Timd2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Timd2
Entrez Gene ID	171284
Full Name	T cell immunoglobulin and mucin domain containing 2
Synonyms	AA816106,AU019358,AU019662,C78111,G9D3,TIM-2,Tim2
General protein information	Preferred Names T cell immunoglobulin and mucin domain containing 2 Names T-cell immunoglobulin and mucin domain-containing protein 2 T-cell immunoglobulin mucin receptor 2 T-cell membrane protein 2 TIMD-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 B1.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_134249.5	NP_599010.4	T-cell immunoglobulin and mucin domain-containing protein 2 precursor
NM_001161355.1	NP_001154827.1	T-cell immunoglobulin and mucin domain-containing protein 2 precursor
NM_001161356.1	NP_001154828.1	T-cell immunoglobulin and mucin domain-containing protein 2 precursor
XM_030245624.1	XP_030101484.1	T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1
XM_030245625.1	XP_030101485.1	T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Timd2	NP_001154827.1
Rattus norvegicus (Norway rat)	Timd2	NP_001013877.1

Gene Ontology
Bibliography

Related articles in PubMed

T-cell immunoglobulin and mucin domain?2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding.
Dewitz C, M?ller-Hackbarth K, Schweigert O, Reiss K, Chalaris A, Scheller J, Rose-John S
The FEBS journal281(1)157-74(2014 Jan)

Tim-2 up-regulation and galectin-9-Tim-3 pathway activation in Th2-biased response in Schistosoma japonicum infection in mice.
Qi Y, Song XR, Shen JL, Xu YH, Shen Q, Luo QL, Zhong ZR, Wang W, Chu DY, Song WJ
Immunology letters144(1-2)60-6(2012 May)

Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells.
Kawamoto T, Abe Y, Ito J, Makino F, Kojima Y, Usui Y, Ma J, Morimoto S, Yagita H, Okumura K, Takasaki Y, Akiba H
Arthritis research & therapy13(2)R47(2011 Mar)

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PloS one6(6)e21208(2011)

Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells.
Han J, Seaman WE, Di X, Wang W, Willingham M, Torti FM, Torti SV
PloS one6(8)e23800(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We concluded that pro-apoptotic effects on Th1 population through galectin-9-Tim-3 pathway and the up-regulation of Tim-2 on Th2 cells might be critical to Th2-biased response of host with schistosomiasis japonica.
Title: Tim-2 up-regulation and galectin-9-Tim-3 pathway activation in Th2-biased response in Schistosoma japonicum infection in mice.

TIM-2 signaling influences both proliferation and antibody production of B cells during the early phase of collagen-induced arthritis
Title: Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells.

TIM-2 can function as an iron uptake pathway.
Title: Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells.

The increased expression of the pro-inflammatory and proapoptotic genes, a higher number of apoptotic cells, and increased injury and mortality of the TIM2-deficient mice suggest a protective role of TIM2 in cisplatin-induced nephrotoxicity.
Title: TIM2 gene deletion results in susceptibility to cisplatin-induced kidney toxicity.

Tim-2 negatively regulates the Th2 differentiation of Ag-primed T-cells and the development of EC during the effector phase.
Title: T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase.

