Laptm5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Laptm5
Entrez Gene ID	16792
Full Name	lysosomal-associated protein transmembrane 5
Synonyms	E3,Stra13
General protein information	Preferred Names lysosomal-associated protein transmembrane 5 Names lysosomal-associated transmembrane protein 5 lysosomal-associated multitransmembrane protein 5 retinoic acid-inducible E3 protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 D2.2

mRNA and Protein(s)

mRNA	Protein	Name
XM_017320001.1	XP_017175490.1	lysosomal-associated transmembrane protein 5 isoform X1
NM_010686.3	NP_034816.1	lysosomal-associated transmembrane protein 5
NM_010686.4	NP_034816.1	lysosomal-associated transmembrane protein 5

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LAPTM5	XP_513264.3
Canis lupus familiaris (dog)	LAPTM5	XP_005617741.1
Gallus gallus (chicken)	LAPTM5	XP_417701.1
Bos taurus (cattle)	LAPTM5	NP_001039583.1
Rattus norvegicus (Norway rat)	Laptm5	NP_445990.2
Xenopus tropicalis (tropical clawed frog)	laptm5	NP_001182638.1
Homo sapiens (human)	LAPTM5	NP_006753.1
	LOC704041	XP_001092380.2
Mus musculus (house mouse)	Laptm5	NP_034816.1

Gene Ontology
Bibliography

Related articles in PubMed

LAPTM5 promotes lysosomal degradation of intracellular CD3? but not of cell surface CD3?.
Kawai Y, Ouchida R, Yamasaki S, Dragone L, Tsubata T, Wang JY
Immunology and cell biology92(6)527-34(2014 Jul)

Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S
Proceedings of the National Academy of Sciences of the United States of America110(6)E507-16(2013 Feb)

A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosome-associated protein transmembrane 5.
Kawano Y, Ouchida R, Wang JY, Yoshikawa S, Yamamoto M, Kitamura D, Karasuyama H
Molecular and cellular biology32(21)4462-71(2012 Nov)

LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages.
Glowacka WK, Alberts P, Ouchida R, Wang JY, Rotin D
The Journal of biological chemistry287(33)27691-702(2012 Aug)

DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.
Abdallah BM, Ditzel N, Mahmood A, Isa A, Traustadottir GA, Schilling AF, Ruiz-Hidalgo MJ, Laborda J, Amling M, Kassem M
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research26(7)1457-71(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results suggest that CD3zeta can be degraded by two pathways: SLAP/c-Cbl, which targets internalized cell surface CD3zeta dependent on TCR signaling, and LAPTM5, which targets intracellular CD3zeta independent of TCR signaling.
Title: LAPTM5 promotes lysosomal degradation of intracellular CD3? but not of cell surface CD3?.

the pre-BCR induces the downmodulation of its own expression through induction of LAPTM5, which promotes the lysosomal transport and degradation of the intracellular pre-BCR pool and limits the supply of pre-BCR to the cell surface
Title: A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosome-associated protein transmembrane 5.

LAPTM5 acts as a positive modulator of inflammatory signaling pathways and hence cytokine secretion in macrophages
Title: LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages.

LAPTM5 physically interacts with the B cell receptor complex and promotes its degradation in the lysosomal compartment in mouse B cells.
Title: A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation.

the lysosomal protein LAPTM5 negatively regulated surface TCR expression by specifically interacting with the invariant signal-transducing CD3zeta chain and promoting its degradation
Title: A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation.

The following Laptm5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Laptm5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu06619	NM_010686.4 Latest version!	Mus musculus lysosomal-associated protein transmembrane 5 (Laptm5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu06619	XM_017320001.1 Latest version!	Mus musculus lysosomal-associated protein transmembrane 5 (Laptm5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu06619	NM_010686.3	Mus musculus lysosomal-associated protein transmembrane 5 (Laptm5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Laptm5 ( NM_010686.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034816.1 Mus musculus lysosomal-associated protein transmembrane 5 (Laptm5), mRNA.

