Rad50 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rad50
Entrez Gene ID	19360
Full Name	RAD50 double strand break repair protein
Synonyms	Mrell,Rad50l
General protein information	Preferred Names RAD50 double strand break repair protein Names DNA repair protein RAD50 RAD50 homolog mRad50
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 B1.3\|11 31.98 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009012.2	NP_033038.2	DNA repair protein RAD50

Pathways from BioSystems

Homologies

Oryza sativa (rice)	Os02g0497500	NP_001046893.1
Xenopus tropicalis (tropical clawed frog)	rad50	XP_004912891.1
	RAD50	XP_001099384.2
Gallus gallus (chicken)	RAD50	XP_004945072.1
Arabidopsis thaliana (thale cress)	RAD50	NP_565733.1
Homo sapiens (human)	RAD50	NP_005723.2
Rattus norvegicus (Norway rat)	Rad50	NP_071582.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003676	XP_313457.4
Pan troglodytes (chimpanzee)	RAD50	XP_001163412.1
Canis lupus familiaris (dog)	RAD50	XP_531901.2
Neurospora crassa	NCU00901	XP_963818.1
Bos taurus (cattle)	RAD50	NP_001193797.1
Mus musculus (house mouse)	Rad50	NP_033038.2
Danio rerio (zebrafish)	rad50	XP_005167995.1
Drosophila melanogaster (fruit fly)	rad50	NP_001246461.1
Magnaporthe oryzae (rice blast fungus)	MGG_11387	XP_003713570.1

Gene Ontology
Bibliography

Related articles in PubMed

MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.
Spehalski E, Capper KM, Smith CJ, Morgan MJ, Dinkelmann M, Buis J, Sekiguchi JM, Ferguson DO
Cancer research77(19)5327-5338(2017 Oct)

RHS6 coordinately regulates the Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4.
Hwang SS, Jang SW, Lee KO, Kim HS, Lee GR
Allergy72(5)772-782(2017 May)

RHS6-mediated chromosomal looping and nuclear substructure binding is required for Th2 cytokine gene expression.
Hwang SS, Jang SW, Lee GR
Biochimica et biophysica acta1860(3)383-391(2017 03)

Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms.
Asai T, Hatlen MA, Lossos C, Ndiaye-Lobry D, Deblasio A, Murata K, Fleisher M, Cortizas EM, Verdun RE, Petrini J, Nimer SD
Scientific reports622760(2016 Mar)

Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.
Hartlerode AJ, Morgan MJ, Wu Y, Buis J, Ferguson DO
Nature structural & molecular biology22(9)736-43(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low RAD50 expression is associated with B-cell lymphomas.
Title: MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.

RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4.
Title: RHS6 coordinately regulates the Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4.

The authors demonstrate that ATM can be activated by DNA double-strand breaks in the absence of the Mre11-Rad50-NBS1 (MRN) sensor complex.
Title: Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.

Rad50 hook domain strongly influences Mre11 complex-dependent DDR signaling, tissue homeostasis, and tumorigenesis.
Title: The Rad50 hook domain regulates DNA damage signaling and tumorigenesis.

RAD50, DNA-PKcs kinase activity, and transcription context are each important to limit incorrect end use during EJ repair of multiple DSBs, but each has distinct roles during repair events requiring end processing
Title: Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context.

The following Rad50 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rad50 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18694	NM_009012.2 Latest version!	Mus musculus RAD50 double strand break repair protein (Rad50), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rad50 ( NM_009012.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033038.2 Mus musculus RAD50 double strand break repair protein (Rad50), mRNA.

