Npm3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Npm3
Entrez Gene ID	18150
Full Name	nucleoplasmin 3
Synonyms	Nub1
General protein information	Preferred Names nucleoplasmin 3 Names nucleoplasmin-3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19 C3\|19 38.75 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008723.2	NP_032749.1	nucleoplasmin-3
NM_008723.1	NP_032749.1	nucleoplasmin-3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NPM3	XP_534995.3
Rattus norvegicus (Norway rat)	Npm3	XP_577868.2
Mus musculus (house mouse)	Npm3	NP_032749.1
Bos taurus (cattle)	NPM3	NP_001192489.1
Homo sapiens (human)	NPM3	NP_008924.1
Pan troglodytes (chimpanzee)	NPM3	XP_507995.2
	NPM3	XP_001111044.1
Gallus gallus (chicken)	NPM3	XP_001233764.2

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

FGF signalling regulates chromatin organisation during neural differentiation via mechanisms that can be uncoupled from transcription.
Patel NS, Rhinn M, Semprich CI, Halley PA, Doll? P, Bickmore WA, Storey KG
PLoS genetics9(7)e1003614(2013)

Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling.
Okuwaki M, Sumi A, Hisaoka M, Saotome-Nakamura A, Akashi S, Nishimura Y, Nagata K
Nucleic acids research40(11)4861-78(2012 Jun)

Identification and characterization of nucleoplasmin 3 as a histone-binding protein in embryonic stem cells.
Motoi N, Suzuki K, Hirota R, Johnson P, Oofusa K, Kikuchi Y, Yoshizato K
Development, growth & differentiation50(5)307-20(2008 Jun)

Identification of evolutionarily conserved regulatory elements in the mouse Fgf8 locus.
Beermann F, Kaloulis K, Hofmann D, Murisier F, Bucher P, Trumpp A
Genesis (New York, N.Y. : 2000)44(1)1-6(2006 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A chromatin remodeling protein responsible for the unique chromatin structure and replicative capacity of embryonic stem cells.
Title: Identification and characterization of nucleoplasmin 3 as a histone-binding protein in embryonic stem cells.

Overexpression of a mutant of NPM3 that did not interact with B23 did not alter pre-rRNA synthesis and processing, suggesting that the interaction of NPM3 with B23 plays a role in the ribosome biogenesis
Title: Protein NPM3 interacts with the multifunctional nucleolar protein B23/nucleophosmin and inhibits ribosome biogenesis.

The following Npm3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Npm3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu02634	NM_008723.2 Latest version!	Mus musculus nucleoplasmin 3 (Npm3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OMu02634	NM_008723.1	Mus musculus nucleoplasmin 3 (Npm3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Npm3 ( NM_008723.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032749.1 Mus musculus nucleoplasmin 3 (Npm3), mRNA.

Price & Availability↑

CloneID	OMu02634
Clone ID Related Accession (Same CDS sequence)	NM_008723.2 , NM_008723.1
Accession Version	NM_008723.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-06
Organism	Mus musculus(house mouse)
Product	nucleoplasmin-3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK146603.1 and AC149086.4. On Feb 7, 2019 this sequence version replaced NM_008723.1. ##Evidence-Data-START## Transcript exon combination :: U64450.1, SRR7652917.1018692.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCCG GCGCGGCGGC TGCTTTAGCG TTCTTGAACC AAGAGAGCCG AGCCCGAGCT 
GGGGGCGTCG GGGGCCTGAG GGTCCCGGCC CCGGTCACAA TGGACAGTTT CTTCTTCGGT 
TGTGAGCTCT CCGGCCACAC CCGCTCCTTC ACTTTCAAGG TTGAGGAGGA GGATGACACG 
GAGCACGTGC TGGCGTTGAA CATGCTGTGC CTTACCGAGG GGGCCACGGA CGAGTGTAAT 
GTGGTGGAAG TTGTGGCCCG GGATCACGAC AATCAGGAGA TTGCAGTTCC TGTGGCCAAC 
CTCAGGTTGT CTTGCCAGCC CATGCTCAGT GTGGATGATT TCCAACTCCA ACCACCTGTC 
ACCTTCCGCC TGAAGTCCGG TTCTGGCCCA GTTCGGATCA CTGGCCGGCA TCAGATCGTT 
TGTATAAACA ACGACCTTTC TGAAGAAGAA AGTGATGATG AGAGCGAAGA AGATGAAATT 
AAGCTGTGTG GCATCCTTCC TGCCAAGAAG CACAGGGGCA GGCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032749.1
CDS	10..537
Translation	MAAGAAAALAFLNQESRARAGGVGGLRVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDTEHVLALNMLCLTEGATDECNVVEVVARDHDNQEIAVPVANLRLSCQPMLSVDDFQLQPPVTFRLKSGSGPVRITGRHQIVCINNDLSEEESDDESEEDEIKLCGILPAKKHRGRP

Target ORF information:

RefSeq Version	NM_008723.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus nucleoplasmin 3 (Npm3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008723.2

ORF Insert Sequence:

ATGGCGGCCG GCGCGGCGGC TGCTTTAGCG TTCTTGAACC AAGAGAGCCG AGCCCGAGCT 
GGGGGCGTCG GGGGCCTGAG GGTCCCGGCC CCGGTCACAA TGGACAGTTT CTTCTTCGGT 
TGTGAGCTCT CCGGCCACAC CCGCTCCTTC ACTTTCAAGG TTGAGGAGGA GGATGACACG 
GAGCACGTGC TGGCGTTGAA CATGCTGTGC CTTACCGAGG GGGCCACGGA CGAGTGTAAT 
GTGGTGGAAG TTGTGGCCCG GGATCACGAC AATCAGGAGA TTGCAGTTCC TGTGGCCAAC 
CTCAGGTTGT CTTGCCAGCC CATGCTCAGT GTGGATGATT TCCAACTCCA ACCACCTGTC 
ACCTTCCGCC TGAAGTCCGG TTCTGGCCCA GTTCGGATCA CTGGCCGGCA TCAGATCGTT 
TGTATAAACA ACGACCTTTC TGAAGAAGAA AGTGATGATG AGAGCGAAGA AGATGAAATT 
AAGCTGTGTG GCATCCTTCC TGCCAAGAAG CACAGGGGCA GGCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Npm3 ( NM_008723.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032749.1 Mus musculus nucleoplasmin 3 (Npm3), mRNA.

Price & Availability↑

CloneID	OMu02634
Clone ID Related Accession (Same CDS sequence)	NM_008723.2 , NM_008723.1
Accession Version	NM_008723.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-10
Organism	Mus musculus(house mouse)
Product	nucleoplasmin-3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U64450.1. On Dec 7, 2005 this sequence version replaced XM_914732.1. ##Evidence-Data-START## Transcript exon combination :: U64450.1, AK011749.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCCG GCGCGGCGGC TGCTTTAGCG TTCTTGAACC AAGAGAGCCG AGCCCGAGCT 
GGGGGCGTCG GGGGCCTGAG GGTCCCGGCC CCGGTCACAA TGGACAGTTT CTTCTTCGGT 
TGTGAGCTCT CCGGCCACAC CCGCTCCTTC ACTTTCAAGG TTGAGGAGGA GGATGACACG 
GAGCACGTGC TGGCGTTGAA CATGCTGTGC CTTACCGAGG GGGCCACGGA CGAGTGTAAT 
GTGGTGGAAG TTGTGGCCCG GGATCACGAC AATCAGGAGA TTGCAGTTCC TGTGGCCAAC 
CTCAGGTTGT CTTGCCAGCC CATGCTCAGT GTGGATGATT TCCAACTCCA ACCACCTGTC 
ACCTTCCGCC TGAAGTCCGG TTCTGGCCCA GTTCGGATCA CTGGCCGGCA TCAGATCGTT 
TGTATAAACA ACGACCTTTC TGAAGAAGAA AGTGATGATG AGAGCGAAGA AGATGAAATT 
AAGCTGTGTG GCATCCTTCC TGCCAAGAAG CACAGGGGCA GGCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032749.1
CDS	8..535
Translation	MAAGAAAALAFLNQESRARAGGVGGLRVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDTEHVLALNMLCLTEGATDECNVVEVVARDHDNQEIAVPVANLRLSCQPMLSVDDFQLQPPVTFRLKSGSGPVRITGRHQIVCINNDLSEEESDDESEEDEIKLCGILPAKKHRGRP

Target ORF information:

RefSeq Version	NM_008723.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus nucleoplasmin 3 (Npm3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008723.1

ORF Insert Sequence:

ATGGCGGCCG GCGCGGCGGC TGCTTTAGCG TTCTTGAACC AAGAGAGCCG AGCCCGAGCT 
GGGGGCGTCG GGGGCCTGAG GGTCCCGGCC CCGGTCACAA TGGACAGTTT CTTCTTCGGT 
TGTGAGCTCT CCGGCCACAC CCGCTCCTTC ACTTTCAAGG TTGAGGAGGA GGATGACACG 
GAGCACGTGC TGGCGTTGAA CATGCTGTGC CTTACCGAGG GGGCCACGGA CGAGTGTAAT 
GTGGTGGAAG TTGTGGCCCG GGATCACGAC AATCAGGAGA TTGCAGTTCC TGTGGCCAAC 
CTCAGGTTGT CTTGCCAGCC CATGCTCAGT GTGGATGATT TCCAACTCCA ACCACCTGTC 
ACCTTCCGCC TGAAGTCCGG TTCTGGCCCA GTTCGGATCA CTGGCCGGCA TCAGATCGTT 
TGTATAAACA ACGACCTTTC TGAAGAAGAA AGTGATGATG AGAGCGAAGA AGATGAAATT 
AAGCTGTGTG GCATCCTTCC TGCCAAGAAG CACAGGGGCA GGCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

FGF signalling regulates chromatin organisation during neural differentiation via mechanisms that can be uncoupled from transcription.
PLoS genetics9(7)e1003614(2013)
Patel NS,Rhinn M,Semprich CI,Halley PA,Doll? P,Bickmore WA,Storey KG

Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling.
Nucleic acids research40(11)4861-78(2012 Jun)
Okuwaki M,Sumi A,Hisaoka M,Saotome-Nakamura A,Akashi S,Nishimura Y,Nagata K

Identification and characterization of nucleoplasmin 3 as a histone-binding protein in embryonic stem cells.
Development, growth & differentiation50(5)307-20(2008 Jun)
Motoi N,Suzuki K,Hirota R,Johnson P,Oofusa K,Kikuchi Y,Yoshizato K

Identification of evolutionarily conserved regulatory elements in the mouse Fgf8 locus.
Genesis (New York, N.Y. : 2000)44(1)1-6(2006 Jan)
Beermann F,Kaloulis K,Hofmann D,Murisier F,Bucher P,Trumpp A

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Npm3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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