The following Timd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Timd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu08113	NM_001161355.1 Latest version!	Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu08113	NM_001161356.1 Latest version!	Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu08113	NM_134249.5 Latest version!	Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu08113	XM_030245625.1 Latest version!	Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu08113	XM_030245624.1 Latest version!	Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Timd2 ( NM_134249.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_599010.4 Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu08113
Clone ID Related Accession (Same CDS sequence)	NM_134249.5 , NM_001161355.1 , NM_001161356.1 , XM_030245624.1 , XM_030245625.1
Accession Version	NM_134249.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Mus musculus(house mouse)
Product	T-cell immunoglobulin and mucin domain-containing protein 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY731803.1, AK163225.1, AK145630.1 and AK166877.1. On May 29, 2009 this sequence version replaced NM_134249.4. Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028829.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGAATCAGA TTCAAGTCTT CATTTCAGGC CTCATACTGC TTCTCCCAGG TGCCGTGGAG 
TCTCATACAG CAGTGCAGGG GCTGGCGGGT CACCCTGTCA CACTTCCATG TATTTATTCG 
ACACACCTTG GTGGAATCGT TCCTATGTGT TGGGGCCTAG GGGAATGCCG CCATTCTTAT 
TGTATACGGT CACTTATCTG GACCAATGGA TATACGGTCA CACATCAGAG GAACAGTCGA 
TACCAGCTAA AGGGGAATAT TTCAGAAGGA AATGTGTCCT TGACCATAGA GAACACTGTT 
GTGGGTGATG GTGGTCCCTA TTGCTGTGTA GTGGAGATAC CTGGAGCGTT CCATTTTGTG 
GACTATATGT TGGAAGTTAA ACCAGAAATT TCCACGAGTC CACCAACAAG GCCCACAGCT 
ACAGGAAGAC CCACAACTAT TTCAACAAGA TCCACACATG TACCAACATC AACCAGAGTC 
TCTACCTCTA CTTCTCCAAC ACCAGCACAC ACAGAGACCT ACAAACCAGA GGCCACTACA 
TTTTATCCAG ATCAGACTAC AGCTGAGGTG ACAGAAACCT TACCCTCTAC TCCTGCAGAC 
TGGCATAACA CTGTGACATC CTCAGATGAC CCTTGGGATG ATAACACTGA AGTAATCCCT 
CCACAGAAGC CACAGAAAAA CCTGAATAAG GGCTTCTATG TTGGCATCTC CATTGCAGCC 
CTGCTGATAT TGATGCTTCT GAGCACCATG GTTATCACCA GGTACGTGGT TATGAAAAGG 
AAGTCAGAAT CTCTGAGCTT CGTTGCCTTC CCTATCTCTA AGATTGGAGC TTCCCCCAAA 
AAAGTGGTCG AACGGACCAG ATGTGAAGAC CAGGTCTACA TTATTGAAGA CACTCCTTAC 
CCCGAAGAAG AGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_599010.4
CDS	180..1097
Translation	MNQIQVFISGLILLLPGAVESHTAVQGLAGHPVTLPCIYSTHLGGIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSRYQLKGNISEGNVSLTIENTVVGDGGPYCCVVEIPGAFHFVDYMLEVKPEISTSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETYKPEATTFYPDQTTAEVTETLPSTPADWHNTVTSSDDPWDDNTEVIPPQKPQKNLNKGFYVGISIAALLILMLLSTMVITRYVVMKRKSESLSFVAFPISKIGASPKKVVERTRCEDQVYIIEDTPYPEEES

Target ORF information:

RefSeq Version	NM_134249.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134249.5

ORF Insert Sequence:

ATGAATCAGA TTCAAGTCTT CATTTCAGGC CTCATACTGC TTCTCCCAGG TGCCGTGGAG 
TCTCATACAG CAGTGCAGGG GCTGGCGGGT CACCCTGTCA CACTTCCATG TATTTATTCG 
ACACACCTTG GTGGAATCGT TCCTATGTGT TGGGGCCTAG GGGAATGCCG CCATTCTTAT 
TGTATACGGT CACTTATCTG GACCAATGGA TATACGGTCA CACATCAGAG GAACAGTCGA 
TACCAGCTAA AGGGGAATAT TTCAGAAGGA AATGTGTCCT TGACCATAGA GAACACTGTT 
GTGGGTGATG GTGGTCCCTA TTGCTGTGTA GTGGAGATAC CTGGAGCGTT CCATTTTGTG 
GACTATATGT TGGAAGTTAA ACCAGAAATT TCCACGAGTC CACCAACAAG GCCCACAGCT 
ACAGGAAGAC CCACAACTAT TTCAACAAGA TCCACACATG TACCAACATC AACCAGAGTC 
TCTACCTCTA CTTCTCCAAC ACCAGCACAC ACAGAGACCT ACAAACCAGA GGCCACTACA 
TTTTATCCAG ATCAGACTAC AGCTGAGGTG ACAGAAACCT TACCCTCTAC TCCTGCAGAC 
TGGCATAACA CTGTGACATC CTCAGATGAC CCTTGGGATG ATAACACTGA AGTAATCCCT 
CCACAGAAGC CACAGAAAAA CCTGAATAAG GGCTTCTATG TTGGCATCTC CATTGCAGCC 
CTGCTGATAT TGATGCTTCT GAGCACCATG GTTATCACCA GGTACGTGGT TATGAAAAGG 
AAGTCAGAAT CTCTGAGCTT CGTTGCCTTC CCTATCTCTA AGATTGGAGC TTCCCCCAAA 
AAAGTGGTCG AACGGACCAG ATGTGAAGAC CAGGTCTACA TTATTGAAGA CACTCCTTAC 
CCCGAAGAAG AGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Timd2 ( NM_001161355.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001154827.1 Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu08113
Clone ID Related Accession (Same CDS sequence)	NM_134249.5 , NM_001161355.1 , NM_001161356.1 , XM_030245624.1 , XM_030245625.1
Accession Version	NM_001161355.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Mus musculus(house mouse)
Product	T-cell immunoglobulin and mucin domain-containing protein 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB953226.1, AK163225.1, AK145630.1 and AK166877.1. Transcript Variant: This variant (1), variant 2 and variant 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK166877.1, AK145630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGAATCAGA TTCAAGTCTT CATTTCAGGC CTCATACTGC TTCTCCCAGG TGCCGTGGAG 
TCTCATACAG CAGTGCAGGG GCTGGCGGGT CACCCTGTCA CACTTCCATG TATTTATTCG 
ACACACCTTG GTGGAATCGT TCCTATGTGT TGGGGCCTAG GGGAATGCCG CCATTCTTAT 
TGTATACGGT CACTTATCTG GACCAATGGA TATACGGTCA CACATCAGAG GAACAGTCGA 
TACCAGCTAA AGGGGAATAT TTCAGAAGGA AATGTGTCCT TGACCATAGA GAACACTGTT 
GTGGGTGATG GTGGTCCCTA TTGCTGTGTA GTGGAGATAC CTGGAGCGTT CCATTTTGTG 
GACTATATGT TGGAAGTTAA ACCAGAAATT TCCACGAGTC CACCAACAAG GCCCACAGCT 
ACAGGAAGAC CCACAACTAT TTCAACAAGA TCCACACATG TACCAACATC AACCAGAGTC 
TCTACCTCTA CTTCTCCAAC ACCAGCACAC ACAGAGACCT ACAAACCAGA GGCCACTACA 
TTTTATCCAG ATCAGACTAC AGCTGAGGTG ACAGAAACCT TACCCTCTAC TCCTGCAGAC 
TGGCATAACA CTGTGACATC CTCAGATGAC CCTTGGGATG ATAACACTGA AGTAATCCCT 
CCACAGAAGC CACAGAAAAA CCTGAATAAG GGCTTCTATG TTGGCATCTC CATTGCAGCC 
CTGCTGATAT TGATGCTTCT GAGCACCATG GTTATCACCA GGTACGTGGT TATGAAAAGG 
AAGTCAGAAT CTCTGAGCTT CGTTGCCTTC CCTATCTCTA AGATTGGAGC TTCCCCCAAA 
AAAGTGGTCG AACGGACCAG ATGTGAAGAC CAGGTCTACA TTATTGAAGA CACTCCTTAC 
CCCGAAGAAG AGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001154827.1
CDS	298..1215
Translation	MNQIQVFISGLILLLPGAVESHTAVQGLAGHPVTLPCIYSTHLGGIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSRYQLKGNISEGNVSLTIENTVVGDGGPYCCVVEIPGAFHFVDYMLEVKPEISTSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETYKPEATTFYPDQTTAEVTETLPSTPADWHNTVTSSDDPWDDNTEVIPPQKPQKNLNKGFYVGISIAALLILMLLSTMVITRYVVMKRKSESLSFVAFPISKIGASPKKVVERTRCEDQVYIIEDTPYPEEES