Price & Availability↑

CloneID	OMu18694
Clone ID Related Accession (Same CDS sequence)	NM_009012.2
Accession Version	NM_009012.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	DNA repair protein RAD50
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL645741.15. On Jul 26, 2007 this sequence version replaced NM_009012.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.176853.1, U66887.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGTCCCGGA TCGAAAAGAT GAGCATTCTG GGCGTGCGAA GTTTTGGGAT AGAGGATAAA 
GATAAGCAGA TTATCTCTTT CTTCAGCCCC CTCACAATTT TGGTTGGACC CAATGGGGCG 
GGGAAGACGA CCATCATTGA ATGTCTAAAG TATATTTGTA CTGGAGATTT CCCTCCTGGA 
ACCAAAGGAA ATACATTTGT TCATGATCCC AAGGTTGCTC AAGAAACAGA CGTGCGGGCC 
CAGATTCGCC TGCAGTTTCG AGATGTGAAT GGAGAGATGG TAGCTGTGCA CAGGTCTATG 
CTTTGCAGTC AGAAAAATAA AAAAACAGAA TTTAAAACCT TGGAAGGAGT CATTACTAGA 
ATGAAGCATG GTGAAAAAGT CAGTCTCAGC TCCAAATGTG CAGAAATCGA CAGAGAAATG 
ATAAGTTGTC TTGGGGTTTC CAAGTCTGTG CTAAACAATG TTATTTTCTG TCACCAAGAA 
GACTCCAACT GGCCTTTAAG TGAAGGAAAG GCTTTGAAGC AAAAATTTGA TGAGATTTTT 
TCGGCAACAA GGTACATTAA AGCCTTAGAT ACACTTCGAC AGGTGCGTCA GACACAGGGT 
CAGAAAGTAA AAGAGTGTCA AACGGAATTG AAATATCTGA AGCAAAATAA GGAGAAAGCG 
TGTGAGATCC GAGATCAGAT TACGAGTAAG GAAGCCCAGT TAGCGTCTTC GCAGGAAATT 
GTCAGGTCCT ACGAGGATGA GCTTGAGCCA TTGAAGAATC GCCTGAAAGA GATTGAACAC 
AACCTGTCTA AAATAATGAA ACTTGATAAT GAAATTAAAG CCTTGGAGAG CCGAAAGAAA 
CAAATGGAGA AAGATAACAG TGAATTAGAA CAGAAAATGG AAAAGGTTTT TCAAGGGACT 
GATGAGCAGC TAAATGACTT GTATCACAAT CACCAGAGAA CAGTAAGGGA GAAAGAAAGG 
CGCCTGGTAG ACTGCCAGCG AGAACTGGAG AAGCTGAATA AAGAAGCACG GCTCCTCAAC 
CAGGAAAAAG CAGAGCTGCT TGTGGAGCAG GGTCGTCTAC AGCTACAGGC AGATCGCCAT 
CAAGAGCACA TCCGAGCCAG AGACTCATTA ATTCAGTCTT TGGCAACACA TCTTGAATTG 
GATGGTTTTG AGCGTGGACC ATTCAGTGAA AGACAGATTA AAAATTTTCA TGAACTTGTG 
AAAGAGAGAC AGGAAAGAGA AGCTAAAACT GCCAGCCAGC TCTTGAGCGA CCTGACAGAC 
AAAGAAGCTC TGAAGCAGAG GCAGCTTGAT GAGCTGAGGG ACAGGAAGAG CGGACTGGGG 
AGGACGATTG AGCTGAAGAC AGAGATCCTC ACGAAGAAGC AGAGCGAGCT GCGGCACGTG 
AGGAGTGAGC TGCAGCAGCT GGAGGGCTCC TCCGACAGGA TTCTGGAACT GGACCAGGAG 
