Phlda2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Phlda2
Entrez Gene ID	22113
Full Name	pleckstrin homology like domain, family A, member 2
Synonyms	Ipl,Tssc3
General protein information	Preferred Names pleckstrin homology like domain, family A, member 2 Names pleckstrin homology-like domain family A member 2 imprinted in placenta and liver protein protein 50C15 tumor-suppressing subchromosomal transferable fragment 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 F5\|7 88.23 cM
Summary	This gene is one of several genes in the imprinted gene domain on chromosome 7. Studies using knockout mice have shown that the product of this gene regulates placental growth. Transcripts from this gene are most abundant in placenta and yolk sac, and are almost entirely transcribed from the maternal allele. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006508597.2	XP_006508660.1	pleckstrin homology-like domain family A member 2 isoform X1
NM_009434.2	NP_033460.1	pleckstrin homology-like domain family A member 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	phlda2	NP_001018432.1
Xenopus tropicalis (tropical clawed frog)	phlda2	NP_001072825.1
Homo sapiens (human)	PHLDA2	NP_003302.1
	PHLDA2	XP_001094620.1
Gallus gallus (chicken)	PHLDA2	NP_001186524.1
Rattus norvegicus (Norway rat)	Phlda2	NP_001093991.1
Pan troglodytes (chimpanzee)	PHLDA2	XP_001155149.1
Bos taurus (cattle)	PHLDA2	NP_001069989.1
Mus musculus (house mouse)	Phlda2	NP_033460.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential requirements for Tousled-like kinases 1 and 2 in mammalian development.
Segura-Bayona S, Knobel PA, Gonz?lez-Bur?n H, Youssef SA, Pe?a-Blanco A, Coyaud ?, L?pez-Rovira T, Rein K, Palenzuela L, Colombelli J, Forrow S, Raught B, Groth A, de Bruin A, Stracker TH
Cell death and differentiation24(11)1872-1885(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Phlda2 manipulates the placenta's demands for maternal resources, a process that must be tightly regulated by epigenetic marks to ensure optimal foetal growth.
Title: The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources.

data support a direct role for elevated Phlda2 in limiting fetal growth but also suggest that growth restriction only manifests when there is limited placental reserve
Title: Isolating the role of elevated Phlda2 in asymmetric late fetal growth restriction in mice.

TSSC3 plays an important role in the differentiation from trophoblast stem cell to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3/PI3K/AKT/MASH2 signaling pathway.
Title: The maternally expressed gene Tssc3 regulates the expression of MASH2 transcription factor in mouse trophoblast stem cells through the AKT-Sp1 signaling pathway.

A critical role for the imprinted Phlda2 gene in regulating glycogen storage in the eutherian placenta is identified.
Title: The imprinted Phlda2 gene regulates extraembryonic energy stores.

Phlda2 gene is imprinted, with preferential expression from the maternal allele in placenta. It acts as a rheostat for placental growth, with overgrowth after gene deletion and growth retardation after loss of imprinting.
Title: Placental growth retardation due to loss of imprinting of Phlda2.

The following Phlda2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Phlda2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14641	NM_009434.2 Latest version!	Mus musculus pleckstrin homology like domain, family A, member 2 (Phlda2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu14641	XM_006508597.2 Latest version!	Mus musculus pleckstrin homology like domain, family A, member 2 (Phlda2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Phlda2 ( NM_009434.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033460.1 Mus musculus pleckstrin homology like domain, family A, member 2 (Phlda2), mRNA.

Price & Availability↑

CloneID	OMu14641
Clone ID Related Accession (Same CDS sequence)	XM_006508597.2 , NM_009434.2
Accession Version	NM_009434.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	pleckstrin homology-like domain family A member 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF615806.1, Y15443.1 and CF617643.1. On Jan 15, 2005 this sequence version replaced NM_009434.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF615806.1, AK131929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 15327781 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCGA AAATCGTGAT GTCTTCGAAA ACCGTGAAGA CCTCCGACGA GATCCTTTGC 
GAGGGCGAGC TGGAGAAGCG AAGCGACAGC CTGTTCCAGG TATGGAAGAA GAAGCGCTGC 
GTGCTCACCG CCGACCGCCT GCGCCTCTTC TCCGGGAAAA CCAGCCCCGC CAAGGAGCTG 
TTTTTCCACT CCATCCTCAA GGTGGACTGC GTGGAGCACA CCTCTAAGTA CGTGTACTTC 
ACCATCGTCA CCAACTATTA CAAGGAGATC GACTTCCGCT GCACGGTGGA GAGCTGCTGG 
AACGCGGCCA TCACCATGGC GCTGATCGAC TTCCAGAACC GTCGGGCGCT GCAAGACTTT 
CCCCGCTACC GGTATCAGCG CTCTGAGTCT GAAATGCCTT CCGAGCCGGG AGAGCAGAGC 
GCTCTGGGTC CGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033460.1
CDS	35..469
Translation	MASKIVMSSKTVKTSDEILCEGELEKRSDSLFQVWKKKRCVLTADRLRLFSGKTSPAKELFFHSILKVDCVEHTSKYVYFTIVTNYYKEIDFRCTVESCWNAAITMALIDFQNRRALQDFPRYRYQRSESEMPSEPGEQSALGP

