Xcl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xcl1
Entrez Gene ID	16963
Full Name	chemokine (C motif) ligand 1
Synonyms	AI661682,ATAC,LTN,Lptn,SCM-1,SCM-1a,Scyc1
General protein information	Preferred Names chemokine (C motif) ligand 1 Names lymphotactin c motif chemokine 1 cytokine SCM-1 lymphotaxin small inducible cytokine subfamily C, member 1 (lymphotactin) small-inducible cytokine C1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H2.2\|1 72.26 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008510.1	NP_032536.1	lymphotactin precursor
NM_008510.2	NP_032536.1	lymphotactin precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	XCL1	XP_524955.2
	LOC100423131	XP_002802105.1
Bos taurus (cattle)	XCL1	NP_783647.1
	XCL1	NP_001028119.1
Canis lupus familiaris (dog)	LOC490356	XP_547477.2
Bos taurus (cattle)	XCL2	XP_002694056.1
Mus musculus (house mouse)	Xcl1	NP_032536.1
Homo sapiens (human)	XCL1	NP_002986.1
Rattus norvegicus (Norway rat)	Xcl1	NP_599188.1

Gene Ontology
Bibliography

Related articles in PubMed

A Novel ?9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases.
Matsumoto N, Kon S, Nakatsuru T, Miyashita T, Inui K, Saitoh K, Kitai Y, Muromoto R, Kashiwakura JI, Uede T, Matsuda T
Journal of immunology (Baltimore, Md. : 1950)199(1)82-90(2017 Jul)

Microglial Inhibition Influences XCL1/XCR1 Expression and Causes Analgesic Effects in a Mouse Model of Diabetic Neuropathy.
Zychowska M, Rojewska E, Piotrowska A, Kreiner G, Mika J
Anesthesiology125(3)573-89(2016 09)

Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis.
Ohta T, Sugiyama M, Hemmi H, Yamazaki C, Okura S, Sasaki I, Fukuda Y, Orimo T, Ishii KJ, Hoshino K, Ginhoux F, Kaisho T
Scientific reports623505(2016 Mar)

Aberrant tissue positioning of metallophilic macrophages in the thymus of XCL1-deficient mice.
Mili?evi? NM, Lali? IM, Despotovi? SZ, ?iri? DN, Westermann J, De Waal Malefyt R, Mili?evi? ?
Anatomical record (Hoboken, N.J. : 2007)297(8)1472-7(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study provides in vitro and in vivo evidence that the interaction between XCL1 and alpha9 integrin has an important role for autoimmune diseases
Title: A Novel ?9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases.

The interaction between XCL1 and XCR1 plays a crucial role in the classical immunology response.
Title: Microglial Inhibition Influences XCL1/XCR1 Expression and Causes Analgesic Effects in a Mouse Model of Diabetic Neuropathy.

Data show that mice lacking either XCL1 or XCR1 exhibit similar specific defects in intestinal T cell populations as XCR1-dendritic cells (DC)-deficient mice. Therefore it is possible that the XCR1-XCL1 axis itself is directly involved in intestinal T cell homeostasis, via a mechanism that might either involve interaction with XCR1+ DCs or be independent of this pathway.
Title: Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis.

T inflammatory memory CD8 T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production
Title: T inflammatory memory CD8 T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production.

XCL1-mediated accumulation of dendritic cells in the thymic medulla contributes to naturally occurring regulatory T cell development and is regulated by Aire.
Title: Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.

The following Xcl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xcl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu02103	NM_008510.2 Latest version!	Mus musculus chemokine (C motif) ligand 1 (Xcl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu02103	NM_008510.1	Mus musculus chemokine (C motif) ligand 1 (Xcl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xcl1 ( NM_008510.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032536.1 Mus musculus chemokine (C motif) ligand 1 (Xcl1), mRNA.

Price & Availability↑

CloneID	OMu02103
Clone ID Related Accession (Same CDS sequence)	NM_008510.1 , NM_008510.2
Accession Version	NM_008510.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Mus musculus(house mouse)
Product	lymphotactin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D43769.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D43769.1, BC062249.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGAGACTTC TCCTCCTGAC TTTCCTGGGA GTCTGCTGCC TCACCCCATG GGTTGTGGAA 
GGTGTGGGGA CTGAAGTCCT AGAAGAGAGT AGCTGTGTGA ACTTACAAAC CCAGCGGCTG 
CCAGTTCAAA AAATCAAGAC CTATATCATC TGGGAGGGGG CCATGAGAGC TGTAATTTTT 
GTCACCAAAC GAGGACTAAA AATTTGTGCT GATCCAGAAG CCAAATGGGT GAAAGCAGCG 
ATCAAGACTG TGGATGGCAG GGCCAGTACC AGAAAGAACA TGGCTGAAAC TGTTCCCACA 
GGAGCCCAGA GGTCCACCAG CACAGCGATA ACCCTGACTG GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032536.1
CDS	21..365
Translation	MRLLLLTFLGVCCLTPWVVEGVGTEVLEESSCVNLQTQRLPVQKIKTYIIWEGAMRAVIFVTKRGLKICADPEAKWVKAAIKTVDGRASTRKNMAETVPTGAQRSTSTAITLTG

