tomaru T,Shibusawa N,Hashimoto K,Yamada M,Mori M

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity.
Proceedings of the National Academy of Sciences of the United States of America104(49)19476-81(2007 Dec)
Couturier C,Sarkis C,S?ron K,Belouzard S,Chen P,Lenain A,Corset L,Dam J,Vauthier V,Dubart A,Mallet J,Froguel P,Rouill? Y,Jockers R

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Leprot cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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