Kcnk3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnk3
Entrez Gene ID	16527
Full Name	potassium channel, subfamily K, member 3
Synonyms	TASK,Task-1,cTBAK-1
General protein information	Preferred Names potassium channel, subfamily K, member 3 Names potassium channel subfamily K member 3 TWIK-related acid-sensitive K(+) channel 1 acid-sensitive potassium channel protein TASK-1 cardiac two pore background K(+) channel two pore K(+) channel KT3.1 two pore potassium channel KT3.1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 B1\|5 16.68 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010608.2	NP_034738.1	potassium channel subfamily K member 3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Kcnk3	NP_203694.1
Danio rerio (zebrafish)	kcnk3	NP_001025333.1
	KCNK3	XP_001087754.1
Canis lupus familiaris (dog)	KCNK3	XP_540117.3
Mus musculus (house mouse)	Kcnk3	NP_034738.1
Homo sapiens (human)	KCNK3	NP_002237.1
Gallus gallus (chicken)	KCNK9	XP_003641103.1
Bos taurus (cattle)	KCNK3	XP_002691504.1

Gene Ontology
Bibliography

Related articles in PubMed

Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity.
Chen Y, Zeng X, Huang X, Serag S, Woolf CJ, Spiegelman BM
Cell171(4)836-848.e13(2017 Nov)

Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice.
Buehler PK, Bleiler D, Tegtmeier I, Heitzmann D, Both C, Georgieff M, Lesage F, Warth R, Thomas J
Respiratory physiology & neurobiology24417-25(2017 Oct)

Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.
Leist M, Rinn? S, Datunashvili M, Aissaoui A, Pape HC, Decher N, Meuth SG, Budde T
The Journal of physiology595(17)5875-5893(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Adipose-specific Kcnk3 knockout mice display increased energy expenditure and are resistant to hypothermia and obesity.
Title: Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity.

While there is compelling evidence that TASK-1 is involved in the pathogenesis of pulmonary arterial hypertension in humans, the mouse does not appear to serve as a suitable model to study the underlying molecular mechanisms
Title: TASK-1 potassium channel is not critically involved in mediating hypoxic pulmonary vasoconstriction of murine intra-pulmonary arteries.

the K(+) channel TASK1 controls the thermogenic activity in brown adipocytes through modulation of beta-adrenergic receptor signaling.
Title: The K+ channel TASK1 modulates ?-adrenergic response in brown adipose tissue through the mineralocorticoid receptor pathway.

KCNK3 channels are not involved in hearing.
Title: KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.

This study showed TASK channels on cholinergic neurons contribute to endogenous EEG oscillations (including gamma activity) and the electrocortical response to histamine at the basal forebrain in vivo.
Title: TASK Channels on Basal Forebrain Cholinergic Neurons Modulate Electrocortical Signatures of Arousal by Histamine.

The following Kcnk3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnk3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21611	NM_010608.2 Latest version!	Mus musculus potassium channel, subfamily K, member 3 (Kcnk3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnk3 ( NM_010608.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034738.1 Mus musculus potassium channel, subfamily K, member 3 (Kcnk3), mRNA.

Price & Availability↑

CloneID	OMu21611
Clone ID Related Accession (Same CDS sequence)	NM_010608.2
Accession Version	NM_010608.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Mus musculus(house mouse)
Product	potassium channel subfamily K member 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC120408.7, AI325858.1 and AC105298.21. On or before May 4, 2006 this sequence version replaced XM_990938.1, NM_010608.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032047.1, AB013345.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCGGC AGAATGTGCG CACGTTGGCT CTCATCGTGT GCACCTTCAC CTACCTGCTG 
GTGGGCGCCG CGGTGTTCGA CGCACTGGAG TCGGAGCCGG AGATGATCGA GCGGCAGCGG 
CTGGAGCTGC GGCAGCTGGA GCTGCGGGCG CGCTACAACC TCAGCGAGGG CGGCTACGAG 
GAGCTGGAGC GCGTCGTGCT GCGCCTCAAG CCGCACAAGG CCGGCGTGCA GTGGCGCTTC 
GCCGGCTCCT TCTACTTCGC CATCACCGTC ATCACCACCA TCGGCTATGG TCATGCGGCG 
CCCAGCACGG ACGGAGGCAA GGTGTTCTGC ATGTTCTACG CGCTGCTGGG CATCCCGCTC 
ACACTAGTCA TGTTCCAGAG CCTGGGTGAA CGCATCAACA CCTTCGTGAG GTACCTGCTG 
CACCGTGCCA AGAGGGGGCT GGGCATGCGG CACGCCGAGG TGTCCATGGC CAACATGGTG 
CTCATCGGTT TCGTGTCGTG CATCAGCACG CTGTGCATCG GCGCAGCTGC CTTCTCCTAC 
TACGAGCGCT GGACTTTCTT CCAGGCCTAT TACTACTGCT TCATCACCCT CACCACCATC 
GGCTTCGGCG ACTATGTGGC GCTGCAGAAG GACCAGGCGC TGCAGACGCA GCCGCAGTAT 
GTGGCCTTCA GCTTCGTGTA CATCCTCACG GGCCTCACGG TCATCGGCGC CTTCCTCAAC 
CTCGTGGTGC TGCGATTCAT GACCATGAAC GCCGAGGACG AGAAGCGTGA TGCGGAGCAC 
CGCGCCCTGC TCACGCACAA CGGCCAGGCT GTCGGCCTGG GTGGCCTGAG CTGCCTGAGC 
GGTAGCCTGG GCGACGGCGT GCGTCCCCGC GACCCAGTCA CATGCGCTGC GGCCGCGGGA 
GGCGTGGGCG TGGGCGTCGG TGGCAGCGGC TTCCGCAACG TCTATGCCGA GGTGCTGCAC 
TTCCAGTCCA TGTGCTCGTG CCTCTGGTAC AAGAGCCGCG AGAAGCTGCA GTACTCCATC 
CCCATGATCA TCCCGCGGGA CCTCTCCACG TCCGACACCT GCGTGGAGCA CAGCCACTCG 
TCGCCGGGAG GCGGCGGCCG CTACAGCGAC ACGCCCTCAC ACCCCTGCCT GTGCAGCGGG 
ACGCAGCGCT CGGCCATCAG CTCGGTGTCC ACGGGCCTGC ACAGCCTGGC TGCCTTCCGC 
GGCCTCATGA AGCGCAGGAG CTCGGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034738.1
CDS	148..1377
Translation	MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPEMIERQRLELRQLELRARYNLSEGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTFVRYLLHRAKRGLGMRHAEVSMANMVLIGFVSCISTLCIGAAAFSYYERWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTHNGQAVGLGGLSCLSGSLGDGVRPRDPVTCAAAAGGVGVGVGGSGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEHSHSSPGGGGRYSDTPSHPCLCSGTQRSAISSVSTGLHSLAAFRGLMKRRSSV

