Oat cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Oat
Entrez Gene ID	18242
Full Name	ornithine aminotransferase
Synonyms	AI194874,rhg
General protein information	Preferred Names ornithine aminotransferase Names ornithine aminotransferase, mitochondrial ornithine--oxo-acid aminotransferase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 F3\|7 76.3 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_016978.2	NP_058674.1	ornithine aminotransferase, mitochondrial precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	OAT	NP_000265.1
Pan troglodytes (chimpanzee)	OAT	XP_508094.2
	OAT	XP_001082545.2
Schizosaccharomyces pombe (fission yeast)	car2	NP_596588.1
Rattus norvegicus (Norway rat)	Oat	NP_071966.1
Gallus gallus (chicken)	OAT	NP_001006567.1
Caenorhabditis elegans (roundworm)	C16A3.10	NP_741194.1
Danio rerio (zebrafish)	oat	XP_701334.3
Drosophila melanogaster (fruit fly)	Oat	NP_649139.1
Eremothecium gossypii	AGOS_AER123W	NP_984982.1
Neurospora crassa	NCU00194	XP_956417.1
Xenopus tropicalis (tropical clawed frog)	oat.1	NP_001016936.1
Canis lupus familiaris (dog)	OAT	XP_866064.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004793	XP_318019.4
Kluyveromyces lactis	KLLA0B05247g	XP_451768.1
Arabidopsis thaliana (thale cress)	DELTA-OAT	NP_199430.1
Oryza sativa (rice)	Os03g0643300	NP_001050753.1
Bos taurus (cattle)	OAT	NP_001029412.1
Mus musculus (house mouse)	Oat	NP_058674.1
Saccharomyces cerevisiae (baker's yeast)	CAR2	NP_013542.1
Magnaporthe oryzae (rice blast fungus)	MGG_06392	XP_003717179.1

Gene Ontology
Bibliography

Related articles in PubMed

The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation.
Rocha AS, Vidal V, Mertz M, Kendall TJ, Charlet A, Okamoto H, Schedl A
Cell reports13(9)1757-64(2015 Dec)

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.
Fairfield H, Srivastava A, Ananda G, Liu R, Kircher M, Lakshminarayana A, Harris BS, Karst SY, Dionne LA, Kane CC, Curtain M, Berry ML, Ward-Bailey PF, Greenstein I, Byers C, Czechanski A, Sharp J, Palmer K, Gudis P, Martin W, Tadenev A, Bogdanik L, Pratt CH, Chang B, Schroeder DG, Cox GA, Cliften P, Milbrandt J, Murray S, Burgess R, Bergstrom DE, Donahue LR, Hamamy H, Masri A, Santoni FA, Makrythanasis P, Antonarakis SE, Shendure J, Reinholdt LG
Genome research25(7)948-57(2015 Jul)

The retarded hair growth (
Bisaillon JJ, Radden LA 2nd, Szabo ET, Hughes SR, Feliciano AM, Nesta AV, Petrovic B, Palanza KM, Lancinskas D, Szmurlo TA, Artus DC, Kapper MA, Mulrooney JP, King TR
Molecular genetics and metabolism reports1378-390(2014)

Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness.
Somma G, Alger HM, McGuire RM, Kretlow JD, Ruiz FR, Yatsenko SA, Stankiewicz P, Harrison W, Funk E, Bergamaschi A, Oghalai JS, Mikos AG, Overbeek PA, Pereira FA
Journal of the Association for Research in Otolaryngology : JARO13(3)335-49(2012 Jun)

Adaptative response of nitrogen metabolism in early endotoxemia: role of ornithine aminotransferase.
Ventura G, Moinard C, Segaud F, Le Plenier S, Cynober L, De Bandt JP
Amino acids39(5)1417-26(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The data highlight the importance of OAT in ornithine metabolism, especially in the liver, and suggest a post-transcriptional regulation of OAT by LPS in the liver.
Title: Adaptative response of nitrogen metabolism in early endotoxemia: role of ornithine aminotransferase.

Sexual dimorphism of Oat expression in the kidney was observed.
Title: Sex-differential expression of ornithine aminotransferase in the mouse kidney.

In H4Flox liver, glutamine synthetase (GS), ornithine aminotransferase (OAT) and thyroid hormone-receptor beta1 (TRbeta1) were exclusively expressed in pericentral hepatocytes.
Title: Hepatic HNF4alpha deficiency induces periportal expression of glutamine synthetase and other pericentral enzymes.

in female and castrated male mice devoided of testosterone, OAT gene is highly expressed and L-ornithine is converted into L-glutamate.
Title: Testosterone down-regulates ornithine aminotransferase gene and up-regulates arginase II and ornithine decarboxylase genes for polyamines synthesis in the murine kidney.

