REG3G cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	REG3G
Entrez Gene ID	19695
Full Name	regenerating islet-derived 3 gamma
Synonyms	AI449515,REG-3-gamma,reg III-gamma
General protein information	Preferred Names regenerating islet-derived 3 gamma Names regenerating islet-derived protein 3-gamma generating islet-derived, mouse homolog 3 gamma pancreatitis-associated protein 3 regenerating islet-derived protein III-gamma
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 6 Map Location: 6\|6 C3
Summary	This gene encodes a C-type lectin that demonstrates bactericidal activity. This gene is predominantly expressed in the distal small intestine where the encoded protein undergoes proteolytic processing by trypsin. Mice lacking the encoded protein exhibit altered mucus distribution, increased bacterial contact with the epithelium, and elevated inflammatory markers in the ileum, and low-grade inflammation. [provided by RefSeq, Jun 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_011260.2	NP_035390.1	regenerating islet-derived protein 3-gamma preproprotein
NM_011260.1	NP_035390.1	regenerating islet-derived protein 3-gamma precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	REG3G	NP_001008388.1
Mus musculus (house mouse)	Reg3g	NP_035390.1
Rattus norvegicus (Norway rat)	Reg3g	NP_775120.1
	LOC711637	XP_001112492.1
Canis lupus familiaris (dog)	LOC100687463	NP_001243464.1
Canis lupus familiaris (dog)	REG3A	NP_001002945.2
Bos taurus (cattle)	REG3A	NP_991356.1
Pan troglodytes (chimpanzee)	REG3G	XP_003309121.1

Gene Ontology
Bibliography

Related articles in PubMed

Acceleration of pancreatic tumorigenesis under immunosuppressive microenvironment induced by Reg3g overexpression.
Liu X, Zhou Z, Cheng Q, Wang H, Cao H, Xu Q, Tuo Y, Jiang L, Zou Y, Ren H, Xiang M
Cell death & disease8(9)e3033(2017 Sep)

Exploiting a host-commensal interaction to promote intestinal barrier function and enteric pathogen tolerance.
Pedicord VA, Lockhart AAK, Rangan KJ, Craig JW, Loschko J, Rogoz A, Hang HC, Mucida D
Science immunology1(3)(2016 Sep)

Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment.
Mukherjee S, Partch CL, Lehotzky RE, Whitham CV, Chu H, Bevins CL, Gardner KH, Hooper LV
The Journal of biological chemistry284(8)4881-8(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Recombinant IFN-I or IFN-I expression induced by RIG-I promoted growth of intestinal organoids in vitro and production of the antimicrobial peptide regenerating islet-derived protein 3 gamma (RegIIIgamma).
Title: RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury.

The study shows that cardiac stress activates Reg3gamma expression and p38 MAPK is an upstream regulator of Reg3gamma gene expression in heart. Altogether the data suggest Reg3gamma is associated with cardiac inflammatory signaling.
Title: Mitogen-activated protein kinase p38 target regenerating islet-derived 3? expression is upregulated in cardiac inflammatory response in the rat heart.

the secretion of regenerating islet-derived IIIgamma (RegIIIgamma) is responsible for the protective effect of Adipose-derived stem cells.
Title: Protective Role of Adipose-Derived Stem Cells in Staphylococcus aureus-Induced Lung Injury is Mediated by RegIII? Secretion.

regenerating islet-derived gene gamma promotes beta cell regeneration and preserves beta cells from autoimmunity damage by increasing regulatory T cell differentiation and inducing tolerated dendritic cells.
Title: Reg3g overexpression promotes ? cell regeneration and induces immune tolerance in nonobese-diabetic mouse model.

Intestinal deficiency in REG3B or REG3G increases numbers of mucosa-associated bacteria and enhances bacterial translocation to the mesenteric lymph nodes and liver.
Title: Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation.

The following REG3G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the REG3G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu07764	NM_011260.2 Latest version!	Mus musculus regenerating islet-derived 3 gamma (Reg3g), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu07764	NM_011260.1	Mus musculus regenerating islet-derived 3 gamma (Reg3g), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

REG3G ( NM_011260.2 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_035390.1 Mus musculus regenerating islet-derived 3 gamma (Reg3g), mRNA.

