Abcb1b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Abcb1b
Entrez Gene ID	18669
Full Name	ATP-binding cassette, sub-family B (MDR/TAP), member 1B
Synonyms	Abcb1,Mdr1,Mdr1b,Pgy-1,Pgy1,mdr
General protein information	Preferred Names ATP-binding cassette, sub-family B (MDR/TAP), member 1B Names multidrug resistance protein 1B ATP-binding cassette sub-family B member 1 P glycoprotein 1 multidrug resistance protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 A1\|5 3.43 cM
Summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene encodes a membrane glycoprotein which confers a multidrug-resistance phenotype. The protein encoded by the human gene is an ATP-dependent drug efflux pump for xenobiotic compounds which is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
XM_030254200.1	XP_030110060.1	ATP-dependent translocase ABCB1 isoform X1
NM_011075.2	NP_035205.1	ATP-dependent translocase ABCB1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Abcb1b	NP_035205.1
Oryza sativa (rice)	Os02g0693700	NP_001047803.1
Arabidopsis thaliana (thale cress)	PGP10	NP_172538.1
Rattus norvegicus (Norway rat)	Abcb1b	NP_036755.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005639	XP_315658.3
Caenorhabditis elegans (roundworm)	pgp-2	NP_491707.2
Drosophila melanogaster (fruit fly)	Mdr49	NP_523724.2
Arabidopsis thaliana (thale cress)	PGP2	NP_194326.2

Gene Ontology
Bibliography

Related articles in PubMed

The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.
Cao W, Kayama H, Chen ML, Delmas A, Sun A, Kim SY, Rangarajan ES, McKevitt K, Beck AP, Jackson CB, Crynen G, Oikonomopoulos A, Lacey PN, Martinez GJ, Izard T, Lorenz RG, Rodriguez-Palacios A, Cominelli F, Abreu MT, Hommes DW, Koralov SB, Takeda K, Sundrud MS
Immunity47(6)1182-1196.e10(2017 Dec)

The Differential Absorption of a Series of P-Glycoprotein Substrates in Isolated Perfused Lungs from Mdr1a/1b Genetic Knockout Mice can be Attributed to Distinct Physico-Chemical Properties: an Insight into Predicting Transporter-Mediated, Pulmonary Specific Disposition.
Price DF, Luscombe CN, Eddershaw PJ, Edwards CD, Gumbleton M
Pharmaceutical research34(12)2498-2516(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mdr1 enforces T Cell homeostasis in the presence of intestinal bile acids.
Title: The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.

Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin.
Title: Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine.

the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity
Title: Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions.

Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way.
Title: Differential effects of the enantiomers of tamsulosin and tolterodine on P-glycoprotein and cytochrome P450 3A4.

Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.
Title: Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia.