Target ORF information:

RefSeq Version	NM_010608.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus potassium channel, subfamily K, member 3 (Kcnk3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010608.2

ORF Insert Sequence:

ATGAAGCGGC AGAATGTGCG CACGTTGGCT CTCATCGTGT GCACCTTCAC CTACCTGCTG 
GTGGGCGCCG CGGTGTTCGA CGCACTGGAG TCGGAGCCGG AGATGATCGA GCGGCAGCGG 
CTGGAGCTGC GGCAGCTGGA GCTGCGGGCG CGCTACAACC TCAGCGAGGG CGGCTACGAG 
GAGCTGGAGC GCGTCGTGCT GCGCCTCAAG CCGCACAAGG CCGGCGTGCA GTGGCGCTTC 
GCCGGCTCCT TCTACTTCGC CATCACCGTC ATCACCACCA TCGGCTATGG TCATGCGGCG 
CCCAGCACGG ACGGAGGCAA GGTGTTCTGC ATGTTCTACG CGCTGCTGGG CATCCCGCTC 
ACACTAGTCA TGTTCCAGAG CCTGGGTGAA CGCATCAACA CCTTCGTGAG GTACCTGCTG 
CACCGTGCCA AGAGGGGGCT GGGCATGCGG CACGCCGAGG TGTCCATGGC CAACATGGTG 
CTCATCGGTT TCGTGTCGTG CATCAGCACG CTGTGCATCG GCGCAGCTGC CTTCTCCTAC 
TACGAGCGCT GGACTTTCTT CCAGGCCTAT TACTACTGCT TCATCACCCT CACCACCATC 
GGCTTCGGCG ACTATGTGGC GCTGCAGAAG GACCAGGCGC TGCAGACGCA GCCGCAGTAT 
GTGGCCTTCA GCTTCGTGTA CATCCTCACG GGCCTCACGG TCATCGGCGC CTTCCTCAAC 
CTCGTGGTGC TGCGATTCAT GACCATGAAC GCCGAGGACG AGAAGCGTGA TGCGGAGCAC 
CGCGCCCTGC TCACGCACAA CGGCCAGGCT GTCGGCCTGG GTGGCCTGAG CTGCCTGAGC 
GGTAGCCTGG GCGACGGCGT GCGTCCCCGC GACCCAGTCA CATGCGCTGC GGCCGCGGGA 
GGCGTGGGCG TGGGCGTCGG TGGCAGCGGC TTCCGCAACG TCTATGCCGA GGTGCTGCAC 
TTCCAGTCCA TGTGCTCGTG CCTCTGGTAC AAGAGCCGCG AGAAGCTGCA GTACTCCATC 
CCCATGATCA TCCCGCGGGA CCTCTCCACG TCCGACACCT GCGTGGAGCA CAGCCACTCG 
TCGCCGGGAG GCGGCGGCCG CTACAGCGAC ACGCCCTCAC ACCCCTGCCT GTGCAGCGGG 
ACGCAGCGCT CGGCCATCAG CTCGGTGTCC ACGGGCCTGC ACAGCCTGGC TGCCTTCCGC 
GGCCTCATGA AGCGCAGGAG CTCGGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity.
Cell171(4)836-848.e13(2017 Nov)
Chen Y,Zeng X,Huang X,Serag S,Woolf CJ,Spiegelman BM

Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice.
Respiratory physiology & neurobiology24417-25(2017 Oct)
Buehler PK,Bleiler D,Tegtmeier I,Heitzmann D,Both C,Georgieff M,Lesage F,Warth R,Thomas J

Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.
The Journal of physiology595(17)5875-5893(2017 Sep)
Leist M,Rinn? S,Datunashvili M,Aissaoui A,Pape HC,Decher N,Meuth SG,Budde T

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Kcnk3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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