Mcm5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mcm5
Entrez Gene ID	17218
Full Name	minichromosome maintenance complex component 5
Synonyms	AA617332,AI324988,AL033333,Cdc46,Mcmd5,P1-CDC46
General protein information	Preferred Names minichromosome maintenance complex component 5 Names DNA replication licensing factor MCM5 CDC46 homolog mini chromosome maintenance deficient 5 minichromosome maintenance deficient 5, cell division cycle 46
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 C1
Summary	The protein encoded by this gene is a member of the oligameric minichromosome maintenance protein complex. During DNA replication, the complex loads onto chromatin in early G1 and is converted into an active replicative helicase during S phase. It functions to limit DNA synthesis to once per cell cycle. During embryogenesis, the encoded protein is negatively regulated through expression of paired box protein Pax 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001302540.1	NP_001289469.1	DNA replication licensing factor MCM5
NM_008566.3	NP_032592.2	DNA replication licensing factor MCM5

Pathways from BioSystems

Homologies

Homo sapiens (human)	MCM5	NP_006730.2
Rattus norvegicus (Norway rat)	Mcm5	NP_001099640.1
Oryza sativa (rice)	Os02g0797400	NP_001048396.1
Pan troglodytes (chimpanzee)	MCM5	XP_001156025.1
Canis lupus familiaris (dog)	MCM5	XP_005626282.1
Caenorhabditis elegans (roundworm)	mcm-5	NP_497858.1
Saccharomyces cerevisiae (baker's yeast)	MCM5	NP_013376.1
Neurospora crassa	NCU01171	XP_961537.1
Xenopus tropicalis (tropical clawed frog)	mcm5	NP_001017327.2
Bos taurus (cattle)	MCM5	NP_001068758.1
Mus musculus (house mouse)	Mcm5	NP_032592.2
Gallus gallus (chicken)	MCM5	NP_001006243.1
Drosophila melanogaster (fruit fly)	Mcm5	NP_524308.2
Kluyveromyces lactis	KLLA0D09262g	XP_453475.1
Schizosaccharomyces pombe (fission yeast)	mcm5	XP_001713071.1
Danio rerio (zebrafish)	mcm5	NP_848523.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004408	XP_313694.2
Eremothecium gossypii	AGOS_AGR276W	NP_986942.1
Magnaporthe oryzae (rice blast fungus)	MGG_08646	XP_003711077.1
Arabidopsis thaliana (thale cress)	MCM5	NP_178812.1

Gene Ontology
Bibliography

Related articles in PubMed

Sox10 regulates skin melanocyte proliferation by activating the DNA replication licensing factor MCM5.
Su Z, Zheng X, Zhang X, Wang Y, Zhu S, Lu F, Qu J, Hou L
Journal of dermatological science85(3)216-225(2017 Mar)

Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity.
De Arras L, Laws R, Leach SM, Pontis K, Freedman JH, Schwartz DA, Alper S
Genetics197(2)485-96(2014 Jun)

Genome-wide microarray comparison reveals downstream genes of Pax6 in the developing mouse cerebellum.
Ha TJ, Swanson DJ, Kirova R, Yeung J, Choi K, Tong Y, Chesler EJ, Goldowitz D
The European journal of neuroscience36(7)2888-98(2012 Oct)

Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload.
Kuipers MA, Stasevich TJ, Sasaki T, Wilson KA, Hazelwood KL, McNally JG, Davidson MW, Gilbert DM
The Journal of cell biology192(1)29-41(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SOX10 directly activates MCM5 transcription by binding to conserved SOX10 consensus DNA sequences in the MCM5 promoter.
Title: Sox10 regulates skin melanocyte proliferation by activating the DNA replication licensing factor MCM5.

The following Mcm5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mcm5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22237	NM_001302540.1 Latest version!	Mus musculus minichromosome maintenance complex component 5 (Mcm5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00
OMu22237	NM_008566.3 Latest version!	Mus musculus minichromosome maintenance complex component 5 (Mcm5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mcm5 ( NM_001302540.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001289469.1 Mus musculus minichromosome maintenance complex component 5 (Mcm5), transcript variant 2, mRNA.

