Mtf1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mtf1
Entrez Gene ID	17764
Full Name	metal response element binding transcription factor 1
Synonyms	MTF-1,Thyls
General protein information	Preferred Names metal response element binding transcription factor 1 Names metal regulatory transcription factor 1 MRE-binding transcription factor metalloregulatory transcription factor transcription factor MTF-1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 D2.2\|4 57.91 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008636.4	NP_032662.3	metal regulatory transcription factor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	MTF1	NP_005946.2
	MTF1	XP_001112790.1
Bos taurus (cattle)	MTF1	NP_001030252.2
Gallus gallus (chicken)	MTF1	NP_001026666.1
Danio rerio (zebrafish)	mtf1	NP_694513.1
Pan troglodytes (chimpanzee)	MTF1	XP_513329.2
Canis lupus familiaris (dog)	MTF1	XP_005628986.1
Mus musculus (house mouse)	Mtf1	NP_032662.3
Xenopus tropicalis (tropical clawed frog)	mtf1	XP_002939525.1
Rattus norvegicus (Norway rat)	Mtf1	NP_001102147.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Reciprocal activation of hypoxia-inducible factor (HIF)-2? and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis.
Lee M, Won Y, Shin Y, Kim JH, Chun JS
Osteoarthritis and cartilage24(1)134-45(2016 Jan)

Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1.
van Loo KM, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, Dalal A, Urbach H, Beck H, Yaari Y, Schoch S, Becker AJ
Nature communications68688(2015 Oct)

A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion.
Chang AC, Garside VC, Fournier M, Smrz J, Vrljicak P, Umlandt P, Fuller M, Robertson G, Zhao Y, Tam A, Jones SJ, Marra MA, Hoodless PA, Karsan A
Developmental dynamics : an official publication of the American Association of Anatomists243(7)894-905(2014 Jul)

Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis.
Kim JH, Jeon J, Shin M, Won Y, Lee M, Kwak JS, Lee G, Rhee J, Ryu JH, Chun CH, Chun JS
Cell156(4)730-43(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings identify a reciprocal activation mechanism involving HIF-2alpha and the zinc-ZIP8-MTF1 axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.
Title: Reciprocal activation of hypoxia-inducible factor (HIF)-2? and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis.

MTF1 mediates the increase of CaV3.2 mRNA and a rise in intracellular Zn(2+) which is associated with status epilepticus.
Title: Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1.

the presence of SUMO moiety allows the MTF-1 protein to interact directly with metal-responsive element
Title: Expression and characterization of SUMO-conjugated metal-responsive transcription factor 1: SIM-dependent cross-interaction and distinct DNA binding activity.

nuclear receptor SHP inhibits zinc-dependent induction of Dnmt1 by antagonizing metal-responsive transcription factor-1.
Title: Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP.

MTF-1 DNA-binding activity is strongly enhanced in the presence of zinc.
Title: Hypoxia acts through multiple signaling pathways to induce metallothionein transactivation by the metal-responsive transcription factor-1 (MTF-1).

The following Mtf1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mtf1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21480	NM_008636.4 Latest version!	Mus musculus metal response element binding transcription factor 1 (Mtf1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mtf1 ( NM_008636.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032662.3 Mus musculus metal response element binding transcription factor 1 (Mtf1), mRNA.