CTCACGAAAG CTGAACGTGA ATTAAGCAAG GCCGAGAAAA ATAGCAGCAT AGAAACCCTA 
AAAGCAGAGG TAATGAGCCT CCAAAATGAG AAAGCTGACC TGGACAGGAG CTTGCGAAAG 
CTGGACCAGG AGATGGAGCA GTTAAACCAT CATACAACAA CCCGCACACA GATGGAGATG 
CTCACCAAAG ACAAAACTGA CAAAGATGAA CAGATCAGAA AAATAAAGTC TAGGCACAGT 
GATGAACTAA CTTCACTGTT GGGGTACTTT CCTAACAAAA AACAGCTTGA AGACTGGCTT 
CATTCTAAAT CCAAAGAAAT TAATCAGACC AGGGACAGAC TTGCCAAACT GAACAAAGAG 
CTAGCTTCAG CTGAACAAAA TAAAAATCAT ATAAATAATG AGCTAAAGAA AAAGGAAGAA 
CAGTTGTCCA GTTATGAAGA TAAGCTATTT GATGTTTGTG GTAGCCAAGA TTTGGAAAGT 
GATTTGGGCA GACTTAAAGA AGAAATTGAA AAGTCCTCAA AGCAGCGAGC CATGCTGGCA 
GGAGCCACAG CAGTTTACTC CCAGTTCATT ACGCAGCTGA CAGATGAAAA CCAGTCCTGC 
TGCCCAGTCT GTCAGAGAGT ATTTCAGACA GAGGCTGAGT TACAGGAAGT CATCAGCGAC 
TTGCAGTCCA AGCTGAGGCT TGCTCCAGAT AAACTCAAGT CAACAGAATC GGAACTGAAG 
AAAAAAGAGC GGCGCCGTGA TGAAATGCTT GGGCTTGTGC CCGTGAGGCA AAGCATAATT 
GATTTGAAGG AAAAGGAAAT ACCAGAATTA AGAAACCGAC TACAGAGTGT CAATAGAGAC 
ATACAGCGCC TAAAGAATGA CATAGAAGAG CAGGAAACAC TCTTGGGTAC AATAATGCCT 
GAAGAAGAAA GTGCTAAAGT GTGCCTGACA GATGTTACAA TCATGGAGAG GTTCCAGATG 
GAGCTGAAAG ATGTTGAAAG GAAAATTGCA CAGCAGGCAG CTAAGCTGCA GGGAGTAGAC 
TTGGACCGGA CTGTCCAGCA GGTTAACCAG GAAAAGCAGG AAAAGCAGCA CAGGCTGGAT 
ACAGTTACCA GTAAGATTGA ATTGAACCGT AAGCTTATAC AGGACCAGCA GGAACAAATC 
CAACACCTGA AAAGTAAAAC AAATGAGCTG AAGTCAGAGA AGCTGCAGAT AGCCACCAAT 
TTGCAACGGC GCCAGCAAAT GGAGGAGCAG AGTGTGGAAT TATCCACTGA AGTCCAGTCT 
TTAAACAGAG AAATAAAGGA TGCTAAAGAA CAAATAAGCC CTTTGGAGAC AGCATTGGAA 
AAGTTGCAGC AGGAAAAAGA AGAATTAATC CACAGAAAAC ATACAAGTAA CAAAATGGCT 
CAGGATAAAA TTAATGATAT CAAAGAGAAA GTTAAAAATA TTCATGGTTA CATGAAAGAC 
ATAGAGAATT ATATTCAAGA TGGAAAAGAT GACTACAAGA AGCAAAAAGA AACTGAACTT 
AATGGAGTTG CTGTTCAACT AAATGAATGT GAGAAACACA GAGAAAAGAT AAATAAAGAC 
ATGGGAACCA TGAGGCAAGA CATCGACACA CAGAAGATAC AGGAAAGGTG GCTACAGGAT 
AACCTTACAC TAAGAAAAAG GAGAGATGAA CTAAAAGAAG TGGAAGAAGA ACGAAAACAA 
CACTTGAAGG AGATGGGACA AATGCAAGTT TTACAAATGA AAAATGAGCA TCAGAAGTTG 
GAAGAGAACA TAGACACTAT AAAGAGAAAT CACAGTTTGG CATTGGGGCG TCAGAAAGGC 
