Mmp7 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp7
Entrez Gene ID	17393
Full Name	matrix metallopeptidase 7
Synonyms	MAT,MMP-7
General protein information	Preferred Names matrix metallopeptidase 7 Names matrilysin matrilysin, uterine matrin matrix metalloproteinase 7 pump-1 protease uterine metalloproteinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9 A1\|9 2.46 cM
Summary	This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein are deficient in functional cryptdins. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001319986.1	NP_001306915.1	matrilysin isoform 2
NM_010810.5	NP_034940.2	matrilysin isoform 1 preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MMP7	NP_001229655.1
Bos taurus (cattle)	MMP7	NP_001068598.1
Homo sapiens (human)	MMP7	NP_002414.1
	MMP7	XP_001097508.2
Arabidopsis thaliana (thale cress)	AT4G16640	NP_193397.1
Rattus norvegicus (Norway rat)	Mmp7	NP_036996.1
Oryza sativa (rice)	Os10g0557900	NP_001065361.2
Pan troglodytes (chimpanzee)	MMP7	XP_508721.2
Mus musculus (house mouse)	Mmp7	NP_034940.2
Gallus gallus (chicken)	MMP7	NP_001006278.1

Gene Ontology
Bibliography

Related articles in PubMed

Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression.
Lyon CA, Williams H, Bianco R, Simmonds SJ, Brown BA, Wadey KS, Smith FCT, Johnson JL, George SJ
Scientific reports7(1)17342(2017 Dec)

Alpha-defensin-dependent enhancement of enteric viral infection.
Wilson SS, Bromme BA, Holly MK, Wiens ME, Gounder AP, Sul Y, Smith JG
PLoS pathogens13(6)e1006446(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MMP7 shedding of syndecan-1/CXCL1 complexes functions as a checkpoint that restricts neutrophil activation at sites of epithelial injury.
Title: Shedding of Syndecan-1/CXCL1 Complexes by Matrix Metalloproteinase 7 Functions as an Epithelial Checkpoint of Neutrophil Activation.

MMP7 exerts a restrictive role on H. pylori-induced gastric injury and the development of premalignant lesions by suppressing M1 macrophage polarization.
Title: Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization.

absence of MMP7 protects mice from LPS-induced intestinal permeability and lethality.
Title: Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation.

regulator of beta-catenin function in injured lung epithelium
Title: Matrilysin (MMP-7) catalytic activity regulates ?-catenin localization and signaling activation in lung epithelial cells.

Angiotensin II suppresses RECK, but induces matrix metalloproteinases both in vivo and in vitro.
Title: Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK.

The following Mmp7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14903	NM_010810.5 Latest version!	Mus musculus matrix metallopeptidase 7 (Mmp7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu76901	NM_001319986.1 Latest version!	Mus musculus matrix metallopeptidase 7 (Mmp7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp7 ( NM_010810.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034940.2 Mus musculus matrix metallopeptidase 7 (Mmp7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu14903
Clone ID Related Accession (Same CDS sequence)	NM_010810.5
Accession Version	NM_010810.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Mus musculus(house mouse)
Product	matrilysin isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL603630.11 and AK144515.1. On Feb 10, 2016 this sequence version replaced NM_010810.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L36244.1, AK144515.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGCTA TGCAGCTCAC CCTGTTCTGC TTTGTGTGTC TGCTGCCAGG CCACCTGGCC 
CTGCCACTGT CCCAGGAAGC TGGAGATGTG AGCGCACATC AGTGGGAACA GGCTCAGAAT 
TATCTTAGAA AATTTTACCC TCATGACTCT AAAACAAAGA AGGTCAATAG TCTAGTGGAC 
AACCTCAAGG AAATGCAGAA GTTCTTTGGC CTGCCCATGA CTGGAAAACT CTCCCCCTAC 
ATCATGGAAA TAATGCAGAA ACCTAGGTGT GGAGTGCCAG ATGTTGCAGA ATACTCACTA 
ATGCCAAACA GTCCAAAATG GCATTCCAGA ATTGTCACCT ACAGAATTGT ATCCTATACT 
TCAGACTTAC CTCGGATCGT AGTGGATCAA ATCGTGAAAA AAGCTCTCAG AATGTGGAGT 
ATGCAGATCC CACTGAACTT CAAGAGGGTT AGTTGGGGGA CTGCGGATAT CATAATTGGC 
TTCGCAAGGA GAGATCATGG AGACAGCTTC CCCTTTGATG GGCCAGGGAA CACTCTAGGT 
CATGCCTTCG CACCTGGGCC AGGCCTAGGC GGAGATGCTC ACTTTGACAA GGATGAGTAC 
TGGACTGATG GTGAGGACGC AGGAGTGAAC TTCCTGTTTG CTGCCACCCA TGAATTTGGC 
CACTCTCTGG GTCTGAGTCA CTCTTCTGTT CCCGGTACTG TGATGTACCC TACCTATCAA 
AGAGACTACT CAGAAGACTT CAGTCTTACA AAGGACGACA TTGCAGGCAT TCAGAAGTTA 
TATGGAAAGA GGAACACGCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034940.2
CDS	37..840
Translation	MAAMQLTLFCFVCLLPGHLALPLSQEAGDVSAHQWEQAQNYLRKFYPHDSKTKKVNSLVDNLKEMQKFFGLPMTGKLSPYIMEIMQKPRCGVPDVAEYSLMPNSPKWHSRIVTYRIVSYTSDLPRIVVDQIVKKALRMWSMQIPLNFKRVSWGTADIIIGFARRDHGDSFPFDGPGNTLGHAFAPGPGLGGDAHFDKDEYWTDGEDAGVNFLFAATHEFGHSLGLSHSSVPGTVMYPTYQRDYSEDFSLTKDDIAGIQKLYGKRNTL

