Upk3a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Upk3a
Entrez Gene ID	22270
Full Name	uroplakin 3A
Synonyms	1110017C07Rik,UP3a,UPIII,Upk3
General protein information	Preferred Names uroplakin 3A Names uroplakin-3a proplakin IIIa uroplakin 3 uroplakin III
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 E2

mRNA and Protein(s)

mRNA	Protein	Name
NM_023478.2	NP_075967.2	uroplakin-3a precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	UPK3A	NP_777134.1
Mus musculus (house mouse)	Upk3a	NP_075967.2
Homo sapiens (human)	UPK3A	NP_008884.1
Gallus gallus (chicken)	UPK3A	XP_004938099.1
Rattus norvegicus (Norway rat)	Upk3a	NP_001123979.1
Xenopus tropicalis (tropical clawed frog)	upk3a	NP_988978.2
Pan troglodytes (chimpanzee)	UPK3A	XP_001135467.1
Canis lupus familiaris (dog)	UPK3A	XP_851414.1

Gene Ontology
Bibliography

Related articles in PubMed

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Rutledge EA, Benazet JD, McMahon AP
Development (Cambridge, England)144(17)3177-3188(2017 09)

Uroplakin 3a
Guha A, Deshpande A, Jain A, Sebastiani P, Cardoso WV
Cell reports19(2)246-254(2017 Apr)

Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration.
Guo C, Balsara ZR, Hill WG, Li X
Development (Cambridge, England)144(3)400-408(2017 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

U-CCs (Uroplakin3a expressing cells )proliferate and generate CCs and ciliated cells in uninjured airways long-term and, like v-CCs, after Nap. U-CCs have a higher propensity to generate ciliated cells than non-U-CCs
Title: Uroplakin 3a

A UPK3A peptide can induce a peptide-specific CD4+ T cell autoimmunity that mediates painful bladder dysfunction in mice.
Title: Uroplakin peptide-specific autoimmunity initiates interstitial cystitis/painful bladder syndrome in mice.

role of uroplakins in CO2 transport through urothelium
Title: Uroplakins do not restrict CO2 transport through urothelium.

The despites a lower level of expression, UPIIIa maintain its plaque association in urothelial preneoplastic lesions.
Title: Expression and localization of four uroplakins in urothelial preneoplastic lesions.

structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography
Title: Structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography.

The following Upk3a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Upk3a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17846	NM_023478.2 Latest version!	Mus musculus uroplakin 3A (Upk3a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Upk3a ( NM_023478.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075967.2 Mus musculus uroplakin 3A (Upk3a), mRNA.

Price & Availability↑

CloneID	OMu17846
Clone ID Related Accession (Same CDS sequence)	NM_023478.2
Accession Version	NM_023478.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	uroplakin-3a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL772308.4, BX512009.1, BY703997.1 and AV022830.1. On Jul 8, 2009 this sequence version replaced NM_023478.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC125336.1, AF222750.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCTCCTGC TCTGGGCCCT GCTGGCTCTC GGATGCCTGC GGTGTGGCTG GACTGTGAAC 
CTCCAGCCCC AACTGGCCAG TGTGACCTTT GCCACCAACA ACCCTACCCT CACCACCGTG 
GCCTTGGAGA AGCCTCTGTG CATGTTTGAT AGCTCAGAGC CACTCAGCGG CTCTTACGAG 
GTTTACCTCT ATGCTATGGT CGACTCAGCC ATGTCCAGGA ATGTGTCTGT ACAGGACAGC 
GCTGGCGTCC CACTGAGCAC CACTTTCCGG CAAACCCAGG GTGGGAGGTC AGGCCCCTAT 
AAAGCTGCGG CCTTTGACCT GACCCCTTGT GGTGACTTGC CCAGCCTGGA TGCTGTTGGA 
GATGTGACCC AGGCCTCAGA GATCCTGAAC GCATACCTAG TCAGGGTGGG CAACAACGGG 
ACCTGTTTTT GGGACCCCAA CTTCCAGGGC CTCTGCAACC CACCCCTGAC AGCGGCCACT 
GAGTACAGAT TCAAGTATGT CCTGGTCAAC ATGTCCACAG GCTTGGTGCA GGACCAGACA 
CTATGGTCAG ATCCCATCTG GACCAACCGG CCCATCCCCT ACTCGGCCAT CGACACGTGG 
CCCGGCCGGC GGAGTGGAGG CATGATTGTC ATCACGTCCA TTCTGGGCTC CCTGCCCTTC 
TTCCTGCTCG TGGGTTTCGC TGGAGCCATC ATCCTCAGCT TTGTGGACAT GGGCAGTTCT 
GATGGGGAAA TGACACACGA CTCACAGATC ACCCAGGAGG CTGTTCCCAA GACCCTGGGG 
ACTTCTGAGC CTTCCTACTC ATCTGTGAAC CGGGGCCCAC CCCTAGACAG AGCAGAGGTG 
TTCTCCAGCA AGCTTCAAGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075967.2
CDS	80..943
Translation	MLLLWALLALGCLRCGWTVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSSEPLSGSYEVYLYAMVDSAMSRNVSVQDSAGVPLSTTFRQTQGGRSGPYKAAAFDLTPCGDLPSLDAVGDVTQASEILNAYLVRVGNNGTCFWDPNFQGLCNPPLTAATEYRFKYVLVNMSTGLVQDQTLWSDPIWTNRPIPYSAIDTWPGRRSGGMIVITSILGSLPFFLLVGFAGAIILSFVDMGSSDGEMTHDSQITQEAVPKTLGTSEPSYSSVNRGPPLDRAEVFSSKLQD