Target ORF information:

RefSeq Version	NM_009434.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus pleckstrin homology like domain, family A, member 2 (Phlda2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009434.2

ORF Insert Sequence:

ATGGCTTCGA AAATCGTGAT GTCTTCGAAA ACCGTGAAGA CCTCCGACGA GATCCTTTGC 
GAGGGCGAGC TGGAGAAGCG AAGCGACAGC CTGTTCCAGG TATGGAAGAA GAAGCGCTGC 
GTGCTCACCG CCGACCGCCT GCGCCTCTTC TCCGGGAAAA CCAGCCCCGC CAAGGAGCTG 
TTTTTCCACT CCATCCTCAA GGTGGACTGC GTGGAGCACA CCTCTAAGTA CGTGTACTTC 
ACCATCGTCA CCAACTATTA CAAGGAGATC GACTTCCGCT GCACGGTGGA GAGCTGCTGG 
AACGCGGCCA TCACCATGGC GCTGATCGAC TTCCAGAACC GTCGGGCGCT GCAAGACTTT 
CCCCGCTACC GGTATCAGCG CTCTGAGTCT GAAATGCCTT CCGAGCCGGG AGAGCAGAGC 
GCTCTGGGTC CGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Phlda2 ( XM_006508597.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006508660.1 Mus musculus pleckstrin homology like domain, family A, member 2 (Phlda2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu14641
Clone ID Related Accession (Same CDS sequence)	XM_006508597.2 , NM_009434.2
Accession Version	XM_006508597.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	pleckstrin homology-like domain family A member 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006508597.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTCGA AAATCGTGAT GTCTTCGAAA ACCGTGAAGA CCTCCGACGA GATCCTTTGC 
GAGGGCGAGC TGGAGAAGCG AAGCGACAGC CTGTTCCAGG TATGGAAGAA GAAGCGCTGC 
GTGCTCACCG CCGACCGCCT GCGCCTCTTC TCCGGGAAAA CCAGCCCCGC CAAGGAGCTG 
TTTTTCCACT CCATCCTCAA GGTGGACTGC GTGGAGCACA CCTCTAAGTA CGTGTACTTC 
ACCATCGTCA CCAACTATTA CAAGGAGATC GACTTCCGCT GCACGGTGGA GAGCTGCTGG 
AACGCGGCCA TCACCATGGC GCTGATCGAC TTCCAGAACC GTCGGGCGCT GCAAGACTTT 
CCCCGCTACC GGTATCAGCG CTCTGAGTCT GAAATGCCTT CCGAGCCGGG AGAGCAGAGC 
GCTCTGGGTC CGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006508660.1
CDS	380..814
Translation	MASKIVMSSKTVKTSDEILCEGELEKRSDSLFQVWKKKRCVLTADRLRLFSGKTSPAKELFFHSILKVDCVEHTSKYVYFTIVTNYYKEIDFRCTVESCWNAAITMALIDFQNRRALQDFPRYRYQRSESEMPSEPGEQSALGP

Target ORF information:

RefSeq Version	XM_006508597.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus pleckstrin homology like domain, family A, member 2 (Phlda2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006508597.2

ORF Insert Sequence:

ATGGCTTCGA AAATCGTGAT GTCTTCGAAA ACCGTGAAGA CCTCCGACGA GATCCTTTGC 
GAGGGCGAGC TGGAGAAGCG AAGCGACAGC CTGTTCCAGG TATGGAAGAA GAAGCGCTGC 
GTGCTCACCG CCGACCGCCT GCGCCTCTTC TCCGGGAAAA CCAGCCCCGC CAAGGAGCTG 
TTTTTCCACT CCATCCTCAA GGTGGACTGC GTGGAGCACA CCTCTAAGTA CGTGTACTTC 
ACCATCGTCA CCAACTATTA CAAGGAGATC GACTTCCGCT GCACGGTGGA GAGCTGCTGG 
AACGCGGCCA TCACCATGGC GCTGATCGAC TTCCAGAACC GTCGGGCGCT GCAAGACTTT 
CCCCGCTACC GGTATCAGCG CTCTGAGTCT GAAATGCCTT CCGAGCCGGG AGAGCAGAGC 
GCTCTGGGTC CGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential requirements for Tousled-like kinases 1 and 2 in mammalian development.
Cell death and differentiation24(11)1872-1885(2017 Nov)
Segura-Bayona S,Knobel PA,Gonz?lez-Bur?n H,Youssef SA,Pe?a-Blanco A,Coyaud ?,L?pez-Rovira T,Rein K,Palenzuela L,Colombelli J,Forrow S,Raught B,Groth A,de Bruin A,Stracker TH

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Phlda2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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