Target ORF information:

RefSeq Version	NM_010810.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrix metallopeptidase 7 (Mmp7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010810.5

ORF Insert Sequence:

ATGGCAGCTA TGCAGCTCAC CCTGTTCTGC TTTGTGTGTC TGCTGCCAGG CCACCTGGCC 
CTGCCACTGT CCCAGGAAGC TGGAGATGTG AGCGCACATC AGTGGGAACA GGCTCAGAAT 
TATCTTAGAA AATTTTACCC TCATGACTCT AAAACAAAGA AGGTCAATAG TCTAGTGGAC 
AACCTCAAGG AAATGCAGAA GTTCTTTGGC CTGCCCATGA CTGGAAAACT CTCCCCCTAC 
ATCATGGAAA TAATGCAGAA ACCTAGGTGT GGAGTGCCAG ATGTTGCAGA ATACTCACTA 
ATGCCAAACA GTCCAAAATG GCATTCCAGA ATTGTCACCT ACAGAATTGT ATCCTATACT 
TCAGACTTAC CTCGGATCGT AGTGGATCAA ATCGTGAAAA AAGCTCTCAG AATGTGGAGT 
ATGCAGATCC CACTGAACTT CAAGAGGGTT AGTTGGGGGA CTGCGGATAT CATAATTGGC 
TTCGCAAGGA GAGATCATGG AGACAGCTTC CCCTTTGATG GGCCAGGGAA CACTCTAGGT 
CATGCCTTCG CACCTGGGCC AGGCCTAGGC GGAGATGCTC ACTTTGACAA GGATGAGTAC 
TGGACTGATG GTGAGGACGC AGGAGTGAAC TTCCTGTTTG CTGCCACCCA TGAATTTGGC 
CACTCTCTGG GTCTGAGTCA CTCTTCTGTT CCCGGTACTG TGATGTACCC TACCTATCAA 
AGAGACTACT CAGAAGACTT CAGTCTTACA AAGGACGACA TTGCAGGCAT TCAGAAGTTA 
TATGGAAAGA GGAACACGCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mmp7 ( NM_001319986.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001306915.1 Mus musculus matrix metallopeptidase 7 (Mmp7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu76901
Clone ID Related Accession (Same CDS sequence)	NM_001319986.1
Accession Version	NM_001319986.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 696bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-20
Organism	Mus musculus(house mouse)
Product	matrilysin isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DV055863.1, AL603630.11 and AK144515.1. Transcript Variant: This variant (2) contains an alterate 5' terminal exon, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start site, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DV055863.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849384 [ECO:0000348] ##Evidence-Data-END##

