Strap cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Strap
Entrez Gene ID	20901
Full Name	serine/threonine kinase receptor associated protein
Synonyms	AW557906,C78091,C79202,Unrip
General protein information	Preferred Names serine/threonine kinase receptor associated protein Names serine-threonine kinase receptor-associated protein UNR-interacting protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 G1

mRNA and Protein(s)

mRNA	Protein	Name
NM_011499.3	NP_035629.2	serine-threonine kinase receptor-associated protein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	STRAP	XP_543790.1
Mus musculus (house mouse)	Strap	NP_035629.2
Danio rerio (zebrafish)	strap	NP_956598.1
Pan troglodytes (chimpanzee)	STRAP	XP_001159216.2
Rattus norvegicus (Norway rat)	Strap	NP_001011969.1
Xenopus tropicalis (tropical clawed frog)	strap	NP_001120495.1
Homo sapiens (human)	STRAP	NP_009109.3
Bos taurus (cattle)	STRAP	NP_001015567.1
Drosophila melanogaster (fruit fly)	wmd	NP_611804.1
Arabidopsis thaliana (thale cress)	AT1G15470	NP_563978.1
Gallus gallus (chicken)	STRAP	NP_001006247.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005029	XP_001688468.1

Gene Ontology
Bibliography

Related articles in PubMed

STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway.
Jin L, Vu T, Yuan G, Datta PK
Cancer research77(20)5464-5478(2017 Oct)

STRAP positively regulates TLR3-triggered signaling pathway.
Huh HD, Lee E, Shin J, Park B, Lee S
Cellular immunology31855-60(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that STRAP is a positive regulator of the TLR3-meditated NF-kappaB and IRF signaling pathway
Title: STRAP positively regulates TLR3-triggered signaling pathway.

findings indicate serine/threonine kinase receptor associated protein (STRAP) is expressed in the mouse ovary and is capable of regulating development of small follicles in a stage-dependent manner
Title: Serine threonine kinase receptor associated protein regulates early follicle development in the mouse ovary.

these results suggest that STRAP increases invasion and metastasis of colorectal cancer partly through inhibiting ubiquitin-dependent degradation of beta-catenin and promoting Wnt/beta-catenin signaling
Title: Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/?-catenin signaling.

STRAP Ser(188) phosphorylation in the liver is tightly associated with cell death and proliferation through ASK1, TGF-beta, p53, and PI3K/PDK1 pathways, resulting in apoptotic cell death.
Title: A crucial role for the phosphorylation of STRAP at Ser(188) by MPK38 in STRAP-dependent cell death through ASK1, TGF-?, p53, and PI3K/PDK1 signaling pathways.

Data indicate serine-threonine kinase receptor-associated protein (STRAP) as a novel regulator of the coordinated translation of collagen alpha1(I) and alpha2(I) mRNAs.
Title: Serine-threonine kinase receptor-associated protein (STRAP) regulates translation of type I collagen mRNAs.

The following Strap gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Strap cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21151	NM_011499.3 Latest version!	Mus musculus serine/threonine kinase receptor associated protein (Strap), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Strap ( NM_011499.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035629.2 Mus musculus serine/threonine kinase receptor associated protein (Strap), mRNA.

