Slc3a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc3a1
Entrez Gene ID	20532
Full Name	solute carrier family 3, member 1
Synonyms	D2H,NBAT,NTAA,RBAT
General protein information	Preferred Names solute carrier family 3, member 1 Names neutral and basic amino acid transport protein rBAT b(0,+)-type amino acid transport protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 E4\|17 55.17 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009205.2	NP_033231.2	neutral and basic amino acid transport protein rBAT

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC3A1	NP_000332.2
Danio rerio (zebrafish)	slc3a1	XP_685969.3
Bos taurus (cattle)	SLC3A1	NP_001029805.1
Mus musculus (house mouse)	Slc3a1	NP_033231.2
Gallus gallus (chicken)	SLC3A1	XP_426125.3
Neurospora crassa	NCU06523	XP_961795.1
Canis lupus familiaris (dog)	SLC3A1	NP_001003109.1
Drosophila melanogaster (fruit fly)	Mal-B1	NP_609522.1
Drosophila melanogaster (fruit fly)	Mal-B2	NP_609523.2
Pan troglodytes (chimpanzee)	SLC3A1	XP_515443.2
	SLC3A1	XP_001112327.2
Magnaporthe oryzae (rice blast fungus)	MGG_07547	XP_003711461.1
Xenopus tropicalis (tropical clawed frog)	slc3a1	NP_001072903.1
Rattus norvegicus (Norway rat)	Slc3a1	NP_058912.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008965	XP_319713.4

Gene Ontology
Bibliography

Related articles in PubMed

?-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria.
Zee T, Bose N, Zee J, Beck JN, Yang S, Parihar J, Yang M, Damodar S, Hall D, O'Leary MN, Ramanathan A, Gerona RR, Killilea DW, Chi T, Tischfield J, Sahota A, Kahn A, Stoller ML, Kapahi P
Nature medicine23(3)288-290(2017 Mar)

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1.
Nagamori S, Wiriyasermkul P, Guarch ME, Okuyama H, Nakagomi S, Tadagaki K, Nishinaka Y, Bodoy S, Takafuji K, Okuda S, Kurokawa J, Ohgaki R, Nunes V, Palac?n M, Kanai Y
Proceedings of the National Academy of Sciences of the United States of America113(3)775-80(2016 Jan)

Novel cystine ester mimics for the treatment of cystinuria-induced urolithiasis in a knockout mouse model.
Sahota A, Parihar JS, Capaccione KM, Yang M, Noll K, Gordon D, Reimer D, Yang I, Buckley BT, Polunas M, Reuhl KR, Lewis MR, Ward MD, Goldfarb DS, Tischfield JA
Urology84(5)1249.e9-15(2014 Nov)

An animal model of type A cystinuria due to spontaneous mutation in 129S2/SvPasCrl mice.
Livrozet M, Vandermeersch S, Mesnard L, Thioulouse E, Jaubert J, Boffa JJ, Haymann JP, Baud L, Bazin D, Daudon M, Letavernier E
PloS one9(7)e102700(2014)

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Templin JS, Bang SJ, Soiza-Reilly M, Berde CB, Commons KG
Brain research14571-12(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a membrane protein AGT1/SLC7A13 is the second partner of rBAT.
Title: Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1.

In 129S2/SvPasCrl mice, the heavy subunit RBAT of the tetrameric transporter of dibasic amino acids was absent in proximal tubules and identified was a single pathogenic mutation in a highly conserved region of the Slc3a1 gene.
Title: An animal model of type A cystinuria due to spontaneous mutation in 129S2/SvPasCrl mice.

This study demonistrated that slc3a1 gene expression in mouse dorsal raphe nucleus
Title: Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.

Slc3A1-deficient mice develop cystinuria type I
Title: A mouse model for cystinuria type I.

a decreasing expression gradient of heterodimeric rBAT-b(0,+)AT along the proximal tubule is responsible for virtually all apical cystine reabsorption
Title: rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney.

The following Slc3a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc3a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14723	NM_009205.2 Latest version!	Mus musculus solute carrier family 3, member 1 (Slc3a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc3a1 ( NM_009205.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033231.2 Mus musculus solute carrier family 3, member 1 (Slc3a1), mRNA.

