Inhbb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Inhbb
Entrez Gene ID	16324
Full Name	inhibin beta-B
General protein information	Preferred Names inhibin beta-B Names inhibin beta B chain activin beta-B chain
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 E2.3\|1 52.29 cM
Summary	This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Homozygous knockout mice for this gene exhibit eyelid defects. [provided by RefSeq, Aug 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008381.4	NP_032407.1	inhibin beta B chain preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	INHBB	NP_002184.2
	INHBB	XP_001090729.2
Rattus norvegicus (Norway rat)	Inhbb	NP_542949.1
Bos taurus (cattle)	INHBB	NP_789822.1
Mus musculus (house mouse)	Inhbb	NP_032407.1
Gallus gallus (chicken)	INHBB	NP_990537.1
Danio rerio (zebrafish)	inhbb	NP_571143.2

Gene Ontology
Bibliography

Related articles in PubMed

Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2
Maresch CC, Stute DC, Ludlow H, Hammes HP, de Kretser DM, Hedger MP, Linn T
Molecular and cellular endocrinology44691-101(2017 May)

Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification.
Gherardi S, Ripoche D, Mikaelian I, Chanal M, Teinturier R, Goehrig D, Cordier-Bussat M, Zhang CX, Hennino A, Bertolino P
Biochimica et biophysica acta1860(4)427-437(2017 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that prolonged exposure to hyperglycemia in the Ins2(Akita+/-) mice leads to progressive testicular disruption mediated by testicular activin activity, rather than hormonal dysregulation.
Title: Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2

Menin binds on the promoter of Inhbb gene where it favours the recruitment of Ezh2 via an indirect mechanism involving Akt-phosphorylation.
Title: Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification.

This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3, as a model of immature Leydig cells.
Title: Endogenous inhibins regulate steroidogenesis in mouse TM3 Leydig cells by altering SMAD2 signalling.

Activin B, a transforming growth factor beta - related ligand, is upregulated during tumorigenesis and drives the loss of insulin expression and beta-cell maturity in a mouse insulinoma model.
Title: ActivinB Is Induced in Insulinoma To Promote Tumor Plasticity through a ?-Cell-Induced Dedifferentiation.

Data suggest Inhbb is physiologically essential for early folliculogenesis; Inhbb appears to participate in regulation of cell cycle progression, apoptosis, and steroidogenesis (estradiol/progesterone synthesis) in ovarian granulosa cells in culture.
Title: RNAi-mediated knockdown of INHBB increases apoptosis and inhibits steroidogenesis in mouse granulosa cells.

The following Inhbb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Inhbb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18448	NM_008381.4 Latest version!	Mus musculus inhibin beta-B (Inhbb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Inhbb ( NM_008381.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032407.1 Mus musculus inhibin beta-B (Inhbb), mRNA.

Price & Availability↑

CloneID	OMu18448
Clone ID Related Accession (Same CDS sequence)	NM_008381.4
Accession Version	NM_008381.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	inhibin beta B chain preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK132352.1, CB245693.1 and BP771405.1. On Aug 4, 2016 this sequence version replaced NM_008381.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC048845.1, AK132352.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGGGC TGCCCGGTCG GGCGTTGGGG GCCGCCTGCC TTCTGCTCCT GGTGGCCGGC 
TGGTTGGGAC CCGAGGCCTG GGGCTCTCCC ACACCCCCGC CGTCGCCCGC TGCGCCGCCC 
CCGCCCCCGC CACCCGGAGC TCCGGGTGGC TCGCAGGACA CCTGTACGTC GTGCGGTGGC 
GGCGGCGGCG GCTTCCGGCG GCCGGAGGAG CTGGGCCGGG TGGACGGTGA CTTCCTGGAG 
GCGGTGAAGA GACACATCTT GAGCCGCCTG CAGTTGCGGG GCCGGCCCAA CATCACGCAC 
GCTGTCCCCA AGGCCGCCAT GGTCACGGCC CTGCGCAAGC TGCACGCCGG CAAGGTGCGC 
GAGGACGGCC GCGTGGAGAT CCCGCACCTC GACGGCCACG CCAGCCCGGG CGCCGACGGC 
CAGGAGCGCG TCTCCGAGAT CATCAGCTTT GCAGAGACAG ATGGCCTCGC CTCCTCCCGG 
GTCCGCCTGT ACTTCTTCGT CTCTAATGAA GGCAACCAGA ACCTATTCGT GGTGCAGGCC 
AGCCTGTGGC TGTACCTGAA ACTGCTCCCC TATGTCCTGG AGAAGGGCAG CAGGAGGAAG 
GTACGGGTCA AGGTGTACTT CCAAGAACAG GGTCACGGAG ACAGGTGGAA TGTGGTGGAG 
AAGAAGGTGG ACCTGAAACG TAGCGGCTGG CATACCTTTC CCATCACAGA GGCCATCCAG 
GCCTTGTTTG AGCGAGGGGA GAGACGCCTT AACCTGGATG TGCAGTGTGA CAGCTGCCAG 
GAGCTGGCCG TGGTGCCTGT GTTCGTGGAC CCCGGTGAGG AGTCACACAG GCCCTTTGTA 
GTGGTGCAGG CCCGCCTGGG CGATAGCAGA CATCGCATCC GCAAACGGGG CCTAGAGTGT 
GATGGGCGGA CCAGCCTCTG TTGCAGGCAA CAGTTCTTCA TCGACTTTCG GCTCATCGGC 
TGGAACGACT GGATCATTGC GCCCACTGGC TACTACGGGA ACTACTGTGA GGGCAGCTGC 
CCGGCCTATC TGGCCGGGGT CCCTGGCTCA GCTTCCTCCT TCCACACAGC CGTGGTGAAC 
CAGTACCGCA TGCGTGGCCT GAACCCTGGG CCCGTGAACT CTTGCTGCAT CCCTACCAAG 
CTGAGCTCCA TGTCCATGCT CTACTTTGAT GACGAGTACA ACATTGTCAA GCGGGATGTG 
CCCAACATGA TCGTGGAGGA GTGTGGCTGC GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032407.1
CDS	1163..2398
Translation	MDGLPGRALGAACLLLLVAGWLGPEAWGSPTPPPSPAAPPPPPPPGAPGGSQDTCTSCGGGGGGFRRPEELGRVDGDFLEAVKRHILSRLQLRGRPNITHAVPKAAMVTALRKLHAGKVREDGRVEIPHLDGHASPGADGQERVSEIISFAETDGLASSRVRLYFFVSNEGNQNLFVVQASLWLYLKLLPYVLEKGSRRKVRVKVYFQEQGHGDRWNVVEKKVDLKRSGWHTFPITEAIQALFERGERRLNLDVQCDSCQELAVVPVFVDPGEESHRPFVVVQARLGDSRHRIRKRGLECDGRTSLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGPVNSCCIPTKLSSMSMLYFDDEYNIVKRDVPNMIVEECGCA

