Lta4h cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lta4h
Entrez Gene ID	16993
Full Name	leukotriene A4 hydrolase
General protein information	Preferred Names leukotriene A4 hydrolase Names leukotriene A-4 hydrolase LTA-4 hydrolase LTA4 hydrodase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 C2
Summary	The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001313897.1	NP_001300826.1	leukotriene A-4 hydrolase isoform 2
NM_008517.2	NP_032543.2	leukotriene A-4 hydrolase isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LTA4H	XP_001145972.1
Bos taurus (cattle)	LTA4H	NP_001029452.1
Mus musculus (house mouse)	Lta4h	NP_032543.2
Rattus norvegicus (Norway rat)	Lta4h	NP_001025202.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009907	XP_319027.4
Xenopus tropicalis (tropical clawed frog)	lta4h	NP_001006898.1
Homo sapiens (human)	LTA4H	NP_000886.1
Gallus gallus (chicken)	LTA4H	NP_001006234.1
Drosophila melanogaster (fruit fly)	CG10602	NP_609916.4
Caenorhabditis elegans (roundworm)	ZC416.6	NP_500385.1
Saccharomyces cerevisiae (baker's yeast)	LAP2	NP_014353.1
Neurospora crassa	NCU06732	XP_960660.1
	LTA4H	XP_002808035.1
Caenorhabditis elegans (roundworm)	C42C1.11	NP_001023056.1
Arabidopsis thaliana (thale cress)	AT5G13520	NP_196856.1
Oryza sativa (rice)	Os03g0819100	NP_001051710.1
Canis lupus familiaris (dog)	LTA4H	XP_539728.3
Danio rerio (zebrafish)	lta4h	NP_998451.1
Kluyveromyces lactis	KLLA0F03883g	XP_455256.1
Schizosaccharomyces pombe (fission yeast)	SPCC1322.05c	NP_588133.1
Magnaporthe oryzae (rice blast fungus)	MGG_09481	XP_003712268.1

Gene Ontology
Bibliography

Related articles in PubMed

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors.
Numao S, Hasler F, Laguerre C, Srinivas H, Wack N, J?ger P, Schmid A, Osmont A, R?thlisberger P, Houguenade J, Bergsdorf C, Dawson J, Carte N, Hofmann A, Markert C, Hardaker L, Billich A, Wolf RM, Penno CA, Bollbuck B, Miltz W, R?hn TA
Scientific reports7(1)13591(2017 Oct)

LTA4H regulates cell cycle and skin carcinogenesis.
Oi N, Yamamoto H, Langfald A, Bai R, Lee MH, Bode AM, Dong Z
Carcinogenesis38(7)728-737(2017 Jul)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.
Poczobutt JM, Nguyen TT, Hanson D, Li H, Sippel TR, Weiser-Evans MC, Gijon M, Murphy RC, Nemenoff RA
Journal of immunology (Baltimore, Md. : 1950)196(2)891-901(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings indicate that LTA4H is critical for skin carcinogenesis and is an important mediator of cell cycle and the data begin to clarify the mechanisms of LTA4H's role in cancer development.
Title: LTA4H regulates cell cycle and skin carcinogenesis.

There is a critical role for the secondary anti-inflammatory activity of LTA4H in acute pulmonary infection.
Title: Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.

CS exposure promotes the development of CS-induced emphysema by suppressing the enzymatic activities of the LTA4H aminopeptidase in lung tissues and accumulating PGP and neutrophils in the airspaces.
Title: Role of leukotriene A4 hydrolase aminopeptidase in the pathogenesis of emphysema.

in acute neutrophil-driven lung inflammation, PGP was degraded by LTA(4)H which facilitated resolution of inflammation; cigarette smoke, a major risk factor for COPD,inhibited LTA(4)H aminopeptidase activity leading to accumulation of PGP and neutrophils
Title: A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.