The following Abcb1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abcb1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu88762	XM_030254200.1 Latest version!	Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OMu21179	NM_011075.2 Latest version!	Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$748.30 $1069.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Abcb1b ( XM_030254200.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030110060.1 Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu88762
Clone ID Related Accession (Same CDS sequence)	XM_030254200.1
Accession Version	XM_030254200.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2670bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	ATP-dependent translocase ABCB1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAAACT TAGAGTTTAA AAATGTTCAC TTCAACTACC CATCGAGAAG CGAAGTTCAG 
ATCTTGAAGG GCCTCAATCT GAAGGTGAAG AGCGGACAGA CGGTGGCCCT GGTTGGCAAC 
AGTGGCTGTG GAAAAAGCAC AACTGTCCAG CTGATGCAGA GGCTCTACGA CCCCCTGGAG 
GGCGTGGTCA GTATCGACGG ACAAGACATC AGAACCATCA ATGTGAGGTA TCTGAGGGAG 
ATCATTGGTG TGGTGAGTCA GGAACCTGTG CTGTTTGCCA CCACGATCGC CGAGAACATT 
CGCTATGGCC GAGAAGATGT CACCATGGAT GAGATTGAGA AAGCTGTCAA GGAAGCCAAT 
GCCTATGACT TCATCATGAA ACTGCCCCAC CAATTTGACA CCCTGGTTGG TGAGAGAGGG 
GCGCAGCTGA GTGGGGGACA GAAACAGAGA ATCGCCATTG CCCGGGCCCT GGTCCGCAAT 
CCCAAGATCC TTTTGTTGGA CGAGGCCACC TCAGCCCTGG ATACAGAAAG TGAAGCTGTG 
GTGCAGGCCG CACTGGATAA GGCTAGAGAA GGCCGGACCA CCATTGTGAT AGCTCATCGC 
TTGTCTACAG TTCGTAATGC TGACGTCATT GCTGGTTTTG ATGGTGGTGT CATTGTGGAG 
CAAGGAAATC ATGATGAGCT CATGAGAGAA AAGGGCATTT ACTTCAAACT TGTCATGACA 
CAGACTAGAG GAAATGAAAT TGAACCAGGA AATAATGCTT ATGGATCCCA GAGTGACACT 
GATGCTTCTG AACTGACTTC AGAAGAATCC AAATCACCTT TAATAAGGAG ATCAATTTAC 
AGAAGTGTCC ACAGAAAGCA AGACCAAGAG AGAAGACTTA GTATGAAAGA GGCTGTGGAT 
GAAGATGTGC CTCTGGTTTC CTTTTGGCGG ATCCTAAATC TAAATCTAAG TGAATGGCCT 
TATTTACTTG TTGGCGTACT TTGCGCTGTT ATAAATGGGT GCATACAACC AGTGTTTGCC 
ATAGTATTTT CAAGGATTGT AGGGGTTTTT TCAAGAGATG ATGACCATGA AACTAAACGA 
CAGAATTGTA ATTTGTTTTC CCTGTTCTTT CTGGTTATGG GGCTGATTTC TTTTGTTACA 
