Serpinf2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpinf2
Entrez Gene ID	18816
Full Name	serine (or cysteine) peptidase inhibitor, clade F, member 2
Synonyms	AI747498,Pli,Serpimf2
General protein information	Preferred Names serine (or cysteine) peptidase inhibitor, clade F, member 2 Names alpha-2-antiplasmin alpha-2-AP alpha-2-PI alpha-2-plasmin inhibitor pigment epithelium derived factor plasmin inhibitor alpha 2 serine (or cysteine) proteinase inhibitor, clade F, member 2 serpin F2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 B5

mRNA and Protein(s)

mRNA	Protein	Name
NM_008878.2	NP_032904.1	alpha-2-antiplasmin precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SERPINF2	XP_003315334.1
	SERPINF2	XP_002800287.1
Rattus norvegicus (Norway rat)	Serpinf2	NP_001011892.1
Homo sapiens (human)	SERPINF2	NP_001159392.1
Danio rerio (zebrafish)	serpinf2b	NP_001073479.1
Danio rerio (zebrafish)	serpinf2a	XP_688797.1
Bos taurus (cattle)	SERPINF2	NP_777095.1
Mus musculus (house mouse)	Serpinf2	NP_032904.1
Canis lupus familiaris (dog)	SERPINF2	XP_854003.1
Xenopus tropicalis (tropical clawed frog)	serpinf2	XP_002937193.1
Gallus gallus (chicken)	SERPINF2	XP_003642447.1

Gene Ontology
Bibliography

Related articles in PubMed

?2-antiplasmin modulates bone formation by negatively regulating osteoblast differentiation and function.
Kanno Y, Ishisaki A, Kuretake H, Maruyama C, Matsuda A, Matsuo O
International journal of molecular medicine40(3)854-858(2017 Sep)

Releasing the Brakes on the Fibrinolytic System in Pulmonary Emboli: Unique Effects of Plasminogen Activation and ?2-Antiplasmin Inactivation.
Singh S, Houng A, Reed GL
Circulation135(11)1011-1020(2017 Mar)

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

alpha2AP has a profibrotic effect probably not by the action as a plasmin inhibitor, and the blocking of alpha2AP exerts an antifibrotic effect in humans and mice with systemic sclerosis
Title: The Antifibrotic Effect of ?2AP Neutralization in Systemic Sclerosis Dermal Fibroblasts and Mouse Models of Systemic Sclerosis.

A2AP is not significantly affected by the Pla protease during pneumonic plague, and although A2AP participates in immune modulation in the lungs, it has limited impact on the course or ultimate outcome of the infection.
Title: Impact of the Pla protease substrate ?2-antiplasmin on the progression of primary pneumonic plague.

a2AP deficiency enhanced thrombus dissolution, increased cerebral blood flow, reduced brain infarction, and decreased brain swelling.
Title: Microvascular thrombosis, fibrinolysis, ischemic injury, and death after cerebral thromboembolism are affected by levels of circulating ?2-antiplasmin.

our findings suggest that alpha2AP is a crucial mediator of motor function, cognitive function, anxiety-like behavior and depression-like behavior, providing new insights into the role of alpha2AP in the brain functions.
Title: Altered behavior in mice with deletion of the alpha2-antiplasmin gene.

Alpha 2 antiplasmin is involved in the recruitment of lymphocytes in the peripheral tissues.Alpha 2 antiplasmin contributes to the maintenance of immunological functions that are related to IgE.
Title: Lack of both ?2-antiplasmin and plasminogen activator inhibitor type-1 induces high IgE production.

The following Serpinf2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpinf2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02971	NM_008878.2 Latest version!	Mus musculus serine (or cysteine) peptidase inhibitor, clade F, member 2 (Serpinf2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpinf2 ( NM_008878.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032904.1 Mus musculus serine (or cysteine) peptidase inhibitor, clade F, member 2 (Serpinf2), mRNA.

