Dner cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dner
Entrez Gene ID	227325
Full Name	delta/notch-like EGF repeat containing
Synonyms	A930026D19Rik,BET,Bret
General protein information	Preferred Names delta/notch-like EGF repeat containing Names delta and Notch-like epidermal growth factor-related receptor brain EGF repeat-containing transmembrane protein delta/notch-like EGF-related receptor transmembrane protein Bet
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 C5

mRNA and Protein(s)

mRNA	Protein	Name
NM_152915.1	NP_690879.1	delta and Notch-like epidermal growth factor-related receptor precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DNER	XP_516135.2
	DNER	XP_002799116.1
Canis lupus familiaris (dog)	DNER	XP_852345.2
Bos taurus (cattle)	DNER	XP_003585822.1
Danio rerio (zebrafish)	dner	XP_002665457.3
Homo sapiens (human)	DNER	NP_620711.3
Mus musculus (house mouse)	Dner	NP_690879.1
Rattus norvegicus (Norway rat)	Dner	XP_001077059.2
Gallus gallus (chicken)	DNER	XP_422604.2
Xenopus tropicalis (tropical clawed frog)	dner	NP_001116263.1

Gene Ontology
Bibliography

Related articles in PubMed

DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway.
Du J, Wang X, Zhang X, Zhang X, Jiang H
Molecular medicine reports17(2)2357-2365(2018 Feb)

DNER and NFIA are expressed by developing and mature AII amacrine cells in the mouse retina.
Keeley PW, Reese BE
The Journal of comparative neurology526(3)467-479(2018 Feb)

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.
Bibollet-Bahena O, Okafuji T, Hokamp K, Tear G, Mitchell KJ
PloS one12(5)e0177977(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DNER plays a redundant role with other Notch ligands in cochlear development
Title: Delta/notch-like EGF-related receptor (DNER) is expressed in hair cells and neurons in the developing and adult mouse inner ear.

These observations suggest that pleiotrophin-PTPzeta signaling controls subcellular localization of DNER and thereby regulates neuritogenesis.
Title: Receptor type protein tyrosine phosphatase zeta-pleiotrophin signaling controls endocytic trafficking of DNER that regulates neuritogenesis.

DNER mediates neuron-glia interaction and promotes morphological differentiation of Bergmann glia through Deltex-dependent Notch signaling.
Title: DNER acts as a neuron-specific Notch ligand during Bergmann glial development.

expression in developing and mature central nervous system
Title: Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons.

The following Dner gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dner cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02658	NM_152915.1 Latest version!	Mus musculus delta/notch-like EGF repeat containing (Dner), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$433.30 $619.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dner ( NM_152915.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_690879.1 Mus musculus delta/notch-like EGF repeat containing (Dner), mRNA.