ATGCTTTCTA ATTATCTTAG AAAATTTTAC CCTCATGACT CTAAAACAAA GAAGGTCAAT 
AGTCTAGTGG ACAACCTCAA GGAAATGCAG AAGTTCTTTG GCCTGCCCAT GACTGGAAAA 
CTCTCCCCCT ACATCATGGA AATAATGCAG AAACCTAGGT GTGGAGTGCC AGATGTTGCA 
GAATACTCAC TAATGCCAAA CAGTCCAAAA TGGCATTCCA GAATTGTCAC CTACAGAATT 
GTATCCTATA CTTCAGACTT ACCTCGGATC GTAGTGGATC AAATCGTGAA AAAAGCTCTC 
AGAATGTGGA GTATGCAGAT CCCACTGAAC TTCAAGAGGG TTAGTTGGGG GACTGCGGAT 
ATCATAATTG GCTTCGCAAG GAGAGATCAT GGAGACAGCT TCCCCTTTGA TGGGCCAGGG 
AACACTCTAG GTCATGCCTT CGCACCTGGG CCAGGCCTAG GCGGAGATGC TCACTTTGAC 
AAGGATGAGT ACTGGACTGA TGGTGAGGAC GCAGGAGTGA ACTTCCTGTT TGCTGCCACC 
CATGAATTTG GCCACTCTCT GGGTCTGAGT CACTCTTCTG TTCCCGGTAC TGTGATGTAC 
CCTACCTATC AAAGAGACTA CTCAGAAGAC TTCAGTCTTA CAAAGGACGA CATTGCAGGC 
ATTCAGAAGT TATATGGAAA GAGGAACACG CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001306915.1
CDS	39..734
Translation	MLSNYLRKFYPHDSKTKKVNSLVDNLKEMQKFFGLPMTGKLSPYIMEIMQKPRCGVPDVAEYSLMPNSPKWHSRIVTYRIVSYTSDLPRIVVDQIVKKALRMWSMQIPLNFKRVSWGTADIIIGFARRDHGDSFPFDGPGNTLGHAFAPGPGLGGDAHFDKDEYWTDGEDAGVNFLFAATHEFGHSLGLSHSSVPGTVMYPTYQRDYSEDFSLTKDDIAGIQKLYGKRNTL

Target ORF information:

RefSeq Version	NM_001319986.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrix metallopeptidase 7 (Mmp7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001319986.1

ORF Insert Sequence:

ATGCTTTCTA ATTATCTTAG AAAATTTTAC CCTCATGACT CTAAAACAAA GAAGGTCAAT 
AGTCTAGTGG ACAACCTCAA GGAAATGCAG AAGTTCTTTG GCCTGCCCAT GACTGGAAAA 
CTCTCCCCCT ACATCATGGA AATAATGCAG AAACCTAGGT GTGGAGTGCC AGATGTTGCA 
GAATACTCAC TAATGCCAAA CAGTCCAAAA TGGCATTCCA GAATTGTCAC CTACAGAATT 
GTATCCTATA CTTCAGACTT ACCTCGGATC GTAGTGGATC AAATCGTGAA AAAAGCTCTC 
AGAATGTGGA GTATGCAGAT CCCACTGAAC TTCAAGAGGG TTAGTTGGGG GACTGCGGAT 
ATCATAATTG GCTTCGCAAG GAGAGATCAT GGAGACAGCT TCCCCTTTGA TGGGCCAGGG 
AACACTCTAG GTCATGCCTT CGCACCTGGG CCAGGCCTAG GCGGAGATGC TCACTTTGAC 
AAGGATGAGT ACTGGACTGA TGGTGAGGAC GCAGGAGTGA ACTTCCTGTT TGCTGCCACC 
CATGAATTTG GCCACTCTCT GGGTCTGAGT CACTCTTCTG TTCCCGGTAC TGTGATGTAC 
CCTACCTATC AAAGAGACTA CTCAGAAGAC TTCAGTCTTA CAAAGGACGA CATTGCAGGC 
ATTCAGAAGT TATATGGAAA GAGGAACACG CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression.
Scientific reports7(1)17342(2017 Dec)
Lyon CA,Williams H,Bianco R,Simmonds SJ,Brown BA,Wadey KS,Smith FCT,Johnson JL,George SJ

Alpha-defensin-dependent enhancement of enteric viral infection.
PLoS pathogens13(6)e1006446(2017 Jun)
Wilson SS,Bromme BA,Holly MK,Wiens ME,Gounder AP,Sul Y,Smith JG

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Mmp7 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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