Siah1b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Siah1b
Entrez Gene ID	20438
Full Name	siah E3 ubiquitin protein ligase 1B
Synonyms	AA960570,Sinh1b,siah-1b
General protein information	Preferred Names siah E3 ubiquitin protein ligase 1B Names E3 ubiquitin-protein ligase SIAH1B RING-type E3 ubiquitin transferase SIAH1B drosophila seven-in-absentia gene product homolog seven in absentia 1B seven in absentia homolog 1b
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X F5\|X 76.11 cM
Summary	This gene encodes a member of the seven in absentia homolog (Siah) family of E3 ubiquitin ligase enzymes that catalyze the transfer of ubiquitin to substrate proteins. The encoded protein targets Pard3A (partitioning defective 3A) protein for proteasome-mediated degradation during the exit of cerebellar granule neurons from their germinal zone niche. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001308386.1	NP_001295315.1	E3 ubiquitin-protein ligase SIAH1B
NM_009173.2	NP_033199.1	E3 ubiquitin-protein ligase SIAH1B
NM_001308385.1	NP_001295314.1	E3 ubiquitin-protein ligase SIAH1B

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Siah1b	NP_033199.1
Arabidopsis thaliana (thale cress)	AT2G41980	NP_181729.1
Oryza sativa (rice)	Os02g0128800	NP_001045773.1
Arabidopsis thaliana (thale cress)	SINAT2	NP_191363.1

Gene Ontology
Bibliography

Related articles in PubMed

Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.
Famulski JK, Trivedi N, Howell D, Yang Y, Tong Y, Gilbertson R, Solecki DJ
Science (New York, N.Y.)330(6012)1834-8(2010 Dec)

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.
Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P, Eppig JJ, Solter D, Knowles BB
Genes & development20(19)2713-27(2006 Oct)

Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis.
Xu Z, Sproul A, Wang W, Kukekov N, Greene LA
The Journal of biological chemistry281(1)303-12(2006 Jan)

Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter.
Fiucci G, Beaucourt S, Duflaut D, Lespagnol A, Stumptner-Cuvelette P, G?ant A, Buchwalter G, Tuynder M, Susini L, Lassalle JM, Wasylyk C, Wasylyk B, Oren M, Amson R, Telerman A
Proceedings of the National Academy of Sciences of the United States of America101(10)3510-5(2004 Mar)

Normal p53 function in primary cells deficient for Siah genes.
Frew IJ, Dickins RA, Cuddihy AR, Del Rosario M, Reinhard C, O'Connell MJ, Bowtell DD
Molecular and cellular biology22(23)8155-64(2002 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings define a Siah-Pard3A signaling pathway that controls adhesion-dependent exit of neuronal progenitors or immature neurons from a germinal zone niche
Title: Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.

Siah1 is a binding partner for POSH (plenty of SH3s), a scaffold component of the apoptotic JNK pathway
Title: Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis.

Results from loss-of-function experiments do not support a general role for Siah genes in p53-mediated responses or mitosis.
Title: Normal p53 function in primary cells deficient for Siah genes.

The following Siah1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Siah1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu03665	NM_001308386.1 Latest version!	Mus musculus siah E3 ubiquitin protein ligase 1B (Siah1b), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu03665	NM_009173.2 Latest version!	Mus musculus siah E3 ubiquitin protein ligase 1B (Siah1b), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu03665	NM_001308385.1 Latest version!	Mus musculus siah E3 ubiquitin protein ligase 1B (Siah1b), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Siah1b ( NM_001308386.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001295315.1 Mus musculus siah E3 ubiquitin protein ligase 1B (Siah1b), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu03665
Clone ID Related Accession (Same CDS sequence)	NM_001308386.1 , NM_009173.2 , NM_001308385.1
Accession Version	NM_001308386.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase SIAH1B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC052887.1, AL732294.18 and DV648408.1. On May 5, 2015 this sequence version replaced XM_006528768.2. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052887.1, SRR1660815.449475.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCGTC AGGCTGCTAC AGCATTATCC ACTGGCACCT CAAAGTGTCC ACCATCCCAG 
AGGGTACCTG CCTTGACTGA CACAACTGCA TCCAACAATG ACTTGGCGAG TCTTTTTGAG 
TGTCCTGTCT GCTTTGACTA TGTGTTGCCA CCTATTCTTC AGTGTCAGAG TGGCCATCTT 
GTTTGTAGCA ACTGTCGCCC CAAACTTACA TGTTGTCCCA CCTGCCGGGG CCCATTGGGA 
TCCATTCGCA ACTTGGCTAT GGAGAAAGTG GCCAACTCAG TACTCTTCCC CTGTAAATAT 
TCCGCTTCTG GATGTGAAAT AACTCTGCCA CACACCAAAA AGGCAGAGCA CGAGGAGCTG 
TGTGAGTTCA GGCCTTACTC CTGCCCCTGC CCTGGTGCTT CCTGTAAATG GCAAGGCTCC 
TTGGATGCTG TCATGCCCCA CCTGATGCAT CAGCACAAGT CCATTACCAC CCTGCAAGGA 
GAAGACATAG TTTTCCTTGC TACAGACATC AACCTTCCTG GTGCTGTTGA CTGGGTGATG 
ATGCAGTCTT GTTTTGGCTT TCATTTCATG TTAGTCTTGG AGAAACAGGA AAAATATGAT 
GGTCATCAGC AGTTCTTTGC AATTGTACAA CTGATAGGAA CACGCAAACA AGCTGAAAAT 
TTTGCCTATC GACTTGAGCT AAATGGTCAT AGGCGCCGAT TAACTTGGGA AGCGACTCCT 
CGATCTATTC ATGAGGGGAT TGCAACAGCC ATTATGAATA GTGATTGCCT AGTGTTTGAC 
ACCAGCATTG CACAGCTTTT TGCAGAAAAT GGTAATCTAG GCATCAATGT AACTATTTCC 
ATGTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001295315.1
CDS	320..1168
Translation	MSRQAATALSTGTSKCPPSQRVPALTDTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYSASGCEITLPHTKKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