Price & Availability↑

CloneID	OMu14723
Clone ID Related Accession (Same CDS sequence)	NM_009205.2
Accession Version	NM_009205.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2058bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	neutral and basic amino acid transport protein rBAT
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA493293.1, AK132275.1 and AI326967.1. On Dec 8, 2006 this sequence version replaced NM_009205.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D88533.1, AK132275.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849378, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGAGG ACAAAGGCAA GAGAGACCCC ATCCAAATGA GTTTGAAGGG ATGCCGAACC 
AATAACGGGT TTGTCCAAAA TGAAGACATT CCGGAGCAGG ACCCAGACCC AGGCTCCAGG 
GACACCCCAC AGCCCAACGC CGTGAGTATC CCTGCTCCAG AGGAGCCTCA CCTAAAGGCG 
GTGCGGCCCT ATGCAGGGAT GCCCAAGGAA GTACTCTTCC AGTTCTCCGG CCAGGCTCGC 
TACCGGGTGC CCCGAGAGAT CCTCTTCTGG CTCACCGTGG TTTCCGTGTT CCTGCTCATT 
GGAGCCACCA TAGCCATCAT CGTCATCTCT CCAAAATGCC TTGACTGGTG GCAAGCAGGT 
CCCATATACC AGATCTACCC GAGGTCTTTT AAGGACAGTG ACAAGGATGG GAATGGAGAC 
CTGAAAGGTA TCCAGGAGAA GCTGGACTAT ATCACTGCTT TAAACATAAA GACTCTTTGG 
ATCACTTCCT TTTATAAATC ATCTTTGAAA GACTTCAGAT ACGCTGTTGA GGATTTCAAA 
GAAATTGACC CTATTTTTGG AACAATGAAA GATTTTGAGA ATTTGGTTGC TGCCATCCAT 
GACAAAGGTT TAAAATTAAT AATTGATTTC ATACCAAACC ACACTAGTGA CAAACATCCT 
TGGTTCCAAT CGAGTAGGAC ACGGAGCGGA AAATACACCG ATTACTACAT CTGGCACAAC 
TGTACCCATG TCAACGGTGT AACCACCCCT CCCAACAACT GGCTGAGTGT GTATGGAAAC 
TCCAGCTGGC ACTTTGATGA AGTACGAAAG CAATGTTATT TTCACCAGTT TTTGAAAGAG 
CAACCAGATT TAAATTTCCG AAATCCTGCT GTTCAAGAGG AAATAAAGGA AATAATAACG 
TTCTGGCTCT CGAAGGGTGT TGATGGGTTT AGTTTTGATG CAGTTAAATT TCTTCTGGAA 
GCGAAGGATC TGAGAAATGA AATCCAAGTG AATACATCCC AAATTCCGGA CACGGTCACC 
CACTACTCAG AGCTGTACCA TGACTTCACC ACAACTCAGG TGGGAATGCA TGACATCGTC 