Price & Availability↑

CloneID	OMu02971
Clone ID Related Accession (Same CDS sequence)	NM_008878.2
Accession Version	NM_008878.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1476bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	alpha-2-antiplasmin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL591496.13, GQ896353.1, AK077563.1 and AA269351.1. On Apr 1, 2010 this sequence version replaced NM_008878.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026756.1, AK077563.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCACTGC TCCGGGGGCT CCTCGTACTC AGCTTGTCCT GCCTGCAAGG TCCCTGTTTC 
ACGTTCTCTC CGGTGAGCGC CGTGGATCTC CCGGGCCAGC AGCCAGTGAG TGAGCAGGCC 
CAGCAGAAGC TGCCCCTGCC TGCCCTCTTC AAGTTGGACA ACCAGGATTT TGGTGACCAT 
GCTACCCTCA AGAGGTCCCC AGGACACTGC AAGAGTGTCC CAACTGCAGA GGAGACTCGC 
AGGCTGGCTC AGGCCATGAT GGCTTTTACT ACTGACCTGT TCTCTTTGGT GGCCCAAACA 
TCTACCAGCT CCAACCTTGT CCTGTCACCC CTTAGTGTGG CCCTAGCACT CTCTCACCTG 
GCACTAGGTG CTCAGAACCA AACACTACAC AGCTTGCATC GAGTGTTGCA CATGAACACA 
GGATCCTGCC TCCCGCATCT ACTGAGCCAT TTCTACCAGA ACCTAGGCCC AGGGACAATC 
CGACTGGCTG CCAGAATATA CCTGCAGAAA GGATTTCCCA TCAAAGACGA TTTCCTGGAG 
CAATCGGAAA GGCTCTTTGG TGCGAAGCCC GTGAAACTGA CTGGAAAGCA GGAGGAAGAC 
CTGGCGAACA TCAACCAATG GGTGAAGGAG GCCACAGAGG GGAAGATTGA GGATTTCCTC 
TCTGAGCTGC CGGATAGCAC CGTGCTGCTT CTCCTCAACG CCATCCACTT TCACGGTTTC 
TGGAGGACCA AGTTTGACCC GAGCCTCACC CAGAAAGATT TCTTCCACCT GGATGAGCGG 
TTCACAGTGT CGGTGGACAT GATGCACGCG GTGTCATATC CTCTTCGATG GTTCCTGCTG 
GAGCAACCTG AGATACAGGT GGCTCATTTC CCCTTTAAGA ACAACATGAG CTTTGTGGTC 
GTGATGCCCA CTTATTTTGA GTGGAACGTG TCCGAGGTAC TAGCCAACCT GACCTGGGAT 
ACTCTGTACC ATCCCTCGCT GCAGGAGAGG CCCACCAAGG TGTGGCTGCC TAAACTCCAT 
CTGCAACAGC AGCTGGACCT GGTGGCCACC CTCAGCCAAC TGGGCCTGCA GGAATTGTTC 
CAGGGCCCAG ACCTTCGTGG GATCTCTGAG CAGAATCTGG TGGTGTCTAG CGTGCAACAT 
CAGTCTACCA TGGAGCTCAG CGAGGCTGGT GTGGAGGCAG CCGCAGCTAC CAGCGTAGCC 
ATGAATCGAA TGTCCCTCTC CTCCTTCACT GTGAACCGAC CCTTCCTCTT CTTCATCATG 
GAGGACACCA TAGGCGTGCC CCTCTTTGTG GGCAGTGTGA GGAACCCTAA CCCCAGCGCG 
CTGCCCCAGC TCCAGGAACA GCGAGATTCC CCTGACAACA GGCTCATAGG CCAGAATGAC 
AAAGCTGACT TCCATGGAGG CAAGACCTTT GGTCCTGACT TGAAACTTGC ACCCCGCATG 
GAGGAAGACT ACCCCCAGTT CAGCTCCCCC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032904.1
CDS	50..1525
Translation	MALLRGLLVLSLSCLQGPCFTFSPVSAVDLPGQQPVSEQAQQKLPLPALFKLDNQDFGDHATLKRSPGHCKSVPTAEETRRLAQAMMAFTTDLFSLVAQTSTSSNLVLSPLSVALALSHLALGAQNQTLHSLHRVLHMNTGSCLPHLLSHFYQNLGPGTIRLAARIYLQKGFPIKDDFLEQSERLFGAKPVKLTGKQEEDLANINQWVKEATEGKIEDFLSELPDSTVLLLLNAIHFHGFWRTKFDPSLTQKDFFHLDERFTVSVDMMHAVSYPLRWFLLEQPEIQVAHFPFKNNMSFVVVMPTYFEWNVSEVLANLTWDTLYHPSLQERPTKVWLPKLHLQQQLDLVATLSQLGLQELFQGPDLRGISEQNLVVSSVQHQSTMELSEAGVEAAAATSVAMNRMSLSSFTVNRPFLFFIMEDTIGVPLFVGSVRNPNPSALPQLQEQRDSPDNRLIGQNDKADFHGGKTFGPDLKLAPRMEEDYPQFSSPK