Target ORF information:

RefSeq Version	NM_001308386.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus siah E3 ubiquitin protein ligase 1B (Siah1b), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308386.1

ORF Insert Sequence:

ATGAGCCGTC AGGCTGCTAC AGCATTATCC ACTGGCACCT CAAAGTGTCC ACCATCCCAG 
AGGGTACCTG CCTTGACTGA CACAACTGCA TCCAACAATG ACTTGGCGAG TCTTTTTGAG 
TGTCCTGTCT GCTTTGACTA TGTGTTGCCA CCTATTCTTC AGTGTCAGAG TGGCCATCTT 
GTTTGTAGCA ACTGTCGCCC CAAACTTACA TGTTGTCCCA CCTGCCGGGG CCCATTGGGA 
TCCATTCGCA ACTTGGCTAT GGAGAAAGTG GCCAACTCAG TACTCTTCCC CTGTAAATAT 
TCCGCTTCTG GATGTGAAAT AACTCTGCCA CACACCAAAA AGGCAGAGCA CGAGGAGCTG 
TGTGAGTTCA GGCCTTACTC CTGCCCCTGC CCTGGTGCTT CCTGTAAATG GCAAGGCTCC 
TTGGATGCTG TCATGCCCCA CCTGATGCAT CAGCACAAGT CCATTACCAC CCTGCAAGGA 
GAAGACATAG TTTTCCTTGC TACAGACATC AACCTTCCTG GTGCTGTTGA CTGGGTGATG 
ATGCAGTCTT GTTTTGGCTT TCATTTCATG TTAGTCTTGG AGAAACAGGA AAAATATGAT 
GGTCATCAGC AGTTCTTTGC AATTGTACAA CTGATAGGAA CACGCAAACA AGCTGAAAAT 
TTTGCCTATC GACTTGAGCT AAATGGTCAT AGGCGCCGAT TAACTTGGGA AGCGACTCCT 
CGATCTATTC ATGAGGGGAT TGCAACAGCC ATTATGAATA GTGATTGCCT AGTGTTTGAC 
ACCAGCATTG CACAGCTTTT TGCAGAAAAT GGTAATCTAG GCATCAATGT AACTATTTCC 
ATGTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Siah1b ( NM_009173.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033199.1 Mus musculus siah E3 ubiquitin protein ligase 1B (Siah1b), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu03665
Clone ID Related Accession (Same CDS sequence)	NM_001308386.1 , NM_009173.2 , NM_001308385.1
Accession Version	NM_009173.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase SIAH1B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC052887.1, CJ063158.1, AL732294.18 and DV648408.1. On May 5, 2015 this sequence version replaced NM_009173.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z19580.1, CJ063158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164133 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCGTC AGGCTGCTAC AGCATTATCC ACTGGCACCT CAAAGTGTCC ACCATCCCAG 
AGGGTACCTG CCTTGACTGA CACAACTGCA TCCAACAATG ACTTGGCGAG TCTTTTTGAG 
TGTCCTGTCT GCTTTGACTA TGTGTTGCCA CCTATTCTTC AGTGTCAGAG TGGCCATCTT 
GTTTGTAGCA ACTGTCGCCC CAAACTTACA TGTTGTCCCA CCTGCCGGGG CCCATTGGGA 
TCCATTCGCA ACTTGGCTAT GGAGAAAGTG GCCAACTCAG TACTCTTCCC CTGTAAATAT 
TCCGCTTCTG GATGTGAAAT AACTCTGCCA CACACCAAAA AGGCAGAGCA CGAGGAGCTG 
TGTGAGTTCA GGCCTTACTC CTGCCCCTGC CCTGGTGCTT CCTGTAAATG GCAAGGCTCC 
TTGGATGCTG TCATGCCCCA CCTGATGCAT CAGCACAAGT CCATTACCAC CCTGCAAGGA 
GAAGACATAG TTTTCCTTGC TACAGACATC AACCTTCCTG GTGCTGTTGA CTGGGTGATG 
ATGCAGTCTT GTTTTGGCTT TCATTTCATG TTAGTCTTGG AGAAACAGGA AAAATATGAT 
GGTCATCAGC AGTTCTTTGC AATTGTACAA CTGATAGGAA CACGCAAACA AGCTGAAAAT 
TTTGCCTATC GACTTGAGCT AAATGGTCAT AGGCGCCGAT TAACTTGGGA AGCGACTCCT 
CGATCTATTC ATGAGGGGAT TGCAACAGCC ATTATGAATA GTGATTGCCT AGTGTTTGAC 
ACCAGCATTG CACAGCTTTT TGCAGAAAAT GGTAATCTAG GCATCAATGT AACTATTTCC 
ATGTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033199.1
CDS	420..1268
Translation	MSRQAATALSTGTSKCPPSQRVPALTDTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYSASGCEITLPHTKKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