In the mouse nervous system ,Immunoreactivity for leukotriene A4 hydrolase showed widespread distribution with preference to the sensory-associated structures.
Title: Sensory system-predominant distribution of leukotriene A4 hydrolase and its colocalization with calretinin in the mouse nervous system.

The following Lta4h gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lta4h cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02122	NM_008517.2 Latest version!	Mus musculus leukotriene A4 hydrolase (Lta4h), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$356.30 $509.00
OMu44246	NM_001313897.1 Latest version!	Mus musculus leukotriene A4 hydrolase (Lta4h), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lta4h ( NM_008517.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032543.2 Mus musculus leukotriene A4 hydrolase (Lta4h), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu02122
Clone ID Related Accession (Same CDS sequence)	NM_008517.2
Accession Version	NM_008517.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1836bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	leukotriene A-4 hydrolase isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY793553.1, AK134931.1, AW121450.1 and BY458968.1. On Oct 27, 2006 this sequence version replaced NM_008517.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK134931.1, M63848.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCGAGG TCGCGGATAC TTGCTCCTTG GCTTCTCCAG CCTCGGTCTG CCGAACCCAG 
CACCTCCATC TTCGCTGCAG CGTCGACTTC GCTCGCCGGA CGCTGACCGG GACGGCCGCG 
CTCACGGTCC AGTCACAGGA GGAGAATCTG CGCAGCCTGA CTTTGGACAC AAAAGACCTC 
ACAATAGAAA AAGTGGTGAT CAATGGACAA GAAGTCAAAT ACACCCTTGG AGAAAGTCAA 
GGTTACAAAG GGTCACCGAT GGAAATCTCT CTTCCCATCG CCCTGAGCAA AAATCAAGAG 
ATCGTTATAG AAATTTCCTT TGAGACATCT CCCAAATCCT CTGCGCTTCA GTGGCTCACT 
CCTGAACAGA CGTCAGGGAA GCAGCATCCG TATCTCTTCA GTCAGTGCCA GGCCATCCAC 
TGCAGGGCCA TCCTCCCTTG CCAAGACACT CCTTCCGTGA AATTAACGTA CACCGCAGAG 