TATGAAGACG AAATTCTTCA CTTTAAAAAG GAGCTCCGAG AACCTCAGTT CCGGGATGCC 
GAGGAAAAGT ACAGAGAAAT GATGATCGTC ATGAGGACCA CAGAGCTGGT GAACAAGGAC 
CTCGACATCT ACTACAAGAC TCTTGACCAA GCAATTATGA AATTTCACAG TATGAAAATG 
GAAGAAATCA ACAAAATTAT TCGTGATCTT TGGCGGAGTA CCTATCGTGG GCAAGATATT 
GAATACATAG AAATTCGATC TGATGCTGAT GAAAATGTAT CGGCTTCTGA TAAAAGGCGA 
AATTACAACT ACCGAGTGGT GATGCTGAAG GGGGACACAG CCTTGGACAT GCGTGGACGA 
TGCAGTGCTG GACAGAAGGT GCTAGCGTCT CTCATCATCC GACTGGCCCT GGCGGAAACC 
TTCTGTCTGA ACTGTGGCAT CCTTGCCTTG GATGAGCCGA CAACAAATCT CGACCGAGAA 
AACATTGAGT CTCTTGCACA TGCTTTGGTT GAGATCATAA AAAGTCGCTC ACAGCAGCGC 
AACTTCCAAC TTCTGGTAAT CACTCACGAT GAAGATTTTG TGGAGCTCTT AGGGCGATCT 
GAGTATGTGG AGAAATTCTA CAGGGTGAAG AAGAACATGG ACCAGTGCTC AGAGATTGTC 
AAGTGCAGCA TCAGCTCCCT GGGTTCTTAT GTTCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033038.2
CDS	265..4203
Translation	MSRIEKMSILGVRSFGIEDKDKQIISFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQIRLQFRDVNGEMVAVHRSMLCSQKNKKTEFKTLEGVITRMKHGEKVSLSSKCAEIDREMISCLGVSKSVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALDTLRQVRQTQGQKVKECQTELKYLKQNKEKACEIRDQITSKEAQLASSQEIVRSYEDELEPLKNRLKEIEHNLSKIMKLDNEIKALESRKKQMEKDNSELEQKMEKVFQGTDEQLNDLYHNHQRTVREKERRLVDCQRELEKLNKEARLLNQEKAELLVEQGRLQLQADRHQEHIRARDSLIQSLATHLELDGFERGPFSERQIKNFHELVKERQEREAKTASQLLSDLTDKEALKQRQLDELRDRKSGLGRTIELKTEILTKKQSELRHVRSELQQLEGSSDRILELDQELTKAERELSKAEKNSSIETLKAEVMSLQNEKADLDRSLRKLDQEMEQLNHHTTTRTQMEMLTKDKTDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASAEQNKNHINNELKKKEEQLSSYEDKLFDVCGSQDLESDLGRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKERRRDEMLGLVPVRQSIIDLKEKEIPELRNRLQSVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGVDLDRTVQQVNQEKQEKQHRLDTVTSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIATNLQRRQQMEEQSVELSTEVQSLNREIKDAKEQISPLETALEKLQQEKEELIHRKHTSNKMAQDKINDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNGVAVQLNECEKHREKINKDMGTMRQDIDTQKIQERWLQDNLTLRKRRDELKEVEEERKQHLKEMGQMQVLQMKNEHQKLEENIDTIKRNHSLALGRQKGYEDEILHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRVKKNMDQCSEIVKCSISSLGSYVH