Target ORF information:

RefSeq Version	NM_001161355.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001161355.1

ORF Insert Sequence:

ATGAATCAGA TTCAAGTCTT CATTTCAGGC CTCATACTGC TTCTCCCAGG TGCCGTGGAG 
TCTCATACAG CAGTGCAGGG GCTGGCGGGT CACCCTGTCA CACTTCCATG TATTTATTCG 
ACACACCTTG GTGGAATCGT TCCTATGTGT TGGGGCCTAG GGGAATGCCG CCATTCTTAT 
TGTATACGGT CACTTATCTG GACCAATGGA TATACGGTCA CACATCAGAG GAACAGTCGA 
TACCAGCTAA AGGGGAATAT TTCAGAAGGA AATGTGTCCT TGACCATAGA GAACACTGTT 
GTGGGTGATG GTGGTCCCTA TTGCTGTGTA GTGGAGATAC CTGGAGCGTT CCATTTTGTG 
GACTATATGT TGGAAGTTAA ACCAGAAATT TCCACGAGTC CACCAACAAG GCCCACAGCT 
ACAGGAAGAC CCACAACTAT TTCAACAAGA TCCACACATG TACCAACATC AACCAGAGTC 
TCTACCTCTA CTTCTCCAAC ACCAGCACAC ACAGAGACCT ACAAACCAGA GGCCACTACA 
TTTTATCCAG ATCAGACTAC AGCTGAGGTG ACAGAAACCT TACCCTCTAC TCCTGCAGAC 
TGGCATAACA CTGTGACATC CTCAGATGAC CCTTGGGATG ATAACACTGA AGTAATCCCT 
CCACAGAAGC CACAGAAAAA CCTGAATAAG GGCTTCTATG TTGGCATCTC CATTGCAGCC 
CTGCTGATAT TGATGCTTCT GAGCACCATG GTTATCACCA GGTACGTGGT TATGAAAAGG 
AAGTCAGAAT CTCTGAGCTT CGTTGCCTTC CCTATCTCTA AGATTGGAGC TTCCCCCAAA 
AAAGTGGTCG AACGGACCAG ATGTGAAGAC CAGGTCTACA TTATTGAAGA CACTCCTTAC 
CCCGAAGAAG AGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Timd2 ( NM_001161356.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001154828.1 Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu08113
Clone ID Related Accession (Same CDS sequence)	NM_134249.5 , NM_001161355.1 , NM_001161356.1 , XM_030245624.1 , XM_030245625.1
Accession Version	NM_001161356.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Mus musculus(house mouse)
Product	T-cell immunoglobulin and mucin domain-containing protein 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB009015.1, AK166877.1 and AK145630.1. Transcript Variant: This variant (3) has an alternate 5' UTR, as compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB009015.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849386, SAMN01164134 [ECO:0000350] ##Evidence-Data-END##

