Tpm2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tpm2
Entrez Gene ID	22004
Full Name	tropomyosin 2, beta
Synonyms	Tpm-2,Trop-2
General protein information	Preferred Names tropomyosin 2, beta Names tropomyosin beta chain
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 A5
Summary	This gene belongs to the tropomyosin family which encodes proteins that bind to actin filaments and stabilize them by regulating access to actin modifying proteins. The encoded protein is a high molecular weight tropomyosin expressed in slow skeletal muscle. In humans, mutations in this gene are associated with nemaline myopathy, cap disease and distal arthrogryposis syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006537780.1	XP_006537843.1	tropomyosin beta chain isoform X1
NM_001277876.1	NP_001264805.1	tropomyosin beta chain isoform Tpm2.1sm/cy
NM_009416.4	NP_033442.2	tropomyosin beta chain isoform Tpm2.2st
NM_001277875.1	NP_001264804.1	tropomyosin beta chain isoform Tpm2.3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TPM2	XP_538720.2
Rattus norvegicus (Norway rat)	Tpm2	NP_001019516.1
Xenopus tropicalis (tropical clawed frog)	tpm2	NP_001025587.1
Mus musculus (house mouse)	Tpm2	NP_001264805.1

Gene Ontology
Bibliography

Related articles in PubMed

A systematic nomenclature for mammalian tropomyosin isoforms.
Geeves MA, Hitchcock-DeGregori SE, Gunning PW
Journal of muscle research and cell motility36(2)147-53(2015 Apr)

Vertebrate tropomyosin: distribution, properties and function.
Perry SV
Journal of muscle research and cell motility22(1)5-49(2001)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Stress fibre formation and up-regulation of alpha-smooth muscle actin (alphaSMA) induced by TGFbeta2 could be reversed by Tpm1/2 knock-down by siRNA.
Title: FGF2 antagonizes aberrant TGF? regulation of tropomyosin: role for posterior capsule opacity.

Trop2 marks fetal glandular epithelial cells of the stomach, growing as spheroids when cultured ex vivo. In adults, upon injury, Trop2 expression is reactivated in regenerative cells together with part of a fetal-like genetic program.
Title: Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage.

Trop-2 promotes an alpha5beta1 integrin-dependent pro-metastatic signaling pathway in PCa cells and that the altered expression of Trop-2 may be utilized for early identification of capsule-invading PCa.
Title: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts.

data suggest that Trop2 regulates cell proliferation and motility and that it does so by regulating the ERK pathway and several critical components of the cell migration apparatus
Title: Trop2 regulates motility and lamellipodia formation in cultured fetal lung fibroblasts.

our findings help to establish a close functional link between Trop2 and MSCs, and to provide a tool for future investigation of Trop2 in other types of stem cells
Title: Trop2 regulates the proliferation and differentiation of murine compact-bone derived MSCs.

The following Tpm2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tpm2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17845	NM_001277876.1 Latest version!	Mus musculus tropomyosin 2, beta (Tpm2), transcript variant Tpm2.1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu17780	NM_001277875.1 Latest version!	Mus musculus tropomyosin 2, beta (Tpm2), transcript variant Tpm2.3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu17820	NM_009416.4 Latest version!	Mus musculus tropomyosin 2, beta (Tpm2), transcript variant Tpm2.2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu32848	XM_006537780.1 Latest version!	Mus musculus tropomyosin 2, beta (Tpm2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tpm2 ( NM_001277876.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001264805.1 Mus musculus tropomyosin 2, beta (Tpm2), transcript variant Tpm2.1, mRNA.

