Mpv17 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mpv17
Entrez Gene ID	17527
Full Name	MpV17 mitochondrial inner membrane protein
Synonyms	Tg.Mpv17
General protein information	Preferred Names MpV17 mitochondrial inner membrane protein Names protein Mpv17
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_008622.6	NP_032648.1	protein Mpv17 isoform 1
NM_001310528.1	NP_001297457.1	protein Mpv17 isoform 3
XM_006503770.2	XP_006503833.1	protein Mpv17 isoform X1
NM_001294322.1	NP_001281251.1	protein Mpv17 isoform 2
NM_001294324.1	NP_001281253.1	protein Mpv17 isoform 1
NM_001310527.1	NP_001297456.1	protein Mpv17 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MPV17	XP_853776.2
Bos taurus (cattle)	MPV17	NP_001039394.1
Saccharomyces cerevisiae (baker's yeast)	SYM1	NP_013352.1
Kluyveromyces lactis	KLLA0F22924g	XP_456102.1
Eremothecium gossypii	AGOS_AFR120C	NP_985667.1
	MPV17	XP_001089329.2
Gallus gallus (chicken)	MPV17	XP_003641100.1
Danio rerio (zebrafish)	mpv17	NP_957459.2
Oryza sativa (rice)	Os01g0228300	NP_001042476.1
Homo sapiens (human)	MPV17	NP_002428.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001778	XP_321299.4
Neurospora crassa	NCU02117	XP_963854.2
Arabidopsis thaliana (thale cress)	AT3G24570	NP_189100.1
Rattus norvegicus (Norway rat)	Mpv17l	NP_001091710.1
Caenorhabditis elegans (roundworm)	T18D3.9	NP_001024916.1
Pan troglodytes (chimpanzee)	MPV17	XP_003308973.2
Mus musculus (house mouse)	Mpv17	NP_032648.1
Magnaporthe oryzae (rice blast fungus)	MGG_00752	XP_003718248.1

Gene Ontology
Bibliography

Related articles in PubMed

Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model.
Moss CF, Dalla Rosa I, Hunt LE, Yasukawa T, Young R, Jones AWE, Reddy K, Desai R, Virtue S, Elgar G, Voshol P, Taylor MS, Holt IJ, Reijns MAM, Spinazzola A
Nucleic acids research45(22)12808-12815(2017 Dec)

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)

MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria.
Dalla Rosa I, C?mara Y, Durigon R, Moss CF, Vidoni S, Akman G, Hunt L, Johnson MA, Grocott S, Wang L, Thorburn DR, Hirano M, Poulton J, Taylor RW, Elgar G, Mart? R, Voshol P, Holt IJ, Spinazzola A
PLoS genetics12(1)e1005779(2016 Jan)

The role of the Mpv17 protein mutations of which cause mitochondrial DNA depletion syndrome (MDDS): lessons from homologs in different species.
L?llgen S, Weiher H
Biological chemistry396(1)13-25(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that elevated rGMP incorporation is associated with early-onset mtDNA depletion in liver and late-onset multiple deletions in brain of Mpv17-/- mice, suggesting aberrant ribonucleotide incorporation is a primary mtDNA abnormality that can result in pathology.
Title: Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model.

changes in the expression of factors involved in mitochondrial deoxynucleotide homeostasis indicate a remodeling of nucleotide metabolism in MPV17 disease models
Title: MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria.

the nuclear gene MPV17, whose mutated forms are associated with hepatocerebral MDDS in humans, plays a so-far unknown role in mtDNA maintenance
Title: The role of the Mpv17 protein mutations of which cause mitochondrial DNA depletion syndrome (MDDS): lessons from homologs in different species.

the inner mitochondrial membrane protein Mpv17 in podocytes is essential for the maintenance of mitochondrial homeostasis and protects podocytes against oxidative stress-induced injury both in vitro and in vivo.
Title: Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro.

A lack of Mpv17 protein function in mitochondria thus seems to initiate tissue-specific cell-death pathways resulting in the pathology seen during the degeneration process.
Title: Missing mitochondrial Mpv17 gene function induces tissue-specific cell-death pathway in the degenerating inner ear.

