Mt1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mt1
Entrez Gene ID	17748
Full Name	metallothionein 1
Synonyms	MT-I,Mt-1
General protein information	Preferred Names metallothionein 1 Names metallothionein-1 metallothionein-I
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 C5\|8 46.34 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_013602.3	NP_038630.1	metallothionein-1
XM_006530752.4	XP_006530815.1	metallothionein-1 isoform X1
XM_006530752.3	XP_006530815.1	metallothionein-1 isoform X1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Metallothionein I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke.
Smith HK, Omura S, Vital SA, Becker F, Senchenkova EY, Kaur G, Tsunoda I, Peirce SM, Gavins FNE
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Dec)

Gnaz couples the circadian and dopaminergic system to G protein-mediated signaling in mouse photoreceptors.
Vancura P, Abdelhadi S, Csicsely E, Baba K, Tosini G, Iuvone PM, Spessert R
PloS one12(10)e0187411(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

blockade of metallothioneins 1 and 2 constitutes a promising approach for the treatment of conditions which result in muscle atrophy.
Title: Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength.

MT-1(/2) protein levels were dramatically increased by Mt1 overexpression throughout the cortex (Cx), which showed a prominent caudal-rostral gradient, and the hippocampus (HC).
Title: Influence of Transgenic Metallothionein-1 on Gliosis, CA1 Neuronal Loss, and Brain Metal Levels of the Tg2576 Mouse Model of Alzheimer's Disease.

These results suggested that both melatonin and MT1 are involved in the downstream reaction of hCG (LH) and they play important roles in luteinization.
Title: Melatonin and its receptor MT1 are involved in the downstream reaction to luteinizing hormone and participate in the regulation of luteinization in different species.

these results demonstrate that MT1 plays a role in CD4+ T cell activation by transducing reactive oxygen species signals into an increased [Zn2+]i that subsequently affects downstream effector function
Title: Metallothionein regulates intracellular zinc signaling during CD4(+) T cell activation.

Cardioprotective effects of MT1/2 seem to be exerted via modulation of contractile elements, antioxidative enzymes, inflammatory response, and myocardial remodeling.
Title: Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice.

The following Mt1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mt1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu22830	NM_013602.3 Latest version!	Mus musculus metallothionein 1 (Mt1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu41275	XM_006530752.4 Latest version!	Mus musculus metallothionein 1 (Mt1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu41275	XM_006530752.3	Mus musculus metallothionein 1 (Mt1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mt1 ( XM_006530752.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006530815.1 Mus musculus metallothionein 1 (Mt1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu41275
Clone ID Related Accession (Same CDS sequence)	XM_006530752.4 , XM_006530752.3
Accession Version	XM_006530752.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	metallothionein-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006530752.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACCCCA ACTGCTCCTG CTCCACCGGC GGCTCCTGCA CTTGCACCAG CTCCTGCGCC 
TGCAAGAACT GCAAGTGCAC CTCCTGCAAG AAGAGTGAGT TGGGACACCT TGGGTGGCGG 
CTAAGGCTAG GGGCGGGGAA CTCCTACAAA ACTGGCTCTG AGAAATGTCC TTTGCTTCCC 
GGAGGCCATT GTATTGTCTC GGGGACAGAA CTATACAGAG AACTATTTAA AAAAACCGAG 
GTCTTCTCTG TTGGGGACAG GAAGCAGAGG TCTTCAGCCA GGCTGACCTC TTCCTCCTCC 
TTTCTAGGCT GCTGCTCCTG CTGTCCCGTG GGCTGCTCCA AATGTGCCCA GGGCTGTGTC 
TGCAAAGGCG CCGCGGACAA GTGCACGTGC TGTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006530815.1
CDS	228..626
Translation	MDPNCSCSTGGSCTCTSSCACKNCKCTSCKKSELGHLGWRLRLGAGNSYKTGSEKCPLLPGGHCIVSGTELYRELFKKTEVFSVGDRKQRSSARLTSSSSFLGCCSCCPVGCSKCAQGCVCKGAADKCTCCA

Target ORF information:

RefSeq Version	XM_006530752.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus metallothionein 1 (Mt1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006530752.3

ORF Insert Sequence:

ATGGACCCCA ACTGCTCCTG CTCCACCGGC GGCTCCTGCA CTTGCACCAG CTCCTGCGCC 
TGCAAGAACT GCAAGTGCAC CTCCTGCAAG AAGAGTGAGT TGGGACACCT TGGGTGGCGG 
CTAAGGCTAG GGGCGGGGAA CTCCTACAAA ACTGGCTCTG AGAAATGTCC TTTGCTTCCC 
GGAGGCCATT GTATTGTCTC GGGGACAGAA CTATACAGAG AACTATTTAA AAAAACCGAG 
GTCTTCTCTG TTGGGGACAG GAAGCAGAGG TCTTCAGCCA GGCTGACCTC TTCCTCCTCC 
TTTCTAGGCT GCTGCTCCTG CTGTCCCGTG GGCTGCTCCA AATGTGCCCA GGGCTGTGTC 
TGCAAAGGCG CCGCGGACAA GTGCACGTGC TGTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mt1 ( NM_013602.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038630.1 Mus musculus metallothionein 1 (Mt1), mRNA.