Price & Availability↑

CloneID	OMu17845
Clone ID Related Accession (Same CDS sequence)	NM_001277876.1
Accession Version	NM_001277876.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Mus musculus(house mouse)
Product	tropomyosin beta chain isoform Tpm2.1sm/cy
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY786644.1, CV560790.1, AA208641.1 and AK132162.1. Transcript Variant: This variant (Tpm2.1, also known as variant 3) differs in the 3' UTR and has multiple differences in the 3' coding region, compared to variant Tpm2.2. It encodes isoform Tpm2.1sm/cy (also known as isoform 3), which is of the same size but has a different internal segment and a distinct C-terminus, compared to isoform Tpm2.2st. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024358.1, X58381.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGCCA TCAAGAAGAA GATGCAGATG CTGAAACTGG ACAAGGAGAA TGCCATCGAC 
CGCGCGGAGC AGGCCGAAGC CGACAAAAAG CAAGCTGAAG ACCGATGCAA GCAGCTGGAG 
GAAGAGCAGC AGGCCCTCCA GAAGAAGCTG AAGGGGACAG AGGACGAGGT GGAAAAGTAT 
TCCGAGTCCG TGAAGGATGC CCAGGAGAAA CTGGAGCAGG CTGAGAAGAA GGCCACCGAC 
GCTGAAGCAG ATGTGGCCTC TCTGAACCGC CGCATTCAGC TCGTAGAGGA GGAGTTGGAT 
CGGGCACAGG AGCGCCTGGC TACAGCCTTG CAAAAGCTGG AGGAGGCTGA GAAAGCCGCG 
GATGAGAGCG AGAGAGGAAT GAAGGTCATT GAAAACCGGG CCATGAAGGA TGAGGAAAAG 
ATGGAGCTGC AGGAGATGCA GCTGAAGGAA GCCAAGCACA TCGCTGAGGA CTCAGACCGC 
AAATATGAGG AGGTGGCCAG GAAGCTGGTG ATCCTGGAAG GGGAGCTGGA GCGCTCGGAA 
GAGAGAGCCG AGGTGGCTGA GAGCCGAGCC AGACAGCTGG AGGAGGAGCT TCGAACCATG 
GACCAAGCCC TCAAGTCGCT GATAGCCTCA GAGGAGGAGT ATTCCACCAA AGAGGACAAA 
TACGAAGAAG AGATCAAACT TCTGGAGGAG AAGCTGAAAG AGGCTGAGAC CCGAGCAGAG 
TTTGCTGAAA GATCTGTGGC AAAGTTGGAG AAAACCATTG ATGATCTGGA AGAGACTTTG 
GCCAGTGCCA AGGAAGAGAA CGTGGAGATA CACCAGACCT TGGACCAGAC CCTTCTGGAA 
CTCAACAACC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264805.1
CDS	201..1055
Translation	MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKDAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESRARQLEEELRTMDQALKSLIASEEEYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTLDQTLLELNNL

Target ORF information:

RefSeq Version	NM_001277876.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus tropomyosin 2, beta (Tpm2), transcript variant Tpm2.1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277876.1

ORF Insert Sequence:

ATGGACGCCA TCAAGAAGAA GATGCAGATG CTGAAACTGG ACAAGGAGAA TGCCATCGAC 
CGCGCGGAGC AGGCCGAAGC CGACAAAAAG CAAGCTGAAG ACCGATGCAA GCAGCTGGAG 
GAAGAGCAGC AGGCCCTCCA GAAGAAGCTG AAGGGGACAG AGGACGAGGT GGAAAAGTAT 
TCCGAGTCCG TGAAGGATGC CCAGGAGAAA CTGGAGCAGG CTGAGAAGAA GGCCACCGAC 
GCTGAAGCAG ATGTGGCCTC TCTGAACCGC CGCATTCAGC TCGTAGAGGA GGAGTTGGAT 
CGGGCACAGG AGCGCCTGGC TACAGCCTTG CAAAAGCTGG AGGAGGCTGA GAAAGCCGCG 
GATGAGAGCG AGAGAGGAAT GAAGGTCATT GAAAACCGGG CCATGAAGGA TGAGGAAAAG 
ATGGAGCTGC AGGAGATGCA GCTGAAGGAA GCCAAGCACA TCGCTGAGGA CTCAGACCGC 
AAATATGAGG AGGTGGCCAG GAAGCTGGTG ATCCTGGAAG GGGAGCTGGA GCGCTCGGAA 
GAGAGAGCCG AGGTGGCTGA GAGCCGAGCC AGACAGCTGG AGGAGGAGCT TCGAACCATG 
GACCAAGCCC TCAAGTCGCT GATAGCCTCA GAGGAGGAGT ATTCCACCAA AGAGGACAAA 
TACGAAGAAG AGATCAAACT TCTGGAGGAG AAGCTGAAAG AGGCTGAGAC CCGAGCAGAG 
TTTGCTGAAA GATCTGTGGC AAAGTTGGAG AAAACCATTG ATGATCTGGA AGAGACTTTG 
GCCAGTGCCA AGGAAGAGAA CGTGGAGATA CACCAGACCT TGGACCAGAC CCTTCTGGAA 
CTCAACAACC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tpm2 ( NM_001277875.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001264804.1 Mus musculus tropomyosin 2, beta (Tpm2), transcript variant Tpm2.3, mRNA.

