Tnnc1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tnnc1
Entrez Gene ID	21924
Full Name	troponin C, cardiac/slow skeletal
Synonyms	AI874626,TnC,cTnC,cTnI,tncc
General protein information	Preferred Names troponin C, cardiac/slow skeletal Names troponin C, slow skeletal and cardiac muscles TN-C
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14 B\|14 19.09 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009393.3	NP_033419.1	troponin C, slow skeletal and cardiac muscles
NM_009393.2	NP_033419.1	troponin C, slow skeletal and cardiac muscles

Pathways from BioSystems

Homologies

	LOC697047	XP_001085656.2
Canis lupus familiaris (dog)	TNNC1	XP_005632514.1
Homo sapiens (human)	TNNC1	NP_003271.1
Xenopus tropicalis (tropical clawed frog)	tnnc1	NP_001004776.1
Bos taurus (cattle)	TNNC1	NP_001029523.1
Rattus norvegicus (Norway rat)	Tnnc1	NP_001029277.1
Gallus gallus (chicken)	TNNC1	NP_990464.1
Pan troglodytes (chimpanzee)	TNNC1	XP_003950175.1
Mus musculus (house mouse)	Tnnc1	NP_033419.1
Danio rerio (zebrafish)	tnnc1a	NP_852475.2

Gene Ontology
Bibliography

Related articles in PubMed

Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.
Dossat AM, Sanchez-Gonzalez MA, Koutnik AP, Leitner S, Ruiz EL, Griffin B, Rosenberg JT, Grant SC, Fincham FD, Pinto JR, Kabbaj M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(6)2492-2506(2017 06)

Dominant-negative
Villani R, Hodgson S, Legrand J, Greaney J, Wong HY, Pichol-Thievend C, Adolphe C, Wainwight B, Francois M, Khosrotehrani K
Development (Cambridge, England)144(10)1887-1895(2017 05)

Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle.
Sakakibara I, Wurmser M, Dos Santos M, Santolini M, Ducommun S, Davaze R, Guernec A, Sakamoto K, Maire P
Skeletal muscle6(1)30(2016)

HIRA Is Required for Heart Development and Directly Regulates Tnni2 and Tnnt3.
Dilg D, Saleh RN, Phelps SE, Rose Y, Dupays L, Murphy C, Mohun T, Anderson RH, Scambler PJ, Chapgier AL
PloS one11(8)e0161096(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle.
Title: Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle.

A region in cTnC associated with increased Ca(2+) sensitivity in skinned fibers was identified, an the F27W reporter mutation affected Ca(2+) sensitivity, maximal force, and ATPase activation of some mutants.
Title: Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.

These results demonstrate that the L29Q mutation enhances the Ca(2+)-binding characteristics of cTnC and that when incorporated into cardiac myocytes, this mutant alters myocyte contractility.
Title: Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility.

Overexpression of sTnC polypeptide in muscle cells is controlled by its rapid degradation.
Title: Overexpression of sTnC polypeptide in muscle cells is controlled by its rapid degradation.

The following Tnnc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tnnc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu04064	NM_009393.3 Latest version!	Mus musculus troponin C, cardiac/slow skeletal (Tnnc1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu04064	NM_009393.2	Mus musculus troponin C, cardiac/slow skeletal (Tnnc1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tnnc1 ( NM_009393.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033419.1 Mus musculus troponin C, cardiac/slow skeletal (Tnnc1), mRNA.

Price & Availability↑

CloneID	OMu04064
Clone ID Related Accession (Same CDS sequence)	NM_009393.3 , NM_009393.2
Accession Version	NM_009393.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-27
Organism	Mus musculus(house mouse)
Product	troponin C, slow skeletal and cardiac muscles
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC108416.5. On Apr 17, 2018 this sequence version replaced NM_009393.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M29793.1, CB596418.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGACA TCTACAAAGC TGCGGTAGAA CAGTTGACAG AGGAGCAGAA GAATGAGTTC 
AAGGCTGCCT TTGATATCTT TGTCCTGGGC GCGGAGGATG GCTGCATCAG CACCAAGGAG 
CTGGGCAAGG TGATGAGGAT GCTGGGCCAG AACCCCACAC CTGAGGAGCT GCAGGAGATG 
ATTGACGAAG TAGACGAGGA TGGCAGTGGC ACAGTGGACT TCGATGAGTT TCTTGTCATG 
ATGGTTCGGT GCATGAAGGA CGACAGCAAA GGGAAGTCTG AGGAGGAGCT GTCGGATCTC 
TTCCGCATGT TTGACAAAAA CGCTGATGGC TACATTGACT TAGATGAGCT GAAGATGATG 
CTGCAGGCCA CAGGTGAGAC CATTACGGAA GATGACATTG AAGAGCTCAT GAAGGACGGT 
GACAAGAACA ACGATGGCCG AATTGACTAT GACGAGTTCC TGGAATTCAT GAAGGGTGTG 
GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033419.1
CDS	44..529
Translation	MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKMMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE

Target ORF information:

RefSeq Version	NM_009393.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus troponin C, cardiac/slow skeletal (Tnnc1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009393.3

ORF Insert Sequence:

ATGGATGACA TCTACAAAGC TGCGGTAGAA CAGTTGACAG AGGAGCAGAA GAATGAGTTC 
AAGGCTGCCT TTGATATCTT TGTCCTGGGC GCGGAGGATG GCTGCATCAG CACCAAGGAG 
CTGGGCAAGG TGATGAGGAT GCTGGGCCAG AACCCCACAC CTGAGGAGCT GCAGGAGATG 
ATTGACGAAG TAGACGAGGA TGGCAGTGGC ACAGTGGACT TCGATGAGTT TCTTGTCATG 
ATGGTTCGGT GCATGAAGGA CGACAGCAAA GGGAAGTCTG AGGAGGAGCT GTCGGATCTC 
TTCCGCATGT TTGACAAAAA CGCTGATGGC TACATTGACT TAGATGAGCT GAAGATGATG 
CTGCAGGCCA CAGGTGAGAC CATTACGGAA GATGACATTG AAGAGCTCAT GAAGGACGGT 
GACAAGAACA ACGATGGCCG AATTGACTAT GACGAGTTCC TGGAATTCAT GAAGGGTGTG 
GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tnnc1 ( NM_009393.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033419.1 Mus musculus troponin C, cardiac/slow skeletal (Tnnc1), mRNA.

Price & Availability↑

CloneID	OMu04064
Clone ID Related Accession (Same CDS sequence)	NM_009393.3 , NM_009393.2
Accession Version	NM_009393.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Mus musculus(house mouse)
Product	troponin C, slow skeletal and cardiac muscles
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC108416.5. On Mar 21, 2007 this sequence version replaced NM_009393.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M29793.1, CA459998.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGATGACA TCTACAAAGC TGCGGTAGAA CAGTTGACAG AGGAGCAGAA GAATGAGTTC 
AAGGCTGCCT TTGATATCTT TGTCCTGGGC GCGGAGGATG GCTGCATCAG CACCAAGGAG 
CTGGGCAAGG TGATGAGGAT GCTGGGCCAG AACCCCACAC CTGAGGAGCT GCAGGAGATG 
ATTGACGAAG TAGACGAGGA TGGCAGTGGC ACAGTGGACT TCGATGAGTT TCTTGTCATG 
ATGGTTCGGT GCATGAAGGA CGACAGCAAA GGGAAGTCTG AGGAGGAGCT GTCGGATCTC 
TTCCGCATGT TTGACAAAAA CGCTGATGGC TACATTGACT TAGATGAGCT GAAGATGATG 
CTGCAGGCCA CAGGTGAGAC CATTACGGAA GATGACATTG AAGAGCTCAT GAAGGACGGT 
GACAAGAACA ACGATGGCCG AATTGACTAT GACGAGTTCC TGGAATTCAT GAAGGGTGTG 
GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033419.1
CDS	44..529
Translation	MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKMMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE

Target ORF information:

RefSeq Version	NM_009393.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus troponin C, cardiac/slow skeletal (Tnnc1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009393.2

ORF Insert Sequence:

ATGGATGACA TCTACAAAGC TGCGGTAGAA CAGTTGACAG AGGAGCAGAA GAATGAGTTC 
AAGGCTGCCT TTGATATCTT TGTCCTGGGC GCGGAGGATG GCTGCATCAG CACCAAGGAG 
CTGGGCAAGG TGATGAGGAT GCTGGGCCAG AACCCCACAC CTGAGGAGCT GCAGGAGATG 
ATTGACGAAG TAGACGAGGA TGGCAGTGGC ACAGTGGACT TCGATGAGTT TCTTGTCATG 
ATGGTTCGGT GCATGAAGGA CGACAGCAAA GGGAAGTCTG AGGAGGAGCT GTCGGATCTC 
TTCCGCATGT TTGACAAAAA CGCTGATGGC TACATTGACT TAGATGAGCT GAAGATGATG 
CTGCAGGCCA CAGGTGAGAC CATTACGGAA GATGACATTG AAGAGCTCAT GAAGGACGGT 
GACAAGAACA ACGATGGCCG AATTGACTAT GACGAGTTCC TGGAATTCAT GAAGGGTGTG 
GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(6)2492-2506(2017 06)
Dossat AM,Sanchez-Gonzalez MA,Koutnik AP,Leitner S,Ruiz EL,Griffin B,Rosenberg JT,Grant SC,Fincham FD,Pinto JR,Kabbaj M

Dominant-negative
Development (Cambridge, England)144(10)1887-1895(2017 05)
Villani R,Hodgson S,Legrand J,Greaney J,Wong HY,Pichol-Thievend C,Adolphe C,Wainwight B,Francois M,Khosrotehrani K

Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle.
Skeletal muscle6(1)30(2016)
Sakakibara I,Wurmser M,Dos Santos M,Santolini M,Ducommun S,Davaze R,Guernec A,Sakamoto K,Maire P

HIRA Is Required for Heart Development and Directly Regulates Tnni2 and Tnnt3.
PloS one11(8)e0161096(2016)
Dilg D,Saleh RN,Phelps SE,Rose Y,Dupays L,Murphy C,Mohun T,Anderson RH,Scambler PJ,Chapgier AL

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Tnnc1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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