Price & Availability↑

CloneID	OMu07764
Clone ID Related Accession (Same CDS sequence)	NM_011260.2 , NM_011260.1
Accession Version	NM_011260.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 525bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Mus musculus(house mouse)
Product	regenerating islet-derived protein 3-gamma preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D63361.1 and BF020649.1. On Jul 2, 2016 this sequence version replaced NM_011260.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061139.1, AK008446.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCTTCCCC GTATAACCAT CACCATCATG TCCTGGATGC TGCTCTCCTG CCTGATGCTC 
CTTTCTCAGG TGCAAGGTGA AGTTGCCAAG AAAGATGCCC CATCTTCACG TAGCAGCTGC 
CCCAAGGGCT CCCGTGCCTA TGGCTCCTAT TGCTATGCCT TGTTTAGTGT ATCTAAAAAC 
TGGTATGATG CAGATATGGC CTGCCAAAAG AGGCCCTCAG GACATCTTGT GTCTGTGCTC 
AGTGGCGCTG AAGCTTCCTT CCTGTCCTCC ATGATCAAAA GCAGTGGTAA CAGTGGCCAA 
TATGTATGGA TTGGGCTCCA TGACCCGACA CTGGGCTATG AACCCAACAG AGGTGGATGG 
GAGTGGAGCA ATGCTGATGT GATGAATTAC ATCAACTGGG AGACGAATCC TTCCTCTTCC 
TCAGGCAATC ACTGTGGTAC CCTGTCAAGA GCCTCAGGAT TTCTGAAGTG GAGAGAGAAT 
TATTGTAACT TAGAGTTACC CTATGTCTGC AAATTCAAGG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035390.1
CDS	33..557
Translation	MLPRITITIMSWMLLSCLMLLSQVQGEVAKKDAPSSRSSCPKGSRAYGSYCYALFSVSKNWYDADMACQKRPSGHLVSVLSGAEASFLSSMIKSSGNSGQYVWIGLHDPTLGYEPNRGGWEWSNADVMNYINWETNPSSSSGNHCGTLSRASGFLKWRENYCNLELPYVCKFKA

Target ORF information:

RefSeq Version	NM_011260.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus regenerating islet-derived 3 gamma (Reg3g), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011260.2

ORF Insert Sequence:

ATGCTTCCCC GTATAACCAT CACCATCATG TCCTGGATGC TGCTCTCCTG CCTGATGCTC 
CTTTCTCAGG TGCAAGGTGA AGTTGCCAAG AAAGATGCCC CATCTTCACG TAGCAGCTGC 
CCCAAGGGCT CCCGTGCCTA TGGCTCCTAT TGCTATGCCT TGTTTAGTGT ATCTAAAAAC 
TGGTATGATG CAGATATGGC CTGCCAAAAG AGGCCCTCAG GACATCTTGT GTCTGTGCTC 
AGTGGCGCTG AAGCTTCCTT CCTGTCCTCC ATGATCAAAA GCAGTGGTAA CAGTGGCCAA 
TATGTATGGA TTGGGCTCCA TGACCCGACA CTGGGCTATG AACCCAACAG AGGTGGATGG 
GAGTGGAGCA ATGCTGATGT GATGAATTAC ATCAACTGGG AGACGAATCC TTCCTCTTCC 
TCAGGCAATC ACTGTGGTAC CCTGTCAAGA GCCTCAGGAT TTCTGAAGTG GAGAGAGAAT 
TATTGTAACT TAGAGTTACC CTATGTCTGC AAATTCAAGG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

REG3G ( NM_011260.1 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_035390.1 Mus musculus regenerating islet-derived 3 gamma (Reg3g), mRNA.

