Nmur2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nmur2
Entrez Gene ID	216749
Full Name	neuromedin U receptor 2
Synonyms	Nmu2r
General protein information	Preferred Names neuromedin U receptor 2 Names neuromedin-U receptor 2 NMU-R2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 B1.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_153079.4	NP_694719.2	neuromedin-U receptor 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	NMUR2	NP_064552.3
Bos taurus (cattle)	NMUR2	NP_001030220.1
Drosophila melanogaster (fruit fly)	capaR	NP_996140.1
Caenorhabditis elegans (roundworm)	nmur-1	NP_509515.2
Mus musculus (house mouse)	Nmur2	NP_694719.2
Gallus gallus (chicken)	NMUR2	XP_425209.2
Xenopus tropicalis (tropical clawed frog)	nmur2	XP_002940961.1
Danio rerio (zebrafish)	LOC566750	XP_695127.2
Pan troglodytes (chimpanzee)	NMUR2	XP_527091.1
Rattus norvegicus (Norway rat)	Nmur2	NP_071611.3
Canis lupus familiaris (dog)	NMUR2	XP_546288.1

Gene Ontology
Bibliography

Related articles in PubMed

Neuromedin U receptor 2 does not play a role in the development of neuropathic pain following nerve injury in mice.
Gilbert AK, Puma C, Xu X, Laird JM
European journal of pain (London, England)17(8)1147-55(2013 Sep)

The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.
Rao SM, Auger JL, Gaillard P, Weissleder R, Wada E, Torres R, Kojima M, Benoist C, Mathis D, Binstadt BA
Arthritis research & therapy14(1)R29(2012 Feb)

Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice.
Egecioglu E, Ploj K, Xu X, Bjursell M, Salom? N, Andersson N, Ohlsson C, Taube M, Hansson C, Bohlooly-Y M, Morgan DG, Dickson SL
American journal of physiology. Endocrinology and metabolism297(3)E708-16(2009 Sep)

Appetite-modifying actions of pro-neuromedin U-derived peptides.
Bechtold DA, Ivanov TR, Luckman SM
American journal of physiology. Endocrinology and metabolism297(2)E545-51(2009 Aug)

The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2).
Peier A, Kosinski J, Cox-York K, Qian Y, Desai K, Feng Y, Trivedi P, Hastings N, Marsh DJ
Endocrinology150(7)3101-9(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The present data do not support a significant contribution of NMUR2 to the development of hypersensitivity after nerve injury or tissue inflammation
Title: Neuromedin U receptor 2 does not play a role in the development of neuropathic pain following nerve injury in mice.

Data show that deficiency of neuromedin receptors NMUR1 and NMUR2 had no impact on arthritis severity.
Title: The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.

Long-term central NMU treatment reduces body weight, food intake, and adiposity and that central NMUR2 signaling is required for these effects in female but not male mice.
Title: Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice.

the pro-nociceptive effects of neuromedin U in mice appear to be mediated through NMUR2, not NMUR1
Title: Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses.

Plays a more significant role in central pain processing than other brain functions including stress/anxiety and regulation of feeding.
Title: Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding.

The following Nmur2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nmur2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19631	NM_153079.4 Latest version!	Mus musculus neuromedin U receptor 2 (Nmur2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nmur2 ( NM_153079.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_694719.2 Mus musculus neuromedin U receptor 2 (Nmur2), mRNA.