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CloneID	OMu22237
Clone ID Related Accession (Same CDS sequence)	NM_001302540.1 , NM_008566.3
Accession Version	NM_001302540.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2205bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	DNA replication licensing factor MCM5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC084823.11, CJ075220.1, AK051795.1 and BY576039.1. On Oct 28, 2014 this sequence version replaced XM_006530750.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK051795.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGGCT TCGACGACCC GGGCATTTTC TACAGCGACA GCTTCGGTGG CGACCCCGGT 
GCGGAAGAGG GCCAGGCCCG CAAGTCGCAA CTGCAGAGGC GATTCAAGGA GTTCCTGAGA 
CAGTACCGAG TGGGCACCGA TCGCACGGGC TTCACCTTCA AGTACAGAGA TGAACTCAAG 
CGGCATTACA ACCTGGGTGA ATACTGGATC GAGGTGGAGA TGGAGGACCT GGCCAGTTTT 
GACGAGGAAC TGGCTGACCA CTTGCATAAA CAGCCGGCCG AGCACTTACA GCTGCTTGAG 
GAAGCTGCCA AGGAGGTGGC AGATGAGGTG ACCCGGCCCC GGCCAGCTGG AGATGAGCTG 
CTCCAAGACA TCCAGGTCAT GCTCAAGTCA GATGCCAGCC CGTCGAGCAT TCGGATTCTG 
AAGTCAGACA TGATGTCACA CCTGGTGAAG ATCCCTGGCA TCATCATTTC AGCCTCTGCA 
GTCCGTGCCA AGGCTACTCG TATCTCCATT CAGTGCCGCA GCTGCCACAA TACCCTCACC 
AATATCGCCA TGCGCCCAGG CCTAGAGGGC TATGCCCTTC CCAGGAAGTG CAATATGGAT 
CAGGCTGGGC GCCCAAAGTG CCCACTGGAT CCATACTTCA TCATGCCTGA CAAGTGCAAG 
TGTGTGGACT TCCAGACTCT GAAACTGCAG GAGCTGCCTG ATGCAGTCCC TCATGGTGAG 
ATGCCCAGGC ACATGCAGCT TTATTGTGAC AGGTACCTGT GTGACAAGGT TGTTCCTGGG 
AACAGGGTCA CCATCATGGG CATTTATTCC ATCAAGAAGT TTGGCTTGAA CCCCAGCAAG 
GGCCGGGACA GGGTAGGTGT GGGCATCCGG AGCTCGTACA TCCGAGTGCT GGGCATCCAG 
GTGGACACAG ATGGCTCTGG CCGAAGCTTT GCTGGGTCTG TCAGCCCACA GGAAGAGGAG 
GAATTTCGTC GCCTGGCTGC CCTCCCCAAC ATATATGAGC TCATCTCCAA GAGCATTTCC 
CCCTCCATCT TTGGGGGCAT GGATATGAAG AAGGCCATTG CCTGCCTGCT TTTTGGGGGT 
TCCCGGAAGA GGCTCCCAGA TGGACTCACT CGCCGAGGTG ATATCAACTT GCTGATGTTG 