Target ORF information:

RefSeq Version	NM_009012.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus RAD50 double strand break repair protein (Rad50), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009012.2

ORF Insert Sequence:

ATGTCCCGGA TCGAAAAGAT GAGCATTCTG GGCGTGCGAA GTTTTGGGAT AGAGGATAAA 
GATAAGCAGA TTATCTCTTT CTTCAGCCCC CTCACAATTT TGGTTGGACC CAATGGGGCG 
GGGAAGACGA CCATCATTGA ATGTCTAAAG TATATTTGTA CTGGAGATTT CCCTCCTGGA 
ACCAAAGGAA ATACATTTGT TCATGATCCC AAGGTTGCTC AAGAAACAGA CGTGCGGGCC 
CAGATTCGCC TGCAGTTTCG AGATGTGAAT GGAGAGATGG TAGCTGTGCA CAGGTCTATG 
CTTTGCAGTC AGAAAAATAA AAAAACAGAA TTTAAAACCT TGGAAGGAGT CATTACTAGA 
ATGAAGCATG GTGAAAAAGT CAGTCTCAGC TCCAAATGTG CAGAAATCGA CAGAGAAATG 
ATAAGTTGTC TTGGGGTTTC CAAGTCTGTG CTAAACAATG TTATTTTCTG TCACCAAGAA 
GACTCCAACT GGCCTTTAAG TGAAGGAAAG GCTTTGAAGC AAAAATTTGA TGAGATTTTT 
TCGGCAACAA GGTACATTAA AGCCTTAGAT ACACTTCGAC AGGTGCGTCA GACACAGGGT 
CAGAAAGTAA AAGAGTGTCA AACGGAATTG AAATATCTGA AGCAAAATAA GGAGAAAGCG 
TGTGAGATCC GAGATCAGAT TACGAGTAAG GAAGCCCAGT TAGCGTCTTC GCAGGAAATT 
GTCAGGTCCT ACGAGGATGA GCTTGAGCCA TTGAAGAATC GCCTGAAAGA GATTGAACAC 
AACCTGTCTA AAATAATGAA ACTTGATAAT GAAATTAAAG CCTTGGAGAG CCGAAAGAAA 
CAAATGGAGA AAGATAACAG TGAATTAGAA CAGAAAATGG AAAAGGTTTT TCAAGGGACT 
GATGAGCAGC TAAATGACTT GTATCACAAT CACCAGAGAA CAGTAAGGGA GAAAGAAAGG 
CGCCTGGTAG ACTGCCAGCG AGAACTGGAG AAGCTGAATA AAGAAGCACG GCTCCTCAAC 
CAGGAAAAAG CAGAGCTGCT TGTGGAGCAG GGTCGTCTAC AGCTACAGGC AGATCGCCAT 
CAAGAGCACA TCCGAGCCAG AGACTCATTA ATTCAGTCTT TGGCAACACA TCTTGAATTG 
GATGGTTTTG AGCGTGGACC ATTCAGTGAA AGACAGATTA AAAATTTTCA TGAACTTGTG 
AAAGAGAGAC AGGAAAGAGA AGCTAAAACT GCCAGCCAGC TCTTGAGCGA CCTGACAGAC 
AAAGAAGCTC TGAAGCAGAG GCAGCTTGAT GAGCTGAGGG ACAGGAAGAG CGGACTGGGG 
AGGACGATTG AGCTGAAGAC AGAGATCCTC ACGAAGAAGC AGAGCGAGCT GCGGCACGTG 
AGGAGTGAGC TGCAGCAGCT GGAGGGCTCC TCCGACAGGA TTCTGGAACT GGACCAGGAG 
CTCACGAAAG CTGAACGTGA ATTAAGCAAG GCCGAGAAAA ATAGCAGCAT AGAAACCCTA 
AAAGCAGAGG TAATGAGCCT CCAAAATGAG AAAGCTGACC TGGACAGGAG CTTGCGAAAG 
CTGGACCAGG AGATGGAGCA GTTAAACCAT CATACAACAA CCCGCACACA GATGGAGATG 
CTCACCAAAG ACAAAACTGA CAAAGATGAA CAGATCAGAA AAATAAAGTC TAGGCACAGT 
GATGAACTAA CTTCACTGTT GGGGTACTTT CCTAACAAAA AACAGCTTGA AGACTGGCTT 
CATTCTAAAT CCAAAGAAAT TAATCAGACC AGGGACAGAC TTGCCAAACT GAACAAAGAG 
CTAGCTTCAG CTGAACAAAA TAAAAATCAT ATAAATAATG AGCTAAAGAA AAAGGAAGAA 
CAGTTGTCCA GTTATGAAGA TAAGCTATTT GATGTTTGTG GTAGCCAAGA TTTGGAAAGT 
GATTTGGGCA GACTTAAAGA AGAAATTGAA AAGTCCTCAA AGCAGCGAGC CATGCTGGCA 
GGAGCCACAG CAGTTTACTC CCAGTTCATT ACGCAGCTGA CAGATGAAAA CCAGTCCTGC 
TGCCCAGTCT GTCAGAGAGT ATTTCAGACA GAGGCTGAGT TACAGGAAGT CATCAGCGAC 
TTGCAGTCCA AGCTGAGGCT TGCTCCAGAT AAACTCAAGT CAACAGAATC GGAACTGAAG 
AAAAAAGAGC GGCGCCGTGA TGAAATGCTT GGGCTTGTGC CCGTGAGGCA AAGCATAATT 
GATTTGAAGG AAAAGGAAAT ACCAGAATTA AGAAACCGAC TACAGAGTGT CAATAGAGAC 
ATACAGCGCC TAAAGAATGA CATAGAAGAG CAGGAAACAC TCTTGGGTAC AATAATGCCT 