Target ORF information:

RefSeq Version	NM_009173.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus siah E3 ubiquitin protein ligase 1B (Siah1b), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009173.2

ORF Insert Sequence:

ATGAGCCGTC AGGCTGCTAC AGCATTATCC ACTGGCACCT CAAAGTGTCC ACCATCCCAG 
AGGGTACCTG CCTTGACTGA CACAACTGCA TCCAACAATG ACTTGGCGAG TCTTTTTGAG 
TGTCCTGTCT GCTTTGACTA TGTGTTGCCA CCTATTCTTC AGTGTCAGAG TGGCCATCTT 
GTTTGTAGCA ACTGTCGCCC CAAACTTACA TGTTGTCCCA CCTGCCGGGG CCCATTGGGA 
TCCATTCGCA ACTTGGCTAT GGAGAAAGTG GCCAACTCAG TACTCTTCCC CTGTAAATAT 
TCCGCTTCTG GATGTGAAAT AACTCTGCCA CACACCAAAA AGGCAGAGCA CGAGGAGCTG 
TGTGAGTTCA GGCCTTACTC CTGCCCCTGC CCTGGTGCTT CCTGTAAATG GCAAGGCTCC 
TTGGATGCTG TCATGCCCCA CCTGATGCAT CAGCACAAGT CCATTACCAC CCTGCAAGGA 
GAAGACATAG TTTTCCTTGC TACAGACATC AACCTTCCTG GTGCTGTTGA CTGGGTGATG 
ATGCAGTCTT GTTTTGGCTT TCATTTCATG TTAGTCTTGG AGAAACAGGA AAAATATGAT 
GGTCATCAGC AGTTCTTTGC AATTGTACAA CTGATAGGAA CACGCAAACA AGCTGAAAAT 
TTTGCCTATC GACTTGAGCT AAATGGTCAT AGGCGCCGAT TAACTTGGGA AGCGACTCCT 
CGATCTATTC ATGAGGGGAT TGCAACAGCC ATTATGAATA GTGATTGCCT AGTGTTTGAC 
ACCAGCATTG CACAGCTTTT TGCAGAAAAT GGTAATCTAG GCATCAATGT AACTATTTCC 
ATGTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Siah1b ( NM_001308385.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001295314.1 Mus musculus siah E3 ubiquitin protein ligase 1B (Siah1b), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu03665
Clone ID Related Accession (Same CDS sequence)	NM_001308386.1 , NM_009173.2 , NM_001308385.1
Accession Version	NM_001308385.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase SIAH1B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CJ094899.1, CF723667.1, BC052887.1, AL732294.18 and DV648408.1. On May 5, 2015 this sequence version replaced XM_006528767.2. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.186215.1, SRR1660817.200761.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCGTC AGGCTGCTAC AGCATTATCC ACTGGCACCT CAAAGTGTCC ACCATCCCAG 
AGGGTACCTG CCTTGACTGA CACAACTGCA TCCAACAATG ACTTGGCGAG TCTTTTTGAG 
TGTCCTGTCT GCTTTGACTA TGTGTTGCCA CCTATTCTTC AGTGTCAGAG TGGCCATCTT 
GTTTGTAGCA ACTGTCGCCC CAAACTTACA TGTTGTCCCA CCTGCCGGGG CCCATTGGGA 
TCCATTCGCA ACTTGGCTAT GGAGAAAGTG GCCAACTCAG TACTCTTCCC CTGTAAATAT 
TCCGCTTCTG GATGTGAAAT AACTCTGCCA CACACCAAAA AGGCAGAGCA CGAGGAGCTG 
TGTGAGTTCA GGCCTTACTC CTGCCCCTGC CCTGGTGCTT CCTGTAAATG GCAAGGCTCC 
TTGGATGCTG TCATGCCCCA CCTGATGCAT CAGCACAAGT CCATTACCAC CCTGCAAGGA 
GAAGACATAG TTTTCCTTGC TACAGACATC AACCTTCCTG GTGCTGTTGA CTGGGTGATG 
ATGCAGTCTT GTTTTGGCTT TCATTTCATG TTAGTCTTGG AGAAACAGGA AAAATATGAT 
GGTCATCAGC AGTTCTTTGC AATTGTACAA CTGATAGGAA CACGCAAACA AGCTGAAAAT 
TTTGCCTATC GACTTGAGCT AAATGGTCAT AGGCGCCGAT TAACTTGGGA AGCGACTCCT 
CGATCTATTC ATGAGGGGAT TGCAACAGCC ATTATGAATA GTGATTGCCT AGTGTTTGAC 
ACCAGCATTG CACAGCTTTT TGCAGAAAAT GGTAATCTAG GCATCAATGT AACTATTTCC 
ATGTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001295314.1
CDS	606..1454
Translation	MSRQAATALSTGTSKCPPSQRVPALTDTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYSASGCEITLPHTKKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