Target ORF information:

RefSeq Version	NM_008878.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus serine (or cysteine) peptidase inhibitor, clade F, member 2 (Serpinf2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008878.2

ORF Insert Sequence:

ATGGCACTGC TCCGGGGGCT CCTCGTACTC AGCTTGTCCT GCCTGCAAGG TCCCTGTTTC 
ACGTTCTCTC CGGTGAGCGC CGTGGATCTC CCGGGCCAGC AGCCAGTGAG TGAGCAGGCC 
CAGCAGAAGC TGCCCCTGCC TGCCCTCTTC AAGTTGGACA ACCAGGATTT TGGTGACCAT 
GCTACCCTCA AGAGGTCCCC AGGACACTGC AAGAGTGTCC CAACTGCAGA GGAGACTCGC 
AGGCTGGCTC AGGCCATGAT GGCTTTTACT ACTGACCTGT TCTCTTTGGT GGCCCAAACA 
TCTACCAGCT CCAACCTTGT CCTGTCACCC CTTAGTGTGG CCCTAGCACT CTCTCACCTG 
GCACTAGGTG CTCAGAACCA AACACTACAC AGCTTGCATC GAGTGTTGCA CATGAACACA 
GGATCCTGCC TCCCGCATCT ACTGAGCCAT TTCTACCAGA ACCTAGGCCC AGGGACAATC 
CGACTGGCTG CCAGAATATA CCTGCAGAAA GGATTTCCCA TCAAAGACGA TTTCCTGGAG 
CAATCGGAAA GGCTCTTTGG TGCGAAGCCC GTGAAACTGA CTGGAAAGCA GGAGGAAGAC 
CTGGCGAACA TCAACCAATG GGTGAAGGAG GCCACAGAGG GGAAGATTGA GGATTTCCTC 
TCTGAGCTGC CGGATAGCAC CGTGCTGCTT CTCCTCAACG CCATCCACTT TCACGGTTTC 
TGGAGGACCA AGTTTGACCC GAGCCTCACC CAGAAAGATT TCTTCCACCT GGATGAGCGG 
TTCACAGTGT CGGTGGACAT GATGCACGCG GTGTCATATC CTCTTCGATG GTTCCTGCTG 
GAGCAACCTG AGATACAGGT GGCTCATTTC CCCTTTAAGA ACAACATGAG CTTTGTGGTC 
GTGATGCCCA CTTATTTTGA GTGGAACGTG TCCGAGGTAC TAGCCAACCT GACCTGGGAT 
ACTCTGTACC ATCCCTCGCT GCAGGAGAGG CCCACCAAGG TGTGGCTGCC TAAACTCCAT 
CTGCAACAGC AGCTGGACCT GGTGGCCACC CTCAGCCAAC TGGGCCTGCA GGAATTGTTC 
CAGGGCCCAG ACCTTCGTGG GATCTCTGAG CAGAATCTGG TGGTGTCTAG CGTGCAACAT 
CAGTCTACCA TGGAGCTCAG CGAGGCTGGT GTGGAGGCAG CCGCAGCTAC CAGCGTAGCC 
ATGAATCGAA TGTCCCTCTC CTCCTTCACT GTGAACCGAC CCTTCCTCTT CTTCATCATG 
GAGGACACCA TAGGCGTGCC CCTCTTTGTG GGCAGTGTGA GGAACCCTAA CCCCAGCGCG 
CTGCCCCAGC TCCAGGAACA GCGAGATTCC CCTGACAACA GGCTCATAGG CCAGAATGAC 
AAAGCTGACT TCCATGGAGG CAAGACCTTT GGTCCTGACT TGAAACTTGC ACCCCGCATG 
GAGGAAGACT ACCCCCAGTT CAGCTCCCCC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

?2-antiplasmin modulates bone formation by negatively regulating osteoblast differentiation and function.
International journal of molecular medicine40(3)854-858(2017 Sep)
Kanno Y,Ishisaki A,Kuretake H,Maruyama C,Matsuda A,Matsuo O

Releasing the Brakes on the Fibrinolytic System in Pulmonary Emboli: Unique Effects of Plasminogen Activation and ?2-Antiplasmin Inactivation.
Circulation135(11)1011-1020(2017 Mar)
Singh S,Houng A,Reed GL

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Scientific reports740495(2017 Jan)
Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO

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Serpinf2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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