TATTTCTTTC AGGGCTTCAC ATTTGGCAAA GCCGGAGAGA TCCTCACCAA GCGAGTCCGA 
TACATGGTTT TCAAATCCAT GCTGAGACAG GATATAAGCT GGTTCGATGA CCATAAGAAC 
AGCACTGGCT CACTGACCAC CAGGCTCGCC AGTGATGCTT CTAGTGTTAA AGGGGCGATG 
GGCGCCAGGC TTGCTGTAGT TACCCAGAAT GTAGCAAACC TCGGGACAGG AGTCATCCTC 
TCCTTAGTCT ATGGCTGGCA GCTGACACTT CTACTTGTAG TAATTATACC GCTCATTGTA 
TTGGGCGGAA TTATTGAAAT GAAGCTGTTG TCTGGCCAAG CCTTGAAGGA CAAGAAACAG 
CTTGAGATCT CTGGGAAGAT TGCTACAGAA GCAATTGAAA ACTTCCGCAC TATTGTCTCT 
TTGACTCGGG AGCAGAAGTT TGAAACCATG TATGCCCAGA GCTTGCAGGT ACCATACAGA 
AATGCGATGA AGAAAGCACA CGTGTTTGGG ATCACGTTCT CCTTCACCCA GGCCATGATG 
TATTTTTCTT ATGCTGCTTG TTTCCGGTTC GGTGCCTACT TGGTGGCACA ACAACTCATG 
ACTTTTGAAA ATGTTATGTT GGTATTTTCT GCTGTTGTCT TTGGTGCCAT GGCAGCTGGG 
AATACTAGTT CATTTGCTCC TGACTATGCG AAAGCCAAAG TATCAGCATC TCATATCATC 
AGGATCATTG AGAAAACCCC TGAGATTGAC AGCTACAGCA CAGAGGGCTT GAAGCCTACT 
CTGTTAGAAG GAAATGTAAA ATTTAATGGA GTCCAGTTTA ACTATCCCAC CCGACCCAAC 
ATCCCAGTGC TTCAGGGGCT GAGCCTCGAG GTGAAGAAGG GCCAGACGTT GGCCCTGGTG 
GGCAGCAGTG GCTGTGGGAA GAGCACAGTG GTCCAGCTGC TCGAGCGCTT CTACGACCCC 
ATGGCTGGAT CAGTGTTTCT AGATGGCAAA GAAATAAAGC AACTGAATGT CCAGTGGCTC 
CGAGCTCACC TTGGCATTGT GTCCCAGGAG CCCATTCTCT TTGACTGCAG CATTGCAGAG 
AACATCGCCT ATGGAGACAA CAGCCGGGCC GTGTCTCATG AGGAGATTGT GAGGGCAGCC 
AAGGAGGCCA ACATCCACCA GTTCATCGAC TCACTGCCTG ATAAATACAA CACCAGAGTA 
GGAGACAAAG GCACTCAGCT GTCGGGTGGG CAGAAGCAGC GCATCGCCAT CGCACGTGCC 
CTCGTCAGAC AGCCTCACAT TTTACTTCTG GACGAAGCAA CATCAGCTCT GGATACAGAA 
AGTGAAAAGG TTGTCCAGGA AGCGCTGGAC AAAGCCAGGG AAGGCCGCAC CTGCATTGTG 
ATCGCTCACC GCCTGTCCAC CATCCAGAAC GCGGACTTGA TCGTGGTGAT TGAGAACGGC 
AAAGTCAAGG AGCACGGCAC CCACCAGCAG CTGCTGGCGC AGAAGGGCAT CTACTTCTCA 
ATGGTCCAGG CTGGAGCAAA GCGCTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030110060.1
CDS	759..3428
Translation	MGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTRGNEIEPGNNAYGSQSDTDASELTSEESKSPLIRRSIYRSVHRKQDQERRLSMKEAVDEDVPLVSFWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDDHETKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVQAGAKRS

Target ORF information:

RefSeq Version	XM_030254200.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030254200.1

ORF Insert Sequence:

ATGGGAAACT TAGAGTTTAA AAATGTTCAC TTCAACTACC CATCGAGAAG CGAAGTTCAG 
ATCTTGAAGG GCCTCAATCT GAAGGTGAAG AGCGGACAGA CGGTGGCCCT GGTTGGCAAC 
AGTGGCTGTG GAAAAAGCAC AACTGTCCAG CTGATGCAGA GGCTCTACGA CCCCCTGGAG 
GGCGTGGTCA GTATCGACGG ACAAGACATC AGAACCATCA ATGTGAGGTA TCTGAGGGAG 
ATCATTGGTG TGGTGAGTCA GGAACCTGTG CTGTTTGCCA CCACGATCGC CGAGAACATT 
CGCTATGGCC GAGAAGATGT CACCATGGAT GAGATTGAGA AAGCTGTCAA GGAAGCCAAT 
GCCTATGACT TCATCATGAA ACTGCCCCAC CAATTTGACA CCCTGGTTGG TGAGAGAGGG 
GCGCAGCTGA GTGGGGGACA GAAACAGAGA ATCGCCATTG CCCGGGCCCT GGTCCGCAAT 
CCCAAGATCC TTTTGTTGGA CGAGGCCACC TCAGCCCTGG ATACAGAAAG TGAAGCTGTG 
GTGCAGGCCG CACTGGATAA GGCTAGAGAA GGCCGGACCA CCATTGTGAT AGCTCATCGC 
TTGTCTACAG TTCGTAATGC TGACGTCATT GCTGGTTTTG ATGGTGGTGT CATTGTGGAG 
CAAGGAAATC ATGATGAGCT CATGAGAGAA AAGGGCATTT ACTTCAAACT TGTCATGACA 
CAGACTAGAG GAAATGAAAT TGAACCAGGA AATAATGCTT ATGGATCCCA GAGTGACACT 
GATGCTTCTG AACTGACTTC AGAAGAATCC AAATCACCTT TAATAAGGAG ATCAATTTAC 
AGAAGTGTCC ACAGAAAGCA AGACCAAGAG AGAAGACTTA GTATGAAAGA GGCTGTGGAT 
GAAGATGTGC CTCTGGTTTC CTTTTGGCGG ATCCTAAATC TAAATCTAAG TGAATGGCCT 
TATTTACTTG TTGGCGTACT TTGCGCTGTT ATAAATGGGT GCATACAACC AGTGTTTGCC 
ATAGTATTTT CAAGGATTGT AGGGGTTTTT TCAAGAGATG ATGACCATGA AACTAAACGA 
CAGAATTGTA ATTTGTTTTC CCTGTTCTTT CTGGTTATGG GGCTGATTTC TTTTGTTACA 
TATTTCTTTC AGGGCTTCAC ATTTGGCAAA GCCGGAGAGA TCCTCACCAA GCGAGTCCGA 
TACATGGTTT TCAAATCCAT GCTGAGACAG GATATAAGCT GGTTCGATGA CCATAAGAAC 
AGCACTGGCT CACTGACCAC CAGGCTCGCC AGTGATGCTT CTAGTGTTAA AGGGGCGATG 
GGCGCCAGGC TTGCTGTAGT TACCCAGAAT GTAGCAAACC TCGGGACAGG AGTCATCCTC 
TCCTTAGTCT ATGGCTGGCA GCTGACACTT CTACTTGTAG TAATTATACC GCTCATTGTA 
TTGGGCGGAA TTATTGAAAT GAAGCTGTTG TCTGGCCAAG CCTTGAAGGA CAAGAAACAG 
CTTGAGATCT CTGGGAAGAT TGCTACAGAA GCAATTGAAA ACTTCCGCAC TATTGTCTCT 
TTGACTCGGG AGCAGAAGTT TGAAACCATG TATGCCCAGA GCTTGCAGGT ACCATACAGA 
AATGCGATGA AGAAAGCACA CGTGTTTGGG ATCACGTTCT CCTTCACCCA GGCCATGATG 
TATTTTTCTT ATGCTGCTTG TTTCCGGTTC GGTGCCTACT TGGTGGCACA ACAACTCATG 
ACTTTTGAAA ATGTTATGTT GGTATTTTCT GCTGTTGTCT TTGGTGCCAT GGCAGCTGGG 
AATACTAGTT CATTTGCTCC TGACTATGCG AAAGCCAAAG TATCAGCATC TCATATCATC 
AGGATCATTG AGAAAACCCC TGAGATTGAC AGCTACAGCA CAGAGGGCTT GAAGCCTACT 
CTGTTAGAAG GAAATGTAAA ATTTAATGGA GTCCAGTTTA ACTATCCCAC CCGACCCAAC 
ATCCCAGTGC TTCAGGGGCT GAGCCTCGAG GTGAAGAAGG GCCAGACGTT GGCCCTGGTG 
GGCAGCAGTG GCTGTGGGAA GAGCACAGTG GTCCAGCTGC TCGAGCGCTT CTACGACCCC 
ATGGCTGGAT CAGTGTTTCT AGATGGCAAA GAAATAAAGC AACTGAATGT CCAGTGGCTC 
CGAGCTCACC TTGGCATTGT GTCCCAGGAG CCCATTCTCT TTGACTGCAG CATTGCAGAG 
AACATCGCCT ATGGAGACAA CAGCCGGGCC GTGTCTCATG AGGAGATTGT GAGGGCAGCC 
AAGGAGGCCA ACATCCACCA GTTCATCGAC TCACTGCCTG ATAAATACAA CACCAGAGTA 
GGAGACAAAG GCACTCAGCT GTCGGGTGGG CAGAAGCAGC GCATCGCCAT CGCACGTGCC 
CTCGTCAGAC AGCCTCACAT TTTACTTCTG GACGAAGCAA CATCAGCTCT GGATACAGAA 
AGTGAAAAGG TTGTCCAGGA AGCGCTGGAC AAAGCCAGGG AAGGCCGCAC CTGCATTGTG 
ATCGCTCACC GCCTGTCCAC CATCCAGAAC GCGGACTTGA TCGTGGTGAT TGAGAACGGC 
AAAGTCAAGG AGCACGGCAC CCACCAGCAG CTGCTGGCGC AGAAGGGCAT CTACTTCTCA 
ATGGTCCAGG CTGGAGCAAA GCGCTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Abcb1b ( NM_011075.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035205.1 Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b), mRNA.