GGAGACCCTG GTACAGCCAA GTCTCAGCTT CTGAAGTTTG TGGAGAAGTG CTCTCCCATT 
GGGGTGTACA CATCTGGGAA AGGTAGCAGT GCTGCTGGCT TGACTGCCTC AGTGATACGG 
GACCCCTCAT CTCGAAACTT CATCATGGAA GGTGGAGCCA TGGTTCTGGC CGATGGTGGG 
GTTGTCTGTA TTGATGAGTT TGACAAGATG CGGGAAGATG ACCGTGTTGC AATCCATGAG 
GCTATGGAGC AGCAGACCAT CTCCATTGCT AAAGCTGGGA TCACTACCAC CTTGAACTCT 
CGCTGCTCTG TTCTGGCTGC AGCCAACTCA GTGTTTGGCC GATGGGATGA GACAAAAGGG 
GAGGACAATA TTGACTTCAT GCCTACCATC TTGTCCCGAT TTGATATGAT CTTCATCGTC 
AAAGATGAGC ACAATGAGGA GAGGGACATG ATGCTAGCCA AACATGTGAT GACTCTGCAT 
GTGAGTGCAC TGACACAGAC ACAGGCTGTG GAGGGTGAGA TCGACCTGGC CAAGATGAAG 
AAGTTCATTG CCTACTGCCG AGCGAGGTGT GGACCTCGGC TATCAGCAGA GGCAGCAGAG 
AAGCTGAAAA ACCGCTACAT CATCATGCGG AGTGGGGCTC GTCAGCATGA GAGGGACAGT 
GACCGGCGTT CCAGCATCCC CATCACTGTG CGGCAGCTGG AGGCTATTGT GCGCATTGCT 
GAGGCCCTCA GTAAGATGAA ACTGCAGCCC TTTGCCACTG AGGCTGATGT AGAGGAGGCA 
TTGAGACTGT TCCAGGTGTC CACACTGGAT GCTGCTTTGT CTGGCAATCT GTCGGGGGTG 
GAGGGCTTCA CTACCCAGGA GGACCAGGAG ATGCTGAGCC GCATTGAGAA GCAACTCAAG 
CGCCGTTTTG CCATTGGCTC TCAGGTGTCT GAACACAGCA TTGTCCAGGA CTTCACCAAA 
CAGAAATATC CAGAGCACGC TATCCGAAAG GTGCTGCAGC TCATGCTACG CAGGGGTGAG 
ATCCAACACC GTATGCAGCG CAAGGTGCTC TATCGCCTCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289469.1
CDS	98..2302
Translation	MSGFDDPGIFYSDSFGGDPGAEEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEELADHLHKQPAEHLQLLEEAAKEVADEVTRPRPAGDELLQDIQVMLKSDASPSSIRILKSDMMSHLVKIPGIIISASAVRAKATRISIQCRSCHNTLTNIAMRPGLEGYALPRKCNMDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLNPSKGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGSVSPQEEEEFRRLAALPNIYELISKSISPSIFGGMDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVIRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDMMLAKHVMTLHVSALTQTQAVEGEIDLAKMKKFIAYCRARCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGNLSGVEGFTTQEDQEMLSRIEKQLKRRFAIGSQVSEHSIVQDFTKQKYPEHAIRKVLQLMLRRGEIQHRMQRKVLYRLK