Price & Availability↑

CloneID	OMu21151
Clone ID Related Accession (Same CDS sequence)	NM_011499.3
Accession Version	NM_011499.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Mus musculus(house mouse)
Product	serine-threonine kinase receptor-associated protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK147179.1 and AK145971.1. On Nov 20, 2007 this sequence version replaced NM_011499.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147179.1, AK154158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCATGA GGCAGACGCC GCTCACTTGC TCGGGCCACA CGCGGCCCGT GGTGGATTTG 
GCCTTCAGCG GCATCACGCC TTACGGCTAC TTTCTGATCA GCGCTTGCAA AGATGGCAAG 
CCCATGCTCC GCCAGGGAGA TACAGGAGAC TGGATTGGAA CATTTTTGGG TCATAAAGGT 
GCTGTTTGGG GTGCAACATT GAATAAGGAT GCCACCAAAG CTGCGACAGC AGCTGCAGAC 
TTCACAGCCA AAGTATGGGA TGCGGTCTCA GGAGATGAAT TGATGACCCT GGCTCATAAG 
CACATTGTCA AGACTGTGGA TTTCACACAG GATAGCAATT ACCTGCTAAC TGGGGGACAG 
GATAAACTGC TGCGCATATA TGACTTGAAC AAACCTGAAG CAGAACCTAA GGAAATCAGT 
GGCCACACTT CTGGTATTAA AAAGGCTCTG TGGTGCAGTG ACGATAAACA GATCCTTTCA 
GCGGATGATA AAACTGTTCG GCTCTGGGAT CATGCCACAA TGACAGAAGT GAAATCTCTG 
AATTTTAATA TGTCTGTTAG CAGCATGGAG TATATTCCTG AAGGAGAGAT TTTGGTTATT 
ACTTATGGAC GATCTATTGC TTTTCATAGT GCAGTAAGTC TGGAGCCAAT TAAATCCTTT 
GAAGCTCCTG CGACCATCAA TTCTGCGTCT CTTCATCCAG AGAAGGAGTT TCTTGTTGCG 
GGTGGAGAAG ACTTTAAACT GTACAAGTAT GATTATAACA GTGGAGAAGA GTTAGAATCC 
TACAAAGGTC ACTTTGGTCC CATTCACTGT GTGAGATTCA GTCCTGATGG GGAACTCTAT 
GCCAGCGGTT CTGAAGATGG GACATTGAGA TTGTGGCAAA CTGTGGTAGG AAAGACCTAT 
GGCCTGTGGA AATGCGTGCT TCCTGAGGAA GACAGCGGGG AACTGGCAAA GCCAAAGATC 
GGATTTCCAG AAACAGCAGA GGAAGAGCTG GAAGAAATTG CTTCAGAGAA TTCAGATTCC 
ATCTATTCAT CAACTCCTGA AGTTAAGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035629.2
CDS	274..1326
Translation	MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSDDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLEPIKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETAEEELEEIASENSDSIYSSTPEVKA

Target ORF information:

RefSeq Version	NM_011499.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus serine/threonine kinase receptor associated protein (Strap), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011499.3

ORF Insert Sequence:

ATGGCCATGA GGCAGACGCC GCTCACTTGC TCGGGCCACA CGCGGCCCGT GGTGGATTTG 
GCCTTCAGCG GCATCACGCC TTACGGCTAC TTTCTGATCA GCGCTTGCAA AGATGGCAAG 
CCCATGCTCC GCCAGGGAGA TACAGGAGAC TGGATTGGAA CATTTTTGGG TCATAAAGGT 
GCTGTTTGGG GTGCAACATT GAATAAGGAT GCCACCAAAG CTGCGACAGC AGCTGCAGAC 
TTCACAGCCA AAGTATGGGA TGCGGTCTCA GGAGATGAAT TGATGACCCT GGCTCATAAG 
CACATTGTCA AGACTGTGGA TTTCACACAG GATAGCAATT ACCTGCTAAC TGGGGGACAG 
GATAAACTGC TGCGCATATA TGACTTGAAC AAACCTGAAG CAGAACCTAA GGAAATCAGT 
GGCCACACTT CTGGTATTAA AAAGGCTCTG TGGTGCAGTG ACGATAAACA GATCCTTTCA 
GCGGATGATA AAACTGTTCG GCTCTGGGAT CATGCCACAA TGACAGAAGT GAAATCTCTG 
AATTTTAATA TGTCTGTTAG CAGCATGGAG TATATTCCTG AAGGAGAGAT TTTGGTTATT 
ACTTATGGAC GATCTATTGC TTTTCATAGT GCAGTAAGTC TGGAGCCAAT TAAATCCTTT 
GAAGCTCCTG CGACCATCAA TTCTGCGTCT CTTCATCCAG AGAAGGAGTT TCTTGTTGCG 
GGTGGAGAAG ACTTTAAACT GTACAAGTAT GATTATAACA GTGGAGAAGA GTTAGAATCC 
TACAAAGGTC ACTTTGGTCC CATTCACTGT GTGAGATTCA GTCCTGATGG GGAACTCTAT 
GCCAGCGGTT CTGAAGATGG GACATTGAGA TTGTGGCAAA CTGTGGTAGG AAAGACCTAT 
GGCCTGTGGA AATGCGTGCT TCCTGAGGAA GACAGCGGGG AACTGGCAAA GCCAAAGATC 
GGATTTCCAG AAACAGCAGA GGAAGAGCTG GAAGAAATTG CTTCAGAGAA TTCAGATTCC 
ATCTATTCAT CAACTCCTGA AGTTAAGGCC TGA