Price & Availability↑

CloneID	OMu17780
Clone ID Related Accession (Same CDS sequence)	NM_001277875.1
Accession Version	NM_001277875.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Mus musculus(house mouse)
Product	tropomyosin beta chain isoform Tpm2.3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY786644.1, DV049735.1, BY439632.1 and AK132162.1. Transcript Variant: This variant (Tpm2.3, also known as variant 2) uses an alternate splice site in the 3' coding region, compared to variant Tpm2.2. It encodes isoform Tpm2.3 (also known as isoform 2) which is of the same size, but has a distinct C-terminus, compared to isoform Tpm2.2st. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M87635.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGCCA TCAAGAAGAA GATGCAGATG CTGAAACTGG ACAAGGAGAA TGCCATCGAC 
CGCGCGGAGC AGGCCGAAGC CGACAAAAAG CAAGCTGAAG ACCGATGCAA GCAGCTGGAG 
GAAGAGCAGC AGGCCCTCCA GAAGAAGCTG AAGGGGACAG AGGACGAGGT GGAAAAGTAT 
TCCGAGTCCG TGAAGGATGC CCAGGAGAAA CTGGAGCAGG CTGAGAAGAA GGCCACCGAC 
GCTGAAGCAG ATGTGGCCTC TCTGAACCGC CGCATTCAGC TCGTAGAGGA GGAGTTGGAT 
CGGGCACAGG AGCGCCTGGC TACAGCCTTG CAAAAGCTGG AGGAGGCTGA GAAAGCCGCG 
GATGAGAGCG AGAGAGGAAT GAAGGTCATT GAAAACCGGG CCATGAAGGA TGAGGAAAAG 
ATGGAGCTGC AGGAGATGCA GCTGAAGGAA GCCAAGCACA TCGCTGAGGA CTCAGACCGC 
AAATATGAGG AGGTGGCCAG GAAGCTGGTG ATCCTGGAAG GGGAGCTGGA GCGCTCGGAA 
GAGAGAGCCG AGGTGGCTGA GAGTAAATGT GGGGACCTAG AGGAGGAGCT GAAAATTGTT 
ACCAACAACT TGAAATCCCT GGAAGCCCAA GCGGACAAGT ATTCCACCAA AGAGGACAAA 
TACGAAGAAG AGATCAAACT TCTGGAGGAG AAGCTGAAAG AGGCTGAGAC CCGAGCAGAG 
TTTGCTGAAA GATCTGTGGC AAAGTTGGAG AAAACCATTG ATGATCTGGA AGAGACTTTG 
GCCAGTGCCA AGGAAGAGAA CGTGGAGATA CACCAGACCT TGGACCAGAC CCTTCTGGAA 
CTCAACAACC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264804.1
CDS	201..1055
Translation	MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKDAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTLDQTLLELNNL

Target ORF information:

RefSeq Version	NM_001277875.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus tropomyosin 2, beta (Tpm2), transcript variant Tpm2.3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277875.1

ORF Insert Sequence:

ATGGACGCCA TCAAGAAGAA GATGCAGATG CTGAAACTGG ACAAGGAGAA TGCCATCGAC 
CGCGCGGAGC AGGCCGAAGC CGACAAAAAG CAAGCTGAAG ACCGATGCAA GCAGCTGGAG 
GAAGAGCAGC AGGCCCTCCA GAAGAAGCTG AAGGGGACAG AGGACGAGGT GGAAAAGTAT 
TCCGAGTCCG TGAAGGATGC CCAGGAGAAA CTGGAGCAGG CTGAGAAGAA GGCCACCGAC 
GCTGAAGCAG ATGTGGCCTC TCTGAACCGC CGCATTCAGC TCGTAGAGGA GGAGTTGGAT 
CGGGCACAGG AGCGCCTGGC TACAGCCTTG CAAAAGCTGG AGGAGGCTGA GAAAGCCGCG 
GATGAGAGCG AGAGAGGAAT GAAGGTCATT GAAAACCGGG CCATGAAGGA TGAGGAAAAG 
ATGGAGCTGC AGGAGATGCA GCTGAAGGAA GCCAAGCACA TCGCTGAGGA CTCAGACCGC 
AAATATGAGG AGGTGGCCAG GAAGCTGGTG ATCCTGGAAG GGGAGCTGGA GCGCTCGGAA 
GAGAGAGCCG AGGTGGCTGA GAGTAAATGT GGGGACCTAG AGGAGGAGCT GAAAATTGTT 
ACCAACAACT TGAAATCCCT GGAAGCCCAA GCGGACAAGT ATTCCACCAA AGAGGACAAA 
TACGAAGAAG AGATCAAACT TCTGGAGGAG AAGCTGAAAG AGGCTGAGAC CCGAGCAGAG 
TTTGCTGAAA GATCTGTGGC AAAGTTGGAG AAAACCATTG ATGATCTGGA AGAGACTTTG 
GCCAGTGCCA AGGAAGAGAA CGTGGAGATA CACCAGACCT TGGACCAGAC CCTTCTGGAA 
CTCAACAACC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tpm2 ( NM_009416.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033442.2 Mus musculus tropomyosin 2, beta (Tpm2), transcript variant Tpm2.2, mRNA.

Price & Availability↑

CloneID	OMu17820
Clone ID Related Accession (Same CDS sequence)	NM_009416.4
Accession Version	NM_009416.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Mus musculus(house mouse)
Product	tropomyosin beta chain isoform Tpm2.2st
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY786644.1, AK003186.1 and AK132162.1. On Apr 25, 2013 this sequence version replaced NM_009416.3. Transcript Variant: This variant (Tpm2.2, also known as variant 1) represents the longest transcript and encodes isoform Tpm2.2st (also known as isoform 1), which is of the same size as isoforms Tpm2.1sm/cy and Tpm2.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M81086.1, AK003186.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGCCA TCAAGAAGAA GATGCAGATG CTGAAACTGG ACAAGGAGAA TGCCATCGAC 
CGCGCGGAGC AGGCCGAAGC CGACAAAAAG CAAGCTGAAG ACCGATGCAA GCAGCTGGAG 
GAAGAGCAGC AGGCCCTCCA GAAGAAGCTG AAGGGGACAG AGGACGAGGT GGAAAAGTAT 
TCCGAGTCCG TGAAGGATGC CCAGGAGAAA CTGGAGCAGG CTGAGAAGAA GGCCACCGAC 
GCTGAAGCAG ATGTGGCCTC TCTGAACCGC CGCATTCAGC TCGTAGAGGA GGAGTTGGAT 
CGGGCACAGG AGCGCCTGGC TACAGCCTTG CAAAAGCTGG AGGAGGCTGA GAAAGCCGCG 
GATGAGAGCG AGAGAGGAAT GAAGGTCATT GAAAACCGGG CCATGAAGGA TGAGGAAAAG 
ATGGAGCTGC AGGAGATGCA GCTGAAGGAA GCCAAGCACA TCGCTGAGGA CTCAGACCGC 
AAATATGAGG AGGTGGCCAG GAAGCTGGTG ATCCTGGAAG GGGAGCTGGA GCGCTCGGAA 
GAGAGAGCCG AGGTGGCTGA GAGTAAATGT GGGGACCTAG AGGAGGAGCT GAAAATTGTT 
ACCAACAACT TGAAATCCCT GGAAGCCCAA GCGGACAAGT ATTCCACCAA AGAGGACAAA 
TACGAAGAAG AGATCAAACT TCTGGAGGAG AAGCTGAAAG AGGCTGAGAC CCGAGCAGAG 
TTTGCTGAAA GATCTGTGGC AAAGTTGGAG AAAACCATTG ATGATCTGGA AGATGAAGTC 
TATGCACAGA AGATGAAGTA CAAGGCCATC AGCGAGGAGC TGGACAACGC ACTCAATGAC 
ATCACTTCCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033442.2
CDS	201..1055
Translation	MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKDAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL

Target ORF information:

RefSeq Version	NM_009416.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus tropomyosin 2, beta (Tpm2), transcript variant Tpm2.2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009416.4

ORF Insert Sequence:

ATGGACGCCA TCAAGAAGAA GATGCAGATG CTGAAACTGG ACAAGGAGAA TGCCATCGAC 
CGCGCGGAGC AGGCCGAAGC CGACAAAAAG CAAGCTGAAG ACCGATGCAA GCAGCTGGAG 
GAAGAGCAGC AGGCCCTCCA GAAGAAGCTG AAGGGGACAG AGGACGAGGT GGAAAAGTAT 
TCCGAGTCCG TGAAGGATGC CCAGGAGAAA CTGGAGCAGG CTGAGAAGAA GGCCACCGAC 
GCTGAAGCAG ATGTGGCCTC TCTGAACCGC CGCATTCAGC TCGTAGAGGA GGAGTTGGAT 
CGGGCACAGG AGCGCCTGGC TACAGCCTTG CAAAAGCTGG AGGAGGCTGA GAAAGCCGCG 
GATGAGAGCG AGAGAGGAAT GAAGGTCATT GAAAACCGGG CCATGAAGGA TGAGGAAAAG 
ATGGAGCTGC AGGAGATGCA GCTGAAGGAA GCCAAGCACA TCGCTGAGGA CTCAGACCGC 
AAATATGAGG AGGTGGCCAG GAAGCTGGTG ATCCTGGAAG GGGAGCTGGA GCGCTCGGAA 
GAGAGAGCCG AGGTGGCTGA GAGTAAATGT GGGGACCTAG AGGAGGAGCT GAAAATTGTT 
ACCAACAACT TGAAATCCCT GGAAGCCCAA GCGGACAAGT ATTCCACCAA AGAGGACAAA 
TACGAAGAAG AGATCAAACT TCTGGAGGAG AAGCTGAAAG AGGCTGAGAC CCGAGCAGAG 
TTTGCTGAAA GATCTGTGGC AAAGTTGGAG AAAACCATTG ATGATCTGGA AGATGAAGTC 
TATGCACAGA AGATGAAGTA CAAGGCCATC AGCGAGGAGC TGGACAACGC ACTCAATGAC 
ATCACTTCCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tpm2 ( XM_006537780.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006537843.1 Mus musculus tropomyosin 2, beta (Tpm2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu32848
Clone ID Related Accession (Same CDS sequence)	XM_006537780.1
Accession Version	XM_006537780.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	tropomyosin beta chain isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACGCCA TCAAGAAGAA GATGCAGATG CTGAAACTGG ACAAGGAGAA TGCCATCGAC 
CGCGCGGAGC AGGCCGAAGC CGACAAAAAG CAAGCTGAAG ACCGATGCAA GCAGCTGGAG 
GAAGAGCAGC AGGCCCTCCA GAAGAAGCTG AAGGGGACAG AGGACGAGGT GGAAAAGTAT 
TCCGAGTCCG TGAAGGATGC CCAGGAGAAA CTGGAGCAGG CTGAGAAGAA GGCCACCGAC 
GCTGAAGCAG ATGTGGCCTC TCTGAACCGC CGCATTCAGC TCGTAGAGGA GGAGTTGGAT 
CGGGCACAGG AGCGCCTGGC TACAGCCTTG CAAAAGCTGG AGGAGGCTGA GAAAGCCGCG 
GATGAGAGCG AGAGAGGAAT GAAGGTCATT GAAAACCGGG CCATGAAGGA TGAGGAAAAG 
ATGGAGCTGC AGGAGATGCA GCTGAAGGAA GCCAAGCACA TCGCTGAGGA CTCAGACCGC 
AAATATGAGG AGGTGGCCAG GAAGCTGGTG ATCCTGGAAG GGGAGCTGGA GCGCTCGGAA 
GAGAGAGCCG AGGTGGCTGA GAGCCGAGCC AGACAGCTGG AGGAGGAGCT TCGAACCATG 
GACCAAGCCC TCAAGTCGCT GATAGCCTCA GAGGAGGAGT ATTCCACCAA AGAGGACAAA 
TACGAAGAAG AGATCAAACT TCTGGAGGAG AAGCTGAAAG AGGCTGAGAC CCGAGCAGAG 
TTTGCTGAAA GATCTGTGGC AAAGTTGGAG AAAACCATTG ATGATCTGGA AGATGAAGTC 
TATGCACAGA AGATGAAGTA CAAGGCCATC AGCGAGGAGC TGGACAACGC ACTCAATGAC 
ATCACTTCCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006537843.1
CDS	230..1084
Translation	MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKDAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESRARQLEEELRTMDQALKSLIASEEEYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL

Target ORF information:

RefSeq Version	XM_006537780.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus tropomyosin 2, beta (Tpm2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006537780.1

ORF Insert Sequence:

ATGGACGCCA TCAAGAAGAA GATGCAGATG CTGAAACTGG ACAAGGAGAA TGCCATCGAC 
CGCGCGGAGC AGGCCGAAGC CGACAAAAAG CAAGCTGAAG ACCGATGCAA GCAGCTGGAG 
GAAGAGCAGC AGGCCCTCCA GAAGAAGCTG AAGGGGACAG AGGACGAGGT GGAAAAGTAT 
TCCGAGTCCG TGAAGGATGC CCAGGAGAAA CTGGAGCAGG CTGAGAAGAA GGCCACCGAC 
GCTGAAGCAG ATGTGGCCTC TCTGAACCGC CGCATTCAGC TCGTAGAGGA GGAGTTGGAT 
CGGGCACAGG AGCGCCTGGC TACAGCCTTG CAAAAGCTGG AGGAGGCTGA GAAAGCCGCG 
GATGAGAGCG AGAGAGGAAT GAAGGTCATT GAAAACCGGG CCATGAAGGA TGAGGAAAAG 
ATGGAGCTGC AGGAGATGCA GCTGAAGGAA GCCAAGCACA TCGCTGAGGA CTCAGACCGC 
AAATATGAGG AGGTGGCCAG GAAGCTGGTG ATCCTGGAAG GGGAGCTGGA GCGCTCGGAA 
GAGAGAGCCG AGGTGGCTGA GAGCCGAGCC AGACAGCTGG AGGAGGAGCT TCGAACCATG 
GACCAAGCCC TCAAGTCGCT GATAGCCTCA GAGGAGGAGT ATTCCACCAA AGAGGACAAA 
TACGAAGAAG AGATCAAACT TCTGGAGGAG AAGCTGAAAG AGGCTGAGAC CCGAGCAGAG 
TTTGCTGAAA GATCTGTGGC AAAGTTGGAG AAAACCATTG ATGATCTGGA AGATGAAGTC 
TATGCACAGA AGATGAAGTA CAAGGCCATC AGCGAGGAGC TGGACAACGC ACTCAATGAC 
ATCACTTCCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A systematic nomenclature for mammalian tropomyosin isoforms.
Journal of muscle research and cell motility36(2)147-53(2015 Apr)
Geeves MA,Hitchcock-DeGregori SE,Gunning PW

Vertebrate tropomyosin: distribution, properties and function.
Journal of muscle research and cell motility22(1)5-49(2001)
Perry SV

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Tpm2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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