The following Oat gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Oat cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15563	NM_016978.2 Latest version!	Mus musculus ornithine aminotransferase (Oat), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Oat ( NM_016978.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058674.1 Mus musculus ornithine aminotransferase (Oat), mRNA.

Price & Availability↑

CloneID	OMu15563
Clone ID Related Accession (Same CDS sequence)	NM_016978.2
Accession Version	NM_016978.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	ornithine aminotransferase, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK145877.1, AK168851.1 and BY435126.1. On Mar 23, 2007 this sequence version replaced NM_016978.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK145877.1, AK168851.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGCTTTCTA AACTAGCAAG TCTGCAGACC ATTGCTGCTC TGCGCCGAGG AGTCCACACC 
TCAGTCGCCT CTGCCACGTC TGTTGCCACA AAGAAGACAG AGCAAGGCCC ACCATCCTCC 
GAGTACATTT TTGAACGGGA ATCTAAATAT GGTGCACACA ATTACCATCC TTTGCCTGTA 
GCCCTGGAGA GAGGAAAAGG CATTTATATG TGGGATGTGG AAGGCAGGCA GTACTTCGAT 
TTCCTGAGTG CTTATGGTGC TGTCAGCCAA GGACACTGCC ACCCAAAGAT CATAGATGCC 
ATGAAGAGTC AGGTGGACAA GCTGACATTA ACATCTCGGG CTTTCTATAA CAATGTCCTT 
GGTGAATACG AGGAGTACAT CACCAAGCTT TTCAACTACA ACAAAGTTCT CCCTATGAAT 
ACAGGAGTGG AGGCTGGAGA GACTGCATGT AAGCTCGCTC GTCGTTGGGG CTACACCGTG 
AAAGGCATCC AGAAATACAA AGCAAAGATT GTTTTTGCTG ATGGGAACTT TTGGGGTCGA 
ACACTATCTG CAATCTCCAG TTCCACAGAT CCGACCAGTT ATGATGGCTT TGGACCCTTC 
ATGCCAGGCT TTGAAACCAT CCCATATAAC GATCTGCCCG CACTGGAGCG TGCTCTTCAG 
GATCCAAATG TTGCTGCCTT CATGGTGGAG CCCATCCAGG GTGAAGCAGG CGTTATCGTT 
CCGGATCCAG GATACCTGAC AGGAGTTCGG GAACTCTGCA CCAGGCACCA GGTCCTGTTT 
ATTGCTGATG AAATACAGAC AGGATTGGCC AGAACTGGTA GATGGCTGGC TGTGGATCAT 
GAGAATGTCA GACCTGATAT GGTTCTTCTT GGGAAGGCCC TTTCTGGCGG TTTATACCCT 
GTGTCTGCAG TGCTGTGTGA CGATGAGATA ATGCTGACCA TTAAACCAGG CGAGCACGGC 
TCCACATACG GCGGAAACCC ACTAGGCTGC CGAATTGCCA TTGCGGCTCT TGAGGTTTTA 
GAAGAGGAGA ATCTTGCTGA GAATGCAGAC AAGATGGGCG CTATCCTGAG GAAGGAGCTC 
ATGAAGCTGC CCTCTGACGT TGTGACCTCA GTGAGAGGGA AAGGGTTGCT AAATGCCATT 
GTCATCAGAG AAACCAAAGA CTGTGATGCT TGGAAGGTGT GCCTGCGACT TCGAGATAAC 
GGGCTTCTGG CCAAGCCAAC CCACGGTGAT ATCATCAGGC TTGCCCCTCC CCTTGTGATC 
AAGGAGGATG AGATCCGGGA GTCCGTGGAG ATCATCAACA AGACTATCTT GTCCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058674.1
CDS	141..1460
Translation	MLSKLASLQTIAALRRGVHTSVASATSVATKKTEQGPPSSEYIFERESKYGAHNYHPLPVALERGKGIYMWDVEGRQYFDFLSAYGAVSQGHCHPKIIDAMKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYNKVLPMNTGVEAGETACKLARRWGYTVKGIQKYKAKIVFADGNFWGRTLSAISSSTDPTSYDGFGPFMPGFETIPYNDLPALERALQDPNVAAFMVEPIQGEAGVIVPDPGYLTGVRELCTRHQVLFIADEIQTGLARTGRWLAVDHENVRPDMVLLGKALSGGLYPVSAVLCDDEIMLTIKPGEHGSTYGGNPLGCRIAIAALEVLEEENLAENADKMGAILRKELMKLPSDVVTSVRGKGLLNAIVIRETKDCDAWKVCLRLRDNGLLAKPTHGDIIRLAPPLVIKEDEIRESVEIINKTILSF

Target ORF information:

RefSeq Version	NM_016978.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ornithine aminotransferase (Oat), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016978.2

ORF Insert Sequence:

ATGCTTTCTA AACTAGCAAG TCTGCAGACC ATTGCTGCTC TGCGCCGAGG AGTCCACACC 
TCAGTCGCCT CTGCCACGTC TGTTGCCACA AAGAAGACAG AGCAAGGCCC ACCATCCTCC 
GAGTACATTT TTGAACGGGA ATCTAAATAT GGTGCACACA ATTACCATCC TTTGCCTGTA 
GCCCTGGAGA GAGGAAAAGG CATTTATATG TGGGATGTGG AAGGCAGGCA GTACTTCGAT 
TTCCTGAGTG CTTATGGTGC TGTCAGCCAA GGACACTGCC ACCCAAAGAT CATAGATGCC 
ATGAAGAGTC AGGTGGACAA GCTGACATTA ACATCTCGGG CTTTCTATAA CAATGTCCTT 
GGTGAATACG AGGAGTACAT CACCAAGCTT TTCAACTACA ACAAAGTTCT CCCTATGAAT 
ACAGGAGTGG AGGCTGGAGA GACTGCATGT AAGCTCGCTC GTCGTTGGGG CTACACCGTG 
AAAGGCATCC AGAAATACAA AGCAAAGATT GTTTTTGCTG ATGGGAACTT TTGGGGTCGA 
ACACTATCTG CAATCTCCAG TTCCACAGAT CCGACCAGTT ATGATGGCTT TGGACCCTTC 
ATGCCAGGCT TTGAAACCAT CCCATATAAC GATCTGCCCG CACTGGAGCG TGCTCTTCAG 
GATCCAAATG TTGCTGCCTT CATGGTGGAG CCCATCCAGG GTGAAGCAGG CGTTATCGTT 
CCGGATCCAG GATACCTGAC AGGAGTTCGG GAACTCTGCA CCAGGCACCA GGTCCTGTTT 
ATTGCTGATG AAATACAGAC AGGATTGGCC AGAACTGGTA GATGGCTGGC TGTGGATCAT 
GAGAATGTCA GACCTGATAT GGTTCTTCTT GGGAAGGCCC TTTCTGGCGG TTTATACCCT 
GTGTCTGCAG TGCTGTGTGA CGATGAGATA ATGCTGACCA TTAAACCAGG CGAGCACGGC 
TCCACATACG GCGGAAACCC ACTAGGCTGC CGAATTGCCA TTGCGGCTCT TGAGGTTTTA 
GAAGAGGAGA ATCTTGCTGA GAATGCAGAC AAGATGGGCG CTATCCTGAG GAAGGAGCTC 
ATGAAGCTGC CCTCTGACGT TGTGACCTCA GTGAGAGGGA AAGGGTTGCT AAATGCCATT 
GTCATCAGAG AAACCAAAGA CTGTGATGCT TGGAAGGTGT GCCTGCGACT TCGAGATAAC 
GGGCTTCTGG CCAAGCCAAC CCACGGTGAT ATCATCAGGC TTGCCCCTCC CCTTGTGATC 
AAGGAGGATG AGATCCGGGA GTCCGTGGAG ATCATCAACA AGACTATCTT GTCCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation.
Cell reports13(9)1757-64(2015 Dec)
Rocha AS,Vidal V,Mertz M,Kendall TJ,Charlet A,Okamoto H,Schedl A

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.
Genome research25(7)948-57(2015 Jul)
Fairfield H,Srivastava A,Ananda G,Liu R,Kircher M,Lakshminarayana A,Harris BS,Karst SY,Dionne LA,Kane CC,Curtain M,Berry ML,Ward-Bailey PF,Greenstein I,Byers C,Czechanski A,Sharp J,Palmer K,Gudis P,Martin W,Tadenev A,Bogdanik L,Pratt CH,Chang B,Schroeder DG,Cox GA,Cliften P,Milbrandt J,Murray S,Burgess R,Bergstrom DE,Donahue LR,Hamamy H,Masri A,Santoni FA,Makrythanasis P,Antonarakis SE,Shendure J,Reinholdt LG

The retarded hair growth (
Molecular genetics and metabolism reports1378-390(2014)
Bisaillon JJ,Radden LA 2nd,Szabo ET,Hughes SR,Feliciano AM,Nesta AV,Petrovic B,Palanza KM,Lancinskas D,Szmurlo TA,Artus DC,Kapper MA,Mulrooney JP,King TR

Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness.
Journal of the Association for Research in Otolaryngology : JARO13(3)335-49(2012 Jun)
Somma G,Alger HM,McGuire RM,Kretlow JD,Ruiz FR,Yatsenko SA,Stankiewicz P,Harrison W,Funk E,Bergamaschi A,Oghalai JS,Mikos AG,Overbeek PA,Pereira FA

Adaptative response of nitrogen metabolism in early endotoxemia: role of ornithine aminotransferase.
Amino acids39(5)1417-26(2010 Nov)
Ventura G,Moinard C,Segaud F,Le Plenier S,Cynober L,De Bandt JP

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Oat cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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