Price & Availability↑

CloneID	OMu21179
Clone ID Related Accession (Same CDS sequence)	NM_011075.2
Accession Version	NM_011075.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	ATP-dependent translocase ABCB1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK030328.1, BQ829721.1, AK139854.1, BG080311.2, DV651684.1 and BY435708.1. On Nov 28, 2007 this sequence version replaced NM_011075.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC141363.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849379, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTTTG AAGAGAACCT TAAGGGAAGA GCAGACAAGA ACTTCTCGAA GATGGGCAAA 
AAGAGTAAAA AGGAGAAGAA AGAAAAGAAA CCTGCTGTTG GCGTATTTGG GATGTTTCGC 
TATGCAGATT GGCTGGACAA GCTGTGCATG ATTCTGGGAA CTCTCGCTGC TATTATCCAT 
GGAACATTAC TTCCCCTCTT GATGCTGGTG TTTGGAAACA TGACAGATAG TTTTACAAAA 
GCAGAAGCCA GTATTCTGCC AAGCATTACT AATCAAAGTG GACCCAACAG TACTCTGATC 
ATCAGCAACA GCAGTCTGGA GGAAGAGATG GCCATATACG CCTACTATTA CACCGGGATT 
GGTGCTGGTG TGCTCATAGT TGCCTACATC CAGGTTTCAC TTTGGTGCCT GGCAGCTGGA 
AGACAGATAC ACAAGATTAG GCAGAAGTTT TTCCATGCTA TAATGAATCA GGAGATAGGC 
TGGTTTGATG TGCATGATGT TGGGGAGCTC AACACCCGGC TCACAGATGA TGTCTCCAAA 
ATTAATGACG GAATTGGTGA CAAAATTGGG ATGTTTTTTC AGTCCATAAC CACATTTTTA 
GCCGGTTTTA TCATAGGATT TATAAGTGGT TGGAAGCTAA CCCTTGTCAT TTTGGCTGTC 
AGCCCTCTTA TTGGATTGTC ATCTGCTTTG TGGGCAAAGG TATTGACTTC ATTTACTAAT 
AAGGAACTCC AGGCTTATGC AAAAGCTGGA GCAGTTGCTG AAGAAGTCTT AGCAGCCATC 
AGAACTGTGA TTGCCTTTGG AGGACAACAG AAGGAACTTG AAAGGTACAA TAAAAATTTA 
GAAGAAGCTA AAAATGTTGG CATAAAGAAA GCTATCACAG CCAGCATTTC GATAGGCATT 
GCCTACCTGT TGGTCTATGC ATCATATGCA CTGGCATTCT GGTATGGGAC ATCCTTGGTC 
CTCTCAAATG AATATTCTAT TGGAGAAGTG CTTACTGTCT TCTTCTCTAT TTTGTTGGGG 
ACTTTTAGTA TTGGACACTT GGCCCCAAAC ATAGAAGCCT TTGCAAACGC ACGAGGGGCA 
GCCTTTGAAA TCTTCAAGAT AATTGATAAC GAGCCAAGCA TTGACAGCTT CTCAACAAAG 
GGCTACAAAC CAGACAGTAT AATGGGAAAC TTAGAGTTTA AAAATGTTCA CTTCAACTAC 
CCATCGAGAA GCGAAGTTCA GATCTTGAAG GGCCTCAATC TGAAGGTGAA GAGCGGACAG 
ACGGTGGCCC TGGTTGGCAA CAGTGGCTGT GGAAAAAGCA CAACTGTCCA GCTGATGCAG 
AGGCTCTACG ACCCCCTGGA GGGCGTGGTC AGTATCGACG GACAAGACAT CAGAACCATC 
AATGTGAGGT ATCTGAGGGA GATCATTGGT GTGGTGAGTC AGGAACCTGT GCTGTTTGCC 
ACCACGATCG CCGAGAACAT TCGCTATGGC CGAGAAGATG TCACCATGGA TGAGATTGAG 
AAAGCTGTCA AGGAAGCCAA TGCCTATGAC TTCATCATGA AACTGCCCCA CCAATTTGAC 
ACCCTGGTTG GTGAGAGAGG GGCGCAGCTG AGTGGGGGAC AGAAACAGAG AATCGCCATT 
GCCCGGGCCC TGGTCCGCAA TCCCAAGATC CTTTTGTTGG ACGAGGCCAC CTCAGCCCTG 
GATACAGAAA GTGAAGCTGT GGTGCAGGCC GCACTGGATA AGGCTAGAGA AGGCCGGACC 
ACCATTGTGA TAGCTCATCG CTTGTCTACA GTTCGTAATG CTGACGTCAT TGCTGGTTTT 
GATGGTGGTG TCATTGTGGA GCAAGGAAAT CATGATGAGC TCATGAGAGA AAAGGGCATT 