The following Mpv17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mpv17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu23700	NM_001294322.1 Latest version!	Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu68214	NM_001310528.1 Latest version!	Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu23698	NM_001310527.1 Latest version!	Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu23698	NM_001294324.1 Latest version!	Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu23698	NM_008622.6 Latest version!	Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu23698	XM_006503770.2 Latest version!	Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mpv17 ( NM_001294322.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001281251.1 Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu23700
Clone ID Related Accession (Same CDS sequence)	NM_001294322.1
Accession Version	NM_001294322.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	protein Mpv17 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY271802.1, BY088136.1, BY258057.1, CK622051.1, DV660230.1, CF731561.1, CD776211.1, CX633035.1 and BY415502.1. On Jun 28, 2014 this sequence version replaced XM_006503772.1. Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 2. It encodes isoform 2, which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660811.284326.1, BY730272.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCACTCT GGCGAGCATA CCAGAGAGCC CTGGCAGCAC ATCCGTGGAA AGTCCAGGTT 
CTGACAGCTG GATCACTGAT GGGCGTAGGT GACATGATCT CACAGCAGCT GGTGGAGAGG 
CGGGGTCTCC AGCAACACCA GGCAGGCCGC ACTCTGACCA TGGTATCCCT GGGCTGTGGC 
TTTGTGGGCC CTGTCGTCGG AGGCTGGTAC AAAGTTTTAG ACCACTTAAT CCCGGGCACC 
ACGAAGGTGC ATGCACTGAA GAAGATGTTG TTAGATCAGG GGGGCTTTGC CCCATGTTTC 
CTAGGCTGCT TTCTCCCACT GGTCGGGATA CTCAATGGAA TGTCAGCCCA GGACAATTGG 
GCCAAACTGA AGCGGCTCTG GCCTGCTGTG CAGTTAGCCA ACTTCTACCT GGTCCCCCTG 
CATTACAGGT TGGCTGTTGT CCAGTGTGTT GCTATTGTCT GGAACTCCTA CCTATCCTGG 
AAGGCACATC AGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001281251.1
CDS	67..564
Translation	MALWRAYQRALAAHPWKVQVLTAGSLMGVGDMISQQLVERRGLQQHQAGRTLTMVSLGCGFVGPVVGGWYKVLDHLIPGTTKVHALKKMLLDQGGFAPCFLGCFLPLVGILNGMSAQDNWAKLKRLWPAVQLANFYLVPLHYRLAVVQCVAIVWNSYLSWKAHQF

Target ORF information:

RefSeq Version	NM_001294322.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001294322.1

ORF Insert Sequence:

ATGGCACTCT GGCGAGCATA CCAGAGAGCC CTGGCAGCAC ATCCGTGGAA AGTCCAGGTT 
CTGACAGCTG GATCACTGAT GGGCGTAGGT GACATGATCT CACAGCAGCT GGTGGAGAGG 
CGGGGTCTCC AGCAACACCA GGCAGGCCGC ACTCTGACCA TGGTATCCCT GGGCTGTGGC 
TTTGTGGGCC CTGTCGTCGG AGGCTGGTAC AAAGTTTTAG ACCACTTAAT CCCGGGCACC 
ACGAAGGTGC ATGCACTGAA GAAGATGTTG TTAGATCAGG GGGGCTTTGC CCCATGTTTC 
CTAGGCTGCT TTCTCCCACT GGTCGGGATA CTCAATGGAA TGTCAGCCCA GGACAATTGG 
GCCAAACTGA AGCGGCTCTG GCCTGCTGTG CAGTTAGCCA ACTTCTACCT GGTCCCCCTG 
CATTACAGGT TGGCTGTTGT CCAGTGTGTT GCTATTGTCT GGAACTCCTA CCTATCCTGG 
AAGGCACATC AGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mpv17 ( NM_001310528.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001297457.1 Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OMu68214
Clone ID Related Accession (Same CDS sequence)	NM_001310528.1
Accession Version	NM_001310528.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	protein Mpv17 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC109608.14. On Jul 15, 2015 this sequence version replaced XM_006503769.2. Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 3, which is longer than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ891824.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCACTCT GGCGAGCATA CCAGAGAGCC CTGGCAGCAC ATCCGTGGAA AGTCCAGGTT 
CTGACAGCTG GATCACTGAT GGGCGTAGGT GACATGATCT CACAGCAGCT GGTGGAGAGG 
CGGGGTCTCC AGCAACACCA GGCAGGCCGC ACTCTGACCA TGGTATCCCT GGGCTGTGGC 
TTTGTGGGCC CTGTCGTCGG AGGCTGGTAC AAAGTTTTAG ACCACTTAAT CCCGGGCACC 
ACGAAGGTGC ATGCACTGAA GAAGATGTTG TTAGATCAGG GGGGCTTTGC CCCATGTTTC 
CTAGGCTGCT TTCTCCCACT GGTCGGGATA CTCAATGGAA TGTCAGCCCA GGACAATTGG 
GCCAAACTGA AGCGGGACTA CCCTGATGCC CTCATCACCA ACTACTATGT AAGACTCTGG 
CCTGCTGTGC AGTTAGCCAA CTTCTACCTG GTCCCCCTGC ATTACAGGTT GGCTGTTGTC 
CAGTGTGTTG CTATTGTCTG GAACTCCTAC CTATCCTGGA AGGCACATCA GTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001297457.1
CDS	67..603
Translation	MALWRAYQRALAAHPWKVQVLTAGSLMGVGDMISQQLVERRGLQQHQAGRTLTMVSLGCGFVGPVVGGWYKVLDHLIPGTTKVHALKKMLLDQGGFAPCFLGCFLPLVGILNGMSAQDNWAKLKRDYPDALITNYYVRLWPAVQLANFYLVPLHYRLAVVQCVAIVWNSYLSWKAHQF