Price & Availability↑

CloneID	OMu19631
Clone ID Related Accession (Same CDS sequence)	NM_153079.4
Accession Version	NM_153079.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	neuromedin-U receptor 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL671969.39. On May 1, 2007 this sequence version replaced NM_153079.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036756.1, BC137611.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGGGAAAAC TTGAAAATGC TTCCTGGATC CACGATTCTC TCATGAAGTA CTTGAACAGC 
ACAGAGGAGT ACTTGGCCTA CCTGTGTGGA CCCAAGCGCA GTGACCTATC CCTTCCAGTG 
TCTGTGGTCT ATGCGCTGAT CTTCGTGGTG GGGGTGATAG GCAATCTTCT GGTGTGCCTG 
GTGATTGCCC GACATCAAAC TTTGAAGACA CCCACCAACT ACTATCTCTT CAGCTTGGCA 
GTCTCAGACT TGCTGGTCCT GCTCTTAGGT ATGCCACTGG AGGTCTACGA GTTGTGGCAC 
AATTATCCCT TCCTGTTTGG GCCGGTGGGA TGCTACTTCA AGACAGCCCT TTTCGAGACT 
GTGTGCTTTG CCTCCATTCT CAGTGTCACC ACGGTTAGCA TTGAGCGCTA CGTGGCCATT 
GTCCATCCGT TCCGAGCCAA GCTGGAGAGC ACACGGCGAC GGGCCCTCAG GATCCTCAGC 
CTAGTCTGGA GCTTCTCTGT GGTCTTTTCT TTGCCCAACA CCAGCATCCA TGGCATCAAG 
TTCCAGCAGT TTCCCAACGG GTCCTCTGTG CCCGGCTCTG CCACCTGCAC AGTCACCAAA 
CCCATATGGG TGTATAACTT CATCATCCAA GCTACCTCCT TCCTCTTCTA CATCCTCCCG 
ATGACCCTCA TCAGCGTCCT CTACTATCTC ATGGGGCTCA GGCTGAAGAG AGATGAATCT 
CTTGAGGCAG ACAAAGTGAC TGTGAATATT CACAGACCCT CCAGAAAATC AGTCACCAAG 
ATGCTGTTTG TCTTGGTCCT CGTGTTTGCT ATCTGTTGGA CCCCTTTCCA TGTGGACAGG 
CTCTTCTTCA GCTTTGTGGA CGAGTGGACT GAGTCCCTGG CTGCTGTGTT CAACCTCATC 
CACGTGGTAT CAGGTGTCTT TTTCTATCTG AGCTCCGCTG TCAACCCCAT TATATATAAC 
CTCCTGTCTC GGCGCTTCCG GGCGGCCTTT CGGAATGTTG TCTCTCCTTC CTGCAAATGG 
TGCCATCCCC AGCATCGCCC ACAGGGGCCT CCAGCCCAGA AGGTTATCTT CTTGACAGAA 
TGCCACCTTG TGGAGCTGAC AGAGGATGCG GGCCCCCAGT TCCCTTGTCA GTCATCCATC 
CACAACACCC AACTTACCAC CGTCCCCTGT GTTGAAGAGG TACCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694719.2
CDS	105..1292
Translation	MGKLENASWIHDSLMKYLNSTEEYLAYLCGPKRSDLSLPVSVVYALIFVVGVIGNLLVCLVIARHQTLKTPTNYYLFSLAVSDLLVLLLGMPLEVYELWHNYPFLFGPVGCYFKTALFETVCFASILSVTTVSIERYVAIVHPFRAKLESTRRRALRILSLVWSFSVVFSLPNTSIHGIKFQQFPNGSSVPGSATCTVTKPIWVYNFIIQATSFLFYILPMTLISVLYYLMGLRLKRDESLEADKVTVNIHRPSRKSVTKMLFVLVLVFAICWTPFHVDRLFFSFVDEWTESLAAVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRAAFRNVVSPSCKWCHPQHRPQGPPAQKVIFLTECHLVELTEDAGPQFPCQSSIHNTQLTTVPCVEEVP

Target ORF information:

RefSeq Version	NM_153079.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus neuromedin U receptor 2 (Nmur2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153079.4

ORF Insert Sequence:

ATGGGAAAAC TTGAAAATGC TTCCTGGATC CACGATTCTC TCATGAAGTA CTTGAACAGC 
ACAGAGGAGT ACTTGGCCTA CCTGTGTGGA CCCAAGCGCA GTGACCTATC CCTTCCAGTG 
TCTGTGGTCT ATGCGCTGAT CTTCGTGGTG GGGGTGATAG GCAATCTTCT GGTGTGCCTG 
GTGATTGCCC GACATCAAAC TTTGAAGACA CCCACCAACT ACTATCTCTT CAGCTTGGCA 
GTCTCAGACT TGCTGGTCCT GCTCTTAGGT ATGCCACTGG AGGTCTACGA GTTGTGGCAC 
AATTATCCCT TCCTGTTTGG GCCGGTGGGA TGCTACTTCA AGACAGCCCT TTTCGAGACT 
GTGTGCTTTG CCTCCATTCT CAGTGTCACC ACGGTTAGCA TTGAGCGCTA CGTGGCCATT 
GTCCATCCGT TCCGAGCCAA GCTGGAGAGC ACACGGCGAC GGGCCCTCAG GATCCTCAGC 
CTAGTCTGGA GCTTCTCTGT GGTCTTTTCT TTGCCCAACA CCAGCATCCA TGGCATCAAG 
TTCCAGCAGT TTCCCAACGG GTCCTCTGTG CCCGGCTCTG CCACCTGCAC AGTCACCAAA 
CCCATATGGG TGTATAACTT CATCATCCAA GCTACCTCCT TCCTCTTCTA CATCCTCCCG 
ATGACCCTCA TCAGCGTCCT CTACTATCTC ATGGGGCTCA GGCTGAAGAG AGATGAATCT 
CTTGAGGCAG ACAAAGTGAC TGTGAATATT CACAGACCCT CCAGAAAATC AGTCACCAAG 
ATGCTGTTTG TCTTGGTCCT CGTGTTTGCT ATCTGTTGGA CCCCTTTCCA TGTGGACAGG 
CTCTTCTTCA GCTTTGTGGA CGAGTGGACT GAGTCCCTGG CTGCTGTGTT CAACCTCATC 
CACGTGGTAT CAGGTGTCTT TTTCTATCTG AGCTCCGCTG TCAACCCCAT TATATATAAC 
CTCCTGTCTC GGCGCTTCCG GGCGGCCTTT CGGAATGTTG TCTCTCCTTC CTGCAAATGG 
TGCCATCCCC AGCATCGCCC ACAGGGGCCT CCAGCCCAGA AGGTTATCTT CTTGACAGAA 
TGCCACCTTG TGGAGCTGAC AGAGGATGCG GGCCCCCAGT TCCCTTGTCA GTCATCCATC 
CACAACACCC AACTTACCAC CGTCCCCTGT GTTGAAGAGG TACCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neuromedin U receptor 2 does not play a role in the development of neuropathic pain following nerve injury in mice.
European journal of pain (London, England)17(8)1147-55(2013 Sep)
Gilbert AK,Puma C,Xu X,Laird JM

The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.
Arthritis research & therapy14(1)R29(2012 Feb)
Rao SM,Auger JL,Gaillard P,Weissleder R,Wada E,Torres R,Kojima M,Benoist C,Mathis D,Binstadt BA

Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice.
American journal of physiology. Endocrinology and metabolism297(3)E708-16(2009 Sep)
Egecioglu E,Ploj K,Xu X,Bjursell M,Salom? N,Andersson N,Ohlsson C,Taube M,Hansson C,Bohlooly-Y M,Morgan DG,Dickson SL

Appetite-modifying actions of pro-neuromedin U-derived peptides.
American journal of physiology. Endocrinology and metabolism297(2)E545-51(2009 Aug)
Bechtold DA,Ivanov TR,Luckman SM

The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2).
Endocrinology150(7)3101-9(2009 Jul)
Peier A,Kosinski J,Cox-York K,Qian Y,Desai K,Feng Y,Trivedi P,Hastings N,Marsh DJ

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Nmur2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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