Target ORF information:

RefSeq Version	NM_023478.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus uroplakin 3A (Upk3a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023478.2

ORF Insert Sequence:

ATGCTCCTGC TCTGGGCCCT GCTGGCTCTC GGATGCCTGC GGTGTGGCTG GACTGTGAAC 
CTCCAGCCCC AACTGGCCAG TGTGACCTTT GCCACCAACA ACCCTACCCT CACCACCGTG 
GCCTTGGAGA AGCCTCTGTG CATGTTTGAT AGCTCAGAGC CACTCAGCGG CTCTTACGAG 
GTTTACCTCT ATGCTATGGT CGACTCAGCC ATGTCCAGGA ATGTGTCTGT ACAGGACAGC 
GCTGGCGTCC CACTGAGCAC CACTTTCCGG CAAACCCAGG GTGGGAGGTC AGGCCCCTAT 
AAAGCTGCGG CCTTTGACCT GACCCCTTGT GGTGACTTGC CCAGCCTGGA TGCTGTTGGA 
GATGTGACCC AGGCCTCAGA GATCCTGAAC GCATACCTAG TCAGGGTGGG CAACAACGGG 
ACCTGTTTTT GGGACCCCAA CTTCCAGGGC CTCTGCAACC CACCCCTGAC AGCGGCCACT 
GAGTACAGAT TCAAGTATGT CCTGGTCAAC ATGTCCACAG GCTTGGTGCA GGACCAGACA 
CTATGGTCAG ATCCCATCTG GACCAACCGG CCCATCCCCT ACTCGGCCAT CGACACGTGG 
CCCGGCCGGC GGAGTGGAGG CATGATTGTC ATCACGTCCA TTCTGGGCTC CCTGCCCTTC 
TTCCTGCTCG TGGGTTTCGC TGGAGCCATC ATCCTCAGCT TTGTGGACAT GGGCAGTTCT 
GATGGGGAAA TGACACACGA CTCACAGATC ACCCAGGAGG CTGTTCCCAA GACCCTGGGG 
ACTTCTGAGC CTTCCTACTC ATCTGTGAAC CGGGGCCCAC CCCTAGACAG AGCAGAGGTG 
TTCTCCAGCA AGCTTCAAGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Development (Cambridge, England)144(17)3177-3188(2017 09)
Rutledge EA,Benazet JD,McMahon AP

Uroplakin 3a
Cell reports19(2)246-254(2017 Apr)
Guha A,Deshpande A,Jain A,Sebastiani P,Cardoso WV

Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration.
Development (Cambridge, England)144(3)400-408(2017 02)
Guo C,Balsara ZR,Hill WG,Li X

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Upk3a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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