Sstr4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sstr4
Entrez Gene ID	20608
Full Name	somatostatin receptor 4
Synonyms	Smstr4,sst4
General protein information	Preferred Names somatostatin receptor 4 Names somatostatin receptor type 4 SS-4-R SS4-R SS4R
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 G3\|2 73.44 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009219.3	NP_033245.2	somatostatin receptor type 4

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sstr4	NP_037168.1
Gallus gallus (chicken)	SSTR4	NP_001026689.1
Mus musculus (house mouse)	Sstr4	NP_033245.2
Drosophila melanogaster (fruit fly)	AlCR2	NP_001262015.1
Anopheles gambiae (African malaria mosquito)	GPRSMS	XP_320274.2
Homo sapiens (human)	SSTR4	NP_001043.2
Pan troglodytes (chimpanzee)	SSTR4	XP_525282.1
Danio rerio (zebrafish)	LOC557645	XP_005172275.1
Xenopus tropicalis (tropical clawed frog)	LOC100496787	XP_004914786.1
	SSTR4	XP_001095303.1

Gene Ontology
Bibliography

Related articles in PubMed

Roles of Hippocampal Somatostatin Receptor Subtypes in Stress Response and Emotionality.
Pr?v?t TD, Gastambide F, Viollet C, Henkous N, Martel G, Epelbaum J, B?racoch?a D, Guillou JL
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology42(8)1647-1656(2017 Jul)

Higher susceptibility of somatostatin 4 receptor gene-deleted mice to chronic stress-induced behavioral and neuroendocrine alterations.
Scheich B, Csek? K, Borb?ly ?, ?brah?m I, Csernus V, Gaszner B, Helyes Z
Neuroscience346320-336(2017 Mar)

Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models.
Scheich B, Gaszner B, Kormos V, L?szl? K, ?dori C, Borb?ly ?, Hajna Z, T?kus V, B?lcskei K, ?brah?m I, Pint?r E, Szolcs?nyi J, Helyes Z
Neuropharmacology101204-15(2016 Feb)

Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.
Radojevic V, Bodmer D
Cell and tissue research358(3)717-27(2014 Dec)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study provides first evidence that somatostatin 4 receptor activation is involved in the behavioral and neuroendocrine alterations induced by chronic stress with a crucial role of plastic changes in the amygdala.
Title: Higher susceptibility of somatostatin 4 receptor gene-deleted mice to chronic stress-induced behavioral and neuroendocrine alterations.

The results of this study revealed that sst4 mediates anxiolytic and antidepressant-like effects by enhancing the stress-responsiveness of several brain regions with special emphasis on the amygdala.
Title: Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models.

The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported.
Title: Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.

SSTR4 and delta-Opioid receptor (dOR) exist in a heteromeric complex and function in synergistic manner.
Title: ?-opioid receptor and somatostatin receptor-4 heterodimerization: possible implications in modulation of pain associated signaling.

SSTR4-like immunoreactivity increases in ApoD(-/) mice in all major nuclei of hypothalamus, median eminence, and ependymal cells of third ventricle.
Title: Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain.

The following Sstr4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sstr4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58244	NM_009219.3 Latest version!	Mus musculus somatostatin receptor 4 (Sstr4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sstr4 ( NM_009219.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033245.2 Mus musculus somatostatin receptor 4 (Sstr4), mRNA.

Price & Availability↑

CloneID	OMu58244
Clone ID Related Accession (Same CDS sequence)	NM_009219.3
Accession Version	NM_009219.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	somatostatin receptor type 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK051189.1 and CB522494.1. On Mar 23, 2007 this sequence version replaced NM_009219.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGAACGCGC CAGCAACTCT GCCTCCGGGG GTCGAGGACA CCACCTGGAC CCCTGGGATC 
AACGCCAGCT GGGCTCCGGA CGAGGAGGAG GAGGATGCGA TGGGGTCCGA CGGCACAGGG 
ACAGCGGGCA TGGTCACTAT CCAGTGCATC TATGCGCTCG TGTGTCTGGT GGGCCTGGTG 
GGAAACGCCC TGGTCATCTT CGTGATCCTA CGCTATGCCA AGATGAAGAC AGCCACCAAC 
ATCTACCTAC TCAACCTGGC CGTCGCCGAT GAGCTCTTCA TGCTCAGCGT GCCATTCGTG 
GCCTCGGCGG CTGCCCTGCG CCACTGGCCG TTCGGGGCGG TGCTGTGTCG CGCAGTGCTT 
AGCGTGGACG GCCTGAACAT GTTCACTAGT GTCTTCTGCC TCACCGTGCT CAGCGTGGAC 
CGCTATGTGG CTGTTGTGCA CCCTCTGCGC GCCGCCACCT ACCGGCGGCC CAGCGTGGCC 
AAGCTAATCA ACCTGGGAGT GTGGCTAGCA TCCTTGCTGG TCACCCTGCC CATCGCAGTC 
TTCGCTGACA CCAGGCCAGC TCGTGGGGGC GAGGCCGTGG CTTGCAACCT GCACTGGCCT 
CACCCGGCCT GGTCTGCGGT CTTTGTGATC TATACTTTTT TGTTGGGCTT CCTACTCCCG 
GTTCTGGCCA TCGGATTATG CTACCTGCTT ATTGTGGGCA AGATGCGCGC TGTGGCCCTG 
CGGGCTGGCT GGCAACAACG GAGGCGCTCA GAGAAGAAGA TCACTAGGCT CGTGCTAATG 
GTGGTGACCG TCTTTGTGCT ATGCTGGATG CCTTTCTATG TGGTGCAGCT TCTGAACCTG 
TTTGTCACCA GCCTCGATGC CACTGTCAAC CATGTGTCCC TCATCCTGAG CTATGCCAAC 
AGCTGTGCCA ATCCCATTCT CTATGGCTTC CTCTCTGACA ACTTCCGGCG CTCTTTCCAG 
CGGGTTCTGT GCCTGCGCTG CTGTCTCCTG GAAACAACTG GAGGTGCTGA GGAAGAGCCC 
CTGGACTACT ATGCCACTGC TCTCAAAAGC AGAGGGGGTG CAGGATGCAT ATGCCCTCCT 
CTGCCCTGCC AGCAGGAGCC CGTGCAAGCA GAACCTGGCT GCAAGCAAGT CCCTTTCACC 
AAGACCACTA CTTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033245.2
CDS	95..1252
Translation	MNAPATLPPGVEDTTWTPGINASWAPDEEEEDAMGSDGTGTAGMVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEEEPLDYYATALKSRGGAGCICPPLPCQQEPVQAEPGCKQVPFTKTTTF