CGAGACTTCC GGCAGACCAT GAACCAGTAC AGCAGGGAGC CTGGCAGATA CCGGTTCATG 
GGGGCCGAAG CCTCAGCTGA GAGCATCGAG AGGACCATGA TGTACTATGG CTTGCCATTT 
ATCCAGGAAG CCGACTTTCC TTTCAACAAG TACTTCACCA CAATAGGCAC TCTCTCTGGG 
CATACTGTCT ATGAAGTTAT CACATCCTGG ATGGAAAACA TGCCTGAAGG AAAATGGCCC 
AATTGGATGA CTGGCGGACC GGAGACTCCT CGGCTGACTT CTCGAGTAGG GAGTGAGTAT 
GTCAACGCCA TGCACATGCT CCTGTTCACA CTCCCGGGAA CGCCCATCAC TTACTATGGA 
GAGGAAATCG GGATGGGAGA CATTTCCGTT ACAAATTTCA ACGAGAGCTA TGATAGTACT 
ACCCTTGTCT CCAAGTCACC GATGCAGTGG GACAATAGTT CCAATGCTGG GTTTACTGAG 
GCCAACCACA CCTGGCTACC CACAAACTCT GACTACCACA CCGTCAATGT GGATGTCCAA 
AAGACCCAGC CGAGCTCAGC ACTGAGGCTG TATCAGGATC TGAGTCTACT CCATGCCACA 
GAGCTGGTCC TCAGCCGGGG CTGGTTTTGC CTCTTGAGAG ACGACAGTCA CTCTGTGGTG 
TACACAAGAG AGCTGGACGG CATAGATAAC GTCTTCCTCG TGGTTCTGAA TTTTGGAGAA 
TCATCAACTG TGCTAAATCT ACAGGGGATC ATTTCAGATC TTCCTCCAGA GCTGAGAATA 
AGGTTAAGTA CCAACTCAGC CTCCAAAGGC AGTGCTGTTG ACACCCGTGC CATTTCTCTG 
GAGAAGGGAG AGGGCCTGGT CTTGGAGCAC AGCACGAAGG CTCCCCTCCA TCAGCAGGCC 
GCTTTCAGAG ACAGATGCTT TGTTTCCAGT CGGGCGTGCT ACTCCAGTGC ACTGGACATC 
CTCTATAGCT CGTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033231.2
CDS	86..2143
Translation	MDEDKGKRDPIQMSLKGCRTNNGFVQNEDIPEQDPDPGSRDTPQPNAVSIPAPEEPHLKAVRPYAGMPKEVLFQFSGQARYRVPREILFWLTVVSVFLLIGATIAIIVISPKCLDWWQAGPIYQIYPRSFKDSDKDGNGDLKGIQEKLDYITALNIKTLWITSFYKSSLKDFRYAVEDFKEIDPIFGTMKDFENLVAAIHDKGLKLIIDFIPNHTSDKHPWFQSSRTRSGKYTDYYIWHNCTHVNGVTTPPNNWLSVYGNSSWHFDEVRKQCYFHQFLKEQPDLNFRNPAVQEEIKEIITFWLSKGVDGFSFDAVKFLLEAKDLRNEIQVNTSQIPDTVTHYSELYHDFTTTQVGMHDIVRDFRQTMNQYSREPGRYRFMGAEASAESIERTMMYYGLPFIQEADFPFNKYFTTIGTLSGHTVYEVITSWMENMPEGKWPNWMTGGPETPRLTSRVGSEYVNAMHMLLFTLPGTPITYYGEEIGMGDISVTNFNESYDSTTLVSKSPMQWDNSSNAGFTEANHTWLPTNSDYHTVNVDVQKTQPSSALRLYQDLSLLHATELVLSRGWFCLLRDDSHSVVYTRELDGIDNVFLVVLNFGESSTVLNLQGIISDLPPELRIRLSTNSASKGSAVDTRAISLEKGEGLVLEHSTKAPLHQQAAFRDRCFVSSRACYSSALDILYSSC