Price & Availability↑

CloneID	OMu06619
Clone ID Related Accession (Same CDS sequence)	XM_017320001.1 , NM_010686.3 , NM_010686.4
Accession Version	NM_010686.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-26
Organism	Mus musculus(house mouse)
Product	lysosomal-associated transmembrane protein 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL627104.16. On Apr 17, 2007 this sequence version replaced NM_010686.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK172486.1, AK171280.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCCC GTGCAGCGCC GGTCAGACAG ACATGCTGTT GTTTCAACAT CCGAGTCGCC 
ACCATAGCCC TGGCCATTTA CCACATAGTC ATGAGTGTCC TGCTGTTCAT TGAGCATGTG 
GTGGAGGTGG CCCGCGGTAA AGTGTCCTGT AGGTTCTTCA AGATGCCGTA CCTCAGGATG 
GCTGACCTGC TCTCCAGCTT CCTGCTCATT GGCGTGCTCT TCATCATCAG CATCAGCCTG 
CTGTTCGGCG TGGTCAAGAA CCGGGAGAAG TACCTGATAC CCTTCCTGTC CCTTCAAATC 
ATGGACTTCC TGCTCTGCCT GCTCACACTG CTGGGCTCCT ACATCGAATT GCCAGCGTAC 
TTGAAGCTTG CCCGGCCCCG GCCTGGTCCT TCTAAGGTCC CCTTGATGAC ACTGCAGCTG 
CTAGACTTCT GTTTGAGTAT CCTGACCCTG TGCAGCTCCT ACATGGAAGT GCCCACCTAC 
CTCAACTTCA AGTCCATGAA CCACATGAAT TACCTCCCAA GCCAGGAGGG TGTGCCGCAC 
AGCCAGTTCA TCAACATGAT GCTCATCTTC TCAGTGGCCT TTATCACCGT GCTCATCCTG 
AAGGTCTACA TGTTCAAGTG TGTGTACACA TGCTACAAAT TCTTGAAGCA CATGAATTCG 
GCCATGGAGG ACAGCAGCTC CAAGATGTTC CTCAAGGTGG CTCTGCCGTC CTACGAGGAA 
GCCTTGTCTC TGCCCCCTAA GACTCCAGAG GGGGACCCTG CACCACCCCC ATACTCAGAA 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034816.1
CDS	19..804
Translation	MASRAAPVRQTCCCFNIRVATIALAIYHIVMSVLLFIEHVVEVARGKVSCRFFKMPYLRMADLLSSFLLIGVLFIISISLLFGVVKNREKYLIPFLSLQIMDFLLCLLTLLGSYIELPAYLKLARPRPGPSKVPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQEGVPHSQFINMMLIFSVAFITVLILKVYMFKCVYTCYKFLKHMNSAMEDSSSKMFLKVALPSYEEALSLPPKTPEGDPAPPPYSEV

Target ORF information:

RefSeq Version	NM_010686.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus lysosomal-associated protein transmembrane 5 (Laptm5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010686.3

ORF Insert Sequence:

ATGGCCTCCC GTGCAGCGCC GGTCAGACAG ACATGCTGTT GTTTCAACAT CCGAGTCGCC 
ACCATAGCCC TGGCCATTTA CCACATAGTC ATGAGTGTCC TGCTGTTCAT TGAGCATGTG 
GTGGAGGTGG CCCGCGGTAA AGTGTCCTGT AGGTTCTTCA AGATGCCGTA CCTCAGGATG 
GCTGACCTGC TCTCCAGCTT CCTGCTCATT GGCGTGCTCT TCATCATCAG CATCAGCCTG 
CTGTTCGGCG TGGTCAAGAA CCGGGAGAAG TACCTGATAC CCTTCCTGTC CCTTCAAATC 
ATGGACTTCC TGCTCTGCCT GCTCACACTG CTGGGCTCCT ACATCGAATT GCCAGCGTAC 
TTGAAGCTTG CCCGGCCCCG GCCTGGTCCT TCTAAGGTCC CCTTGATGAC ACTGCAGCTG 
CTAGACTTCT GTTTGAGTAT CCTGACCCTG TGCAGCTCCT ACATGGAAGT GCCCACCTAC 
CTCAACTTCA AGTCCATGAA CCACATGAAT TACCTCCCAA GCCAGGAGGG TGTGCCGCAC 
AGCCAGTTCA TCAACATGAT GCTCATCTTC TCAGTGGCCT TTATCACCGT GCTCATCCTG 
AAGGTCTACA TGTTCAAGTG TGTGTACACA TGCTACAAAT TCTTGAAGCA CATGAATTCG 
GCCATGGAGG ACAGCAGCTC CAAGATGTTC CTCAAGGTGG CTCTGCCGTC CTACGAGGAA 
GCCTTGTCTC TGCCCCCTAA GACTCCAGAG GGGGACCCTG CACCACCCCC ATACTCAGAA 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Laptm5 ( NM_010686.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034816.1 Mus musculus lysosomal-associated protein transmembrane 5 (Laptm5), mRNA.

Price & Availability↑

CloneID	OMu06619
Clone ID Related Accession (Same CDS sequence)	XM_017320001.1 , NM_010686.3 , NM_010686.4
Accession Version	NM_010686.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Mus musculus(house mouse)
Product	lysosomal-associated transmembrane protein 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL627104.16. On Aug 17, 2018 this sequence version replaced NM_010686.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK153877.1, AK163146.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCCC GTGCAGCGCC GGTCAGACAG ACATGCTGTT GTTTCAACAT CCGAGTCGCC 
ACCATAGCCC TGGCCATTTA CCACATAGTC ATGAGTGTCC TGCTGTTCAT TGAGCATGTG 
GTGGAGGTGG CCCGCGGTAA AGTGTCCTGT AGGTTCTTCA AGATGCCGTA CCTCAGGATG 
GCTGACCTGC TCTCCAGCTT CCTGCTCATT GGCGTGCTCT TCATCATCAG CATCAGCCTG 
CTGTTCGGCG TGGTCAAGAA CCGGGAGAAG TACCTGATAC CCTTCCTGTC CCTTCAAATC 
ATGGACTTCC TGCTCTGCCT GCTCACACTG CTGGGCTCCT ACATCGAATT GCCAGCGTAC 
TTGAAGCTTG CCCGGCCCCG GCCTGGTCCT TCTAAGGTCC CCTTGATGAC ACTGCAGCTG 
CTAGACTTCT GTTTGAGTAT CCTGACCCTG TGCAGCTCCT ACATGGAAGT GCCCACCTAC 
CTCAACTTCA AGTCCATGAA CCACATGAAT TACCTCCCAA GCCAGGAGGG TGTGCCGCAC 
AGCCAGTTCA TCAACATGAT GCTCATCTTC TCAGTGGCCT TTATCACCGT GCTCATCCTG 
AAGGTCTACA TGTTCAAGTG TGTGTACACA TGCTACAAAT TCTTGAAGCA CATGAATTCG 
GCCATGGAGG ACAGCAGCTC CAAGATGTTC CTCAAGGTGG CTCTGCCGTC CTACGAGGAA 
GCCTTGTCTC TGCCCCCTAA GACTCCAGAG GGGGACCCTG CACCACCCCC ATACTCAGAA 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034816.1
CDS	33..818
Translation	MASRAAPVRQTCCCFNIRVATIALAIYHIVMSVLLFIEHVVEVARGKVSCRFFKMPYLRMADLLSSFLLIGVLFIISISLLFGVVKNREKYLIPFLSLQIMDFLLCLLTLLGSYIELPAYLKLARPRPGPSKVPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQEGVPHSQFINMMLIFSVAFITVLILKVYMFKCVYTCYKFLKHMNSAMEDSSSKMFLKVALPSYEEALSLPPKTPEGDPAPPPYSEV

Target ORF information:

RefSeq Version	NM_010686.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus lysosomal-associated protein transmembrane 5 (Laptm5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010686.4

ORF Insert Sequence:

ATGGCCTCCC GTGCAGCGCC GGTCAGACAG ACATGCTGTT GTTTCAACAT CCGAGTCGCC 
ACCATAGCCC TGGCCATTTA CCACATAGTC ATGAGTGTCC TGCTGTTCAT TGAGCATGTG 
GTGGAGGTGG CCCGCGGTAA AGTGTCCTGT AGGTTCTTCA AGATGCCGTA CCTCAGGATG 
GCTGACCTGC TCTCCAGCTT CCTGCTCATT GGCGTGCTCT TCATCATCAG CATCAGCCTG 
CTGTTCGGCG TGGTCAAGAA CCGGGAGAAG TACCTGATAC CCTTCCTGTC CCTTCAAATC 
ATGGACTTCC TGCTCTGCCT GCTCACACTG CTGGGCTCCT ACATCGAATT GCCAGCGTAC 
TTGAAGCTTG CCCGGCCCCG GCCTGGTCCT TCTAAGGTCC CCTTGATGAC ACTGCAGCTG 
CTAGACTTCT GTTTGAGTAT CCTGACCCTG TGCAGCTCCT ACATGGAAGT GCCCACCTAC 
CTCAACTTCA AGTCCATGAA CCACATGAAT TACCTCCCAA GCCAGGAGGG TGTGCCGCAC 
AGCCAGTTCA TCAACATGAT GCTCATCTTC TCAGTGGCCT TTATCACCGT GCTCATCCTG 
AAGGTCTACA TGTTCAAGTG TGTGTACACA TGCTACAAAT TCTTGAAGCA CATGAATTCG 
GCCATGGAGG ACAGCAGCTC CAAGATGTTC CTCAAGGTGG CTCTGCCGTC CTACGAGGAA 
GCCTTGTCTC TGCCCCCTAA GACTCCAGAG GGGGACCCTG CACCACCCCC ATACTCAGAA 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Laptm5 ( XM_017320001.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017175490.1 Mus musculus lysosomal-associated protein transmembrane 5 (Laptm5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu06619
Clone ID Related Accession (Same CDS sequence)	XM_017320001.1 , NM_010686.3 , NM_010686.4
Accession Version	XM_017320001.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	lysosomal-associated transmembrane protein 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTCCC GTGCAGCGCC GGTCAGACAG ACATGCTGTT GTTTCAACAT CCGAGTCGCC 
ACCATAGCCC TGGCCATTTA CCACATAGTC ATGAGTGTCC TGCTGTTCAT TGAGCATGTG 
GTGGAGGTGG CCCGCGGTAA AGTGTCCTGT AGGTTCTTCA AGATGCCGTA CCTCAGGATG 
GCTGACCTGC TCTCCAGCTT CCTGCTCATT GGCGTGCTCT TCATCATCAG CATCAGCCTG 
CTGTTCGGCG TGGTCAAGAA CCGGGAGAAG TACCTGATAC CCTTCCTGTC CCTTCAAATC 
ATGGACTTCC TGCTCTGCCT GCTCACACTG CTGGGCTCCT ACATCGAATT GCCAGCGTAC 
TTGAAGCTTG CCCGGCCCCG GCCTGGTCCT TCTAAGGTCC CCTTGATGAC ACTGCAGCTG 
CTAGACTTCT GTTTGAGTAT CCTGACCCTG TGCAGCTCCT ACATGGAAGT GCCCACCTAC 
CTCAACTTCA AGTCCATGAA CCACATGAAT TACCTCCCAA GCCAGGAGGG TGTGCCGCAC 
AGCCAGTTCA TCAACATGAT GCTCATCTTC TCAGTGGCCT TTATCACCGT GCTCATCCTG 
AAGGTCTACA TGTTCAAGTG TGTGTACACA TGCTACAAAT TCTTGAAGCA CATGAATTCG 
GCCATGGAGG ACAGCAGCTC CAAGATGTTC CTCAAGGTGG CTCTGCCGTC CTACGAGGAA 
GCCTTGTCTC TGCCCCCTAA GACTCCAGAG GGGGACCCTG CACCACCCCC ATACTCAGAA 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017175490.1
CDS	164..949
Translation	MASRAAPVRQTCCCFNIRVATIALAIYHIVMSVLLFIEHVVEVARGKVSCRFFKMPYLRMADLLSSFLLIGVLFIISISLLFGVVKNREKYLIPFLSLQIMDFLLCLLTLLGSYIELPAYLKLARPRPGPSKVPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQEGVPHSQFINMMLIFSVAFITVLILKVYMFKCVYTCYKFLKHMNSAMEDSSSKMFLKVALPSYEEALSLPPKTPEGDPAPPPYSEV