GAAGAAGAAA GTGCTAAAGT GTGCCTGACA GATGTTACAA TCATGGAGAG GTTCCAGATG 
GAGCTGAAAG ATGTTGAAAG GAAAATTGCA CAGCAGGCAG CTAAGCTGCA GGGAGTAGAC 
TTGGACCGGA CTGTCCAGCA GGTTAACCAG GAAAAGCAGG AAAAGCAGCA CAGGCTGGAT 
ACAGTTACCA GTAAGATTGA ATTGAACCGT AAGCTTATAC AGGACCAGCA GGAACAAATC 
CAACACCTGA AAAGTAAAAC AAATGAGCTG AAGTCAGAGA AGCTGCAGAT AGCCACCAAT 
TTGCAACGGC GCCAGCAAAT GGAGGAGCAG AGTGTGGAAT TATCCACTGA AGTCCAGTCT 
TTAAACAGAG AAATAAAGGA TGCTAAAGAA CAAATAAGCC CTTTGGAGAC AGCATTGGAA 
AAGTTGCAGC AGGAAAAAGA AGAATTAATC CACAGAAAAC ATACAAGTAA CAAAATGGCT 
CAGGATAAAA TTAATGATAT CAAAGAGAAA GTTAAAAATA TTCATGGTTA CATGAAAGAC 
ATAGAGAATT ATATTCAAGA TGGAAAAGAT GACTACAAGA AGCAAAAAGA AACTGAACTT 
AATGGAGTTG CTGTTCAACT AAATGAATGT GAGAAACACA GAGAAAAGAT AAATAAAGAC 
ATGGGAACCA TGAGGCAAGA CATCGACACA CAGAAGATAC AGGAAAGGTG GCTACAGGAT 
AACCTTACAC TAAGAAAAAG GAGAGATGAA CTAAAAGAAG TGGAAGAAGA ACGAAAACAA 
CACTTGAAGG AGATGGGACA AATGCAAGTT TTACAAATGA AAAATGAGCA TCAGAAGTTG 
GAAGAGAACA TAGACACTAT AAAGAGAAAT CACAGTTTGG CATTGGGGCG TCAGAAAGGC 
TATGAAGACG AAATTCTTCA CTTTAAAAAG GAGCTCCGAG AACCTCAGTT CCGGGATGCC 
GAGGAAAAGT ACAGAGAAAT GATGATCGTC ATGAGGACCA CAGAGCTGGT GAACAAGGAC 
CTCGACATCT ACTACAAGAC TCTTGACCAA GCAATTATGA AATTTCACAG TATGAAAATG 
GAAGAAATCA ACAAAATTAT TCGTGATCTT TGGCGGAGTA CCTATCGTGG GCAAGATATT 
GAATACATAG AAATTCGATC TGATGCTGAT GAAAATGTAT CGGCTTCTGA TAAAAGGCGA 
AATTACAACT ACCGAGTGGT GATGCTGAAG GGGGACACAG CCTTGGACAT GCGTGGACGA 
TGCAGTGCTG GACAGAAGGT GCTAGCGTCT CTCATCATCC GACTGGCCCT GGCGGAAACC 
TTCTGTCTGA ACTGTGGCAT CCTTGCCTTG GATGAGCCGA CAACAAATCT CGACCGAGAA 
AACATTGAGT CTCTTGCACA TGCTTTGGTT GAGATCATAA AAAGTCGCTC ACAGCAGCGC 
AACTTCCAAC TTCTGGTAAT CACTCACGAT GAAGATTTTG TGGAGCTCTT AGGGCGATCT 
GAGTATGTGG AGAAATTCTA CAGGGTGAAG AAGAACATGG ACCAGTGCTC AGAGATTGTC 
AAGTGCAGCA TCAGCTCCCT GGGTTCTTAT GTTCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.
Cancer research77(19)5327-5338(2017 Oct)
Spehalski E,Capper KM,Smith CJ,Morgan MJ,Dinkelmann M,Buis J,Sekiguchi JM,Ferguson DO

RHS6 coordinately regulates the Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4.
Allergy72(5)772-782(2017 May)
Hwang SS,Jang SW,Lee KO,Kim HS,Lee GR

RHS6-mediated chromosomal looping and nuclear substructure binding is required for Th2 cytokine gene expression.
Biochimica et biophysica acta1860(3)383-391(2017 03)
Hwang SS,Jang SW,Lee GR

Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms.
Scientific reports622760(2016 Mar)
Asai T,Hatlen MA,Lossos C,Ndiaye-Lobry D,Deblasio A,Murata K,Fleisher M,Cortizas EM,Verdun RE,Petrini J,Nimer SD

Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.
Nature structural & molecular biology22(9)736-43(2015 Sep)
Hartlerode AJ,Morgan MJ,Wu Y,Buis J,Ferguson DO

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Rad50 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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