Target ORF information:

RefSeq Version	NM_001302540.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus minichromosome maintenance complex component 5 (Mcm5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302540.1

ORF Insert Sequence:

ATGTCGGGCT TCGACGACCC GGGCATTTTC TACAGCGACA GCTTCGGTGG CGACCCCGGT 
GCGGAAGAGG GCCAGGCCCG CAAGTCGCAA CTGCAGAGGC GATTCAAGGA GTTCCTGAGA 
CAGTACCGAG TGGGCACCGA TCGCACGGGC TTCACCTTCA AGTACAGAGA TGAACTCAAG 
CGGCATTACA ACCTGGGTGA ATACTGGATC GAGGTGGAGA TGGAGGACCT GGCCAGTTTT 
GACGAGGAAC TGGCTGACCA CTTGCATAAA CAGCCGGCCG AGCACTTACA GCTGCTTGAG 
GAAGCTGCCA AGGAGGTGGC AGATGAGGTG ACCCGGCCCC GGCCAGCTGG AGATGAGCTG 
CTCCAAGACA TCCAGGTCAT GCTCAAGTCA GATGCCAGCC CGTCGAGCAT TCGGATTCTG 
AAGTCAGACA TGATGTCACA CCTGGTGAAG ATCCCTGGCA TCATCATTTC AGCCTCTGCA 
GTCCGTGCCA AGGCTACTCG TATCTCCATT CAGTGCCGCA GCTGCCACAA TACCCTCACC 
AATATCGCCA TGCGCCCAGG CCTAGAGGGC TATGCCCTTC CCAGGAAGTG CAATATGGAT 
CAGGCTGGGC GCCCAAAGTG CCCACTGGAT CCATACTTCA TCATGCCTGA CAAGTGCAAG 
TGTGTGGACT TCCAGACTCT GAAACTGCAG GAGCTGCCTG ATGCAGTCCC TCATGGTGAG 
ATGCCCAGGC ACATGCAGCT TTATTGTGAC AGGTACCTGT GTGACAAGGT TGTTCCTGGG 
AACAGGGTCA CCATCATGGG CATTTATTCC ATCAAGAAGT TTGGCTTGAA CCCCAGCAAG 
GGCCGGGACA GGGTAGGTGT GGGCATCCGG AGCTCGTACA TCCGAGTGCT GGGCATCCAG 
GTGGACACAG ATGGCTCTGG CCGAAGCTTT GCTGGGTCTG TCAGCCCACA GGAAGAGGAG 
GAATTTCGTC GCCTGGCTGC CCTCCCCAAC ATATATGAGC TCATCTCCAA GAGCATTTCC 
CCCTCCATCT TTGGGGGCAT GGATATGAAG AAGGCCATTG CCTGCCTGCT TTTTGGGGGT 
TCCCGGAAGA GGCTCCCAGA TGGACTCACT CGCCGAGGTG ATATCAACTT GCTGATGTTG 
GGAGACCCTG GTACAGCCAA GTCTCAGCTT CTGAAGTTTG TGGAGAAGTG CTCTCCCATT 
GGGGTGTACA CATCTGGGAA AGGTAGCAGT GCTGCTGGCT TGACTGCCTC AGTGATACGG 
GACCCCTCAT CTCGAAACTT CATCATGGAA GGTGGAGCCA TGGTTCTGGC CGATGGTGGG 
GTTGTCTGTA TTGATGAGTT TGACAAGATG CGGGAAGATG ACCGTGTTGC AATCCATGAG 
GCTATGGAGC AGCAGACCAT CTCCATTGCT AAAGCTGGGA TCACTACCAC CTTGAACTCT 
CGCTGCTCTG TTCTGGCTGC AGCCAACTCA GTGTTTGGCC GATGGGATGA GACAAAAGGG 
GAGGACAATA TTGACTTCAT GCCTACCATC TTGTCCCGAT TTGATATGAT CTTCATCGTC 
AAAGATGAGC ACAATGAGGA GAGGGACATG ATGCTAGCCA AACATGTGAT GACTCTGCAT 
GTGAGTGCAC TGACACAGAC ACAGGCTGTG GAGGGTGAGA TCGACCTGGC CAAGATGAAG 
AAGTTCATTG CCTACTGCCG AGCGAGGTGT GGACCTCGGC TATCAGCAGA GGCAGCAGAG 