Price & Availability↑

CloneID	OMu22830
Clone ID Related Accession (Same CDS sequence)	NM_013602.3
Accession Version	NM_013602.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	metallothionein-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC131733.3, AK018727.1 and AA050166.1. On Dec 30, 2008 this sequence version replaced NM_013602.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CK793634.1, BU938576.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGACCCCA ACTGCTCCTG CTCCACCGGC GGCTCCTGCA CTTGCACCAG CTCCTGCGCC 
TGCAAGAACT GCAAGTGCAC CTCCTGCAAG AAGAGCTGCT GCTCCTGCTG TCCCGTGGGC 
TGCTCCAAAT GTGCCCAGGG CTGTGTCTGC AAAGGCGCCG CGGACAAGTG CACGTGCTGT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038630.1
CDS	223..408
Translation	MDPNCSCSTGGSCTCTSSCACKNCKCTSCKKSCCSCCPVGCSKCAQGCVCKGAADKCTCCA

Target ORF information:

RefSeq Version	NM_013602.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus metallothionein 1 (Mt1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013602.3

ORF Insert Sequence:

ATGGACCCCA ACTGCTCCTG CTCCACCGGC GGCTCCTGCA CTTGCACCAG CTCCTGCGCC 
TGCAAGAACT GCAAGTGCAC CTCCTGCAAG AAGAGCTGCT GCTCCTGCTG TCCCGTGGGC 
TGCTCCAAAT GTGCCCAGGG CTGTGTCTGC AAAGGCGCCG CGGACAAGTG CACGTGCTGT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mt1 ( XM_006530752.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006530815.1 Mus musculus metallothionein 1 (Mt1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu41275
Clone ID Related Accession (Same CDS sequence)	XM_006530752.4 , XM_006530752.3
Accession Version	XM_006530752.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	metallothionein-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006530752.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACCCCA ACTGCTCCTG CTCCACCGGC GGCTCCTGCA CTTGCACCAG CTCCTGCGCC 
TGCAAGAACT GCAAGTGCAC CTCCTGCAAG AAGAGTGAGT TGGGACACCT TGGGTGGCGG 
CTAAGGCTAG GGGCGGGGAA CTCCTACAAA ACTGGCTCTG AGAAATGTCC TTTGCTTCCC 
GGAGGCCATT GTATTGTCTC GGGGACAGAA CTATACAGAG AACTATTTAA AAAAACCGAG 
GTCTTCTCTG TTGGGGACAG GAAGCAGAGG TCTTCAGCCA GGCTGACCTC TTCCTCCTCC 
TTTCTAGGCT GCTGCTCCTG CTGTCCCGTG GGCTGCTCCA AATGTGCCCA GGGCTGTGTC 
TGCAAAGGCG CCGCGGACAA GTGCACGTGC TGTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006530815.1
CDS	429..827
Translation	MDPNCSCSTGGSCTCTSSCACKNCKCTSCKKSELGHLGWRLRLGAGNSYKTGSEKCPLLPGGHCIVSGTELYRELFKKTEVFSVGDRKQRSSARLTSSSSFLGCCSCCPVGCSKCAQGCVCKGAADKCTCCA

Target ORF information:

RefSeq Version	XM_006530752.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus metallothionein 1 (Mt1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006530752.4

ORF Insert Sequence:

ATGGACCCCA ACTGCTCCTG CTCCACCGGC GGCTCCTGCA CTTGCACCAG CTCCTGCGCC 
TGCAAGAACT GCAAGTGCAC CTCCTGCAAG AAGAGTGAGT TGGGACACCT TGGGTGGCGG 
CTAAGGCTAG GGGCGGGGAA CTCCTACAAA ACTGGCTCTG AGAAATGTCC TTTGCTTCCC 
GGAGGCCATT GTATTGTCTC GGGGACAGAA CTATACAGAG AACTATTTAA AAAAACCGAG 
GTCTTCTCTG TTGGGGACAG GAAGCAGAGG TCTTCAGCCA GGCTGACCTC TTCCTCCTCC 
TTTCTAGGCT GCTGCTCCTG CTGTCCCGTG GGCTGCTCCA AATGTGCCCA GGGCTGTGTC 
TGCAAAGGCG CCGCGGACAA GTGCACGTGC TGTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Metallothionein I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Dec)
Smith HK,Omura S,Vital SA,Becker F,Senchenkova EY,Kaur G,Tsunoda I,Peirce SM,Gavins FNE

Gnaz couples the circadian and dopaminergic system to G protein-mediated signaling in mouse photoreceptors.
PloS one12(10)e0187411(2017)
Vancura P,Abdelhadi S,Csicsely E,Baba K,Tosini G,Iuvone PM,Spessert R

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Mt1 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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