ATGAATCAGA TTCAAGTCTT CATTTCAGGC CTCATACTGC TTCTCCCAGG TGCCGTGGAG 
TCTCATACAG CAGTGCAGGG GCTGGCGGGT CACCCTGTCA CACTTCCATG TATTTATTCG 
ACACACCTTG GTGGAATCGT TCCTATGTGT TGGGGCCTAG GGGAATGCCG CCATTCTTAT 
TGTATACGGT CACTTATCTG GACCAATGGA TATACGGTCA CACATCAGAG GAACAGTCGA 
TACCAGCTAA AGGGGAATAT TTCAGAAGGA AATGTGTCCT TGACCATAGA GAACACTGTT 
GTGGGTGATG GTGGTCCCTA TTGCTGTGTA GTGGAGATAC CTGGAGCGTT CCATTTTGTG 
GACTATATGT TGGAAGTTAA ACCAGAAATT TCCACGAGTC CACCAACAAG GCCCACAGCT 
ACAGGAAGAC CCACAACTAT TTCAACAAGA TCCACACATG TACCAACATC AACCAGAGTC 
TCTACCTCTA CTTCTCCAAC ACCAGCACAC ACAGAGACCT ACAAACCAGA GGCCACTACA 
TTTTATCCAG ATCAGACTAC AGCTGAGGTG ACAGAAACCT TACCCTCTAC TCCTGCAGAC 
TGGCATAACA CTGTGACATC CTCAGATGAC CCTTGGGATG ATAACACTGA AGTAATCCCT 
CCACAGAAGC CACAGAAAAA CCTGAATAAG GGCTTCTATG TTGGCATCTC CATTGCAGCC 
CTGCTGATAT TGATGCTTCT GAGCACCATG GTTATCACCA GGTACGTGGT TATGAAAAGG 
AAGTCAGAAT CTCTGAGCTT CGTTGCCTTC CCTATCTCTA AGATTGGAGC TTCCCCCAAA 
AAAGTGGTCG AACGGACCAG ATGTGAAGAC CAGGTCTACA TTATTGAAGA CACTCCTTAC 
CCCGAAGAAG AGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001154828.1
CDS	71..988
Translation	MNQIQVFISGLILLLPGAVESHTAVQGLAGHPVTLPCIYSTHLGGIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSRYQLKGNISEGNVSLTIENTVVGDGGPYCCVVEIPGAFHFVDYMLEVKPEISTSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETYKPEATTFYPDQTTAEVTETLPSTPADWHNTVTSSDDPWDDNTEVIPPQKPQKNLNKGFYVGISIAALLILMLLSTMVITRYVVMKRKSESLSFVAFPISKIGASPKKVVERTRCEDQVYIIEDTPYPEEES

Target ORF information:

RefSeq Version	NM_001161356.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001161356.1

ORF Insert Sequence:

ATGAATCAGA TTCAAGTCTT CATTTCAGGC CTCATACTGC TTCTCCCAGG TGCCGTGGAG 
TCTCATACAG CAGTGCAGGG GCTGGCGGGT CACCCTGTCA CACTTCCATG TATTTATTCG 
ACACACCTTG GTGGAATCGT TCCTATGTGT TGGGGCCTAG GGGAATGCCG CCATTCTTAT 
TGTATACGGT CACTTATCTG GACCAATGGA TATACGGTCA CACATCAGAG GAACAGTCGA 
TACCAGCTAA AGGGGAATAT TTCAGAAGGA AATGTGTCCT TGACCATAGA GAACACTGTT 
GTGGGTGATG GTGGTCCCTA TTGCTGTGTA GTGGAGATAC CTGGAGCGTT CCATTTTGTG 
GACTATATGT TGGAAGTTAA ACCAGAAATT TCCACGAGTC CACCAACAAG GCCCACAGCT 
ACAGGAAGAC CCACAACTAT TTCAACAAGA TCCACACATG TACCAACATC AACCAGAGTC 
TCTACCTCTA CTTCTCCAAC ACCAGCACAC ACAGAGACCT ACAAACCAGA GGCCACTACA 
TTTTATCCAG ATCAGACTAC AGCTGAGGTG ACAGAAACCT TACCCTCTAC TCCTGCAGAC 
TGGCATAACA CTGTGACATC CTCAGATGAC CCTTGGGATG ATAACACTGA AGTAATCCCT 
CCACAGAAGC CACAGAAAAA CCTGAATAAG GGCTTCTATG TTGGCATCTC CATTGCAGCC 
CTGCTGATAT TGATGCTTCT GAGCACCATG GTTATCACCA GGTACGTGGT TATGAAAAGG 
AAGTCAGAAT CTCTGAGCTT CGTTGCCTTC CCTATCTCTA AGATTGGAGC TTCCCCCAAA 
AAAGTGGTCG AACGGACCAG ATGTGAAGAC CAGGTCTACA TTATTGAAGA CACTCCTTAC 
CCCGAAGAAG AGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Timd2 ( XM_030245624.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030101484.1 Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu08113
Clone ID Related Accession (Same CDS sequence)	NM_134249.5 , NM_001161355.1 , NM_001161356.1 , XM_030245624.1 , XM_030245625.1
Accession Version	XM_030245624.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATCAGA TTCAAGTCTT CATTTCAGGC CTCATACTGC TTCTCCCAGG TGCCGTGGAG 
TCTCATACAG CAGTGCAGGG GCTGGCGGGT CACCCTGTCA CACTTCCATG TATTTATTCG 
ACACACCTTG GTGGAATCGT TCCTATGTGT TGGGGCCTAG GGGAATGCCG CCATTCTTAT 
TGTATACGGT CACTTATCTG GACCAATGGA TATACGGTCA CACATCAGAG GAACAGTCGA 
TACCAGCTAA AGGGGAATAT TTCAGAAGGA AATGTGTCCT TGACCATAGA GAACACTGTT 
GTGGGTGATG GTGGTCCCTA TTGCTGTGTA GTGGAGATAC CTGGAGCGTT CCATTTTGTG 
GACTATATGT TGGAAGTTAA ACCAGAAATT TCCACGAGTC CACCAACAAG GCCCACAGCT 
ACAGGAAGAC CCACAACTAT TTCAACAAGA TCCACACATG TACCAACATC AACCAGAGTC 
TCTACCTCTA CTTCTCCAAC ACCAGCACAC ACAGAGACCT ACAAACCAGA GGCCACTACA 
TTTTATCCAG ATCAGACTAC AGCTGAGGTG ACAGAAACCT TACCCTCTAC TCCTGCAGAC 
TGGCATAACA CTGTGACATC CTCAGATGAC CCTTGGGATG ATAACACTGA AGTAATCCCT 
CCACAGAAGC CACAGAAAAA CCTGAATAAG GGCTTCTATG TTGGCATCTC CATTGCAGCC 
CTGCTGATAT TGATGCTTCT GAGCACCATG GTTATCACCA GGTACGTGGT TATGAAAAGG 
AAGTCAGAAT CTCTGAGCTT CGTTGCCTTC CCTATCTCTA AGATTGGAGC TTCCCCCAAA 
AAAGTGGTCG AACGGACCAG ATGTGAAGAC CAGGTCTACA TTATTGAAGA CACTCCTTAC 
CCCGAAGAAG AGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030101484.1
CDS	249..1166
Translation	MNQIQVFISGLILLLPGAVESHTAVQGLAGHPVTLPCIYSTHLGGIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSRYQLKGNISEGNVSLTIENTVVGDGGPYCCVVEIPGAFHFVDYMLEVKPEISTSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETYKPEATTFYPDQTTAEVTETLPSTPADWHNTVTSSDDPWDDNTEVIPPQKPQKNLNKGFYVGISIAALLILMLLSTMVITRYVVMKRKSESLSFVAFPISKIGASPKKVVERTRCEDQVYIIEDTPYPEEES

Target ORF information:

RefSeq Version	XM_030245624.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030245624.1

ORF Insert Sequence:

ATGAATCAGA TTCAAGTCTT CATTTCAGGC CTCATACTGC TTCTCCCAGG TGCCGTGGAG 
TCTCATACAG CAGTGCAGGG GCTGGCGGGT CACCCTGTCA CACTTCCATG TATTTATTCG 
ACACACCTTG GTGGAATCGT TCCTATGTGT TGGGGCCTAG GGGAATGCCG CCATTCTTAT 
TGTATACGGT CACTTATCTG GACCAATGGA TATACGGTCA CACATCAGAG GAACAGTCGA 
TACCAGCTAA AGGGGAATAT TTCAGAAGGA AATGTGTCCT TGACCATAGA GAACACTGTT 
GTGGGTGATG GTGGTCCCTA TTGCTGTGTA GTGGAGATAC CTGGAGCGTT CCATTTTGTG 
GACTATATGT TGGAAGTTAA ACCAGAAATT TCCACGAGTC CACCAACAAG GCCCACAGCT 
ACAGGAAGAC CCACAACTAT TTCAACAAGA TCCACACATG TACCAACATC AACCAGAGTC 
TCTACCTCTA CTTCTCCAAC ACCAGCACAC ACAGAGACCT ACAAACCAGA GGCCACTACA 
TTTTATCCAG ATCAGACTAC AGCTGAGGTG ACAGAAACCT TACCCTCTAC TCCTGCAGAC 
TGGCATAACA CTGTGACATC CTCAGATGAC CCTTGGGATG ATAACACTGA AGTAATCCCT 
CCACAGAAGC CACAGAAAAA CCTGAATAAG GGCTTCTATG TTGGCATCTC CATTGCAGCC 
CTGCTGATAT TGATGCTTCT GAGCACCATG GTTATCACCA GGTACGTGGT TATGAAAAGG 
AAGTCAGAAT CTCTGAGCTT CGTTGCCTTC CCTATCTCTA AGATTGGAGC TTCCCCCAAA 
AAAGTGGTCG AACGGACCAG ATGTGAAGAC CAGGTCTACA TTATTGAAGA CACTCCTTAC 
CCCGAAGAAG AGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Timd2 ( XM_030245625.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030101485.1 Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant X2, mRNA.

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CloneID	OMu08113
Clone ID Related Accession (Same CDS sequence)	NM_134249.5 , NM_001161355.1 , NM_001161356.1 , XM_030245624.1 , XM_030245625.1
Accession Version	XM_030245625.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATCAGA TTCAAGTCTT CATTTCAGGC CTCATACTGC TTCTCCCAGG TGCCGTGGAG 
TCTCATACAG CAGTGCAGGG GCTGGCGGGT CACCCTGTCA CACTTCCATG TATTTATTCG 
ACACACCTTG GTGGAATCGT TCCTATGTGT TGGGGCCTAG GGGAATGCCG CCATTCTTAT 
TGTATACGGT CACTTATCTG GACCAATGGA TATACGGTCA CACATCAGAG GAACAGTCGA 
TACCAGCTAA AGGGGAATAT TTCAGAAGGA AATGTGTCCT TGACCATAGA GAACACTGTT 
GTGGGTGATG GTGGTCCCTA TTGCTGTGTA GTGGAGATAC CTGGAGCGTT CCATTTTGTG 
GACTATATGT TGGAAGTTAA ACCAGAAATT TCCACGAGTC CACCAACAAG GCCCACAGCT 
ACAGGAAGAC CCACAACTAT TTCAACAAGA TCCACACATG TACCAACATC AACCAGAGTC 
TCTACCTCTA CTTCTCCAAC ACCAGCACAC ACAGAGACCT ACAAACCAGA GGCCACTACA 
TTTTATCCAG ATCAGACTAC AGCTGAGGTG ACAGAAACCT TACCCTCTAC TCCTGCAGAC 
TGGCATAACA CTGTGACATC CTCAGATGAC CCTTGGGATG ATAACACTGA AGTAATCCCT 
CCACAGAAGC CACAGAAAAA CCTGAATAAG GGCTTCTATG TTGGCATCTC CATTGCAGCC 
CTGCTGATAT TGATGCTTCT GAGCACCATG GTTATCACCA GGTACGTGGT TATGAAAAGG 
AAGTCAGAAT CTCTGAGCTT CGTTGCCTTC CCTATCTCTA AGATTGGAGC TTCCCCCAAA 
AAAGTGGTCG AACGGACCAG ATGTGAAGAC CAGGTCTACA TTATTGAAGA CACTCCTTAC 
CCCGAAGAAG AGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030101485.1
CDS	246..1163
Translation	MNQIQVFISGLILLLPGAVESHTAVQGLAGHPVTLPCIYSTHLGGIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSRYQLKGNISEGNVSLTIENTVVGDGGPYCCVVEIPGAFHFVDYMLEVKPEISTSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETYKPEATTFYPDQTTAEVTETLPSTPADWHNTVTSSDDPWDDNTEVIPPQKPQKNLNKGFYVGISIAALLILMLLSTMVITRYVVMKRKSESLSFVAFPISKIGASPKKVVERTRCEDQVYIIEDTPYPEEES