Target ORF information:

RefSeq Version	NM_001310528.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001310528.1

ORF Insert Sequence:

ATGGCACTCT GGCGAGCATA CCAGAGAGCC CTGGCAGCAC ATCCGTGGAA AGTCCAGGTT 
CTGACAGCTG GATCACTGAT GGGCGTAGGT GACATGATCT CACAGCAGCT GGTGGAGAGG 
CGGGGTCTCC AGCAACACCA GGCAGGCCGC ACTCTGACCA TGGTATCCCT GGGCTGTGGC 
TTTGTGGGCC CTGTCGTCGG AGGCTGGTAC AAAGTTTTAG ACCACTTAAT CCCGGGCACC 
ACGAAGGTGC ATGCACTGAA GAAGATGTTG TTAGATCAGG GGGGCTTTGC CCCATGTTTC 
CTAGGCTGCT TTCTCCCACT GGTCGGGATA CTCAATGGAA TGTCAGCCCA GGACAATTGG 
GCCAAACTGA AGCGGGACTA CCCTGATGCC CTCATCACCA ACTACTATGT AAGACTCTGG 
CCTGCTGTGC AGTTAGCCAA CTTCTACCTG GTCCCCCTGC ATTACAGGTT GGCTGTTGTC 
CAGTGTGTTG CTATTGTCTG GAACTCCTAC CTATCCTGGA AGGCACATCA GTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mpv17 ( NM_008622.6 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032648.1 Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu23698
Clone ID Related Accession (Same CDS sequence)	NM_008622.6 , XM_006503770.2 , NM_001294324.1 , NM_001310527.1
Accession Version	NM_008622.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	protein Mpv17 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY271802.1, BY088136.1, BY258057.1, CK622051.1, DV660230.1, CF731561.1, CD776211.1, CX633035.1 and BY415502.1. On Jun 29, 2014 this sequence version replaced NM_008622.5. Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1, 2, and 4 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013452.1, M36411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCACTCT GGCGAGCATA CCAGAGAGCC CTGGCAGCAC ATCCGTGGAA AGTCCAGGTT 
CTGACAGCTG GATCACTGAT GGGCGTAGGT GACATGATCT CACAGCAGCT GGTGGAGAGG 
CGGGGTCTCC AGCAACACCA GGCAGGCCGC ACTCTGACCA TGGTATCCCT GGGCTGTGGC 
TTTGTGGGCC CTGTCGTCGG AGGCTGGTAC AAAGTTTTAG ACCACTTAAT CCCGGGCACC 
ACGAAGGTGC ATGCACTGAA GAAGATGTTG TTAGATCAGG GGGGCTTTGC CCCATGTTTC 
CTAGGCTGCT TTCTCCCACT GGTCGGGATA CTCAATGGAA TGTCAGCCCA GGACAATTGG 
GCCAAACTGA AGCGGGACTA CCCTGATGCC CTCATCACCA ACTACTATCT CTGGCCTGCT 
GTGCAGTTAG CCAACTTCTA CCTGGTCCCC CTGCATTACA GGTTGGCTGT TGTCCAGTGT 
GTTGCTATTG TCTGGAACTC CTACCTATCC TGGAAGGCAC ATCAGTTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032648.1
CDS	67..597
Translation	MALWRAYQRALAAHPWKVQVLTAGSLMGVGDMISQQLVERRGLQQHQAGRTLTMVSLGCGFVGPVVGGWYKVLDHLIPGTTKVHALKKMLLDQGGFAPCFLGCFLPLVGILNGMSAQDNWAKLKRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAIVWNSYLSWKAHQF

Target ORF information:

RefSeq Version	NM_008622.6
Organism	Mus musculus(house mouse)
Definition	Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008622.6

ORF Insert Sequence:

ATGGCACTCT GGCGAGCATA CCAGAGAGCC CTGGCAGCAC ATCCGTGGAA AGTCCAGGTT 
CTGACAGCTG GATCACTGAT GGGCGTAGGT GACATGATCT CACAGCAGCT GGTGGAGAGG 
CGGGGTCTCC AGCAACACCA GGCAGGCCGC ACTCTGACCA TGGTATCCCT GGGCTGTGGC 
TTTGTGGGCC CTGTCGTCGG AGGCTGGTAC AAAGTTTTAG ACCACTTAAT CCCGGGCACC 
ACGAAGGTGC ATGCACTGAA GAAGATGTTG TTAGATCAGG GGGGCTTTGC CCCATGTTTC 
CTAGGCTGCT TTCTCCCACT GGTCGGGATA CTCAATGGAA TGTCAGCCCA GGACAATTGG 
GCCAAACTGA AGCGGGACTA CCCTGATGCC CTCATCACCA ACTACTATCT CTGGCCTGCT 
GTGCAGTTAG CCAACTTCTA CCTGGTCCCC CTGCATTACA GGTTGGCTGT TGTCCAGTGT 
GTTGCTATTG TCTGGAACTC CTACCTATCC TGGAAGGCAC ATCAGTTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mpv17 ( NM_001294324.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001281253.1 Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu23698
Clone ID Related Accession (Same CDS sequence)	NM_008622.6 , XM_006503770.2 , NM_001294324.1 , NM_001310527.1
Accession Version	NM_001294324.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	protein Mpv17 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV062332.1, DV660230.1, CF731561.1, CD776211.1, CX633035.1 and BY415502.1. Transcript Variant: This variant (2) represents the longest transcript and encodes isoform 1. Variants 1, 2, and 4 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DV062332.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCACTCT GGCGAGCATA CCAGAGAGCC CTGGCAGCAC ATCCGTGGAA AGTCCAGGTT 
CTGACAGCTG GATCACTGAT GGGCGTAGGT GACATGATCT CACAGCAGCT GGTGGAGAGG 
CGGGGTCTCC AGCAACACCA GGCAGGCCGC ACTCTGACCA TGGTATCCCT GGGCTGTGGC 
TTTGTGGGCC CTGTCGTCGG AGGCTGGTAC AAAGTTTTAG ACCACTTAAT CCCGGGCACC 
ACGAAGGTGC ATGCACTGAA GAAGATGTTG TTAGATCAGG GGGGCTTTGC CCCATGTTTC 
CTAGGCTGCT TTCTCCCACT GGTCGGGATA CTCAATGGAA TGTCAGCCCA GGACAATTGG 
GCCAAACTGA AGCGGGACTA CCCTGATGCC CTCATCACCA ACTACTATCT CTGGCCTGCT 
GTGCAGTTAG CCAACTTCTA CCTGGTCCCC CTGCATTACA GGTTGGCTGT TGTCCAGTGT 
GTTGCTATTG TCTGGAACTC CTACCTATCC TGGAAGGCAC ATCAGTTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001281253.1
CDS	96..626
Translation	MALWRAYQRALAAHPWKVQVLTAGSLMGVGDMISQQLVERRGLQQHQAGRTLTMVSLGCGFVGPVVGGWYKVLDHLIPGTTKVHALKKMLLDQGGFAPCFLGCFLPLVGILNGMSAQDNWAKLKRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAIVWNSYLSWKAHQF

Target ORF information:

RefSeq Version	NM_001294324.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001294324.1

ORF Insert Sequence:

ATGGCACTCT GGCGAGCATA CCAGAGAGCC CTGGCAGCAC ATCCGTGGAA AGTCCAGGTT 
CTGACAGCTG GATCACTGAT GGGCGTAGGT GACATGATCT CACAGCAGCT GGTGGAGAGG 
CGGGGTCTCC AGCAACACCA GGCAGGCCGC ACTCTGACCA TGGTATCCCT GGGCTGTGGC 
TTTGTGGGCC CTGTCGTCGG AGGCTGGTAC AAAGTTTTAG ACCACTTAAT CCCGGGCACC 
ACGAAGGTGC ATGCACTGAA GAAGATGTTG TTAGATCAGG GGGGCTTTGC CCCATGTTTC 
CTAGGCTGCT TTCTCCCACT GGTCGGGATA CTCAATGGAA TGTCAGCCCA GGACAATTGG 
GCCAAACTGA AGCGGGACTA CCCTGATGCC CTCATCACCA ACTACTATCT CTGGCCTGCT 
GTGCAGTTAG CCAACTTCTA CCTGGTCCCC CTGCATTACA GGTTGGCTGT TGTCCAGTGT 
GTTGCTATTG TCTGGAACTC CTACCTATCC TGGAAGGCAC ATCAGTTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mpv17 ( NM_001310527.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001297456.1 Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu23698
Clone ID Related Accession (Same CDS sequence)	NM_008622.6 , XM_006503770.2 , NM_001294324.1 , NM_001310527.1
Accession Version	NM_001310527.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	protein Mpv17 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC109608.14. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Variants 1, 2, and 4 encode the same isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR7345562.797052.1, SRR5189670.9139.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCACTCT GGCGAGCATA CCAGAGAGCC CTGGCAGCAC ATCCGTGGAA AGTCCAGGTT 
CTGACAGCTG GATCACTGAT GGGCGTAGGT GACATGATCT CACAGCAGCT GGTGGAGAGG 
CGGGGTCTCC AGCAACACCA GGCAGGCCGC ACTCTGACCA TGGTATCCCT GGGCTGTGGC 
TTTGTGGGCC CTGTCGTCGG AGGCTGGTAC AAAGTTTTAG ACCACTTAAT CCCGGGCACC 
ACGAAGGTGC ATGCACTGAA GAAGATGTTG TTAGATCAGG GGGGCTTTGC CCCATGTTTC 
CTAGGCTGCT TTCTCCCACT GGTCGGGATA CTCAATGGAA TGTCAGCCCA GGACAATTGG 
GCCAAACTGA AGCGGGACTA CCCTGATGCC CTCATCACCA ACTACTATCT CTGGCCTGCT 
GTGCAGTTAG CCAACTTCTA CCTGGTCCCC CTGCATTACA GGTTGGCTGT TGTCCAGTGT 
GTTGCTATTG TCTGGAACTC CTACCTATCC TGGAAGGCAC ATCAGTTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001297456.1
CDS	79..609
Translation	MALWRAYQRALAAHPWKVQVLTAGSLMGVGDMISQQLVERRGLQQHQAGRTLTMVSLGCGFVGPVVGGWYKVLDHLIPGTTKVHALKKMLLDQGGFAPCFLGCFLPLVGILNGMSAQDNWAKLKRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAIVWNSYLSWKAHQF

Target ORF information:

RefSeq Version	NM_001310527.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001310527.1

ORF Insert Sequence:

ATGGCACTCT GGCGAGCATA CCAGAGAGCC CTGGCAGCAC ATCCGTGGAA AGTCCAGGTT 
CTGACAGCTG GATCACTGAT GGGCGTAGGT GACATGATCT CACAGCAGCT GGTGGAGAGG 
CGGGGTCTCC AGCAACACCA GGCAGGCCGC ACTCTGACCA TGGTATCCCT GGGCTGTGGC 
TTTGTGGGCC CTGTCGTCGG AGGCTGGTAC AAAGTTTTAG ACCACTTAAT CCCGGGCACC 
ACGAAGGTGC ATGCACTGAA GAAGATGTTG TTAGATCAGG GGGGCTTTGC CCCATGTTTC 
CTAGGCTGCT TTCTCCCACT GGTCGGGATA CTCAATGGAA TGTCAGCCCA GGACAATTGG 
GCCAAACTGA AGCGGGACTA CCCTGATGCC CTCATCACCA ACTACTATCT CTGGCCTGCT 
GTGCAGTTAG CCAACTTCTA CCTGGTCCCC CTGCATTACA GGTTGGCTGT TGTCCAGTGT 
GTTGCTATTG TCTGGAACTC CTACCTATCC TGGAAGGCAC ATCAGTTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mpv17 ( XM_006503770.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006503833.1 Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant X2, mRNA.

