Scrg1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scrg1
Entrez Gene ID	20284
Full Name	scrapie responsive gene 1
Synonyms	AW124307
General protein information	Preferred Names scrapie responsive gene 1 Names scrapie-responsive protein 1 scRG-1 scrapie responsive protein one scrapie-responsive gene 1 protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 B2\|8 29.8 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_017312622.2	XP_017168111.1	scrapie-responsive protein 1 isoform X1
NM_009136.3	NP_033162.1	scrapie-responsive protein 1 precursor
XM_017312622.1	XP_017168111.1	scrapie-responsive protein 1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SCRG1	NP_009212.1
Bos taurus (cattle)	SCRG1	NP_001093840.1
Xenopus tropicalis (tropical clawed frog)	scrg1	XP_002933372.2
Pan troglodytes (chimpanzee)	SCRG1	NP_001229357.1
Gallus gallus (chicken)	SCRG1	XP_420523.2
	SCRG1	XP_001085609.1
Mus musculus (house mouse)	Scrg1	NP_033162.1
Rattus norvegicus (Norway rat)	Scrg1	NP_277034.1

Gene Ontology
Bibliography

Related articles in PubMed

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

Scrg1 is induced in TSE and brain injuries, and associated with autophagy.
Dron M, Bailly Y, Beringue V, Haeberl? AM, Griffond B, Risold PY, Tovey MG, Laude H, Dandoy-Dron F
The European journal of neuroscience22(1)133-46(2005 Jul)

Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells.
Dandoy-Dron F, Griffond B, Mishal Z, Tovey MG, Dron M
The European journal of neuroscience18(9)2449-59(2003 Nov)

Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7).
Durkin ME, Yuan BZ, Thorgeirsson SS, Popescu NC
Gene288(1-2)119-27(2002 Apr)

Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures.
Dron M, Tartare X, Guillo F, Haik S, Barbin G, Maury C, Tovey M, Dandoy-Dron F
Genomics70(1)140-9(2000 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Taken together, our results indicate that Scrg1 is associated with neurodegenerative processes in TSE, but is not directly linked to dysregulation of prion protein.
Title: Scrg1 is induced in TSE and brain injuries, and associated with autophagy.

Scrg1 is associated with the secretory pathway of neuronal cells.
Title: Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells.

The following Scrg1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scrg1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu03583	NM_009136.3 Latest version!	Mus musculus scrapie responsive gene 1 (Scrg1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu03583	XM_017312622.2 Latest version!	Mus musculus scrapie responsive gene 1 (Scrg1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu03583	XM_017312622.1	Mus musculus scrapie responsive gene 1 (Scrg1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scrg1 ( NM_009136.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033162.1 Mus musculus scrapie responsive gene 1 (Scrg1), mRNA.

Price & Availability↑

CloneID	OMu03583
Clone ID Related Accession (Same CDS sequence)	XM_017312622.2 , NM_009136.3 , XM_017312622.1
Accession Version	NM_009136.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 297bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	scrapie-responsive protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ223206.1. On Dec 9, 2006 this sequence version replaced NM_009136.2. ##Evidence-Data-START## Transcript exon combination :: AJ223206.1, CX203583.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGAAAT CTGTGGTACT TGTCATCCTT GGGCTAACTT TGCTGTTAGA AACACAAGCC 
ATGCCTTCAA GTCGCCTCTC CTGCTACAGA AAGTTGCTAA AGGATCGCAA TTGTCACAAC 
CTTCCGGAGG GCAGAGCCGA CCTGAAGCTG ATAGATGCAA ATGTCCAGCA TCATTTCTGG 
GATGGGAAGG GATGCGAGAT GATCTGCTAC TGCAACTTCA GCGAACTGCT CTGCTGCCCA 
AAAGATGTCT TCTTTGGACC AAAGATCTCC TTTGTGATCC CCTGCAACAA CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033162.1
CDS	217..513
Translation	MMKSVVLVILGLTLLLETQAMPSSRLSCYRKLLKDRNCHNLPEGRADLKLIDANVQHHFWDGKGCEMICYCNFSELLCCPKDVFFGPKISFVIPCNNH

Target ORF information:

RefSeq Version	NM_009136.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus scrapie responsive gene 1 (Scrg1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009136.3

ORF Insert Sequence:

ATGATGAAAT CTGTGGTACT TGTCATCCTT GGGCTAACTT TGCTGTTAGA AACACAAGCC 
ATGCCTTCAA GTCGCCTCTC CTGCTACAGA AAGTTGCTAA AGGATCGCAA TTGTCACAAC 
CTTCCGGAGG GCAGAGCCGA CCTGAAGCTG ATAGATGCAA ATGTCCAGCA TCATTTCTGG 
GATGGGAAGG GATGCGAGAT GATCTGCTAC TGCAACTTCA GCGAACTGCT CTGCTGCCCA 
AAAGATGTCT TCTTTGGACC AAAGATCTCC TTTGTGATCC CCTGCAACAA CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scrg1 ( XM_017312622.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017168111.1 Mus musculus scrapie responsive gene 1 (Scrg1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu03583
Clone ID Related Accession (Same CDS sequence)	XM_017312622.2 , NM_009136.3 , XM_017312622.1
Accession Version	XM_017312622.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 297bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	scrapie-responsive protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017312622.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGAAAT CTGTGGTACT TGTCATCCTT GGGCTAACTT TGCTGTTAGA AACACAAGCC 
ATGCCTTCAA GTCGCCTCTC CTGCTACAGA AAGTTGCTAA AGGATCGCAA TTGTCACAAC 
CTTCCGGAGG GCAGAGCCGA CCTGAAGCTG ATAGATGCAA ATGTCCAGCA TCATTTCTGG 
GATGGGAAGG GATGCGAGAT GATCTGCTAC TGCAACTTCA GCGAACTGCT CTGCTGCCCA 
AAAGATGTCT TCTTTGGACC AAAGATCTCC TTTGTGATCC CCTGCAACAA CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017168111.1
CDS	452..748
Translation	MMKSVVLVILGLTLLLETQAMPSSRLSCYRKLLKDRNCHNLPEGRADLKLIDANVQHHFWDGKGCEMICYCNFSELLCCPKDVFFGPKISFVIPCNNH

Target ORF information:

RefSeq Version	XM_017312622.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus scrapie responsive gene 1 (Scrg1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017312622.2

ORF Insert Sequence:

ATGATGAAAT CTGTGGTACT TGTCATCCTT GGGCTAACTT TGCTGTTAGA AACACAAGCC 
ATGCCTTCAA GTCGCCTCTC CTGCTACAGA AAGTTGCTAA AGGATCGCAA TTGTCACAAC 
CTTCCGGAGG GCAGAGCCGA CCTGAAGCTG ATAGATGCAA ATGTCCAGCA TCATTTCTGG 
GATGGGAAGG GATGCGAGAT GATCTGCTAC TGCAACTTCA GCGAACTGCT CTGCTGCCCA 
AAAGATGTCT TCTTTGGACC AAAGATCTCC TTTGTGATCC CCTGCAACAA CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scrg1 ( XM_017312622.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017168111.1 Mus musculus scrapie responsive gene 1 (Scrg1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu03583
Clone ID Related Accession (Same CDS sequence)	XM_017312622.2 , NM_009136.3 , XM_017312622.1
Accession Version	XM_017312622.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 297bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	scrapie-responsive protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGAAAT CTGTGGTACT TGTCATCCTT GGGCTAACTT TGCTGTTAGA AACACAAGCC 
ATGCCTTCAA GTCGCCTCTC CTGCTACAGA AAGTTGCTAA AGGATCGCAA TTGTCACAAC 
CTTCCGGAGG GCAGAGCCGA CCTGAAGCTG ATAGATGCAA ATGTCCAGCA TCATTTCTGG 
GATGGGAAGG GATGCGAGAT GATCTGCTAC TGCAACTTCA GCGAACTGCT CTGCTGCCCA 
AAAGATGTCT TCTTTGGACC AAAGATCTCC TTTGTGATCC CCTGCAACAA CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017168111.1
CDS	454..750
Translation	MMKSVVLVILGLTLLLETQAMPSSRLSCYRKLLKDRNCHNLPEGRADLKLIDANVQHHFWDGKGCEMICYCNFSELLCCPKDVFFGPKISFVIPCNNH

Target ORF information:

RefSeq Version	XM_017312622.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus scrapie responsive gene 1 (Scrg1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017312622.1

ORF Insert Sequence:

ATGATGAAAT CTGTGGTACT TGTCATCCTT GGGCTAACTT TGCTGTTAGA AACACAAGCC 
ATGCCTTCAA GTCGCCTCTC CTGCTACAGA AAGTTGCTAA AGGATCGCAA TTGTCACAAC 
CTTCCGGAGG GCAGAGCCGA CCTGAAGCTG ATAGATGCAA ATGTCCAGCA TCATTTCTGG 
GATGGGAAGG GATGCGAGAT GATCTGCTAC TGCAACTTCA GCGAACTGCT CTGCTGCCCA 
AAAGATGTCT TCTTTGGACC AAAGATCTCC TTTGTGATCC CCTGCAACAA CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

Scrg1 is induced in TSE and brain injuries, and associated with autophagy.
The European journal of neuroscience22(1)133-46(2005 Jul)
Dron M,Bailly Y,Beringue V,Haeberl? AM,Griffond B,Risold PY,Tovey MG,Laude H,Dandoy-Dron F

Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells.
The European journal of neuroscience18(9)2449-59(2003 Nov)
Dandoy-Dron F,Griffond B,Mishal Z,Tovey MG,Dron M

Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7).
Gene288(1-2)119-27(2002 Apr)
Durkin ME,Yuan BZ,Thorgeirsson SS,Popescu NC

Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures.
Genomics70(1)140-9(2000 Nov)
Dron M,Tartare X,Guillo F,Haik S,Barbin G,Maury C,Tovey M,Dandoy-Dron F