AAGCTGAAAA ACCGCTACAT CATCATGCGG AGTGGGGCTC GTCAGCATGA GAGGGACAGT 
GACCGGCGTT CCAGCATCCC CATCACTGTG CGGCAGCTGG AGGCTATTGT GCGCATTGCT 
GAGGCCCTCA GTAAGATGAA ACTGCAGCCC TTTGCCACTG AGGCTGATGT AGAGGAGGCA 
TTGAGACTGT TCCAGGTGTC CACACTGGAT GCTGCTTTGT CTGGCAATCT GTCGGGGGTG 
GAGGGCTTCA CTACCCAGGA GGACCAGGAG ATGCTGAGCC GCATTGAGAA GCAACTCAAG 
CGCCGTTTTG CCATTGGCTC TCAGGTGTCT GAACACAGCA TTGTCCAGGA CTTCACCAAA 
CAGAAATATC CAGAGCACGC TATCCGAAAG GTGCTGCAGC TCATGCTACG CAGGGGTGAG 
ATCCAACACC GTATGCAGCG CAAGGTGCTC TATCGCCTCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mcm5 ( NM_008566.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032592.2 Mus musculus minichromosome maintenance complex component 5 (Mcm5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu22237
Clone ID Related Accession (Same CDS sequence)	NM_001302540.1 , NM_008566.3
Accession Version	NM_008566.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2205bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	DNA replication licensing factor MCM5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC084823.11, CJ075220.1 and AK033196.1. On Oct 28, 2014 this sequence version replaced NM_008566.2. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK033196.1, AK133826.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGGCT TCGACGACCC GGGCATTTTC TACAGCGACA GCTTCGGTGG CGACCCCGGT 
GCGGAAGAGG GCCAGGCCCG CAAGTCGCAA CTGCAGAGGC GATTCAAGGA GTTCCTGAGA 
CAGTACCGAG TGGGCACCGA TCGCACGGGC TTCACCTTCA AGTACAGAGA TGAACTCAAG 
CGGCATTACA ACCTGGGTGA ATACTGGATC GAGGTGGAGA TGGAGGACCT GGCCAGTTTT 
GACGAGGAAC TGGCTGACCA CTTGCATAAA CAGCCGGCCG AGCACTTACA GCTGCTTGAG 
GAAGCTGCCA AGGAGGTGGC AGATGAGGTG ACCCGGCCCC GGCCAGCTGG AGATGAGCTG 
CTCCAAGACA TCCAGGTCAT GCTCAAGTCA GATGCCAGCC CGTCGAGCAT TCGGATTCTG 
AAGTCAGACA TGATGTCACA CCTGGTGAAG ATCCCTGGCA TCATCATTTC AGCCTCTGCA 
GTCCGTGCCA AGGCTACTCG TATCTCCATT CAGTGCCGCA GCTGCCACAA TACCCTCACC 
AATATCGCCA TGCGCCCAGG CCTAGAGGGC TATGCCCTTC CCAGGAAGTG CAATATGGAT 
CAGGCTGGGC GCCCAAAGTG CCCACTGGAT CCATACTTCA TCATGCCTGA CAAGTGCAAG 
TGTGTGGACT TCCAGACTCT GAAACTGCAG GAGCTGCCTG ATGCAGTCCC TCATGGTGAG 
ATGCCCAGGC ACATGCAGCT TTATTGTGAC AGGTACCTGT GTGACAAGGT TGTTCCTGGG 
AACAGGGTCA CCATCATGGG CATTTATTCC ATCAAGAAGT TTGGCTTGAA CCCCAGCAAG 