Price & Availability↑

CloneID	OMu07764
Clone ID Related Accession (Same CDS sequence)	NM_011260.2 , NM_011260.1
Accession Version	NM_011260.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 525bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	regenerating islet-derived protein 3-gamma precursor
Comment

ATGCTTCCCC GTATAACCAT CACCATCATG TCCTGGATGC TGCTCTCCTG CCTGATGCTC 
CTTTCTCAGG TGCAAGGTGA AGTTGCCAAG AAAGATGCCC CATCTTCACG TAGCAGCTGC 
CCCAAGGGCT CCCGTGCCTA TGGCTCCTAT TGCTATGCCT TGTTTAGTGT ATCTAAAAAC 
TGGTATGATG CAGATATGGC CTGCCAAAAG AGGCCCTCAG GACATCTTGT GTCTGTGCTC 
AGTGGCGCTG AAGCTTCCTT CCTGTCCTCC ATGATCAAAA GCAGTGGTAA CAGTGGCCAA 
TATGTATGGA TTGGGCTCCA TGACCCGACA CTGGGCTATG AACCCAACAG AGGTGGATGG 
GAGTGGAGCA ATGCTGATGT GATGAATTAC ATCAACTGGG AGACGAATCC TTCCTCTTCC 
TCAGGCAATC ACTGTGGTAC CCTGTCAAGA GCCTCAGGAT TTCTGAAGTG GAGAGAGAAT 
TATTGTAACT TAGAGTTACC CTATGTCTGC AAATTCAAGG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035390.1
Translation	MLPRITITIMSWMLLSCLMLLSQVQGEVAKKDAPSSRSSCPKGSRAYGSYCYALFSVSKNWYDADMACQKRPSGHLVSVLSGAEASFLSSMIKSSGNSGQYVWIGLHDPTLGYEPNRGGWEWSNADVMNYINWETNPSSSSGNHCGTLSRASGFLKWRENYCNLELPYVCKFKA

Target ORF information:

RefSeq Version	NM_011260.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus regenerating islet-derived 3 gamma (Reg3g), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011260.1

ORF Insert Sequence:

ATGCTTCCCC GTATAACCAT CACCATCATG TCCTGGATGC TGCTCTCCTG CCTGATGCTC 
CTTTCTCAGG TGCAAGGTGA AGTTGCCAAG AAAGATGCCC CATCTTCACG TAGCAGCTGC 
CCCAAGGGCT CCCGTGCCTA TGGCTCCTAT TGCTATGCCT TGTTTAGTGT ATCTAAAAAC 
TGGTATGATG CAGATATGGC CTGCCAAAAG AGGCCCTCAG GACATCTTGT GTCTGTGCTC 
AGTGGCGCTG AAGCTTCCTT CCTGTCCTCC ATGATCAAAA GCAGTGGTAA CAGTGGCCAA 
TATGTATGGA TTGGGCTCCA TGACCCGACA CTGGGCTATG AACCCAACAG AGGTGGATGG 
GAGTGGAGCA ATGCTGATGT GATGAATTAC ATCAACTGGG AGACGAATCC TTCCTCTTCC 
TCAGGCAATC ACTGTGGTAC CCTGTCAAGA GCCTCAGGAT TTCTGAAGTG GAGAGAGAAT 
TATTGTAACT TAGAGTTACC CTATGTCTGC AAATTCAAGG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Acceleration of pancreatic tumorigenesis under immunosuppressive microenvironment induced by Reg3g overexpression.
Cell death & disease8(9)e3033(2017 Sep)
Liu X,Zhou Z,Cheng Q,Wang H,Cao H,Xu Q,Tuo Y,Jiang L,Zou Y,Ren H,Xiang M

Exploiting a host-commensal interaction to promote intestinal barrier function and enteric pathogen tolerance.
Science immunology1(3)(2016 Sep)
Pedicord VA,Lockhart AAK,Rangan KJ,Craig JW,Loschko J,Rogoz A,Hang HC,Mucida D

Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment.
The Journal of biological chemistry284(8)4881-8(2009 Feb)
Mukherjee S,Partch CL,Lehotzky RE,Whitham CV,Chu H,Bevins CL,Gardner KH,Hooper LV

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REG3G cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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