GTGTCTGTCC CGAAAGAACT GGTGGCTCTC ATGAGTGCCA TCCGTGATGG AGAAGCCCCT 
GACCCAGAAG ACCCCAGCAG GAAGATTTAC AGATTCAACC AGAGGGTTCC CATACCATGC 
TACCTGATTG CTTTGGTTGT TGGAGCTTTA GAAAGCAGAC AAATTGGCCC AAGAACTCTG 
GTGTGGTCCG AGAAAGAGCA GGTGGAGAAA TCTGCTAATG AATTTTCTGA GACCGAATCC 
ATGCTTAAAA TTGCAGAAGA TCTGGGGGGG CCCTATGTTT GGGGGCAGTA CGACCTCTTG 
GTTCTGCCCC CATCCTTCCC GTACGGTGGC ATGGAGAACC CTTGTCTCAC GTTCGTAACG 
CCTACGCTAC TGGCAGGTGA CAAGTCACTC TCCAACGTTA TTGCACATGA AATATCTCAT 
AGCTGGACAG GAAACCTAGT GACTAACAAG ACGTGGGATC ACTTTTGGTT AAACGAAGGA 
CATACTGTCT ACTTAGAGCG CCACATTTGT GGACGGTTGT TTGGGGAAAA GTTCAGACAT 
TTCCATGCTT TGGGAGGATG GGGAGAGCTA CAGAATACGA TAAAAACATT TGGGGAGTCC 
CACCCCTTCA CCAAGCTCGT GGTTGATCTG AAGGACGTAG ACCCCGATGT AGCCTATTCC 
TCCATCCCCT ATGAGAAGGG CTTTGCGCTA CTCTTCTACC TTGAACAGCT TCTTGGGGGA 
CCAGAGGTGT TTCTAGGATT CTTAAAGGCT TATGTTAAGA AGTTTTCCTA CCAAAGTGTA 
ACGACTGATG ACTGGAAGAG CTTCCTATAT TCCCACTTTA AAGACAAGGT GGATCTTCTC 
AATCAAGTTG ATTGGAACAC CTGGCTCTAC GCTCCGGGCC TGCCTCCTGT CAAGCCCAAT 
TACGACGTGA CTCTGACAAA TGCTTGCATT GCCTTAAGTC AAAGATGGGT TACTGCCAAA 
GAGGAAGATT TAAGCTCATT CAGCATCGCA GACCTGAAGG ATCTCTCGTC CCATCAGCTG 
AATGAGTTCC TGGCACAGGT GCTTCAGAAG GCACCTCTTC CCTTGGGGCA CATAAAGCGA 
ATGCAAGAGG TGTACAACTT CAATGCCATT AACAATTCTG AAATACGATT CAGATGGTTA 
CGGCTCTGCA TTCAATCGAA ATGGGAGGAA GCAATTCCTT TGGCCCTAAA GATGGCAACT 
GAACAAGGAA GGATGAAATT CACACGTCCT CTATTCAAGG ATCTCGCTGC CTTCGACAAA 
TCCCATGATC AAGCTGTCCA CACCTACCAA GAGCATAAAG CCAGCATGCA TCCCGTGACT 
GCGATGCTGG TGGGGAGAGA TCTGAAAGTG GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032543.2
CDS	115..1950
Translation	MPEVADTCSLASPASVCRTQHLHLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDLTIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSANEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDDWKSFLYSHFKDKVDLLNQVDWNTWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAKEEDLSSFSIADLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVHTYQEHKASMHPVTAMLVGRDLKVD

