Rap1b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rap1b
Entrez Gene ID	215449
Full Name	RAS related protein 1b
Synonyms	2810443E11Rik
General protein information	Preferred Names RAS related protein 1b Names ras-related protein Rap-1b GTP-binding protein smg p21B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 D2

mRNA and Protein(s)

mRNA	Protein	Name
NM_024457.2	NP_077777.1	ras-related protein Rap-1b

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	rap1b	NP_955827.1
Rattus norvegicus (Norway rat)	Rap1b	NP_599173.2
Homo sapiens (human)	RAP1B	NP_056461.1
Pan troglodytes (chimpanzee)	RAP1B	NP_001092015.1
Mus musculus (house mouse)	Rap1b	NP_077777.1
Gallus gallus (chicken)	RAP1B	NP_001007853.1
Saccharomyces cerevisiae (baker's yeast)	RSR1	NP_011668.3
Kluyveromyces lactis	KLLA0C12001g	XP_452736.1
Xenopus tropicalis (tropical clawed frog)	rap1b	NP_001008195.1
Canis lupus familiaris (dog)	RAP1B	XP_851250.1
	RAP1B	XP_001117189.1
Bos taurus (cattle)	RAP1B	NP_787018.1
Caenorhabditis elegans (roundworm)	rap-1	NP_501549.1

Gene Ontology
Bibliography

Related articles in PubMed

Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X
eLife7(2018 Jan)

PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors.
Zhao XF, Kohen R, Parent R, Duan Y, Fisher GL, Korn MJ, Ji L, Wan G, Jin J, P?schel AW, Dolan DF, Parent JM, Corfas G, Murphy GG, Giger RJ
Cell reports22(2)456-470(2018 Jan)

Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier.
Lakshmikanthan S, Sobczak M, Li Calzi S, Shaw L, Grant MB, Chrzanowska-Wodnicka M
Journal of cell science131(1)(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings reveal key roles for the bidirectional synaptic expression of the Rap1b small GTPase and an associated local synaptic protein translation network in this process.
Title: Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling.

Rap1 deficiency impaired T-cell homeostasis.
Title: Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis.

These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.
Title: SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.

Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature
Title: Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature.

Rap1b deficiency promoted the transcellular route of diapedesis through endothelial cell. Increased transcellular migration of Rap1b-deficient neutrophils in vitro was selectively mediated by enhanced PI3K-Akt activation and invadopodia-like protrusions.
Title: The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation.

The following Rap1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rap1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15756	NM_024457.2 Latest version!	Mus musculus RAS related protein 1b (Rap1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rap1b ( NM_024457.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_077777.1 Mus musculus RAS related protein 1b (Rap1b), mRNA.

Price & Availability↑

CloneID	OMu15756
Clone ID Related Accession (Same CDS sequence)	NM_024457.2
Accession Version	NM_024457.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	ras-related protein Rap-1b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU848028.1, CK793274.1, CO803632.1, AK180095.1 and BY369341.1. On Nov 10, 2006 this sequence version replaced NM_024457.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052480.1, SRR1660811.134610.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164133 [ECO:0000348] ##Evidence-Data-END##

ATGCGTGAAT ATAAGCTCGT CGTGCTTGGA TCAGGAGGCG TTGGGAAGTC AGCCCTGACT 
GTACAGTTTG TTCAAGGAAT TTTTGTTGAA AAATATGATC CTACGATAGA AGATTCTTAT 
AGAAAGCAAG TTGAAGTAGA TGCACAGCAG TGTATGCTTG AAATCTTGGA CACTGCAGGA 
ACGGAGCAAT TCACAGCCAT GAGGGACCTG TACATGAAGA ACGGACAAGG CTTCGCTCTG 
GTTTACTCCA TCACAGCACA GTCGACATTT AACGACTTAC AAGATCTAAG AGAGCAGATT 
CTGCGGGTTA AAGACACTGA TGATGTTCCA ATGATTCTGG TTGGCAATAA ATGCGACTTG 
GAAGATGAAA GAGTTGTAGG AAAGGAACAA GGTCAGAACC TAGCAAGACA GTGGAACAAC 
TGTGCATTCT TAGAATCCTC TGCAAAGTCC AAAATAAATG TTAATGAGAT CTTTTATGAC 
CTAGTGCGGC AAATTAACAG AAAAACTCCA GTGCCTGGGA AGGCCCGCAA AAAGTCATCG 
TGTCAGCTGC TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077777.1
CDS	169..723
Translation	MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQLL

Target ORF information:

RefSeq Version	NM_024457.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus RAS related protein 1b (Rap1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024457.2

ORF Insert Sequence:

ATGCGTGAAT ATAAGCTCGT CGTGCTTGGA TCAGGAGGCG TTGGGAAGTC AGCCCTGACT 
GTACAGTTTG TTCAAGGAAT TTTTGTTGAA AAATATGATC CTACGATAGA AGATTCTTAT 
AGAAAGCAAG TTGAAGTAGA TGCACAGCAG TGTATGCTTG AAATCTTGGA CACTGCAGGA 
ACGGAGCAAT TCACAGCCAT GAGGGACCTG TACATGAAGA ACGGACAAGG CTTCGCTCTG 
GTTTACTCCA TCACAGCACA GTCGACATTT AACGACTTAC AAGATCTAAG AGAGCAGATT 
CTGCGGGTTA AAGACACTGA TGATGTTCCA ATGATTCTGG TTGGCAATAA ATGCGACTTG 
GAAGATGAAA GAGTTGTAGG AAAGGAACAA GGTCAGAACC TAGCAAGACA GTGGAACAAC 
TGTGCATTCT TAGAATCCTC TGCAAAGTCC AAAATAAATG TTAATGAGAT CTTTTATGAC 
CTAGTGCGGC AAATTAACAG AAAAACTCCA GTGCCTGGGA AGGCCCGCAA AAAGTCATCG 
TGTCAGCTGC TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
eLife7(2018 Jan)
Collins TN,Mao Y,Li H,Bouaziz M,Hong A,Feng GS,Wang F,Quilliam LA,Chen L,Park T,Curran T,Zhang X

PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors.
Cell reports22(2)456-470(2018 Jan)
Zhao XF,Kohen R,Parent R,Duan Y,Fisher GL,Korn MJ,Ji L,Wan G,Jin J,P?schel AW,Dolan DF,Parent JM,Corfas G,Murphy GG,Giger RJ

Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier.
Journal of cell science131(1)(2018 Jan)
Lakshmikanthan S,Sobczak M,Li Calzi S,Shaw L,Grant MB,Chrzanowska-Wodnicka M

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Rap1b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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