Pitpna cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pitpna
Entrez Gene ID	18738
Full Name	phosphatidylinositol transfer protein, alpha
Synonyms	Pitpn,vb,vibrator
General protein information	Preferred Names phosphatidylinositol transfer protein, alpha Names phosphatidylinositol transfer protein alpha isoform PI-TP-alpha Pitp alpha ptdIns transfer protein alpha ptdInsTP alpha
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 B5\|11 45.92 cM
Summary	This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate by phosphoinositide-3-kinase. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008850.2	NP_032876.1	phosphatidylinositol transfer protein alpha isoform

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PITPNA	XP_001154250.1
	PITPNA	XP_002800284.1
Canis lupus familiaris (dog)	PITPNA	XP_537767.3
Xenopus tropicalis (tropical clawed frog)	pitpna	NP_001090832.1
Mus musculus (house mouse)	Pitpna	NP_032876.1
Rattus norvegicus (Norway rat)	Pitpna	NP_058927.1
Bos taurus (cattle)	PITPNA	NP_001040047.1
Gallus gallus (chicken)	LOC100859747	XP_003642444.2
Homo sapiens (human)	PITPNA	NP_006215.1
Danio rerio (zebrafish)	pitpnab	XP_002663601.1

Gene Ontology
Bibliography

Related articles in PubMed

Phosphatidylinositol transfer protein-? in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis.
Zhao L, Thorsheim CL, Suzuki A, Stalker TJ, Min SH, Lian L, Fairn GD, Cockcroft S, Durham A, Krishnaswamy S, Abrams CS
Nature communications8(1)1216(2017 Oct)

Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects.
Concepcion D, Ross KD, Hutt KR, Yeo GW, Hamilton BA
PLoS genetics11(4)e1005123(2015 Apr)

Modifier genes for mouse phosphatidylinositol transfer protein ? (vibrator) that bypass juvenile lethality.
Concepcion D, Johannes F, Lo YH, Yao J, Fong J, Hamilton BA
Genetics187(4)1185-91(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate a mechanism of suppression that bypasses a quantitative requirement for PITPalpha function.
Title: Modifier genes for mouse phosphatidylinositol transfer protein ? (vibrator) that bypass juvenile lethality.

phosphatidylinositol binding is an essential functional property of PITPalpha in vivo, and suggest a causal linkage between defects in lipid transport and glucose homeostasis and cerebellar inflammatory disease
Title: The pathologies associated with functional titration of phosphatidylinositol transfer protein alpha activity in mice.

These results identify a crucial role for PlTPalpha in netrin-1-induced neurite outgrowth, revealing a signalling mechanism for DCC/neogenin and PlTPalpha regulation.
Title: Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth.

The PITPalpha function in murine cells has no deleterious consequences for growth and bulk phospholipid metabolism.
Title: Biological functions of phosphatidylinositol transfer proteins.

Involved in phosphoionoitide homeostasis and signal transsduction (review)
Title: Phosphatidylinositol transfer protein function in the mouse.

The following Pitpna gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pitpna cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu76885	NM_008850.2 Latest version!	Mus musculus phosphatidylinositol transfer protein, alpha (Pitpna), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pitpna ( NM_008850.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032876.1 Mus musculus phosphatidylinositol transfer protein, alpha (Pitpna), mRNA.