Target ORF information:

RefSeq Version	NM_008517.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus leukotriene A4 hydrolase (Lta4h), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008517.2

ORF Insert Sequence:

ATGCCCGAGG TCGCGGATAC TTGCTCCTTG GCTTCTCCAG CCTCGGTCTG CCGAACCCAG 
CACCTCCATC TTCGCTGCAG CGTCGACTTC GCTCGCCGGA CGCTGACCGG GACGGCCGCG 
CTCACGGTCC AGTCACAGGA GGAGAATCTG CGCAGCCTGA CTTTGGACAC AAAAGACCTC 
ACAATAGAAA AAGTGGTGAT CAATGGACAA GAAGTCAAAT ACACCCTTGG AGAAAGTCAA 
GGTTACAAAG GGTCACCGAT GGAAATCTCT CTTCCCATCG CCCTGAGCAA AAATCAAGAG 
ATCGTTATAG AAATTTCCTT TGAGACATCT CCCAAATCCT CTGCGCTTCA GTGGCTCACT 
CCTGAACAGA CGTCAGGGAA GCAGCATCCG TATCTCTTCA GTCAGTGCCA GGCCATCCAC 
TGCAGGGCCA TCCTCCCTTG CCAAGACACT CCTTCCGTGA AATTAACGTA CACCGCAGAG 
GTGTCTGTCC CGAAAGAACT GGTGGCTCTC ATGAGTGCCA TCCGTGATGG AGAAGCCCCT 
GACCCAGAAG ACCCCAGCAG GAAGATTTAC AGATTCAACC AGAGGGTTCC CATACCATGC 
TACCTGATTG CTTTGGTTGT TGGAGCTTTA GAAAGCAGAC AAATTGGCCC AAGAACTCTG 
GTGTGGTCCG AGAAAGAGCA GGTGGAGAAA TCTGCTAATG AATTTTCTGA GACCGAATCC 
ATGCTTAAAA TTGCAGAAGA TCTGGGGGGG CCCTATGTTT GGGGGCAGTA CGACCTCTTG 
GTTCTGCCCC CATCCTTCCC GTACGGTGGC ATGGAGAACC CTTGTCTCAC GTTCGTAACG 
CCTACGCTAC TGGCAGGTGA CAAGTCACTC TCCAACGTTA TTGCACATGA AATATCTCAT 
AGCTGGACAG GAAACCTAGT GACTAACAAG ACGTGGGATC ACTTTTGGTT AAACGAAGGA 
CATACTGTCT ACTTAGAGCG CCACATTTGT GGACGGTTGT TTGGGGAAAA GTTCAGACAT 
TTCCATGCTT TGGGAGGATG GGGAGAGCTA CAGAATACGA TAAAAACATT TGGGGAGTCC 
CACCCCTTCA CCAAGCTCGT GGTTGATCTG AAGGACGTAG ACCCCGATGT AGCCTATTCC 
TCCATCCCCT ATGAGAAGGG CTTTGCGCTA CTCTTCTACC TTGAACAGCT TCTTGGGGGA 
CCAGAGGTGT TTCTAGGATT CTTAAAGGCT TATGTTAAGA AGTTTTCCTA CCAAAGTGTA 
ACGACTGATG ACTGGAAGAG CTTCCTATAT TCCCACTTTA AAGACAAGGT GGATCTTCTC 
AATCAAGTTG ATTGGAACAC CTGGCTCTAC GCTCCGGGCC TGCCTCCTGT CAAGCCCAAT 
TACGACGTGA CTCTGACAAA TGCTTGCATT GCCTTAAGTC AAAGATGGGT TACTGCCAAA 
GAGGAAGATT TAAGCTCATT CAGCATCGCA GACCTGAAGG ATCTCTCGTC CCATCAGCTG 
AATGAGTTCC TGGCACAGGT GCTTCAGAAG GCACCTCTTC CCTTGGGGCA CATAAAGCGA 
ATGCAAGAGG TGTACAACTT CAATGCCATT AACAATTCTG AAATACGATT CAGATGGTTA 
CGGCTCTGCA TTCAATCGAA ATGGGAGGAA GCAATTCCTT TGGCCCTAAA GATGGCAACT 
GAACAAGGAA GGATGAAATT CACACGTCCT CTATTCAAGG ATCTCGCTGC CTTCGACAAA 
TCCCATGATC AAGCTGTCCA CACCTACCAA GAGCATAAAG CCAGCATGCA TCCCGTGACT 
GCGATGCTGG TGGGGAGAGA TCTGAAAGTG GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lta4h ( NM_001313897.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001300826.1 Mus musculus leukotriene A4 hydrolase (Lta4h), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu44246
Clone ID Related Accession (Same CDS sequence)	NM_001313897.1