Price & Availability↑

CloneID	OMu21480
Clone ID Related Accession (Same CDS sequence)	NM_008636.4
Accession Version	NM_008636.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2028bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	metal regulatory transcription factor 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV658365.1, AK150295.1, AK030284.1, AK036233.1, AK030868.1, CK380917.1, CF354134.1 and AK021268.1. On May 17, 2008 this sequence version replaced NM_008636.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK030284.1, X71327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGAAC ACAGTCCAGA CGACAATATC ATCTTCTTTA AGGGAGAGGA GGATGACCTA 
ACCCCGCATG ACAAGATGCT CAGGTTTGTG GATGACAACG GACTGGTGCC TTCCTCATCT 
GGAACTGTTT ATGATAGGAC CACTGTTCTC ATAGAACAGG ACCCTGGCAC TTTGGAGGAT 
GATGAAGACG ATGGACAGTG TGGAGAACCC TTGCCTTTTC TGGTGGAAGG TGAAGAGGGC 
TTCTTAATAG ATCAGGAAGC AATGTCCCAG GGTTACGTAC AACACATTAT CTCACCAGAT 
CAGATTCATT TGACTATAAA CCCTGGTTCC ACACCCATGC CAAGAAACAT TGAAGGTGCA 
ACTCTTACTC TGCAGTCGGA ATGTCCAGAA ACGAAACGGA AAGAAGTAAA GCGGTACCAG 
TGCACCTTTG AGGGATGCCC TCGCACCTAC AGCACAGCAG GCAACCTGCG CACCCACCAG 
AAGACTCACC GAGGAGAGTA CACCTTCGTC TGTAATCAGG AGGGCTGTGG CAAGGCCTTC 
CTCACCTCCT ACAGCCTCAG GATCCATGTG CGAGTGCACA CAAAGGAGAA GCCATTTGAG 
TGTGACGTGC AGGGCTGTGA GAAGGCGTTC AACACACTGT ACAGGTTGAA AGCACATCAG 
AGGCTTCACA CAGGGAAAAC GTTTAACTGT GAATCTCAAG GCTGCAGCAA ATACTTCACC 
ACACTCAGTG ACCTGCGGAA GCACATTCGG ACCCATACAG GAGAAAAGCC ATTTCGATGT 
GATCACGACG GCTGTGGGAA AGCGTTTGCA GCGAGCCACC ACCTTAAAAC TCACGTCCGG 
ACGCACACTG GTGAAAGACC CTTCTTCTGC CCCAGCAACG GCTGTGAGAA GACGTTTAGC 
ACTCAGTACA GTCTCAAAAG TCACATGAAA GGTCATGATA ACAAAGGCAC TGCATACAGT 
GCACTTCCAC AGCACAATGG ATCAGAGGAT ACAAATCACT CACTTTATCT GAGTGAGCTG 
GGCCTTCTGT CCACAGATTC TGAACTGCAA GAAAATTCCA GTTCGACACA GGACCAGGAC 