Target ORF information:

RefSeq Version	NM_008510.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C motif) ligand 1 (Xcl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008510.1

ORF Insert Sequence:

ATGAGACTTC TCCTCCTGAC TTTCCTGGGA GTCTGCTGCC TCACCCCATG GGTTGTGGAA 
GGTGTGGGGA CTGAAGTCCT AGAAGAGAGT AGCTGTGTGA ACTTACAAAC CCAGCGGCTG 
CCAGTTCAAA AAATCAAGAC CTATATCATC TGGGAGGGGG CCATGAGAGC TGTAATTTTT 
GTCACCAAAC GAGGACTAAA AATTTGTGCT GATCCAGAAG CCAAATGGGT GAAAGCAGCG 
ATCAAGACTG TGGATGGCAG GGCCAGTACC AGAAAGAACA TGGCTGAAAC TGTTCCCACA 
GGAGCCCAGA GGTCCACCAG CACAGCGATA ACCCTGACTG GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Xcl1 ( NM_008510.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032536.1 Mus musculus chemokine (C motif) ligand 1 (Xcl1), mRNA.

Price & Availability↑

CloneID	OMu02103
Clone ID Related Accession (Same CDS sequence)	NM_008510.1 , NM_008510.2
Accession Version	NM_008510.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Mus musculus(house mouse)
Product	lymphotactin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK079820.1 and BC062249.1. On Feb 14, 2018 this sequence version replaced NM_008510.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062249.1, BB634137.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGACTTC TCCTCCTGAC TTTCCTGGGA GTCTGCTGCC TCACCCCATG GGTTGTGGAA 
GGTGTGGGGA CTGAAGTCCT AGAAGAGAGT AGCTGTGTGA ACTTACAAAC CCAGCGGCTG 
CCAGTTCAAA AAATCAAGAC CTATATCATC TGGGAGGGGG CCATGAGAGC TGTAATTTTT 
GTCACCAAAC GAGGACTAAA AATTTGTGCT GATCCAGAAG CCAAATGGGT GAAAGCAGCG 
ATCAAGACTG TGGATGGCAG GGCCAGTACC AGAAAGAACA TGGCTGAAAC TGTTCCCACA 
GGAGCCCAGA GGTCCACCAG CACAGCGATA ACCCTGACTG GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032536.1
CDS	33..377
Translation	MRLLLLTFLGVCCLTPWVVEGVGTEVLEESSCVNLQTQRLPVQKIKTYIIWEGAMRAVIFVTKRGLKICADPEAKWVKAAIKTVDGRASTRKNMAETVPTGAQRSTSTAITLTG

Target ORF information:

RefSeq Version	NM_008510.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C motif) ligand 1 (Xcl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008510.2

ORF Insert Sequence:

ATGAGACTTC TCCTCCTGAC TTTCCTGGGA GTCTGCTGCC TCACCCCATG GGTTGTGGAA 
GGTGTGGGGA CTGAAGTCCT AGAAGAGAGT AGCTGTGTGA ACTTACAAAC CCAGCGGCTG 
CCAGTTCAAA AAATCAAGAC CTATATCATC TGGGAGGGGG CCATGAGAGC TGTAATTTTT 
GTCACCAAAC GAGGACTAAA AATTTGTGCT GATCCAGAAG CCAAATGGGT GAAAGCAGCG 
ATCAAGACTG TGGATGGCAG GGCCAGTACC AGAAAGAACA TGGCTGAAAC TGTTCCCACA 
GGAGCCCAGA GGTCCACCAG CACAGCGATA ACCCTGACTG GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Novel ?9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases.
Journal of immunology (Baltimore, Md. : 1950)199(1)82-90(2017 Jul)
Matsumoto N,Kon S,Nakatsuru T,Miyashita T,Inui K,Saitoh K,Kitai Y,Muromoto R,Kashiwakura JI,Uede T,Matsuda T

Microglial Inhibition Influences XCL1/XCR1 Expression and Causes Analgesic Effects in a Mouse Model of Diabetic Neuropathy.
Anesthesiology125(3)573-89(2016 09)
Zychowska M,Rojewska E,Piotrowska A,Kreiner G,Mika J

Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis.
Scientific reports623505(2016 Mar)
Ohta T,Sugiyama M,Hemmi H,Yamazaki C,Okura S,Sasaki I,Fukuda Y,Orimo T,Ishii KJ,Hoshino K,Ginhoux F,Kaisho T

Aberrant tissue positioning of metallophilic macrophages in the thymus of XCL1-deficient mice.
Anatomical record (Hoboken, N.J. : 2007)297(8)1472-7(2014 Aug)
Mili?evi? NM,Lali? IM,Despotovi? SZ,?iri? DN,Westermann J,De Waal Malefyt R,Mili?evi? ?

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Xcl1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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