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CloneID	OMu23698
Clone ID Related Accession (Same CDS sequence)	NM_008622.6 , XM_006503770.2 , NM_001294324.1 , NM_001310527.1
Accession Version	XM_006503770.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	protein Mpv17 isoform X1
Comment

ATGGCACTCT GGCGAGCATA CCAGAGAGCC CTGGCAGCAC ATCCGTGGAA AGTCCAGGTT 
CTGACAGCTG GATCACTGAT GGGCGTAGGT GACATGATCT CACAGCAGCT GGTGGAGAGG 
CGGGGTCTCC AGCAACACCA GGCAGGCCGC ACTCTGACCA TGGTATCCCT GGGCTGTGGC 
TTTGTGGGCC CTGTCGTCGG AGGCTGGTAC AAAGTTTTAG ACCACTTAAT CCCGGGCACC 
ACGAAGGTGC ATGCACTGAA GAAGATGTTG TTAGATCAGG GGGGCTTTGC CCCATGTTTC 
CTAGGCTGCT TTCTCCCACT GGTCGGGATA CTCAATGGAA TGTCAGCCCA GGACAATTGG 
GCCAAACTGA AGCGGGACTA CCCTGATGCC CTCATCACCA ACTACTATCT CTGGCCTGCT 
GTGCAGTTAG CCAACTTCTA CCTGGTCCCC CTGCATTACA GGTTGGCTGT TGTCCAGTGT 
GTTGCTATTG TCTGGAACTC CTACCTATCC TGGAAGGCAC ATCAGTTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006503833.1
Translation	MALWRAYQRALAAHPWKVQVLTAGSLMGVGDMISQQLVERRGLQQHQAGRTLTMVSLGCGFVGPVVGGWYKVLDHLIPGTTKVHALKKMLLDQGGFAPCFLGCFLPLVGILNGMSAQDNWAKLKRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAIVWNSYLSWKAHQF

Target ORF information:

RefSeq Version	XM_006503770.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus MpV17 mitochondrial inner membrane protein (Mpv17), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006503770.2

ORF Insert Sequence:

ATGGCACTCT GGCGAGCATA CCAGAGAGCC CTGGCAGCAC ATCCGTGGAA AGTCCAGGTT 
CTGACAGCTG GATCACTGAT GGGCGTAGGT GACATGATCT CACAGCAGCT GGTGGAGAGG 
CGGGGTCTCC AGCAACACCA GGCAGGCCGC ACTCTGACCA TGGTATCCCT GGGCTGTGGC 
TTTGTGGGCC CTGTCGTCGG AGGCTGGTAC AAAGTTTTAG ACCACTTAAT CCCGGGCACC 
ACGAAGGTGC ATGCACTGAA GAAGATGTTG TTAGATCAGG GGGGCTTTGC CCCATGTTTC 
CTAGGCTGCT TTCTCCCACT GGTCGGGATA CTCAATGGAA TGTCAGCCCA GGACAATTGG 
GCCAAACTGA AGCGGGACTA CCCTGATGCC CTCATCACCA ACTACTATCT CTGGCCTGCT 
GTGCAGTTAG CCAACTTCTA CCTGGTCCCC CTGCATTACA GGTTGGCTGT TGTCCAGTGT 
GTTGCTATTG TCTGGAACTC CTACCTATCC TGGAAGGCAC ATCAGTTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model.
Nucleic acids research45(22)12808-12815(2017 Dec)
Moss CF,Dalla Rosa I,Hunt LE,Yasukawa T,Young R,Jones AWE,Reddy K,Desai R,Virtue S,Elgar G,Voshol P,Taylor MS,Holt IJ,Reijns MAM,Spinazzola A

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
PLoS genetics12(9)e1006355(2016 Sep)
Wu Y,Wei FY,Kawarada L,Suzuki T,Araki K,Komohara Y,Fujimura A,Kaitsuka T,Takeya M,Oike Y,Suzuki T,Tomizawa K

MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria.
PLoS genetics12(1)e1005779(2016 Jan)
Dalla Rosa I,C?mara Y,Durigon R,Moss CF,Vidoni S,Akman G,Hunt L,Johnson MA,Grocott S,Wang L,Thorburn DR,Hirano M,Poulton J,Taylor RW,Elgar G,Mart? R,Voshol P,Holt IJ,Spinazzola A

The role of the Mpv17 protein mutations of which cause mitochondrial DNA depletion syndrome (MDDS): lessons from homologs in different species.
Biological chemistry396(1)13-25(2015 Jan)
L?llgen S,Weiher H

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Mpv17 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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