CTCAGCACAA TTTCACCAGC AATCATCTTT GAATCAATGT TCCAGAATTC CGACGACCCT 
GGGATTCAGG ACGACCCTCT GCAGACAGCT GCCTTGATTG ACAGTTTTAA TGGTGATGCA 
GAGTCCGTCA TTGATGTCCC ACCGCCTGCA GGAAATTCGG CGTCTTTATC TCTTCCACTC 
GTACTGCAGT CTGGCATCTC CGAGCCACCC CAGCCTCTGC TACCAGCAAC AGCTCCGTCC 
GCTCCTCCAC CTGCTCCCTC CCTAGGACCT GGTTCCCAGC CAGCTGCATT TGGCAGCCCC 
CCTGCTCTCT TACAACCTCC AGAAGTGCCT GTTCCCCACA GCACACAGTT TGCTGCTAAT 
CATCAAGAGT TTCTTCCGCA CCCCCAGGCG CCACCCCAGA CCATCGTACC AGGACTTTCT 
GTTGTTGCTG GGGCTCCTGC ATCAGCAGCA ACAGTGGCGT CAGCCGTGGC AGCACCAGCC 
CCACCACAAA GTACTACTGA GCCCCTGCCT GCTATGGTCC AGACTCTGCC CCTGGGTGCC 
AACTCTGTCC TAACTAATAA TCCCACCATA ACCATCACCC CAACTCCTAA CACGGCAATC 
CTGCAGTCCA GCCTAGTCAT GGGAGAACAG AACTTACAGT GGATATTGAA CGGTGCCACC 
AGTTCACCAC AAAACCAAGA ACAAATTCAG CAAGCATCGA AAGTGGAGCA GGTGTACTTC 
GCCACCGCTG TACCAGTGGC CAGTGGCACA GGGAGCTCTG TTCAGCAGAT TGGCCTCAGT 
GTTCCTGTGA TCATCATCAA ACAAGAGGAG GCCTGTCAGT GTCAGTGCGC GTGCCGGGAC 
TCTGCGAAGG AGCGGGCGGC CGGCCGGAGA AAGGGATGTT CTTCCCCACC CCCTCCAGAG 
CCGAACCCCC AGCCTCCTGA TGGGCCCAGC CTGCAGCTGC CACCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032662.3
CDS	147..2174
Translation	MGEHSPDDNIIFFKGEEDDLTPHDKMLRFVDDNGLVPSSSGTVYDRTTVLIEQDPGTLEDDEDDGQCGEPLPFLVEGEEGFLIDQEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESQGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGTAYSALPQHNGSEDTNHSLYLSELGLLSTDSELQENSSSTQDQDLSTISPAIIFESMFQNSDDPGIQDDPLQTAALIDSFNGDAESVIDVPPPAGNSASLSLPLVLQSGISEPPQPLLPATAPSAPPPAPSLGPGSQPAAFGSPPALLQPPEVPVPHSTQFAANHQEFLPHPQAPPQTIVPGLSVVAGAPASAATVASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLTNNPTITITPTPNTAILQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEQVYFATAVPVASGTGSSVQQIGLSVPVIIIKQEEACQCQCACRDSAKERAAGRRKGCSSPPPPEPNPQPPDGPSLQLPP

