Selenow cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Selenow
Entrez Gene ID	20364
Full Name	selenoprotein W
Synonyms	Sepw1,selW
General protein information	Preferred Names selenoprotein W Names selenoprotein W selenoprotein W, muscle 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 A2
Summary	This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, and has been shown to function as a glutathione-dependent antioxidant in vivo. Studies in mouse suggest that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. [provided by RefSeq, Apr 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_009156.2	NP_033182.1	selenoprotein W

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sepw1	NP_037159.4
Pan troglodytes (chimpanzee)	SEPW1	NP_001148049.1
Gallus gallus (chicken)	SEPW1	NP_001159799.1
Danio rerio (zebrafish)	sepw1	NP_840072.3
Homo sapiens (human)	SEPW1	NP_003000.1
Bos taurus (cattle)	SEPW1	NP_001156697.1
	SEPW1	NP_001036202.1
Canis lupus familiaris (dog)	SEPW1	NP_001108484.1
Mus musculus (house mouse)	Sepw1	NP_033182.1

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Selenoprotein W enhances skeletal muscle differentiation by inhibiting TAZ binding to 14-3-3 protein.
Jeon YH, Park YH, Lee JH, Hong JH, Kim IY
Biochimica et biophysica acta1843(7)1356-64(2014 Jul)

Selenoprotein W promotes cell cycle recovery from G2 arrest through the activation of CDC25B.
Park YH, Jeon YH, Kim IY
Biochimica et biophysica acta1823(12)2217-26(2012 Dec)

Selenoprotein W during development and oxidative stress.
Loflin J, Lopez N, Whanger PD, Kioussi C
Journal of inorganic biochemistry100(10)1679-84(2006 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SelW enhances myoblast differentiation by inhibiting TAZ binding to 14-3-3.
Title: Selenoprotein W enhances skeletal muscle differentiation by inhibiting TAZ binding to 14-3-3 protein.

SelW gene was activated by the binding of MyoD to a specific E-box during early skeletal muscle differentiation.
Title: Transcriptional regulation of selenoprotein W by MyoD during early skeletal muscle differentiation.

The main function of SelW in muscle cells is not in the antioxidative system.
Title: Selenoprotein W depletion in vitro might indicate that its main function is not as an antioxidative enzyme.

Data show that the loss of SelT elevates expression of another selenoprotein, selenoprotein W, suggesting that SepW1 may functionally compensate for SelT.
Title: Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells.

increased in mouse brains of postnatal day 8 and 20 relative to embryonic day 15; siRNA-transfected neurons are more sensitive to the oxidative stress-induced apoptosis
Title: Antioxidative role of selenoprotein W in oxidant-induced mouse embryonic neuronal cell death.

The following Selenow gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Selenow cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17989	NM_009156.2 Latest version!	Mus musculus selenoprotein W (Selenow), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Selenow ( NM_009156.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033182.1 Mus musculus selenoprotein W (Selenow), mRNA.

Price & Availability↑

CloneID	OMu17989
Clone ID Related Accession (Same CDS sequence)	NM_009156.2
Accession Version	NM_009156.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 267bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Mus musculus(house mouse)
Product	selenoprotein W
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU604713.1 and AF015284.1. On Jul 26, 2006 this sequence version replaced NM_009156.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF015284.1, BU524484.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID:9256076) protein contains selenocysteine :: PMID: 9256076, 12062442 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCTCG CCGTTCGAGT CGTGTATTGT GGAGCTTGAG GCTATAAGCC CAAGTACCTC 
CAGCTCAAGG AGAAGCTAGA ACATGAGTTC CCCGGATGCC TGGACATTTG TGGCGAGGGG 
ACTCCCCAGG TCACCGGGTT CTTTGAAGTG ACAGTAGCCG GGAAGTTGGT CCACTCCAAG 
AAGAGAGGTG ATGGCTATGT GGATACAGAG AGCAAGTTCC GGAAACTGGT GACCGCCATC 
AAAGCTGCCT TGGCTCAGTG CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033182.1
CDS	92..358
Translation	MALAVRVVYCGA*GYKPKYLQLKEKLEHEFPGCLDICGEGTPQVTGFFEVTVAGKLVHSKKRGDGYVDTESKFRKLVTAIKAALAQCQ

Target ORF information:

RefSeq Version	NM_009156.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus selenoprotein W (Selenow), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009156.2

ORF Insert Sequence:

ATGGCGCTCG CCGTTCGAGT CGTGTATTGT GGAGCTTGAG GCTATAAGCC CAAGTACCTC 
CAGCTCAAGG AGAAGCTAGA ACATGAGTTC CCCGGATGCC TGGACATTTG TGGCGAGGGG 
ACTCCCCAGG TCACCGGGTT CTTTGAAGTG ACAGTAGCCG GGAAGTTGGT CCACTCCAAG 
AAGAGAGGTG ATGGCTATGT GGATACAGAG AGCAAGTTCC GGAAACTGGT GACCGCCATC 
AAAGCTGCCT TGGCTCAGTG CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Selenoprotein W enhances skeletal muscle differentiation by inhibiting TAZ binding to 14-3-3 protein.
Biochimica et biophysica acta1843(7)1356-64(2014 Jul)
Jeon YH,Park YH,Lee JH,Hong JH,Kim IY

Selenoprotein W promotes cell cycle recovery from G2 arrest through the activation of CDC25B.
Biochimica et biophysica acta1823(12)2217-26(2012 Dec)
Park YH,Jeon YH,Kim IY

Selenoprotein W during development and oxidative stress.
Journal of inorganic biochemistry100(10)1679-84(2006 Oct)
Loflin J,Lopez N,Whanger PD,Kioussi C

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Selenow cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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