Accession Version	NM_001313897.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1599bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	leukotriene A-4 hydrolase isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY793553.1, AK134931.1, BF018223.1 and BG807829.1. On Sep 10, 2015 this sequence version replaced XM_006513286.2. Transcript Variant: This variant (2) lacks an alternate coding exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCGAGG TCGCGGATAC TTGCTCCTTG GCTTCTCCAG CCTCGGTCTG CCGAACCCAG 
CACCTCCATC TTCGCTGCAG CGTCGACTTC GCTCGCCGGA CGCTGACCGG GACGGCCGCG 
CTCACGGTCC AGTCACAGGA GGAGAATCTG CGCAGCCTGA CTTTGGACAC AAAAGACCTC 
ACAATAGAAA AAGTGGTGAT CAATGGACAA GAAGTCAAAT ACACCCTTGG AGAAAGTCAA 
GGTTACAAAG GGTCACCGAT GGAAATCTCT CTTCCCATCG CCCTGAGCAA AAATCAAGAG 
ATCGTTATAG AAATTTCCTT TGAGACATCT CCCAAATCCT CTGCGCTTCA GTGGCTCACT 
CCTGAACAGA CGTCAGGGAA GCAGCATCCG TATCTCTTCA GTCAGTGCCA GGCCATCCAC 
TGCAGGGCCA TCCTCCCTTG CCAAGACACT CCTTCCGTGA AATTAACGTA CACCGCAGAG 
GTGTCTGTCC CGAAAGAACT GGTGGCTCTC ATGAGTGCCA TCCGTGATGG AGAAGCCCCT 
GACCCAGAAG ACCCCAGCAG GAAGATTTAC AGATTCAACC AGAGGGTTCC CATACCATGC 
TACCTGATTG CTTTGGTTGT TGGAGCTTTA GAAAGCAGAC AAATTGGCCC AAGAACTCTG 
GTGTGGTCCG AGAAAGAGCA GGTGGAGAAA TCTGCTAATG AATTTTCTGA GACCGAATCC 
ATGCTTAAAA TTGCAGAAGA TCTGGGGGGG CCCTATGTTT GGGGGCAGTA CGACCTCTTG 
GTTCTGCCCC CATCCTTCCC GTACGGTGGC ATGGAGAACC CTTGTCTCAC GTTCGTAACG 
CCTACGCTAC TGGCAGGTGA CAAGTCACTC TCCAACGTTA TTGCACATGA AATATCTCAT 
AGCTGGACAG GAAACCTAGT GACTAACAAG ACGTGGGATC ACTTTTGGTT AAACGAAGGA 
CATACTGTCT ACTTAGAGCG CCACATTTGT GGACGGTTGT TTGGGGAAAA GTTCAGACAT 
TTCCATGCTT TGGGAGGATG GGGAGAGCTA CAGAATACGA TAAAAACATT TGGGGAGTCC 
CACCCCTTCA CCAAGCTCGT GGTTGATCTG AAGGACGTAG ACCCCGATGT AGCCTATTCC 
TCCATCCCCT ATGAGAAGGG CTTTGCGCTA CTCTTCTACC TTGAACAGCT TCTTGGGGGA 
CCAGAGGTGT TTCTAGGATT CTTAAAGGCT TATGTTAAGA AGTTTTCCTA CCAAAGTGTA 
ACGACTGATG ACTGGAAGAG CTTCCTATAT TCCCACTTTA AAGACAAGGT GGATCTTCTC 
AATCAAGTTG ATTGGAACAC CTGGCTCTAC GCTCCGGGCC TGCCTCCTGT CAAGCCCAAT 
TACGACGTGA CTCTGACAAA TGCTTGCATT GCCTTAAGTC AAAGATGGGT TACTGCCAAA 
GAGGAAGATT TAAGCTCATT CAGCATCGCA GACCTGAAGG ATCTCTCGTC CCATCAGCTG 
AATGAGTTCC TGGCACAGGT GCTTCAGAAG ATGGTTACGG CTCTGCATTC AATCGAAATG 
GGAGGAAGCA ATTCCTTTGG CCCTAAAGAT GGCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001300826.1
CDS	115..1713
Translation	MPEVADTCSLASPASVCRTQHLHLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDLTIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSANEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDDWKSFLYSHFKDKVDLLNQVDWNTWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAKEEDLSSFSIADLKDLSSHQLNEFLAQVLQKMVTALHSIEMGGSNSFGPKDGN