GGCCGGGACA GGGTAGGTGT GGGCATCCGG AGCTCGTACA TCCGAGTGCT GGGCATCCAG 
GTGGACACAG ATGGCTCTGG CCGAAGCTTT GCTGGGTCTG TCAGCCCACA GGAAGAGGAG 
GAATTTCGTC GCCTGGCTGC CCTCCCCAAC ATATATGAGC TCATCTCCAA GAGCATTTCC 
CCCTCCATCT TTGGGGGCAT GGATATGAAG AAGGCCATTG CCTGCCTGCT TTTTGGGGGT 
TCCCGGAAGA GGCTCCCAGA TGGACTCACT CGCCGAGGTG ATATCAACTT GCTGATGTTG 
GGAGACCCTG GTACAGCCAA GTCTCAGCTT CTGAAGTTTG TGGAGAAGTG CTCTCCCATT 
GGGGTGTACA CATCTGGGAA AGGTAGCAGT GCTGCTGGCT TGACTGCCTC AGTGATACGG 
GACCCCTCAT CTCGAAACTT CATCATGGAA GGTGGAGCCA TGGTTCTGGC CGATGGTGGG 
GTTGTCTGTA TTGATGAGTT TGACAAGATG CGGGAAGATG ACCGTGTTGC AATCCATGAG 
GCTATGGAGC AGCAGACCAT CTCCATTGCT AAAGCTGGGA TCACTACCAC CTTGAACTCT 
CGCTGCTCTG TTCTGGCTGC AGCCAACTCA GTGTTTGGCC GATGGGATGA GACAAAAGGG 
GAGGACAATA TTGACTTCAT GCCTACCATC TTGTCCCGAT TTGATATGAT CTTCATCGTC 
AAAGATGAGC ACAATGAGGA GAGGGACATG ATGCTAGCCA AACATGTGAT GACTCTGCAT 
GTGAGTGCAC TGACACAGAC ACAGGCTGTG GAGGGTGAGA TCGACCTGGC CAAGATGAAG 
AAGTTCATTG CCTACTGCCG AGCGAGGTGT GGACCTCGGC TATCAGCAGA GGCAGCAGAG 
AAGCTGAAAA ACCGCTACAT CATCATGCGG AGTGGGGCTC GTCAGCATGA GAGGGACAGT 
GACCGGCGTT CCAGCATCCC CATCACTGTG CGGCAGCTGG AGGCTATTGT GCGCATTGCT 
GAGGCCCTCA GTAAGATGAA ACTGCAGCCC TTTGCCACTG AGGCTGATGT AGAGGAGGCA 
TTGAGACTGT TCCAGGTGTC CACACTGGAT GCTGCTTTGT CTGGCAATCT GTCGGGGGTG 
GAGGGCTTCA CTACCCAGGA GGACCAGGAG ATGCTGAGCC GCATTGAGAA GCAACTCAAG 
CGCCGTTTTG CCATTGGCTC TCAGGTGTCT GAACACAGCA TTGTCCAGGA CTTCACCAAA 
CAGAAATATC CAGAGCACGC TATCCGAAAG GTGCTGCAGC TCATGCTACG CAGGGGTGAG 
ATCCAACACC GTATGCAGCG CAAGGTGCTC TATCGCCTCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032592.2
CDS	122..2326
Translation	MSGFDDPGIFYSDSFGGDPGAEEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEELADHLHKQPAEHLQLLEEAAKEVADEVTRPRPAGDELLQDIQVMLKSDASPSSIRILKSDMMSHLVKIPGIIISASAVRAKATRISIQCRSCHNTLTNIAMRPGLEGYALPRKCNMDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLNPSKGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGSVSPQEEEEFRRLAALPNIYELISKSISPSIFGGMDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVIRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDMMLAKHVMTLHVSALTQTQAVEGEIDLAKMKKFIAYCRARCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGNLSGVEGFTTQEDQEMLSRIEKQLKRRFAIGSQVSEHSIVQDFTKQKYPEHAIRKVLQLMLRRGEIQHRMQRKVLYRLK

