Inhbe cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Inhbe
Entrez Gene ID	16326
Full Name	inhibin beta-E
General protein information	Preferred Names inhibin beta-E Names inhibin beta E chain activin beta-E chain
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 D3\|10 74.5 cM
Summary	This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008382.3	NP_032408.2	inhibin beta E chain preproprotein

Pathways from BioSystems

Homologies

	INHBE	XP_001115958.1
Rattus norvegicus (Norway rat)	Inhbe	NP_114003.2
Xenopus tropicalis (tropical clawed frog)	inhbc	XP_002939474.1
Pan troglodytes (chimpanzee)	INHBE	XP_509161.2
Mus musculus (house mouse)	Inhbe	NP_032408.2
Homo sapiens (human)	INHBE	NP_113667.1
Canis lupus familiaris (dog)	INHBE	XP_005625595.1
Bos taurus (cattle)	INHBE	NP_001192771.1

Gene Ontology
Bibliography

Related articles in PubMed

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Transforming growth factor-? superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis.
Suragani RN, Cadena SM, Cawley SM, Sako D, Mitchell D, Li R, Davies MV, Alexander MJ, Devine M, Loveday KS, Underwood KW, Grinberg AV, Quisel JD, Chopra R, Pearsall RS, Seehra J, Kumar R
Nature medicine20(4)408-14(2014 Apr)

Regulation of muscle mass by follistatin and activins.
Lee SJ, Lee YS, Zimmers TA, Soleimani A, Matzuk MM, Tsuchida K, Cohn RD, Barton ER
Molecular endocrinology (Baltimore, Md.)24(10)1998-2008(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Taking these results together, activin E may act as a regulator of the hypothalamic-pituitary-adrenal axis.
Title: Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E.

activin E has a role in regulating the proliferation of pancreatic exocrine cells
Title: Impaired growth of pancreatic exocrine cells in transgenic mice expressing human activin betaE subunit.

results indicate that the beta(C) and beta(E) subunits of activin form homo- and heterodimers, and that the functions of the two subunits are quite different
Title: Comparison of the function of the beta(C) and beta(E) subunits of activin in AML12 hepatocytes.

The following Inhbe gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Inhbe cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01816	NM_008382.3 Latest version!	Mus musculus inhibin beta-E (Inhbe), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Inhbe ( NM_008382.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032408.2 Mus musculus inhibin beta-E (Inhbe), mRNA.

Price & Availability↑

CloneID	OMu01816
Clone ID Related Accession (Same CDS sequence)	NM_008382.3
Accession Version	NM_008382.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	inhibin beta E chain preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC114678.20, BY139130.1, AI452079.1 and CJ238406.1. On Sep 3, 2016 this sequence version replaced NM_008382.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U96386.1, BC010404.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTTC CAAAAGCCCA GCTCTGGCTA ATACTGCTGT GGGCATTGGT GTGGGTGCAG 
AGTACAAGAT CTGCGTGCCC GTCCTGTGGG GGCCCAACAC TGGCACCCCA AGGAGAACGC 
GCTCTGGTCC TGGAGCTAGC CAAGCAGCAA ATCCTGGAGG GACTGCACCT AACCAGCCGT 
CCCAGAATAA CTCGGCCTCT GCCCCAGGCA GCACTGACCA GAGCCCTCCG GAGACTGCAG 
CCCAAGAGCA TGGTCCCTGG CAACCGAGAG AAAGTCATCA GCTTTGCTAC CATCATAGAC 
AAATCCACTT CAACCTACCG CTCCATGCTC ACCTTCCAGC TGTCCCCTCT TTGGTCCCAC 
CACCTGTACC ATGCCCGCCT CTGGCTGCAT GTGCCTCCCT CTTTTCCGGG CACTCTGTAC 
CTGAGGATCT TCCGTTGCGG CACCACTAGG TGCCGAGGAT TCCGCACCTT CCTAGCTGAG 
CACCAAACCA CTTCCTCTGG CTGGCACGCC CTGACTCTGC CCTCTAGCGG CTTGCGGAGT 
GAGGACTCTG GCGTCGTGAA ACTCCAACTG GAATTTAGAC CCCTGGACCT TAACAGCACC 
GCTGCGGGAC TGCCACGGCT GCTCTTGGAC ACAGCGGGAC AGCAACGTCC CTTCTTGGAA 
CTTAAGATCC GAGCTAATGA ACCTGGAGCA GGTCGGGCCA GGAGGAGGAC TCCCACCTGT 
GAGCCTGAGA CCCCCTTATG TTGTAGGCGA GACCACTATG TAGACTTCCA GGAGCTGGGG 
TGGCGGGATT GGATCCTGCA GCCGGAGGGA TACCAGCTGA ATTACTGCAG TGGGCAGTGC 
CCGCCCCACC TGGCTGGCAG TCCTGGCATT GCTGCCTCCT TCCATTCTGC CGTCTTTAGC 
CTCCTCAAAG CCAACAACCC TTGGCCTGCG GGTTCTTCCT GCTGTGTCCC CACTGCACGA 
AGGCCTCTCT CTCTCCTCTA CCTTGACCAT AATGGCAATG TGGTCAAGAC CGATGTGCCA 
GACATGGTAG TAGAGGCCTG TGGCTGCAGC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032408.2
CDS	304..1356
Translation	MKLPKAQLWLILLWALVWVQSTRSACPSCGGPTLAPQGERALVLELAKQQILEGLHLTSRPRITRPLPQAALTRALRRLQPKSMVPGNREKVISFATIIDKSTSTYRSMLTFQLSPLWSHHLYHARLWLHVPPSFPGTLYLRIFRCGTTRCRGFRTFLAEHQTTSSGWHALTLPSSGLRSEDSGVVKLQLEFRPLDLNSTAAGLPRLLLDTAGQQRPFLELKIRANEPGAGRARRRTPTCEPETPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPAGSSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS

Target ORF information:

RefSeq Version	NM_008382.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus inhibin beta-E (Inhbe), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008382.3

ORF Insert Sequence:

ATGAAGCTTC CAAAAGCCCA GCTCTGGCTA ATACTGCTGT GGGCATTGGT GTGGGTGCAG 
AGTACAAGAT CTGCGTGCCC GTCCTGTGGG GGCCCAACAC TGGCACCCCA AGGAGAACGC 
GCTCTGGTCC TGGAGCTAGC CAAGCAGCAA ATCCTGGAGG GACTGCACCT AACCAGCCGT 
CCCAGAATAA CTCGGCCTCT GCCCCAGGCA GCACTGACCA GAGCCCTCCG GAGACTGCAG 
CCCAAGAGCA TGGTCCCTGG CAACCGAGAG AAAGTCATCA GCTTTGCTAC CATCATAGAC 
AAATCCACTT CAACCTACCG CTCCATGCTC ACCTTCCAGC TGTCCCCTCT TTGGTCCCAC 
CACCTGTACC ATGCCCGCCT CTGGCTGCAT GTGCCTCCCT CTTTTCCGGG CACTCTGTAC 
CTGAGGATCT TCCGTTGCGG CACCACTAGG TGCCGAGGAT TCCGCACCTT CCTAGCTGAG 
CACCAAACCA CTTCCTCTGG CTGGCACGCC CTGACTCTGC CCTCTAGCGG CTTGCGGAGT 
GAGGACTCTG GCGTCGTGAA ACTCCAACTG GAATTTAGAC CCCTGGACCT TAACAGCACC 
GCTGCGGGAC TGCCACGGCT GCTCTTGGAC ACAGCGGGAC AGCAACGTCC CTTCTTGGAA 
CTTAAGATCC GAGCTAATGA ACCTGGAGCA GGTCGGGCCA GGAGGAGGAC TCCCACCTGT 
GAGCCTGAGA CCCCCTTATG TTGTAGGCGA GACCACTATG TAGACTTCCA GGAGCTGGGG 
TGGCGGGATT GGATCCTGCA GCCGGAGGGA TACCAGCTGA ATTACTGCAG TGGGCAGTGC 
CCGCCCCACC TGGCTGGCAG TCCTGGCATT GCTGCCTCCT TCCATTCTGC CGTCTTTAGC 
CTCCTCAAAG CCAACAACCC TTGGCCTGCG GGTTCTTCCT GCTGTGTCCC CACTGCACGA 
AGGCCTCTCT CTCTCCTCTA CCTTGACCAT AATGGCAATG TGGTCAAGAC CGATGTGCCA 
GACATGGTAG TAGAGGCCTG TGGCTGCAGC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Transforming growth factor-? superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis.
Nature medicine20(4)408-14(2014 Apr)
Suragani RN,Cadena SM,Cawley SM,Sako D,Mitchell D,Li R,Davies MV,Alexander MJ,Devine M,Loveday KS,Underwood KW,Grinberg AV,Quisel JD,Chopra R,Pearsall RS,Seehra J,Kumar R

Regulation of muscle mass by follistatin and activins.
Molecular endocrinology (Baltimore, Md.)24(10)1998-2008(2010 Oct)
Lee SJ,Lee YS,Zimmers TA,Soleimani A,Matzuk MM,Tsuchida K,Cohn RD,Barton ER

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Inhbe cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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