Price & Availability↑

CloneID	OMu02658
Clone ID Related Accession (Same CDS sequence)	NM_152915.1
Accession Version	NM_152915.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2214bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-30
Organism	Mus musculus(house mouse)
Product	delta and Notch-like epidermal growth factor-related receptor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC034634.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034634.1, AK044597.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGCCTCCCC GCCGCGCCCA GGCGCCCGGT GCCCCGCTGC TGCCCGTGCT GGCCCTGCTG 
CCCCTGCTGC TGGGTGCTGG GCCCCAAAGC GGCTGCTTGG CTAGCCCGGT GTCCGCCGCG 
CCCCTGCCTG CTCCGGGACC GTGCGCCTCC CAGCCCTGTC GGAACGGGGG CGTGTGCACT 
CCGCGTTCGG TGACCGACCA AGAGCACCCT GCGGCCGATG CTGAGCCCCG CTACAGCTGC 
ACCTGTCCCG CTGGGGTCTC TGGCACCTAT TGTCAGTTTG TTGCAGATCC TTGTGCCAGC 
AACCCTTGTC ACCATGGTAA CTGCAGCAGC AGCAGCAGCA GCAGCAGCGA CAGCTACCTC 
TGCATTTGCA ACGACGGCTA TGAAGGTCTT AACTGTGAAC AACCACTTCC CAGTATTCCA 
ACCTCTGGCT GGACAGAGTC CACGGCACCC AGACAGCTTC AGCCTGTCCC CGCCACCCAG 
GAGCCTGACA TAATCCTGCC CCGCTCTCAG GCAACCGTGA CACTGCCAAC TTGGCAGCCA 
AAAACAGGGC AGAAAGTTGT AGAAATGAAA TGGGATCAAG TAGAGGTGGT CCCTGATGTT 
GCCTGTGGGA ATGCCAGTTC CAACAACTCT GCGGGTGGCC GCCTAGTGTC TTTTGAAGTG 
CCACAGAACA CCTCTGTAAA GATTCGGCAG GATGCCAATT CTTTGCTGAT CTTGCTGTGG 
AAGGTCACAG CCACAGGCTT TCAACAGTGT TCCCTCATAG ATGGTCGAAG TGTGACACCC 
CTCCAGGCTC CAGGGGGCCT TGTCCTGCTA GAGGAGATGC TGGCCTTGGG ACCCAACCAC 
TTCATTGGTT TTGTGAATGA CTCTGTTGCT AAATCCATTG TGGCTTTGCG TTTAACACTT 
GTGGTGAAGG CTAGCAACTG TGTTCCGGGG GACAGCCACT CAAATGACTT AGAGTGTTCG 
GGAAAAGGAA AATGTGCCAC GAAGCCATCA GAGGCAACCT TTTCCTGCAC CTGCCAGGAC 
CAGTACATTG GCACCTTCTG TGAAGAATTT GATGCCTGCC AGAGGAAACC CTGCCAGAAT 
GAGGCGAGCT GTATTGATGC AAATGAGAAG CAGGATGGGA GCAATTTCAC TTGCCTTTGT 
CTTCCAGGTT ATACTGGAGA GCTTTGCCAG TCCAAGATTG ATTACTGTGT CCTAGACCCA 
TGCAGAAATG GAGCCACATG TGTGTCCAGC CTCAGCGGGT TCACCTGCCA GTGTCTGGAA 
GGGTACTTCG GCTCCGCTTG TGAAGAGAAG GTGGACCCTT GCATGTCCTC TCCATGCCAG 
AACAATGGCA CTTGCTACGT GGATGGCGTG CATTTCACCT GCAGCTGCAG CCCAGGCTTC 
ACAGGGCCTA CGTGTGCCCA GCTGGTGGAC TTCTGCGCCC TCAGTCCGTG TGCTCATGGC 
ATGTGCCGTA GCGTGGGCAC CAGCTACAAG TGCCTCTGCG ATCCAGGTTA CCATGGCCTC 
TACTGTGAGG AGGAATACAA TGAGTGCCTG TCGGCCCCTT GCCTGAATGC CGCCACCTGC 
CGGGACCTCA TCAATGGCTA TGAGTGTGTG TGCCTGGCAG AATATAAAGG AACACACTGC 
GAACTGTACA AGGACCCCTG TGCTAACATC AGCTGTCTGA ATGGAGGTAC CTGTGACAGC 
GAGGGGCTGA ATGGCACGTG CATCTGTGCA CCCGGGTTCA CAGGTGAAGA GTGTGACATT 
GACATCAATG AATGTGATAG TAACCCATGT CATCATGCTG GAACCTGCTT GGACCAGCCC 
AATGGTTACA CCTGCCACTG TCCTCATGGC TGGGTGGGAG CAAACTGTGA AATCCACCTG 
CAGTGGAAGT CTGGGCACAT GGCCGAGAGC CTCACCAACA TGCCTCGGCA CTCCCTCTAC 
ATCATCATCG GAGCCCTCTG CGTCGCCTTC ATCCTCATGC TCATCATCCT GATTGTGGGC 
ATCTGCCGCA TCAGCCGCAT CGAGTACCAG GGCTCCTCCC GGCCAGCCTA TGAGGAGTTC 
TACAACTGCC GCAGCATTGA CAGTGAGTTC AGCAATGCCA TCGCATCCAT CCGGCATGCC 
AGGTTTGGGA AGAAGTCTCG GCCTGCCATG TACGACGTGA CTCCCATTGC CTACGAGGAT 
TACAGTCCCG ATGACAAACC CTTGGTCACA CTGATTAAAA CAAAAGATTT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_690879.1
CDS	494..2707
Translation	MPPRRAQAPGAPLLPVLALLPLLLGAGPQSGCLASPVSAAPLPAPGPCASQPCRNGGVCTPRSVTDQEHPAADAEPRYSCTCPAGVSGTYCQFVADPCASNPCHHGNCSSSSSSSSDSYLCICNDGYEGLNCEQPLPSIPTSGWTESTAPRQLQPVPATQEPDIILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVVPDVACGNASSNNSAGGRLVSFEVPQNTSVKIRQDANSLLILLWKVTATGFQQCSLIDGRSVTPLQAPGGLVLLEEMLALGPNHFIGFVNDSVAKSIVALRLTLVVKASNCVPGDSHSNDLECSGKGKCATKPSEATFSCTCQDQYIGTFCEEFDACQRKPCQNEASCIDANEKQDGSNFTCLCLPGYTGELCQSKIDYCVLDPCRNGATCVSSLSGFTCQCLEGYFGSACEEKVDPCMSSPCQNNGTCYVDGVHFTCSCSPGFTGPTCAQLVDFCALSPCAHGMCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLINGYECVCLAEYKGTHCELYKDPCANISCLNGGTCDSEGLNGTCICAPGFTGEECDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYEDYSPDDKPLVTLIKTKDL

Target ORF information:

RefSeq Version	NM_152915.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus delta/notch-like EGF repeat containing (Dner), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152915.1

ORF Insert Sequence:

ATGCCTCCCC GCCGCGCCCA GGCGCCCGGT GCCCCGCTGC TGCCCGTGCT GGCCCTGCTG 
CCCCTGCTGC TGGGTGCTGG GCCCCAAAGC GGCTGCTTGG CTAGCCCGGT GTCCGCCGCG 
CCCCTGCCTG CTCCGGGACC GTGCGCCTCC CAGCCCTGTC GGAACGGGGG CGTGTGCACT 
CCGCGTTCGG TGACCGACCA AGAGCACCCT GCGGCCGATG CTGAGCCCCG CTACAGCTGC 
ACCTGTCCCG CTGGGGTCTC TGGCACCTAT TGTCAGTTTG TTGCAGATCC TTGTGCCAGC 
AACCCTTGTC ACCATGGTAA CTGCAGCAGC AGCAGCAGCA GCAGCAGCGA CAGCTACCTC 
TGCATTTGCA ACGACGGCTA TGAAGGTCTT AACTGTGAAC AACCACTTCC CAGTATTCCA 
ACCTCTGGCT GGACAGAGTC CACGGCACCC AGACAGCTTC AGCCTGTCCC CGCCACCCAG 
GAGCCTGACA TAATCCTGCC CCGCTCTCAG GCAACCGTGA CACTGCCAAC TTGGCAGCCA 
AAAACAGGGC AGAAAGTTGT AGAAATGAAA TGGGATCAAG TAGAGGTGGT CCCTGATGTT 
GCCTGTGGGA ATGCCAGTTC CAACAACTCT GCGGGTGGCC GCCTAGTGTC TTTTGAAGTG 
CCACAGAACA CCTCTGTAAA GATTCGGCAG GATGCCAATT CTTTGCTGAT CTTGCTGTGG 
AAGGTCACAG CCACAGGCTT TCAACAGTGT TCCCTCATAG ATGGTCGAAG TGTGACACCC 
CTCCAGGCTC CAGGGGGCCT TGTCCTGCTA GAGGAGATGC TGGCCTTGGG ACCCAACCAC 
TTCATTGGTT TTGTGAATGA CTCTGTTGCT AAATCCATTG TGGCTTTGCG TTTAACACTT 
GTGGTGAAGG CTAGCAACTG TGTTCCGGGG GACAGCCACT CAAATGACTT AGAGTGTTCG 
GGAAAAGGAA AATGTGCCAC GAAGCCATCA GAGGCAACCT TTTCCTGCAC CTGCCAGGAC 
CAGTACATTG GCACCTTCTG TGAAGAATTT GATGCCTGCC AGAGGAAACC CTGCCAGAAT 
GAGGCGAGCT GTATTGATGC AAATGAGAAG CAGGATGGGA GCAATTTCAC TTGCCTTTGT 
CTTCCAGGTT ATACTGGAGA GCTTTGCCAG TCCAAGATTG ATTACTGTGT CCTAGACCCA 
TGCAGAAATG GAGCCACATG TGTGTCCAGC CTCAGCGGGT TCACCTGCCA GTGTCTGGAA 
GGGTACTTCG GCTCCGCTTG TGAAGAGAAG GTGGACCCTT GCATGTCCTC TCCATGCCAG 
AACAATGGCA CTTGCTACGT GGATGGCGTG CATTTCACCT GCAGCTGCAG CCCAGGCTTC 
ACAGGGCCTA CGTGTGCCCA GCTGGTGGAC TTCTGCGCCC TCAGTCCGTG TGCTCATGGC 
ATGTGCCGTA GCGTGGGCAC CAGCTACAAG TGCCTCTGCG ATCCAGGTTA CCATGGCCTC 
TACTGTGAGG AGGAATACAA TGAGTGCCTG TCGGCCCCTT GCCTGAATGC CGCCACCTGC 
CGGGACCTCA TCAATGGCTA TGAGTGTGTG TGCCTGGCAG AATATAAAGG AACACACTGC 
GAACTGTACA AGGACCCCTG TGCTAACATC AGCTGTCTGA ATGGAGGTAC CTGTGACAGC 
GAGGGGCTGA ATGGCACGTG CATCTGTGCA CCCGGGTTCA CAGGTGAAGA GTGTGACATT 
GACATCAATG AATGTGATAG TAACCCATGT CATCATGCTG GAACCTGCTT GGACCAGCCC 
AATGGTTACA CCTGCCACTG TCCTCATGGC TGGGTGGGAG CAAACTGTGA AATCCACCTG 
CAGTGGAAGT CTGGGCACAT GGCCGAGAGC CTCACCAACA TGCCTCGGCA CTCCCTCTAC 
ATCATCATCG GAGCCCTCTG CGTCGCCTTC ATCCTCATGC TCATCATCCT GATTGTGGGC 
ATCTGCCGCA TCAGCCGCAT CGAGTACCAG GGCTCCTCCC GGCCAGCCTA TGAGGAGTTC 
TACAACTGCC GCAGCATTGA CAGTGAGTTC AGCAATGCCA TCGCATCCAT CCGGCATGCC 
AGGTTTGGGA AGAAGTCTCG GCCTGCCATG TACGACGTGA CTCCCATTGC CTACGAGGAT 
TACAGTCCCG ATGACAAACC CTTGGTCACA CTGATTAAAA CAAAAGATTT GTAA