Target ORF information:

RefSeq Version	NM_001313897.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus leukotriene A4 hydrolase (Lta4h), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001313897.1

ORF Insert Sequence:

ATGCCCGAGG TCGCGGATAC TTGCTCCTTG GCTTCTCCAG CCTCGGTCTG CCGAACCCAG 
CACCTCCATC TTCGCTGCAG CGTCGACTTC GCTCGCCGGA CGCTGACCGG GACGGCCGCG 
CTCACGGTCC AGTCACAGGA GGAGAATCTG CGCAGCCTGA CTTTGGACAC AAAAGACCTC 
ACAATAGAAA AAGTGGTGAT CAATGGACAA GAAGTCAAAT ACACCCTTGG AGAAAGTCAA 
GGTTACAAAG GGTCACCGAT GGAAATCTCT CTTCCCATCG CCCTGAGCAA AAATCAAGAG 
ATCGTTATAG AAATTTCCTT TGAGACATCT CCCAAATCCT CTGCGCTTCA GTGGCTCACT 
CCTGAACAGA CGTCAGGGAA GCAGCATCCG TATCTCTTCA GTCAGTGCCA GGCCATCCAC 
TGCAGGGCCA TCCTCCCTTG CCAAGACACT CCTTCCGTGA AATTAACGTA CACCGCAGAG 
GTGTCTGTCC CGAAAGAACT GGTGGCTCTC ATGAGTGCCA TCCGTGATGG AGAAGCCCCT 
GACCCAGAAG ACCCCAGCAG GAAGATTTAC AGATTCAACC AGAGGGTTCC CATACCATGC 
TACCTGATTG CTTTGGTTGT TGGAGCTTTA GAAAGCAGAC AAATTGGCCC AAGAACTCTG 
GTGTGGTCCG AGAAAGAGCA GGTGGAGAAA TCTGCTAATG AATTTTCTGA GACCGAATCC 
ATGCTTAAAA TTGCAGAAGA TCTGGGGGGG CCCTATGTTT GGGGGCAGTA CGACCTCTTG 
GTTCTGCCCC CATCCTTCCC GTACGGTGGC ATGGAGAACC CTTGTCTCAC GTTCGTAACG 
CCTACGCTAC TGGCAGGTGA CAAGTCACTC TCCAACGTTA TTGCACATGA AATATCTCAT 
AGCTGGACAG GAAACCTAGT GACTAACAAG ACGTGGGATC ACTTTTGGTT AAACGAAGGA 
CATACTGTCT ACTTAGAGCG CCACATTTGT GGACGGTTGT TTGGGGAAAA GTTCAGACAT 
TTCCATGCTT TGGGAGGATG GGGAGAGCTA CAGAATACGA TAAAAACATT TGGGGAGTCC 
CACCCCTTCA CCAAGCTCGT GGTTGATCTG AAGGACGTAG ACCCCGATGT AGCCTATTCC 
TCCATCCCCT ATGAGAAGGG CTTTGCGCTA CTCTTCTACC TTGAACAGCT TCTTGGGGGA 
CCAGAGGTGT TTCTAGGATT CTTAAAGGCT TATGTTAAGA AGTTTTCCTA CCAAAGTGTA 
ACGACTGATG ACTGGAAGAG CTTCCTATAT TCCCACTTTA AAGACAAGGT GGATCTTCTC 
AATCAAGTTG ATTGGAACAC CTGGCTCTAC GCTCCGGGCC TGCCTCCTGT CAAGCCCAAT 
TACGACGTGA CTCTGACAAA TGCTTGCATT GCCTTAAGTC AAAGATGGGT TACTGCCAAA 
GAGGAAGATT TAAGCTCATT CAGCATCGCA GACCTGAAGG ATCTCTCGTC CCATCAGCTG 
AATGAGTTCC TGGCACAGGT GCTTCAGAAG ATGGTTACGG CTCTGCATTC AATCGAAATG 
GGAGGAAGCA ATTCCTTTGG CCCTAAAGAT GGCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors.
Scientific reports7(1)13591(2017 Oct)
Numao S,Hasler F,Laguerre C,Srinivas H,Wack N,J?ger P,Schmid A,Osmont A,R?thlisberger P,Houguenade J,Bergsdorf C,Dawson J,Carte N,Hofmann A,Markert C,Hardaker L,Billich A,Wolf RM,Penno CA,Bollbuck B,Miltz W,R?hn TA

LTA4H regulates cell cycle and skin carcinogenesis.
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High-throughput discovery of novel developmental phenotypes.
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Lta4h cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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