Price & Availability↑

CloneID	OMu76885
Clone ID Related Accession (Same CDS sequence)	NM_008850.2
Accession Version	NM_008850.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	phosphatidylinositol transfer protein alpha isoform
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY316588.1, AK153569.1, AK168720.1 and BQ176339.1. On Sep 17, 2015 this sequence version replaced NM_008850.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK168720.1, U96725.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGCTGC TCAAGGAGTA TCGGGTCATC CTGCCTGTGT CTGTAGATGA GTATCAAGTG 
GGGCAGCTGT ATTCTGTGGC TGAAGCCAGT AAAAATGAAA CTGGTGGTGG GGAAGGTGTG 
GAGGTCCTGG TGAATGAGCC CTACGAGAAG GACGATGGCG AGAAAGGCCA GTACACACAC 
AAGATCTACC ACTTACAGAG CAAAGTACCC ACCTTTGTTC GAATGCTGGC CCCAGAAGGC 
GCCCTGAATA TACACGAGAA AGCCTGGAAT GCCTACCCTT ACTGCAGAAC CGTTATTACA 
AATGAGTACA TGAAAGAAGA TTTTCTGATT AAAATTGAAA CCTGGCACAA GCCAGACCTT 
GGCACCCAGG AGAATGTGCA TAAACTGGAG CCTGAGGCAT GGAAACATGT GGAAGCTATA 
TATATAGACA TCGCTGATCG AAGCCAAGTA CTTAGCAAGG ATTACAAGGC AGAGGAAGAC 
CCAGCAAAAT TTAAATCTGT CAAAACAGGA CGCGGACCTT TGGGCCCGAA TTGGAAGCAA 
GAACTTGTCA ATCAGAAAGA CTGCCCATAT ATGTGTGCAT ACAAACTGGT TACTGTCAAG 
TTCAAGTGGT GGGGCTTGCA GAACAAAGTG GAAAACTTTA TACATAAGCA AGAGAAGCGT 
CTGTTTACAA ACTTTCACAG GCAGCTGTTC TGTTGGCTCG ATAAATGGGT TGATCTGACT 
ATGGATGACA TTCGGAGGAT GGAAGAAGAG ACGAAGAGAC AGCTGGATGA GATGAGACAA 
AAGGACCCAG TGAAAGGAAT GACAGCAGAC GACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032876.1
CDS	255..1070
Translation	MVLLKEYRVILPVSVDEYQVGQLYSVAEASKNETGGGEGVEVLVNEPYEKDDGEKGQYTHKIYHLQSKVPTFVRMLAPEGALNIHEKAWNAYPYCRTVITNEYMKEDFLIKIETWHKPDLGTQENVHKLEPEAWKHVEAIYIDIADRSQVLSKDYKAEEDPAKFKSVKTGRGPLGPNWKQELVNQKDCPYMCAYKLVTVKFKWWGLQNKVENFIHKQEKRLFTNFHRQLFCWLDKWVDLTMDDIRRMEEETKRQLDEMRQKDPVKGMTADD

Target ORF information:

RefSeq Version	NM_008850.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus phosphatidylinositol transfer protein, alpha (Pitpna), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008850.2

ORF Insert Sequence:

ATGGTGCTGC TCAAGGAGTA TCGGGTCATC CTGCCTGTGT CTGTAGATGA GTATCAAGTG 
GGGCAGCTGT ATTCTGTGGC TGAAGCCAGT AAAAATGAAA CTGGTGGTGG GGAAGGTGTG 
GAGGTCCTGG TGAATGAGCC CTACGAGAAG GACGATGGCG AGAAAGGCCA GTACACACAC 
AAGATCTACC ACTTACAGAG CAAAGTACCC ACCTTTGTTC GAATGCTGGC CCCAGAAGGC 
GCCCTGAATA TACACGAGAA AGCCTGGAAT GCCTACCCTT ACTGCAGAAC CGTTATTACA 
AATGAGTACA TGAAAGAAGA TTTTCTGATT AAAATTGAAA CCTGGCACAA GCCAGACCTT 
GGCACCCAGG AGAATGTGCA TAAACTGGAG CCTGAGGCAT GGAAACATGT GGAAGCTATA 
TATATAGACA TCGCTGATCG AAGCCAAGTA CTTAGCAAGG ATTACAAGGC AGAGGAAGAC 
CCAGCAAAAT TTAAATCTGT CAAAACAGGA CGCGGACCTT TGGGCCCGAA TTGGAAGCAA 
GAACTTGTCA ATCAGAAAGA CTGCCCATAT ATGTGTGCAT ACAAACTGGT TACTGTCAAG 
TTCAAGTGGT GGGGCTTGCA GAACAAAGTG GAAAACTTTA TACATAAGCA AGAGAAGCGT 
CTGTTTACAA ACTTTCACAG GCAGCTGTTC TGTTGGCTCG ATAAATGGGT TGATCTGACT 
ATGGATGACA TTCGGAGGAT GGAAGAAGAG ACGAAGAGAC AGCTGGATGA GATGAGACAA 
AAGGACCCAG TGAAAGGAAT GACAGCAGAC GACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosphatidylinositol transfer protein-? in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis.
Nature communications8(1)1216(2017 Oct)
Zhao L,Thorsheim CL,Suzuki A,Stalker TJ,Min SH,Lian L,Fairn GD,Cockcroft S,Durham A,Krishnaswamy S,Abrams CS

Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects.
PLoS genetics11(4)e1005123(2015 Apr)
Concepcion D,Ross KD,Hutt KR,Yeo GW,Hamilton BA

Modifier genes for mouse phosphatidylinositol transfer protein ? (vibrator) that bypass juvenile lethality.
Genetics187(4)1185-91(2011 Apr)
Concepcion D,Johannes F,Lo YH,Yao J,Fong J,Hamilton BA

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Pitpna cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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