Target ORF information:

RefSeq Version	NM_008566.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus minichromosome maintenance complex component 5 (Mcm5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008566.3

ORF Insert Sequence:

ATGTCGGGCT TCGACGACCC GGGCATTTTC TACAGCGACA GCTTCGGTGG CGACCCCGGT 
GCGGAAGAGG GCCAGGCCCG CAAGTCGCAA CTGCAGAGGC GATTCAAGGA GTTCCTGAGA 
CAGTACCGAG TGGGCACCGA TCGCACGGGC TTCACCTTCA AGTACAGAGA TGAACTCAAG 
CGGCATTACA ACCTGGGTGA ATACTGGATC GAGGTGGAGA TGGAGGACCT GGCCAGTTTT 
GACGAGGAAC TGGCTGACCA CTTGCATAAA CAGCCGGCCG AGCACTTACA GCTGCTTGAG 
GAAGCTGCCA AGGAGGTGGC AGATGAGGTG ACCCGGCCCC GGCCAGCTGG AGATGAGCTG 
CTCCAAGACA TCCAGGTCAT GCTCAAGTCA GATGCCAGCC CGTCGAGCAT TCGGATTCTG 
AAGTCAGACA TGATGTCACA CCTGGTGAAG ATCCCTGGCA TCATCATTTC AGCCTCTGCA 
GTCCGTGCCA AGGCTACTCG TATCTCCATT CAGTGCCGCA GCTGCCACAA TACCCTCACC 
AATATCGCCA TGCGCCCAGG CCTAGAGGGC TATGCCCTTC CCAGGAAGTG CAATATGGAT 
CAGGCTGGGC GCCCAAAGTG CCCACTGGAT CCATACTTCA TCATGCCTGA CAAGTGCAAG 
TGTGTGGACT TCCAGACTCT GAAACTGCAG GAGCTGCCTG ATGCAGTCCC TCATGGTGAG 
ATGCCCAGGC ACATGCAGCT TTATTGTGAC AGGTACCTGT GTGACAAGGT TGTTCCTGGG 
AACAGGGTCA CCATCATGGG CATTTATTCC ATCAAGAAGT TTGGCTTGAA CCCCAGCAAG 
GGCCGGGACA GGGTAGGTGT GGGCATCCGG AGCTCGTACA TCCGAGTGCT GGGCATCCAG 
GTGGACACAG ATGGCTCTGG CCGAAGCTTT GCTGGGTCTG TCAGCCCACA GGAAGAGGAG 
GAATTTCGTC GCCTGGCTGC CCTCCCCAAC ATATATGAGC TCATCTCCAA GAGCATTTCC 
CCCTCCATCT TTGGGGGCAT GGATATGAAG AAGGCCATTG CCTGCCTGCT TTTTGGGGGT 
TCCCGGAAGA GGCTCCCAGA TGGACTCACT CGCCGAGGTG ATATCAACTT GCTGATGTTG 
GGAGACCCTG GTACAGCCAA GTCTCAGCTT CTGAAGTTTG TGGAGAAGTG CTCTCCCATT 
GGGGTGTACA CATCTGGGAA AGGTAGCAGT GCTGCTGGCT TGACTGCCTC AGTGATACGG 
GACCCCTCAT CTCGAAACTT CATCATGGAA GGTGGAGCCA TGGTTCTGGC CGATGGTGGG 
GTTGTCTGTA TTGATGAGTT TGACAAGATG CGGGAAGATG ACCGTGTTGC AATCCATGAG 
GCTATGGAGC AGCAGACCAT CTCCATTGCT AAAGCTGGGA TCACTACCAC CTTGAACTCT 
CGCTGCTCTG TTCTGGCTGC AGCCAACTCA GTGTTTGGCC GATGGGATGA GACAAAAGGG 
GAGGACAATA TTGACTTCAT GCCTACCATC TTGTCCCGAT TTGATATGAT CTTCATCGTC 
AAAGATGAGC ACAATGAGGA GAGGGACATG ATGCTAGCCA AACATGTGAT GACTCTGCAT 
GTGAGTGCAC TGACACAGAC ACAGGCTGTG GAGGGTGAGA TCGACCTGGC CAAGATGAAG 
AAGTTCATTG CCTACTGCCG AGCGAGGTGT GGACCTCGGC TATCAGCAGA GGCAGCAGAG 
AAGCTGAAAA ACCGCTACAT CATCATGCGG AGTGGGGCTC GTCAGCATGA GAGGGACAGT 
GACCGGCGTT CCAGCATCCC CATCACTGTG CGGCAGCTGG AGGCTATTGT GCGCATTGCT 
GAGGCCCTCA GTAAGATGAA ACTGCAGCCC TTTGCCACTG AGGCTGATGT AGAGGAGGCA 
TTGAGACTGT TCCAGGTGTC CACACTGGAT GCTGCTTTGT CTGGCAATCT GTCGGGGGTG 
GAGGGCTTCA CTACCCAGGA GGACCAGGAG ATGCTGAGCC GCATTGAGAA GCAACTCAAG 
CGCCGTTTTG CCATTGGCTC TCAGGTGTCT GAACACAGCA TTGTCCAGGA CTTCACCAAA 
CAGAAATATC CAGAGCACGC TATCCGAAAG GTGCTGCAGC TCATGCTACG CAGGGGTGAG 
ATCCAACACC GTATGCAGCG CAAGGTGCTC TATCGCCTCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sox10 regulates skin melanocyte proliferation by activating the DNA replication licensing factor MCM5.
Journal of dermatological science85(3)216-225(2017 Mar)
Su Z,Zheng X,Zhang X,Wang Y,Zhu S,Lu F,Qu J,Hou L

Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity.
Genetics197(2)485-96(2014 Jun)
De Arras L,Laws R,Leach SM,Pontis K,Freedman JH,Schwartz DA,Alper S

Genome-wide microarray comparison reveals downstream genes of Pax6 in the developing mouse cerebellum.
The European journal of neuroscience36(7)2888-98(2012 Oct)
Ha TJ,Swanson DJ,Kirova R,Yeung J,Choi K,Tong Y,Chesler EJ,Goldowitz D

Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload.
The Journal of cell biology192(1)29-41(2011 Jan)
Kuipers MA,Stasevich TJ,Sasaki T,Wilson KA,Hazelwood KL,McNally JG,Davidson MW,Gilbert DM

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Mcm5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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