Target ORF information:

RefSeq Version	NM_009219.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus somatostatin receptor 4 (Sstr4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009219.3

ORF Insert Sequence:

ATGAACGCGC CAGCAACTCT GCCTCCGGGG GTCGAGGACA CCACCTGGAC CCCTGGGATC 
AACGCCAGCT GGGCTCCGGA CGAGGAGGAG GAGGATGCGA TGGGGTCCGA CGGCACAGGG 
ACAGCGGGCA TGGTCACTAT CCAGTGCATC TATGCGCTCG TGTGTCTGGT GGGCCTGGTG 
GGAAACGCCC TGGTCATCTT CGTGATCCTA CGCTATGCCA AGATGAAGAC AGCCACCAAC 
ATCTACCTAC TCAACCTGGC CGTCGCCGAT GAGCTCTTCA TGCTCAGCGT GCCATTCGTG 
GCCTCGGCGG CTGCCCTGCG CCACTGGCCG TTCGGGGCGG TGCTGTGTCG CGCAGTGCTT 
AGCGTGGACG GCCTGAACAT GTTCACTAGT GTCTTCTGCC TCACCGTGCT CAGCGTGGAC 
CGCTATGTGG CTGTTGTGCA CCCTCTGCGC GCCGCCACCT ACCGGCGGCC CAGCGTGGCC 
AAGCTAATCA ACCTGGGAGT GTGGCTAGCA TCCTTGCTGG TCACCCTGCC CATCGCAGTC 
TTCGCTGACA CCAGGCCAGC TCGTGGGGGC GAGGCCGTGG CTTGCAACCT GCACTGGCCT 
CACCCGGCCT GGTCTGCGGT CTTTGTGATC TATACTTTTT TGTTGGGCTT CCTACTCCCG 
GTTCTGGCCA TCGGATTATG CTACCTGCTT ATTGTGGGCA AGATGCGCGC TGTGGCCCTG 
CGGGCTGGCT GGCAACAACG GAGGCGCTCA GAGAAGAAGA TCACTAGGCT CGTGCTAATG 
GTGGTGACCG TCTTTGTGCT ATGCTGGATG CCTTTCTATG TGGTGCAGCT TCTGAACCTG 
TTTGTCACCA GCCTCGATGC CACTGTCAAC CATGTGTCCC TCATCCTGAG CTATGCCAAC 
AGCTGTGCCA ATCCCATTCT CTATGGCTTC CTCTCTGACA ACTTCCGGCG CTCTTTCCAG 
CGGGTTCTGT GCCTGCGCTG CTGTCTCCTG GAAACAACTG GAGGTGCTGA GGAAGAGCCC 
CTGGACTACT ATGCCACTGC TCTCAAAAGC AGAGGGGGTG CAGGATGCAT ATGCCCTCCT 
CTGCCCTGCC AGCAGGAGCC CGTGCAAGCA GAACCTGGCT GCAAGCAAGT CCCTTTCACC 
AAGACCACTA CTTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Roles of Hippocampal Somatostatin Receptor Subtypes in Stress Response and Emotionality.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology42(8)1647-1656(2017 Jul)
Pr?v?t TD,Gastambide F,Viollet C,Henkous N,Martel G,Epelbaum J,B?racoch?a D,Guillou JL

Higher susceptibility of somatostatin 4 receptor gene-deleted mice to chronic stress-induced behavioral and neuroendocrine alterations.
Neuroscience346320-336(2017 Mar)
Scheich B,Csek? K,Borb?ly ?,?brah?m I,Csernus V,Gaszner B,Helyes Z

Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models.
Neuropharmacology101204-15(2016 Feb)
Scheich B,Gaszner B,Kormos V,L?szl? K,?dori C,Borb?ly ?,Hajna Z,T?kus V,B?lcskei K,?brah?m I,Pint?r E,Szolcs?nyi J,Helyes Z

Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.
Cell and tissue research358(3)717-27(2014 Dec)
Radojevic V,Bodmer D

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Sstr4 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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