Target ORF information:

RefSeq Version	NM_009205.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 3, member 1 (Slc3a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009205.2

ORF Insert Sequence:

ATGGATGAGG ACAAAGGCAA GAGAGACCCC ATCCAAATGA GTTTGAAGGG ATGCCGAACC 
AATAACGGGT TTGTCCAAAA TGAAGACATT CCGGAGCAGG ACCCAGACCC AGGCTCCAGG 
GACACCCCAC AGCCCAACGC CGTGAGTATC CCTGCTCCAG AGGAGCCTCA CCTAAAGGCG 
GTGCGGCCCT ATGCAGGGAT GCCCAAGGAA GTACTCTTCC AGTTCTCCGG CCAGGCTCGC 
TACCGGGTGC CCCGAGAGAT CCTCTTCTGG CTCACCGTGG TTTCCGTGTT CCTGCTCATT 
GGAGCCACCA TAGCCATCAT CGTCATCTCT CCAAAATGCC TTGACTGGTG GCAAGCAGGT 
CCCATATACC AGATCTACCC GAGGTCTTTT AAGGACAGTG ACAAGGATGG GAATGGAGAC 
CTGAAAGGTA TCCAGGAGAA GCTGGACTAT ATCACTGCTT TAAACATAAA GACTCTTTGG 
ATCACTTCCT TTTATAAATC ATCTTTGAAA GACTTCAGAT ACGCTGTTGA GGATTTCAAA 
GAAATTGACC CTATTTTTGG AACAATGAAA GATTTTGAGA ATTTGGTTGC TGCCATCCAT 
GACAAAGGTT TAAAATTAAT AATTGATTTC ATACCAAACC ACACTAGTGA CAAACATCCT 
TGGTTCCAAT CGAGTAGGAC ACGGAGCGGA AAATACACCG ATTACTACAT CTGGCACAAC 
TGTACCCATG TCAACGGTGT AACCACCCCT CCCAACAACT GGCTGAGTGT GTATGGAAAC 
TCCAGCTGGC ACTTTGATGA AGTACGAAAG CAATGTTATT TTCACCAGTT TTTGAAAGAG 
CAACCAGATT TAAATTTCCG AAATCCTGCT GTTCAAGAGG AAATAAAGGA AATAATAACG 
TTCTGGCTCT CGAAGGGTGT TGATGGGTTT AGTTTTGATG CAGTTAAATT TCTTCTGGAA 
GCGAAGGATC TGAGAAATGA AATCCAAGTG AATACATCCC AAATTCCGGA CACGGTCACC 
CACTACTCAG AGCTGTACCA TGACTTCACC ACAACTCAGG TGGGAATGCA TGACATCGTC 
CGAGACTTCC GGCAGACCAT GAACCAGTAC AGCAGGGAGC CTGGCAGATA CCGGTTCATG 
GGGGCCGAAG CCTCAGCTGA GAGCATCGAG AGGACCATGA TGTACTATGG CTTGCCATTT 
ATCCAGGAAG CCGACTTTCC TTTCAACAAG TACTTCACCA CAATAGGCAC TCTCTCTGGG 
CATACTGTCT ATGAAGTTAT CACATCCTGG ATGGAAAACA TGCCTGAAGG AAAATGGCCC 
AATTGGATGA CTGGCGGACC GGAGACTCCT CGGCTGACTT CTCGAGTAGG GAGTGAGTAT 
GTCAACGCCA TGCACATGCT CCTGTTCACA CTCCCGGGAA CGCCCATCAC TTACTATGGA 
GAGGAAATCG GGATGGGAGA CATTTCCGTT ACAAATTTCA ACGAGAGCTA TGATAGTACT 
ACCCTTGTCT CCAAGTCACC GATGCAGTGG GACAATAGTT CCAATGCTGG GTTTACTGAG 
GCCAACCACA CCTGGCTACC CACAAACTCT GACTACCACA CCGTCAATGT GGATGTCCAA 
AAGACCCAGC CGAGCTCAGC ACTGAGGCTG TATCAGGATC TGAGTCTACT CCATGCCACA 
GAGCTGGTCC TCAGCCGGGG CTGGTTTTGC CTCTTGAGAG ACGACAGTCA CTCTGTGGTG 
TACACAAGAG AGCTGGACGG CATAGATAAC GTCTTCCTCG TGGTTCTGAA TTTTGGAGAA 
TCATCAACTG TGCTAAATCT ACAGGGGATC ATTTCAGATC TTCCTCCAGA GCTGAGAATA 
AGGTTAAGTA CCAACTCAGC CTCCAAAGGC AGTGCTGTTG ACACCCGTGC CATTTCTCTG 
GAGAAGGGAG AGGGCCTGGT CTTGGAGCAC AGCACGAAGG CTCCCCTCCA TCAGCAGGCC 
GCTTTCAGAG ACAGATGCTT TGTTTCCAGT CGGGCGTGCT ACTCCAGTGC ACTGGACATC 
CTCTATAGCT CGTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

?-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria.
Nature medicine23(3)288-290(2017 Mar)
Zee T,Bose N,Zee J,Beck JN,Yang S,Parihar J,Yang M,Damodar S,Hall D,O'Leary MN,Ramanathan A,Gerona RR,Killilea DW,Chi T,Tischfield J,Sahota A,Kahn A,Stoller ML,Kapahi P

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1.
Proceedings of the National Academy of Sciences of the United States of America113(3)775-80(2016 Jan)
Nagamori S,Wiriyasermkul P,Guarch ME,Okuyama H,Nakagomi S,Tadagaki K,Nishinaka Y,Bodoy S,Takafuji K,Okuda S,Kurokawa J,Ohgaki R,Nunes V,Palac?n M,Kanai Y

Novel cystine ester mimics for the treatment of cystinuria-induced urolithiasis in a knockout mouse model.
Urology84(5)1249.e9-15(2014 Nov)
Sahota A,Parihar JS,Capaccione KM,Yang M,Noll K,Gordon D,Reimer D,Yang I,Buckley BT,Polunas M,Reuhl KR,Lewis MR,Ward MD,Goldfarb DS,Tischfield JA

An animal model of type A cystinuria due to spontaneous mutation in 129S2/SvPasCrl mice.
PloS one9(7)e102700(2014)
Livrozet M,Vandermeersch S,Mesnard L,Thioulouse E,Jaubert J,Boffa JJ,Haymann JP,Baud L,Bazin D,Daudon M,Letavernier E

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Brain research14571-12(2012 May)
Templin JS,Bang SJ,Soiza-Reilly M,Berde CB,Commons KG

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Slc3a1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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