Target ORF information:

RefSeq Version	NM_008636.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus metal response element binding transcription factor 1 (Mtf1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008636.4

ORF Insert Sequence:

ATGGGGGAAC ACAGTCCAGA CGACAATATC ATCTTCTTTA AGGGAGAGGA GGATGACCTA 
ACCCCGCATG ACAAGATGCT CAGGTTTGTG GATGACAACG GACTGGTGCC TTCCTCATCT 
GGAACTGTTT ATGATAGGAC CACTGTTCTC ATAGAACAGG ACCCTGGCAC TTTGGAGGAT 
GATGAAGACG ATGGACAGTG TGGAGAACCC TTGCCTTTTC TGGTGGAAGG TGAAGAGGGC 
TTCTTAATAG ATCAGGAAGC AATGTCCCAG GGTTACGTAC AACACATTAT CTCACCAGAT 
CAGATTCATT TGACTATAAA CCCTGGTTCC ACACCCATGC CAAGAAACAT TGAAGGTGCA 
ACTCTTACTC TGCAGTCGGA ATGTCCAGAA ACGAAACGGA AAGAAGTAAA GCGGTACCAG 
TGCACCTTTG AGGGATGCCC TCGCACCTAC AGCACAGCAG GCAACCTGCG CACCCACCAG 
AAGACTCACC GAGGAGAGTA CACCTTCGTC TGTAATCAGG AGGGCTGTGG CAAGGCCTTC 
CTCACCTCCT ACAGCCTCAG GATCCATGTG CGAGTGCACA CAAAGGAGAA GCCATTTGAG 
TGTGACGTGC AGGGCTGTGA GAAGGCGTTC AACACACTGT ACAGGTTGAA AGCACATCAG 
AGGCTTCACA CAGGGAAAAC GTTTAACTGT GAATCTCAAG GCTGCAGCAA ATACTTCACC 
ACACTCAGTG ACCTGCGGAA GCACATTCGG ACCCATACAG GAGAAAAGCC ATTTCGATGT 
GATCACGACG GCTGTGGGAA AGCGTTTGCA GCGAGCCACC ACCTTAAAAC TCACGTCCGG 
ACGCACACTG GTGAAAGACC CTTCTTCTGC CCCAGCAACG GCTGTGAGAA GACGTTTAGC 
ACTCAGTACA GTCTCAAAAG TCACATGAAA GGTCATGATA ACAAAGGCAC TGCATACAGT 
GCACTTCCAC AGCACAATGG ATCAGAGGAT ACAAATCACT CACTTTATCT GAGTGAGCTG 
GGCCTTCTGT CCACAGATTC TGAACTGCAA GAAAATTCCA GTTCGACACA GGACCAGGAC 
CTCAGCACAA TTTCACCAGC AATCATCTTT GAATCAATGT TCCAGAATTC CGACGACCCT 
GGGATTCAGG ACGACCCTCT GCAGACAGCT GCCTTGATTG ACAGTTTTAA TGGTGATGCA 
GAGTCCGTCA TTGATGTCCC ACCGCCTGCA GGAAATTCGG CGTCTTTATC TCTTCCACTC 
GTACTGCAGT CTGGCATCTC CGAGCCACCC CAGCCTCTGC TACCAGCAAC AGCTCCGTCC 
GCTCCTCCAC CTGCTCCCTC CCTAGGACCT GGTTCCCAGC CAGCTGCATT TGGCAGCCCC 
CCTGCTCTCT TACAACCTCC AGAAGTGCCT GTTCCCCACA GCACACAGTT TGCTGCTAAT 
CATCAAGAGT TTCTTCCGCA CCCCCAGGCG CCACCCCAGA CCATCGTACC AGGACTTTCT 
GTTGTTGCTG GGGCTCCTGC ATCAGCAGCA ACAGTGGCGT CAGCCGTGGC AGCACCAGCC 
CCACCACAAA GTACTACTGA GCCCCTGCCT GCTATGGTCC AGACTCTGCC CCTGGGTGCC 
AACTCTGTCC TAACTAATAA TCCCACCATA ACCATCACCC CAACTCCTAA CACGGCAATC 
CTGCAGTCCA GCCTAGTCAT GGGAGAACAG AACTTACAGT GGATATTGAA CGGTGCCACC 
AGTTCACCAC AAAACCAAGA ACAAATTCAG CAAGCATCGA AAGTGGAGCA GGTGTACTTC 
GCCACCGCTG TACCAGTGGC CAGTGGCACA GGGAGCTCTG TTCAGCAGAT TGGCCTCAGT 
GTTCCTGTGA TCATCATCAA ACAAGAGGAG GCCTGTCAGT GTCAGTGCGC GTGCCGGGAC 
TCTGCGAAGG AGCGGGCGGC CGGCCGGAGA AAGGGATGTT CTTCCCCACC CCCTCCAGAG 
CCGAACCCCC AGCCTCCTGA TGGGCCCAGC CTGCAGCTGC CACCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Reciprocal activation of hypoxia-inducible factor (HIF)-2? and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis.
Osteoarthritis and cartilage24(1)134-45(2016 Jan)
Lee M,Won Y,Shin Y,Kim JH,Chun JS

Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1.
Nature communications68688(2015 Oct)
van Loo KM,Schaub C,Pitsch J,Kulbida R,Opitz T,Ekstein D,Dalal A,Urbach H,Beck H,Yaari Y,Schoch S,Becker AJ

A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion.
Developmental dynamics : an official publication of the American Association of Anatomists243(7)894-905(2014 Jul)
Chang AC,Garside VC,Fournier M,Smrz J,Vrljicak P,Umlandt P,Fuller M,Robertson G,Zhao Y,Tam A,Jones SJ,Marra MA,Hoodless PA,Karsan A

Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis.
Cell156(4)730-43(2014 Feb)
Kim JH,Jeon J,Shin M,Won Y,Lee M,Kwak JS,Lee G,Rhee J,Ryu JH,Chun CH,Chun JS

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Mtf1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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