Mc1r cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mc1r
Entrez Gene ID	17199
Full Name	melanocortin 1 receptor
Synonyms	Mcr1,Mshra,Tob,e
General protein information	Preferred Names melanocortin 1 receptor Names melanocyte-stimulating hormone receptor MC1-R MSH-R extension recessive yellow melanocortin receptor 1 tobacco darkening
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 E1\|8 72.1 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008559.2	NP_032585.2	melanocyte-stimulating hormone receptor

Pathways from BioSystems

Homologies

Homo sapiens (human)	MC1R	NP_002377.4
Bos taurus (cattle)	MC1R	NP_776533.1
Pan troglodytes (chimpanzee)	MC1R	NP_001009152.1
Mus musculus (house mouse)	Mc1r	NP_032585.2
Canis lupus familiaris (dog)	MC1R	NP_001014304.1
Rattus norvegicus (Norway rat)	Mc1r	XP_006255857.1
Xenopus tropicalis (tropical clawed frog)	mc1r	XP_002937630.2
Gallus gallus (chicken)	MC1R	NP_001026633.1
Danio rerio (zebrafish)	mc1r	NP_851301.1

Gene Ontology
Bibliography

Related articles in PubMed

Widespread dynamic and pleiotropic expression of the melanocortin-1-receptor (MC1R) system is conserved across chick, mouse and human embryonic development.
Thomas AC, Heux P, Santos C, Arulvasan W, Solanky N, Carey ME, Gerrelli D, Kinsler VA, Etchevers HC
Birth defects research(2018 Jan)

Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E
Rinne P, Kadiri JJ, Velasco-Delgado M, Nuutinen S, Viitala M, Hollm?n M, Rami M, Savontaus E, Steffens S
Arteriosclerosis, thrombosis, and vascular biology(2017 Dec)

Palmitoylation-dependent activation of MC1R prevents melanomagenesis.
Chen S, Zhu B, Yin C, Liu W, Han C, Chen B, Liu T, Li X, Chen X, Li C, Hu L, Zhou J, Xu ZX, Gao X, Wu X, Goding CR, Cui R
Nature549(7672)399-403(2017 09)

Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages.
Rinne P, Rami M, Nuutinen S, Santovito D, van der Vorst EPC, Guillamat-Prats R, Lyytik?inen LP, Raitoharju E, Oksala N, Ring L, Cai M, Hruby VJ, Lehtim?ki T, Weber C, Steffens S
Circulation136(1)83-97(2017 Jul)

A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin.
Mujahid N, Liang Y, Murakami R, Choi HG, Dobry AS, Wang J, Suita Y, Weng QY, Allouche J, Kemeny LV, Hermann AL, Roider EM, Gray NS, Fisher DE
Cell reports19(11)2177-2184(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Activation of Mc1r prevents cholesterol uptake and confers protection against macrophage foam cell formation.
Title: Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages.

We conclude that MC1R plays an important role in regulating melanoma growth and morphology
Title: Inhibition of melanocortin 1 receptor slows melanoma growth, reduces tumor heterogeneity and increases survival.

MR importantly contributes to diabetes-associated vascular dysfunction by inducing oxidative stress and by increasing the activity of redox-sensitive proteins
Title: Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type?2 diabetes mellitus.

MC1-mediated effects were reduced, and MC3 anti-inflammatory circuits predominated. Mice bearing a nonfunctional MC1 displayed a transient exacerbation of neutrophil recruitment after global I/R, which diminished by 2 hours.
Title: Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment.

A melanin-independent interaction between Mc1r and Met signaling pathways is required for hepatocyte growth factor-dependent melanoma.
Title: A melanin-independent interaction between Mc1r and Met signaling pathways is required for HGF-dependent melanoma.

The following Mc1r gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mc1r cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14242	NM_008559.2 Latest version!	Mus musculus melanocortin 1 receptor (Mc1r), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mc1r ( NM_008559.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032585.2 Mus musculus melanocortin 1 receptor (Mc1r), mRNA.