TACTTCAAAC TTGTCATGAC ACAGACTAGA GGAAATGAAA TTGAACCAGG AAATAATGCT 
TATGGATCCC AGAGTGACAC TGATGCTTCT GAACTGACTT CAGAAGAATC CAAATCACCT 
TTAATAAGGA GATCAATTTA CAGAAGTGTC CACAGAAAGC AAGACCAAGA GAGAAGACTT 
AGTATGAAAG AGGCTGTGGA TGAAGATGTG CCTCTGGTTT CCTTTTGGCG GATCCTAAAT 
CTAAATCTAA GTGAATGGCC TTATTTACTT GTTGGCGTAC TTTGCGCTGT TATAAATGGG 
TGCATACAAC CAGTGTTTGC CATAGTATTT TCAAGGATTG TAGGGGTTTT TTCAAGAGAT 
GATGACCATG AAACTAAACG ACAGAATTGT AATTTGTTTT CCCTGTTCTT TCTGGTTATG 
GGGCTGATTT CTTTTGTTAC ATATTTCTTT CAGGGCTTCA CATTTGGCAA AGCCGGAGAG 
ATCCTCACCA AGCGAGTCCG ATACATGGTT TTCAAATCCA TGCTGAGACA GGATATAAGC 
TGGTTCGATG ACCATAAGAA CAGCACTGGC TCACTGACCA CCAGGCTCGC CAGTGATGCT 
TCTAGTGTTA AAGGGGCGAT GGGCGCCAGG CTTGCTGTAG TTACCCAGAA TGTAGCAAAC 
CTCGGGACAG GAGTCATCCT CTCCTTAGTC TATGGCTGGC AGCTGACACT TCTACTTGTA 
GTAATTATAC CGCTCATTGT ATTGGGCGGA ATTATTGAAA TGAAGCTGTT GTCTGGCCAA 
GCCTTGAAGG ACAAGAAACA GCTTGAGATC TCTGGGAAGA TTGCTACAGA AGCAATTGAA 
AACTTCCGCA CTATTGTCTC TTTGACTCGG GAGCAGAAGT TTGAAACCAT GTATGCCCAG 
AGCTTGCAGG TACCATACAG AAATGCGATG AAGAAAGCAC ACGTGTTTGG GATCACGTTC 
TCCTTCACCC AGGCCATGAT GTATTTTTCT TATGCTGCTT GTTTCCGGTT CGGTGCCTAC 
TTGGTGGCAC AACAACTCAT GACTTTTGAA AATGTTATGT TGGTATTTTC TGCTGTTGTC 
TTTGGTGCCA TGGCAGCTGG GAATACTAGT TCATTTGCTC CTGACTATGC GAAAGCCAAA 
GTATCAGCAT CTCATATCAT CAGGATCATT GAGAAAACCC CTGAGATTGA CAGCTACAGC 
ACAGAGGGCT TGAAGCCTAC TCTGTTAGAA GGAAATGTAA AATTTAATGG AGTCCAGTTT 
AACTATCCCA CCCGACCCAA CATCCCAGTG CTTCAGGGGC TGAGCCTCGA GGTGAAGAAG 
GGCCAGACGT TGGCCCTGGT GGGCAGCAGT GGCTGTGGGA AGAGCACAGT GGTCCAGCTG 
CTCGAGCGCT TCTACGACCC CATGGCTGGA TCAGTGTTTC TAGATGGCAA AGAAATAAAG 
CAACTGAATG TCCAGTGGCT CCGAGCTCAC CTTGGCATTG TGTCCCAGGA GCCCATTCTC 
TTTGACTGCA GCATTGCAGA GAACATCGCC TATGGAGACA ACAGCCGGGC CGTGTCTCAT 
GAGGAGATTG TGAGGGCAGC CAAGGAGGCC AACATCCACC AGTTCATCGA CTCACTGCCT 
GATAAATACA ACACCAGAGT AGGAGACAAA GGCACTCAGC TGTCGGGTGG GCAGAAGCAG 
CGCATCGCCA TCGCACGTGC CCTCGTCAGA CAGCCTCACA TTTTACTTCT GGACGAAGCA 
ACATCAGCTC TGGATACAGA AAGTGAAAAG GTTGTCCAGG AAGCGCTGGA CAAAGCCAGG 
GAAGGCCGCA CCTGCATTGT GATCGCTCAC CGCCTGTCCA CCATCCAGAA CGCGGACTTG 
ATCGTGGTGA TTGAGAACGG CAAAGTCAAG GAGCACGGCA CCCACCAGCA GCTGCTGGCG 
CAGAAGGGCA TCTACTTCTC AATGGTCCAG GCTGGAGCAA AGCGCTCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035205.1
CDS	150..3980
Translation	MEFEENLKGRADKNFSKMGKKSKKEKKEKKPAVGVFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSITNQSGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGYKPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTRGNEIEPGNNAYGSQSDTDASELTSEESKSPLIRRSIYRSVHRKQDQERRLSMKEAVDEDVPLVSFWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDDHETKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVQAGAKRS

Target ORF information:

RefSeq Version	NM_011075.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011075.2

ORF Insert Sequence:

ATGGAGTTTG AAGAGAACCT TAAGGGAAGA GCAGACAAGA ACTTCTCGAA GATGGGCAAA 
AAGAGTAAAA AGGAGAAGAA AGAAAAGAAA CCTGCTGTTG GCGTATTTGG GATGTTTCGC 
TATGCAGATT GGCTGGACAA GCTGTGCATG ATTCTGGGAA CTCTCGCTGC TATTATCCAT 
GGAACATTAC TTCCCCTCTT GATGCTGGTG TTTGGAAACA TGACAGATAG TTTTACAAAA 
GCAGAAGCCA GTATTCTGCC AAGCATTACT AATCAAAGTG GACCCAACAG TACTCTGATC 
ATCAGCAACA GCAGTCTGGA GGAAGAGATG GCCATATACG CCTACTATTA CACCGGGATT 
GGTGCTGGTG TGCTCATAGT TGCCTACATC CAGGTTTCAC TTTGGTGCCT GGCAGCTGGA 
AGACAGATAC ACAAGATTAG GCAGAAGTTT TTCCATGCTA TAATGAATCA GGAGATAGGC 
TGGTTTGATG TGCATGATGT TGGGGAGCTC AACACCCGGC TCACAGATGA TGTCTCCAAA 
ATTAATGACG GAATTGGTGA CAAAATTGGG ATGTTTTTTC AGTCCATAAC CACATTTTTA 
GCCGGTTTTA TCATAGGATT TATAAGTGGT TGGAAGCTAA CCCTTGTCAT TTTGGCTGTC 
AGCCCTCTTA TTGGATTGTC ATCTGCTTTG TGGGCAAAGG TATTGACTTC ATTTACTAAT 
AAGGAACTCC AGGCTTATGC AAAAGCTGGA GCAGTTGCTG AAGAAGTCTT AGCAGCCATC 
AGAACTGTGA TTGCCTTTGG AGGACAACAG AAGGAACTTG AAAGGTACAA TAAAAATTTA 
GAAGAAGCTA AAAATGTTGG CATAAAGAAA GCTATCACAG CCAGCATTTC GATAGGCATT 
GCCTACCTGT TGGTCTATGC ATCATATGCA CTGGCATTCT GGTATGGGAC ATCCTTGGTC 
CTCTCAAATG AATATTCTAT TGGAGAAGTG CTTACTGTCT TCTTCTCTAT TTTGTTGGGG 
ACTTTTAGTA TTGGACACTT GGCCCCAAAC ATAGAAGCCT TTGCAAACGC ACGAGGGGCA 
GCCTTTGAAA TCTTCAAGAT AATTGATAAC GAGCCAAGCA TTGACAGCTT CTCAACAAAG 
GGCTACAAAC CAGACAGTAT AATGGGAAAC TTAGAGTTTA AAAATGTTCA CTTCAACTAC 
CCATCGAGAA GCGAAGTTCA GATCTTGAAG GGCCTCAATC TGAAGGTGAA GAGCGGACAG 
ACGGTGGCCC TGGTTGGCAA CAGTGGCTGT GGAAAAAGCA CAACTGTCCA GCTGATGCAG 
AGGCTCTACG ACCCCCTGGA GGGCGTGGTC AGTATCGACG GACAAGACAT CAGAACCATC 
AATGTGAGGT ATCTGAGGGA GATCATTGGT GTGGTGAGTC AGGAACCTGT GCTGTTTGCC 
ACCACGATCG CCGAGAACAT TCGCTATGGC CGAGAAGATG TCACCATGGA TGAGATTGAG 
AAAGCTGTCA AGGAAGCCAA TGCCTATGAC TTCATCATGA AACTGCCCCA CCAATTTGAC 
ACCCTGGTTG GTGAGAGAGG GGCGCAGCTG AGTGGGGGAC AGAAACAGAG AATCGCCATT 
GCCCGGGCCC TGGTCCGCAA TCCCAAGATC CTTTTGTTGG ACGAGGCCAC CTCAGCCCTG 
GATACAGAAA GTGAAGCTGT GGTGCAGGCC GCACTGGATA AGGCTAGAGA AGGCCGGACC 
ACCATTGTGA TAGCTCATCG CTTGTCTACA GTTCGTAATG CTGACGTCAT TGCTGGTTTT 
GATGGTGGTG TCATTGTGGA GCAAGGAAAT CATGATGAGC TCATGAGAGA AAAGGGCATT 
TACTTCAAAC TTGTCATGAC ACAGACTAGA GGAAATGAAA TTGAACCAGG AAATAATGCT 
TATGGATCCC AGAGTGACAC TGATGCTTCT GAACTGACTT CAGAAGAATC CAAATCACCT 
TTAATAAGGA GATCAATTTA CAGAAGTGTC CACAGAAAGC AAGACCAAGA GAGAAGACTT 
AGTATGAAAG AGGCTGTGGA TGAAGATGTG CCTCTGGTTT CCTTTTGGCG GATCCTAAAT 
CTAAATCTAA GTGAATGGCC TTATTTACTT GTTGGCGTAC TTTGCGCTGT TATAAATGGG 
TGCATACAAC CAGTGTTTGC CATAGTATTT TCAAGGATTG TAGGGGTTTT TTCAAGAGAT 