Target ORF information:

RefSeq Version	NM_008381.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus inhibin beta-B (Inhbb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008381.4

ORF Insert Sequence:

ATGGACGGGC TGCCCGGTCG GGCGTTGGGG GCCGCCTGCC TTCTGCTCCT GGTGGCCGGC 
TGGTTGGGAC CCGAGGCCTG GGGCTCTCCC ACACCCCCGC CGTCGCCCGC TGCGCCGCCC 
CCGCCCCCGC CACCCGGAGC TCCGGGTGGC TCGCAGGACA CCTGTACGTC GTGCGGTGGC 
GGCGGCGGCG GCTTCCGGCG GCCGGAGGAG CTGGGCCGGG TGGACGGTGA CTTCCTGGAG 
GCGGTGAAGA GACACATCTT GAGCCGCCTG CAGTTGCGGG GCCGGCCCAA CATCACGCAC 
GCTGTCCCCA AGGCCGCCAT GGTCACGGCC CTGCGCAAGC TGCACGCCGG CAAGGTGCGC 
GAGGACGGCC GCGTGGAGAT CCCGCACCTC GACGGCCACG CCAGCCCGGG CGCCGACGGC 
CAGGAGCGCG TCTCCGAGAT CATCAGCTTT GCAGAGACAG ATGGCCTCGC CTCCTCCCGG 
GTCCGCCTGT ACTTCTTCGT CTCTAATGAA GGCAACCAGA ACCTATTCGT GGTGCAGGCC 
AGCCTGTGGC TGTACCTGAA ACTGCTCCCC TATGTCCTGG AGAAGGGCAG CAGGAGGAAG 
GTACGGGTCA AGGTGTACTT CCAAGAACAG GGTCACGGAG ACAGGTGGAA TGTGGTGGAG 
AAGAAGGTGG ACCTGAAACG TAGCGGCTGG CATACCTTTC CCATCACAGA GGCCATCCAG 
GCCTTGTTTG AGCGAGGGGA GAGACGCCTT AACCTGGATG TGCAGTGTGA CAGCTGCCAG 
GAGCTGGCCG TGGTGCCTGT GTTCGTGGAC CCCGGTGAGG AGTCACACAG GCCCTTTGTA 
GTGGTGCAGG CCCGCCTGGG CGATAGCAGA CATCGCATCC GCAAACGGGG CCTAGAGTGT 
GATGGGCGGA CCAGCCTCTG TTGCAGGCAA CAGTTCTTCA TCGACTTTCG GCTCATCGGC 
TGGAACGACT GGATCATTGC GCCCACTGGC TACTACGGGA ACTACTGTGA GGGCAGCTGC 
CCGGCCTATC TGGCCGGGGT CCCTGGCTCA GCTTCCTCCT TCCACACAGC CGTGGTGAAC 
CAGTACCGCA TGCGTGGCCT GAACCCTGGG CCCGTGAACT CTTGCTGCAT CCCTACCAAG 
CTGAGCTCCA TGTCCATGCT CTACTTTGAT GACGAGTACA ACATTGTCAA GCGGGATGTG 
CCCAACATGA TCGTGGAGGA GTGTGGCTGC GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2
Molecular and cellular endocrinology44691-101(2017 May)
Maresch CC,Stute DC,Ludlow H,Hammes HP,de Kretser DM,Hedger MP,Linn T

Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification.
Biochimica et biophysica acta1860(4)427-437(2017 04)
Gherardi S,Ripoche D,Mikaelian I,Chanal M,Teinturier R,Goehrig D,Cordier-Bussat M,Zhang CX,Hennino A,Bertolino P

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Inhbb cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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