Price & Availability↑

CloneID	OMu14242
Clone ID Related Accession (Same CDS sequence)	NM_008559.2
Accession Version	NM_008559.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	melanocyte-stimulating hormone receptor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY740794.1, BC119294.1, AC122266.2 and BF460761.1. On Jan 31, 2007 this sequence version replaced NM_008559.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGTCCACTC AGGAGCCCCA GAAGAGTCTT CTGGGTTCTC TCAACTCCAA TGCCACCTCT 
CACCTTGGAC TGGCCACCAA CCAGTCAGAG CCTTGGTGCC TGTATGTGTC CATCCCAGAT 
GGCCTCTTCC TCAGCCTAGG GCTGGTGAGT CTGGTGGAGA ATGTGCTGGT TGTGATAGCC 
ATCACCAAAA ACCGCAACCT GCACTCGCCC ATGTATTACT TCATCTGCTG CCTGGCCCTG 
TCTGACCTGA TGGTAAGTGT CAGCATCGTG CTGGAGACTA CTATCATCCT GCTGCTGGAG 
GCGGGCATCC TGGTGGCCAG AGTGGCTTTG GTGCAGCAGC TGGACAACCT CATTGACGTG 
CTCATCTGTG GCTCCATGGT GTCCAGTCTC TGCTTCCTGG GCATCATTGC TATAGACCGC 
TACATCTCCA TCTTCTATGC GCTGCGTTAT CACAGCATCG TGACGCTGCC CAGAGCACGA 
CGGGCTGTCG TGGGCATCTG GATGGTCAGC ATCGTCTCCA GCACCCTCTT TATCACCTAC 
TACAAGCACA CAGCCGTTCT GCTCTGCCTC GTCACTTTCT TTCTAGCCAT GCTGGCACTC 
ATGGCGATTC TGTATGCCCA CATGTTCACG AGAGCGTGCC AGCACGCTCA GGGCATTGCC 
CAGCTCCACA AAAGGCGGCG GTCCATCCGC CAAGGCTTCT GCCTCAAGGG TGCTGCCACC 
CTTACTATCC TTCTGGGGAT TTTCTTCCTG TGCTGGGGCC CCTTCTTCCT GCATCTCTTG 
CTCATCGTCC TCTGCCCTCA GCACCCCACC TGCAGCTGCA TCTTCAAGAA CTTCAACCTC 
TTCCTCCTCC TCATCGTCCT CAGCTCCACT GTTGACCCCC TCATCTATGC TTTCCGCAGC 
CAGGAGCTCC GCATGACACT CAAGGAGGTG CTGCTGTGCT CCTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032585.2
CDS	429..1376
Translation	MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW

Target ORF information:

RefSeq Version	NM_008559.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus melanocortin 1 receptor (Mc1r), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008559.2

ORF Insert Sequence:

ATGTCCACTC AGGAGCCCCA GAAGAGTCTT CTGGGTTCTC TCAACTCCAA TGCCACCTCT 
CACCTTGGAC TGGCCACCAA CCAGTCAGAG CCTTGGTGCC TGTATGTGTC CATCCCAGAT 
GGCCTCTTCC TCAGCCTAGG GCTGGTGAGT CTGGTGGAGA ATGTGCTGGT TGTGATAGCC 
ATCACCAAAA ACCGCAACCT GCACTCGCCC ATGTATTACT TCATCTGCTG CCTGGCCCTG 
TCTGACCTGA TGGTAAGTGT CAGCATCGTG CTGGAGACTA CTATCATCCT GCTGCTGGAG 
GCGGGCATCC TGGTGGCCAG AGTGGCTTTG GTGCAGCAGC TGGACAACCT CATTGACGTG 
CTCATCTGTG GCTCCATGGT GTCCAGTCTC TGCTTCCTGG GCATCATTGC TATAGACCGC 
TACATCTCCA TCTTCTATGC GCTGCGTTAT CACAGCATCG TGACGCTGCC CAGAGCACGA 
CGGGCTGTCG TGGGCATCTG GATGGTCAGC ATCGTCTCCA GCACCCTCTT TATCACCTAC 
TACAAGCACA CAGCCGTTCT GCTCTGCCTC GTCACTTTCT TTCTAGCCAT GCTGGCACTC 
ATGGCGATTC TGTATGCCCA CATGTTCACG AGAGCGTGCC AGCACGCTCA GGGCATTGCC 
CAGCTCCACA AAAGGCGGCG GTCCATCCGC CAAGGCTTCT GCCTCAAGGG TGCTGCCACC 
CTTACTATCC TTCTGGGGAT TTTCTTCCTG TGCTGGGGCC CCTTCTTCCT GCATCTCTTG 
CTCATCGTCC TCTGCCCTCA GCACCCCACC TGCAGCTGCA TCTTCAAGAA CTTCAACCTC 
TTCCTCCTCC TCATCGTCCT CAGCTCCACT GTTGACCCCC TCATCTATGC TTTCCGCAGC 
CAGGAGCTCC GCATGACACT CAAGGAGGTG CTGCTGTGCT CCTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Widespread dynamic and pleiotropic expression of the melanocortin-1-receptor (MC1R) system is conserved across chick, mouse and human embryonic development.
Birth defects research(2018 Jan)
Thomas AC,Heux P,Santos C,Arulvasan W,Solanky N,Carey ME,Gerrelli D,Kinsler VA,Etchevers HC

Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E
Arteriosclerosis, thrombosis, and vascular biology(2017 Dec)
Rinne P,Kadiri JJ,Velasco-Delgado M,Nuutinen S,Viitala M,Hollm?n M,Rami M,Savontaus E,Steffens S

Palmitoylation-dependent activation of MC1R prevents melanomagenesis.
Nature549(7672)399-403(2017 09)
Chen S,Zhu B,Yin C,Liu W,Han C,Chen B,Liu T,Li X,Chen X,Li C,Hu L,Zhou J,Xu ZX,Gao X,Wu X,Goding CR,Cui R

Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages.
Circulation136(1)83-97(2017 Jul)
Rinne P,Rami M,Nuutinen S,Santovito D,van der Vorst EPC,Guillamat-Prats R,Lyytik?inen LP,Raitoharju E,Oksala N,Ring L,Cai M,Hruby VJ,Lehtim?ki T,Weber C,Steffens S

A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin.
Cell reports19(11)2177-2184(2017 Jun)
Mujahid N,Liang Y,Murakami R,Choi HG,Dobry AS,Wang J,Suita Y,Weng QY,Allouche J,Kemeny LV,Hermann AL,Roider EM,Gray NS,Fisher DE

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Mc1r cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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