Target ORF information:

RefSeq Version	NM_001308385.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus siah E3 ubiquitin protein ligase 1B (Siah1b), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308385.1

ORF Insert Sequence:

ATGAGCCGTC AGGCTGCTAC AGCATTATCC ACTGGCACCT CAAAGTGTCC ACCATCCCAG 
AGGGTACCTG CCTTGACTGA CACAACTGCA TCCAACAATG ACTTGGCGAG TCTTTTTGAG 
TGTCCTGTCT GCTTTGACTA TGTGTTGCCA CCTATTCTTC AGTGTCAGAG TGGCCATCTT 
GTTTGTAGCA ACTGTCGCCC CAAACTTACA TGTTGTCCCA CCTGCCGGGG CCCATTGGGA 
TCCATTCGCA ACTTGGCTAT GGAGAAAGTG GCCAACTCAG TACTCTTCCC CTGTAAATAT 
TCCGCTTCTG GATGTGAAAT AACTCTGCCA CACACCAAAA AGGCAGAGCA CGAGGAGCTG 
TGTGAGTTCA GGCCTTACTC CTGCCCCTGC CCTGGTGCTT CCTGTAAATG GCAAGGCTCC 
TTGGATGCTG TCATGCCCCA CCTGATGCAT CAGCACAAGT CCATTACCAC CCTGCAAGGA 
GAAGACATAG TTTTCCTTGC TACAGACATC AACCTTCCTG GTGCTGTTGA CTGGGTGATG 
ATGCAGTCTT GTTTTGGCTT TCATTTCATG TTAGTCTTGG AGAAACAGGA AAAATATGAT 
GGTCATCAGC AGTTCTTTGC AATTGTACAA CTGATAGGAA CACGCAAACA AGCTGAAAAT 
TTTGCCTATC GACTTGAGCT AAATGGTCAT AGGCGCCGAT TAACTTGGGA AGCGACTCCT 
CGATCTATTC ATGAGGGGAT TGCAACAGCC ATTATGAATA GTGATTGCCT AGTGTTTGAC 
ACCAGCATTG CACAGCTTTT TGCAGAAAAT GGTAATCTAG GCATCAATGT AACTATTTCC 
ATGTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.
Science (New York, N.Y.)330(6012)1834-8(2010 Dec)
Famulski JK,Trivedi N,Howell D,Yang Y,Tong Y,Gilbertson R,Solecki DJ

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.
Genes & development20(19)2713-27(2006 Oct)
Evsikov AV,Graber JH,Brockman JM,Hampl A,Holbrook AE,Singh P,Eppig JJ,Solter D,Knowles BB

Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis.
The Journal of biological chemistry281(1)303-12(2006 Jan)
Xu Z,Sproul A,Wang W,Kukekov N,Greene LA

Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter.
Proceedings of the National Academy of Sciences of the United States of America101(10)3510-5(2004 Mar)
Fiucci G,Beaucourt S,Duflaut D,Lespagnol A,Stumptner-Cuvelette P,G?ant A,Buchwalter G,Tuynder M,Susini L,Lassalle JM,Wasylyk C,Wasylyk B,Oren M,Amson R,Telerman A

Normal p53 function in primary cells deficient for Siah genes.
Molecular and cellular biology22(23)8155-64(2002 Dec)
Frew IJ,Dickins RA,Cuddihy AR,Del Rosario M,Reinhard C,O'Connell MJ,Bowtell DD

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Siah1b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報