Target ORF information:

RefSeq Version	XM_017320001.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus lysosomal-associated protein transmembrane 5 (Laptm5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017320001.1

ORF Insert Sequence:

ATGGCCTCCC GTGCAGCGCC GGTCAGACAG ACATGCTGTT GTTTCAACAT CCGAGTCGCC 
ACCATAGCCC TGGCCATTTA CCACATAGTC ATGAGTGTCC TGCTGTTCAT TGAGCATGTG 
GTGGAGGTGG CCCGCGGTAA AGTGTCCTGT AGGTTCTTCA AGATGCCGTA CCTCAGGATG 
GCTGACCTGC TCTCCAGCTT CCTGCTCATT GGCGTGCTCT TCATCATCAG CATCAGCCTG 
CTGTTCGGCG TGGTCAAGAA CCGGGAGAAG TACCTGATAC CCTTCCTGTC CCTTCAAATC 
ATGGACTTCC TGCTCTGCCT GCTCACACTG CTGGGCTCCT ACATCGAATT GCCAGCGTAC 
TTGAAGCTTG CCCGGCCCCG GCCTGGTCCT TCTAAGGTCC CCTTGATGAC ACTGCAGCTG 
CTAGACTTCT GTTTGAGTAT CCTGACCCTG TGCAGCTCCT ACATGGAAGT GCCCACCTAC 
CTCAACTTCA AGTCCATGAA CCACATGAAT TACCTCCCAA GCCAGGAGGG TGTGCCGCAC 
AGCCAGTTCA TCAACATGAT GCTCATCTTC TCAGTGGCCT TTATCACCGT GCTCATCCTG 
AAGGTCTACA TGTTCAAGTG TGTGTACACA TGCTACAAAT TCTTGAAGCA CATGAATTCG 
GCCATGGAGG ACAGCAGCTC CAAGATGTTC CTCAAGGTGG CTCTGCCGTC CTACGAGGAA 
GCCTTGTCTC TGCCCCCTAA GACTCCAGAG GGGGACCCTG CACCACCCCC ATACTCAGAA 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LAPTM5 promotes lysosomal degradation of intracellular CD3? but not of cell surface CD3?.
Immunology and cell biology92(6)527-34(2014 Jul)
Kawai Y,Ouchida R,Yamasaki S,Dragone L,Tsubata T,Wang JY

Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
Proceedings of the National Academy of Sciences of the United States of America110(6)E507-16(2013 Feb)
Lumayag S,Haldin CE,Corbett NJ,Wahlin KJ,Cowan C,Turturro S,Larsen PE,Kovacs B,Witmer PD,Valle D,Zack DJ,Nicholson DA,Xu S

A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosome-associated protein transmembrane 5.
Molecular and cellular biology32(21)4462-71(2012 Nov)
Kawano Y,Ouchida R,Wang JY,Yoshikawa S,Yamamoto M,Kitamura D,Karasuyama H

LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages.
The Journal of biological chemistry287(33)27691-702(2012 Aug)
Glowacka WK,Alberts P,Ouchida R,Wang JY,Rotin D

DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research26(7)1457-71(2011 Jul)
Abdallah BM,Ditzel N,Mahmood A,Isa A,Traustadottir GA,Schilling AF,Ruiz-Hidalgo MJ,Laborda J,Amling M,Kassem M

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Laptm5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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