Target ORF information:

RefSeq Version	XM_030245625.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus T cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030245625.1

ORF Insert Sequence:

ATGAATCAGA TTCAAGTCTT CATTTCAGGC CTCATACTGC TTCTCCCAGG TGCCGTGGAG 
TCTCATACAG CAGTGCAGGG GCTGGCGGGT CACCCTGTCA CACTTCCATG TATTTATTCG 
ACACACCTTG GTGGAATCGT TCCTATGTGT TGGGGCCTAG GGGAATGCCG CCATTCTTAT 
TGTATACGGT CACTTATCTG GACCAATGGA TATACGGTCA CACATCAGAG GAACAGTCGA 
TACCAGCTAA AGGGGAATAT TTCAGAAGGA AATGTGTCCT TGACCATAGA GAACACTGTT 
GTGGGTGATG GTGGTCCCTA TTGCTGTGTA GTGGAGATAC CTGGAGCGTT CCATTTTGTG 
GACTATATGT TGGAAGTTAA ACCAGAAATT TCCACGAGTC CACCAACAAG GCCCACAGCT 
ACAGGAAGAC CCACAACTAT TTCAACAAGA TCCACACATG TACCAACATC AACCAGAGTC 
TCTACCTCTA CTTCTCCAAC ACCAGCACAC ACAGAGACCT ACAAACCAGA GGCCACTACA 
TTTTATCCAG ATCAGACTAC AGCTGAGGTG ACAGAAACCT TACCCTCTAC TCCTGCAGAC 
TGGCATAACA CTGTGACATC CTCAGATGAC CCTTGGGATG ATAACACTGA AGTAATCCCT 
CCACAGAAGC CACAGAAAAA CCTGAATAAG GGCTTCTATG TTGGCATCTC CATTGCAGCC 
CTGCTGATAT TGATGCTTCT GAGCACCATG GTTATCACCA GGTACGTGGT TATGAAAAGG 
AAGTCAGAAT CTCTGAGCTT CGTTGCCTTC CCTATCTCTA AGATTGGAGC TTCCCCCAAA 
AAAGTGGTCG AACGGACCAG ATGTGAAGAC CAGGTCTACA TTATTGAAGA CACTCCTTAC 
CCCGAAGAAG AGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

T-cell immunoglobulin and mucin domain?2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding.
The FEBS journal281(1)157-74(2014 Jan)
Dewitz C,M?ller-Hackbarth K,Schweigert O,Reiss K,Chalaris A,Scheller J,Rose-John S

Tim-2 up-regulation and galectin-9-Tim-3 pathway activation in Th2-biased response in Schistosoma japonicum infection in mice.
Immunology letters144(1-2)60-6(2012 May)
Qi Y,Song XR,Shen JL,Xu YH,Shen Q,Luo QL,Zhong ZR,Wang W,Chu DY,Song WJ

Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells.
Arthritis research & therapy13(2)R47(2011 Mar)
Kawamoto T,Abe Y,Ito J,Makino F,Kojima Y,Usui Y,Ma J,Morimoto S,Yagita H,Okumura K,Takasaki Y,Akiba H

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
PloS one6(6)e21208(2011)
Tang F,Barbacioru C,Nordman E,Bao S,Lee C,Wang X,Tuch BB,Heard E,Lao K,Surani MA

Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells.
PloS one6(8)e23800(2011)
Han J,Seaman WE,Di X,Wang W,Willingham M,Torti FM,Torti SV

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Timd2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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