GATGACCATG AAACTAAACG ACAGAATTGT AATTTGTTTT CCCTGTTCTT TCTGGTTATG 
GGGCTGATTT CTTTTGTTAC ATATTTCTTT CAGGGCTTCA CATTTGGCAA AGCCGGAGAG 
ATCCTCACCA AGCGAGTCCG ATACATGGTT TTCAAATCCA TGCTGAGACA GGATATAAGC 
TGGTTCGATG ACCATAAGAA CAGCACTGGC TCACTGACCA CCAGGCTCGC CAGTGATGCT 
TCTAGTGTTA AAGGGGCGAT GGGCGCCAGG CTTGCTGTAG TTACCCAGAA TGTAGCAAAC 
CTCGGGACAG GAGTCATCCT CTCCTTAGTC TATGGCTGGC AGCTGACACT TCTACTTGTA 
GTAATTATAC CGCTCATTGT ATTGGGCGGA ATTATTGAAA TGAAGCTGTT GTCTGGCCAA 
GCCTTGAAGG ACAAGAAACA GCTTGAGATC TCTGGGAAGA TTGCTACAGA AGCAATTGAA 
AACTTCCGCA CTATTGTCTC TTTGACTCGG GAGCAGAAGT TTGAAACCAT GTATGCCCAG 
AGCTTGCAGG TACCATACAG AAATGCGATG AAGAAAGCAC ACGTGTTTGG GATCACGTTC 
TCCTTCACCC AGGCCATGAT GTATTTTTCT TATGCTGCTT GTTTCCGGTT CGGTGCCTAC 
TTGGTGGCAC AACAACTCAT GACTTTTGAA AATGTTATGT TGGTATTTTC TGCTGTTGTC 
TTTGGTGCCA TGGCAGCTGG GAATACTAGT TCATTTGCTC CTGACTATGC GAAAGCCAAA 
GTATCAGCAT CTCATATCAT CAGGATCATT GAGAAAACCC CTGAGATTGA CAGCTACAGC 
ACAGAGGGCT TGAAGCCTAC TCTGTTAGAA GGAAATGTAA AATTTAATGG AGTCCAGTTT 
AACTATCCCA CCCGACCCAA CATCCCAGTG CTTCAGGGGC TGAGCCTCGA GGTGAAGAAG 
GGCCAGACGT TGGCCCTGGT GGGCAGCAGT GGCTGTGGGA AGAGCACAGT GGTCCAGCTG 
CTCGAGCGCT TCTACGACCC CATGGCTGGA TCAGTGTTTC TAGATGGCAA AGAAATAAAG 
CAACTGAATG TCCAGTGGCT CCGAGCTCAC CTTGGCATTG TGTCCCAGGA GCCCATTCTC 
TTTGACTGCA GCATTGCAGA GAACATCGCC TATGGAGACA ACAGCCGGGC CGTGTCTCAT 
GAGGAGATTG TGAGGGCAGC CAAGGAGGCC AACATCCACC AGTTCATCGA CTCACTGCCT 
GATAAATACA ACACCAGAGT AGGAGACAAA GGCACTCAGC TGTCGGGTGG GCAGAAGCAG 
CGCATCGCCA TCGCACGTGC CCTCGTCAGA CAGCCTCACA TTTTACTTCT GGACGAAGCA 
ACATCAGCTC TGGATACAGA AAGTGAAAAG GTTGTCCAGG AAGCGCTGGA CAAAGCCAGG 
GAAGGCCGCA CCTGCATTGT GATCGCTCAC CGCCTGTCCA CCATCCAGAA CGCGGACTTG 
ATCGTGGTGA TTGAGAACGG CAAAGTCAAG GAGCACGGCA CCCACCAGCA GCTGCTGGCG 
CAGAAGGGCA TCTACTTCTC AATGGTCCAG GCTGGAGCAA AGCGCTCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.
Immunity47(6)1182-1196.e10(2017 Dec)
Cao W,Kayama H,Chen ML,Delmas A,Sun A,Kim SY,Rangarajan ES,McKevitt K,Beck AP,Jackson CB,Crynen G,Oikonomopoulos A,Lacey PN,Martinez GJ,Izard T,Lorenz RG,Rodriguez-Palacios A,Cominelli F,Abreu MT,Hommes DW,Koralov SB,Takeda K,Sundrud MS

The Differential Absorption of a Series of P-Glycoprotein Substrates in Isolated Perfused Lungs from Mdr1a/1b Genetic Knockout Mice can be Attributed to Distinct Physico-Chemical Properties: an Insight into Predicting Transporter-Mediated, Pulmonary Specific Disposition.
Pharmaceutical research34(12)2498-2516(2017 Dec)
Price DF,Luscombe CN,Eddershaw PJ,Edwards CD,Gumbleton M

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Abcb1b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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